公开(公告)号：US20160245746A1

公开(公告)日：2016-08-25

申请号：US15031825

申请日：2014-10-30

Applicant: KONICA MINOLTA, INC.

Inventor： Tetsuya NODA ,  Masataka MATSUO ,  Yoshimasa HAMANO ,  Hiroshi HIRAYAMA

IPC: G01N21/552 ,  G01N21/13

CPC classification number: G01N21/553 ,  G01N21/13 ,  G01N21/648 ,  G01N2021/135 ,  G01N2021/8455

Abstract: In the present invention, excitation light is irradiated onto an analysis chip that has been placed in a chip holder, reflected light or transmitted light from the analysis chip is detected, and as a result the position information of the analysis chip is obtained. On the basis of this position information, the chip holder is moved by a conveyance stage and thereby moved to a measurement position. Excitation light is irradiated onto the analysis chip that is disposed at the measurement position, and fluorescence emitted from a fluorescent substance that marks the substance to be detected is detected.

Abstract translation: 在本发明中，将激发光照射到已经放置在芯片保持器中的分析芯片上，检测到来自分析芯片的反射光或透射光，结果获得了分析芯片的位置信息。 基于该位置信息，芯片保持器通过输送台移动，从而移动到测量位置。 激发光被照射到设置在测量位置的分析芯片上，并且检测从标记待检测物质的荧光物质发出的荧光。

公开(公告)号：US20210285874A1

公开(公告)日：2021-09-16

申请号：US16328437

申请日：2017-09-06

Applicant: Konica Minolta, Inc.

Inventor： Tetsuya NODA ,  Fumio NAGAI ,  Youichi AOKI ,  Makiko OTANI

IPC: G01N21/552 ,  G01N21/49 ,  G01N33/543 ,  G01N21/64 ,  G01N33/49

Abstract: A measurement chip including a prism, a metal film, and a capturing body is prepared. In a state in which a specimen is present on the metal film, scattered light obtained when first light which passes through the metal film and the specimen is scattered in the specimen when the first light is applied to the metal film from a prism side at a first incident angle smaller than a critical angle is detected. In a state in which a substance to be measured is captured by the capturing body and the specimen is not present on the metal film, a signal indicating an amount of the substance to be measured generated in the measurement chip when second light is applied to the metal film at a second incident angle not smaller than the critical angle from the prism side is detected. On the basis of a hematocrit value of the specimen determined from a light amount of the scattered light, a measurement value indicating the amount of the substance to be measured determined from the signal is corrected.

公开(公告)号：US20200018775A1

公开(公告)日：2020-01-16

申请号：US16491373

申请日：2018-03-02

Applicant: KONICA MINOLTA, INC.

Inventor： Hiromi FUJII ,  Teiji TANAKA ,  Tatsuya YAMAZAKI ,  Tomoharu NAKAGAWA ,  Tetsuya NODA ,  Atsuo IWASHITA ,  Yuuya SHOUJI

IPC: G01N35/10

Abstract: Provided is a temperature control system applied to an apparatus for analyzing a sample using a pipette nozzle and a reaction container, including a pipette tip temperature controller that heats a pipette tip which is fitted on the pipette nozzle and aspirates or discharges liquid and a reaction container temperature controller that heats the reaction container. The pipette tip temperature controller heats, in a concentrated manner, at least a distal end portion of the pipette tip of the pipette nozzle located at a predetermined heating position with hot air emitted from a heat source and is configured such that a distal end is capable of arriving at the reaction container by lowering the pipette nozzle from the heating position.

公开(公告)号：US20200003688A1

公开(公告)日：2020-01-02

申请号：US16570567

申请日：2019-09-13

Applicant: KONICA MINOLTA, INC.

Inventor： Hideyuki FUJII ,  Tetsuya NODA ,  Yukito NAKAMURA

IPC: G01N21/64 ,  G01N21/552 ,  G01N33/543

Abstract: A surface plasmon fluorescence analysis device that has a chip holder, a light source, an angle adjustment unit, a light sensor, a filter holder, an excitation light cut filter, a scattered light transmission unit, a transmission adjustment unit, and a control unit. As seen in plan view, the area occupied by the scattered light transmission unit is arranged on the excitation light cut filter or on the filter holder and is smaller than the area of a fluorescence transmission region as seen in plan view.

公开(公告)号：US20190187125A1

公开(公告)日：2019-06-20

申请号：US16322190

申请日：2017-08-09

Applicant: Konica Minolta, Inc

Inventor： Makiko OTANI ,  Tetsuya NODA ,  Fumio NAGAI

IPC: G01N33/49 ,  G01N21/64 ,  G01N27/327

CPC classification number: G01N33/49 ,  G01N21/6428 ,  G01N21/648 ,  G01N27/3274 ,  G01N2021/6439

Abstract: A specimen containing blood is divided into a first specimen and a second specimen. The blood in the second specimen is hemolyzed. The first specimen containing a substance to be measured is introduced into an accommodating unit and a measurement value indicating an amount of the substance to be measured in the first specimen in a state in which the blood is not hemolyzed is acquired. In a state in which the second specimen in a state in which the blood is hemolyzed is present in the accommodating unit of a measurement chip, second light acquired when first light including light of a wavelength absorbed by a red blood cell passes through the second specimen in the accommodating unit is detected. On the basis of a detection result of the second light, a hematocrit value of the specimen is determined. The measurement value is corrected on the basis of the hematocrit value.

公开(公告)号：US20190091679A1

公开(公告)日：2019-03-28

申请号：US15772558

申请日：2016-10-27

Applicant: Konica Minolta, Inc.

Inventor： Tetsuya NODA ,  Masataka MATSUO ,  Youichi AOKI

IPC: B01L3/02 ,  G01N35/10

Abstract: A reaction method includes a reaction step of reacting two or more substances with each other by using a pipette tip, attached to a pipette nozzle, for sucking or discharging a liquid to supply a liquid to a reaction field and remove the liquid from the reaction field a plurality of times. The reaction method further includes: a first process of, prior to the reaction step, detecting an end height of the pipette tip and setting a reference height of the pipette nozzle on the basis of the end height of the pipette tip; and a second process of correcting, in a course of the reaction step, the height of the pipette nozzle from the reference height so as to cancel out variation in the end height of the pipette tip due to a change in the temperature of the pipette tip.

公开(公告)号：US20180321152A1

公开(公告)日：2018-11-08

申请号：US15773910

申请日：2016-10-25

Applicant: KONICA MINOLTA, INC.

Inventor： Fumio NAGAI ,  Tetsuya NODA

IPC: G01N21/64 ,  G01N21/552

CPC classification number: G01N21/648 ,  G01N21/553 ,  G01N21/6428 ,  G02B5/04

Abstract: An optical sample detection system includes: a sensor chip including a dielectric member, a metal film adjacent to an upper surface of the dielectric member, a reaction layer adjacent to an upper surface of the metal film, and a lid member disposed on an upper surface of the reaction layer; a chip holding unit for holding the sensor chip; and a light projecting unit that irradiates the metal film with excitation light through the dielectric member. A sample is detected by irradiating the metal film with excitation light through the dielectric member. The lid member is wider than the dielectric member in an optical path cross section of the excitation light.

公开(公告)号：US20180080873A1

公开(公告)日：2018-03-22

申请号：US15558526

申请日：2016-03-08

Applicant: KONICA MINOLTA, INC.

Inventor： Tetsuya NODA ,  Fumio NAGAI ,  Nobuhiro YAMAUCHI ,  Yuichi KYOGOKU

IPC: G01N21/64

CPC classification number: G01N21/648 ,  G01N21/553 ,  G01N21/64 ,  G01N21/6428 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/0638 ,  G01N2201/0806

Abstract: This detection device has a holder, light irradiation unit, angle adjustment unit, light receiving sensor, light receiving optical system, optical filter, and a control unit. The light receiving optical system guides light from a detection chip to the light receiving sensor. The optical filter is disposed in the light receiving optical system, blocks a part of plasmon scattered light, and passes, out of the light emitted from the detection chip, a part of the plasmon scattered light, and fluorescence emitted from a fluorescent material. The light receiving sensor detects the fluorescent light, and the part of the plasmon scattered light, which have been emitted from the detection chip and passed the optical filter. On the basis of the detection results of the plasmon scattered light, the control unit controls the angle adjustment unit, and adjusts the incident angle of the excitation light to a predetermined incident angle.

公开(公告)号：US20180059130A1

公开(公告)日：2018-03-01

申请号：US15551757

申请日：2016-01-19

Applicant: Konica Minolta, Inc.

Inventor： Atsuo IWASHITA ,  Tetsuya NODA ,  Masataka MATSUO ,  Koji MIYAZAKI ,  Yuuya SHOUJI

IPC: G01N35/10 ,  B01L3/02 ,  G01N35/00

CPC classification number: G01N35/1011 ,  B01L3/0217 ,  B01L2200/146 ,  B01L2200/148 ,  B01L2400/0487 ,  G01N35/00623 ,  G01N35/10 ,  G01N35/1016

Abstract: In a detection method, a first pressure within a pipette tip is measured when air is sucked into or expelled from the leading end of the pipette tip in a state where the leading end of the pipette tip and a reference part of a solid are separated. A second pressure within the pipette tip is measured when air is sucked into or expelled from the leading end of the pipette tip in a state where the leading end of the pipette tip and the reference part of the solid are closer than in the first step. After the first step and second step, the position of the leading end of the pipette tip in relation to the reference part is detected on the basis of the difference between the first pressure measured in the first step and the second pressure measured in the second step.