公开(公告)号：US20210115016A1

公开(公告)日：2021-04-22

申请号：US16631738

申请日：2018-07-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  Alice Chen RICO ,  James Clifford SUTTON, Jr.

IPC: C07D401/12 ,  C07D403/12 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  C07D215/12 ,  C07D217/18 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

公开(公告)号：US20210002297A1

公开(公告)日：2021-01-07

申请号：US17023980

申请日：2020-09-17

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  James Clifford SUTTON, JR.

IPC: C07D498/04 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D513/04 ,  C07D519/00

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US20230039955A1

公开(公告)日：2023-02-09

申请号：US17853647

申请日：2022-06-29

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  James Clifford SUTTON, JR.

IPC: C07D498/04 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D513/04 ,  C07D519/00

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2e and R2d have the meanings provided in the specification.

公开(公告)号：US20190270754A1

公开(公告)日：2019-09-05

申请号：US16268444

申请日：2019-02-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  James Clifford SUTTON, JR.

IPC: C07D498/04 ,  A61P35/00 ,  C07D487/04 ,  C07D491/107 ,  C07D513/04 ,  C07D471/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US20220340875A1

公开(公告)日：2022-10-27

申请号：US17260936

申请日：2019-07-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Fred ASWAD ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  Yujiro HATA ,  Alice Chen RICO ,  James Clifford SUTTON, Jr.

IPC: C12N5/0789 ,  A61K35/28

Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae: wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

公开(公告)号：US20220106276A1

公开(公告)日：2022-04-07

申请号：US17311873

申请日：2019-12-09

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Leah CLEARY ,  Melissa FLEURY ,  Zhonghua PEI ,  Richard STEEL ,  James SUTTON ,  John E. KNOX ,  Zachary E. R. NEWBY

IPC: C07D239/95 ,  C07D401/04 ,  C07D405/12 ,  C07D417/04 ,  C07D403/04 ,  C07D413/04 ,  A61P35/00 ,  C07D239/96 ,  C07D471/04

Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

公开(公告)号：US20210254006A1

公开(公告)日：2021-08-19

申请号：US16972181

申请日：2019-06-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Fred ASWAD ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  Yujiro HATA ,  James Clifford SUTTON, Jr.

IPC: C12N5/0789 ,  A61K35/28 ,  A61L29/16 ,  A61L31/16

Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, at least in part, by using lactam compounds that antagonize AhR. The compounds are represented by formula (I): wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided below. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.