公开(公告)号：US20200271593A1

公开(公告)日：2020-08-27

申请号：US16645619

申请日：2018-06-22

Applicant: Konica Minolta, Inc.

Inventor： Tetsuya NODA ,  Masanao MAJIMA ,  Yuuya SHOUJI

IPC: G01N21/94 ,  G01N21/552 ,  G01N21/958 ,  G01N21/64

Abstract: An analysis method for detecting an amount of a substance by irradiating an analysis chip containing the substance and detecting a quantity of light output from the analysis chip. The analysis method including irradiating an incident surface of the analysis chip and another surface adjacent to the incident surface with detection light while changing a relative position of the detection light with respect to the analysis chip, detecting reflected light from the incident surface of the analysis chip, and acquiring information on a position of the analysis chip from a relationship between a quantity of the reflected light detected and the relative position. The analysis method determines if the analysis chip is abnormal when a quantity of target reflected light is equal to or lower than a predetermined light quantity.

公开(公告)号：US20190285545A1

公开(公告)日：2019-09-19

申请号：US16318315

申请日：2017-07-11

Applicant: KONICA MINOLTA, INC.

Inventor： Fumio NAGAI ,  Tetsuya NODA ,  Kenichi KUBO

IPC: G01N21/64 ,  G01N21/552 ,  G01N21/13 ,  G01N21/84

Abstract: A light irradiation angle is set with respect to a first surface so as to detect only either first reflected light or second reflected light. Then, light is emitted from a light irradiation part at the set irradiation angle while a detection chip is kept in motion, either the first reflected light or the second reflected light is detected by a reflected light detection part, and positional information of the detection chip is acquired on the basis of the result of the detection of the first or second reflected light. The detection chip is moved, on the basis of the acquired positional information, to a detection position where detection of a substance to be detected is performed. While the detection chip is kept at the detection position, detection of the substance to be detected is performed through detection of sample light.

公开(公告)号：US20190033183A1

公开(公告)日：2019-01-31

申请号：US16073353

申请日：2016-01-29

Applicant: Konica Minolta, Inc.

Inventor： Youichi AOKI ,  Masataka MATSUO ,  Tetsuya NODA

IPC: G01N1/34 ,  G01N21/64 ,  G01N35/10 ,  B01L3/02

Abstract: The purpose of the present invention is to provide a detection method which can safely recover a remaining sample from a detection device without causing a biological disaster. In order to achieve at least one of these goals, this detection method involves: a sample collection step for collecting a sample from the sample holding well, and transferring the same to a detection chip; a detection step for detecting the detected substance captured in the detection chip by means of a detection unit; and, after the sample collection step, a remaining sample recovery step for collecting the sample remaining in the sample holding well and transferring this to a sample recovery well. At that time, after the remaining sample recovery step, the surface area of the opening in the sample recovery well is smaller than the surface area of the opening in the sample holding well.

公开(公告)号：US20170153182A1

公开(公告)日：2017-06-01

申请号：US15314264

申请日：2015-05-29

Applicant: Konica Minolta, Inc.

Inventor： Masataka MATSUO ,  Hiroshi HIRAYAMA ,  Yoshimasa HAMANO ,  Tetsuya NODA ,  Yoshihiro OKUMURA

IPC: G01N21/64

CPC classification number: G01N21/648 ,  G01N21/64

Abstract: First, an analytical chip having a prism, a metal film that includes a trapping region having immobilized on the surface thereof a trapping element for trapping a substance to be analyzed, and a mark in which the scatter of emitted plasmon scattered light differs from the scatter of plasmon scattered light emitted from the surrounding region, is disposed in a chip holder. Next, the rear surface of the metal film is irradiated with excitation light, plasmon scattered light emitted from the proximity of the mark is detected, and, on the basis of the detected plasmon scattered light, location information for the trap region is obtained. Next, the portion of the rear surface of the metal film that corresponds to the trap region arranged at the detected location is irradiated with excitation light, and fluorescence emitted by a fluorescent substance is detected.

公开(公告)号：US20200025784A1

公开(公告)日：2020-01-23

申请号：US16491381

申请日：2018-03-02

Applicant: KONICA MINOLTA, INC.

Inventor： Hiromi FUJII ,  Atsushi HOSOTANI ,  Yasuhiro MIYAKE ,  Takefumi ASOU ,  Tetsuya NODA ,  Atsuo IWASHITA ,  Yuuya SHOUJI

IPC: G01N35/10 ,  B01L3/02

Abstract: A pipette tip leading end detection device for detecting that a leading end of a pipette tip is close to a reference surface set to a reaction vessel includes a pipette nozzle, pump, nozzle driver, pressure sensor that detects a pressure generated between the pipette tip and pump, and hardware processor. The hardware processor obtains a determination value using an AD conversion value obtained from the pressure while the pipette nozzle is being lowered, and detects that the leading end of the pipette tip is close to the reference surface on the basis that the determination value is a threshold value or more. The determination value is a calculation value indicating a pressure change speed calculated from AD conversion values within a past certain time and the threshold value is a value larger than maximum noise.

公开(公告)号：US20170138859A1

公开(公告)日：2017-05-18

申请号：US15320099

申请日：2015-06-16

Applicant: Konica Minolta, Inc.

Inventor： Ichiro FUJIYO ,  Tetsuya NODA

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/645 ,  G01N21/648 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2201/0806

Abstract: A detection device comprises a chip holder, a light source, a light-guide rod, a wavelength separation filter, and an optical sensor. Given the relationship between the angle of incidence and light intensity of fluorescence on a light reception surface of the optical sensor, the optical transmittance of the wavelength separation filter at the dominant wavelength of the rays of fluorescence incident on the light reception surface at a peak angle of incidence at which the light intensity is the highest is greater than the optical transmittance of the wavelength separation filter at the dominant wavelength of the rays of excitation light incident on the light reception surface at the peak angle of incidence and is higher than the optical transmittance of the wavelength separation filter at the dominant wavelength of the rays of fluorescence incident on the light reception surface at an angle of incidence of 0 DEG.

公开(公告)号：US20160356717A1

公开(公告)日：2016-12-08

申请号：US15116631

申请日：2015-02-04

Applicant: KONICA MINOLTA, INC.

Inventor： Hideyuki FUJII ,  Tetsuya NODA ,  Yukito NAKAMURA

IPC: G01N21/64 ,  G01N33/543

CPC classification number: G01N21/648 ,  G01N21/253 ,  G01N21/553 ,  G01N21/6428 ,  G01N33/54373 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2201/0612 ,  G01N2201/0633 ,  G01N2201/068

Abstract: A surface plasmon fluorescence analysis device that has a chip holder, a light source, an angle adjustment unit, a light sensor, a filter holder, an excitation light cut filter, a scattered light transmission unit, a transmission adjustment unit, and a control unit. As seen in plan view, the area occupied by the scattered light transmission unit is arranged on the excitation light cut filter or on the filter holder and is smaller than the area of a fluorescence transmission region as seen in plan view.

Abstract translation: 一种具有芯片保持器，光源，角度调整单元，光传感器，滤光器保持器，激发截止滤光器，散射光透射单元，透射调节单元和控制单元的表面等离子体荧光分析装置 。 如平面图所示，散射光透射单元所占据的面积被布置在激发光截止滤光器上或滤光器支架上，并且比在平面图中看到的荧光发射区域的面积小。

公开(公告)号：US20210025821A1

公开(公告)日：2021-01-28

申请号：US16466781

申请日：2017-12-05

Applicant: KONICA MINOLTA, INC.

Inventor： Youichi AOKI ,  Tetsuya NODA

IPC: G01N21/64 ,  G01N21/896 ,  G01N21/94

Abstract: Presently disclosed is a way to provide a measuring device capable of easily detecting measurement abnormality without increasing load in hardware. The measuring device may include: an emission means that may emit light to a measurement target region; a light measurement means that may measure light output from the measurement target region by emission with the emission means; a driving means that may move a position of at least one of the measurement target region and the emission means; and a determination means that may compare measurement values of the light measured a plurality of times by the light measurement means while changing positions of the measurement target region by the driving means and thereby determines abnormality of a measurement result. The determination means may determine measurement abnormality in a case where a reference measurement value being a measurement value obtained for a first time is lower than a comparison measurement value being a highest measurement value among measurement values obtained for second and subsequent times.

公开(公告)号：US20200269231A1

公开(公告)日：2020-08-27

申请号：US16754217

申请日：2018-10-15

Applicant: Konica Minolta, Inc.

Inventor： Youichi AOKI ,  Yuuya SHOUJI ,  Tetsuya NODA ,  Atsuo IWASHITA

IPC: B01L3/02

Abstract: Disclosed is a reaction method that includes a reaction process using a pipette tip to allow substances to cause a reaction, the method including: providing a heater for heating the pipette tip in accordance with a preset temperature; attaching the pipette tip to a pipette nozzle and heating the pipette tip by a first preset temperature; when a period of heating by the first preset temperature exceeds a preset period, switching an output of the heater from the first preset temperature to a lower second preset temperature; detecting a distal end position of the pipette tip at or after the switching; and executing the reaction process while controlling the distal end position of the pipette tip with reference to the detected distal end position, in which the temperature of the pipette tip is kept by the second preset temperature at least until operation of the pipette tip.

公开(公告)号：US20180321151A1

公开(公告)日：2018-11-08

申请号：US15772346

申请日：2016-11-02

Applicant: Konica Minolta, Inc.

Inventor： Masataka MATSUO ,  Tetsuya NODA

IPC: G01N21/64 ,  G01N21/01

CPC classification number: G01N21/648 ,  G01N21/01 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/11 ,  G01N35/00 ,  G01N35/10 ,  G01N2021/6482

Abstract: To provide an inspection system capable of performing a target biological reaction under temperature conditions suitable for the reaction even with reciprocal liquid feeding.An inspection system including at least: a sensor chip with a flow path having a reaction site for performing biological reactions; a liquid feeder that causes reaction liquid to flow into and out of the flow path; and a first temperature adjuster that adjusts temperature of reaction liquid flowed in the flow path, where the system performs reciprocal liquid feeding by the liquid feeder where some of the reaction liquid flowed in the flow path is caused to flow out of the flow path and to flow in again. The inspection system includes a second temperature adjuster that, during reciprocal liquid feeding, adjusts temperature of the reaction liquid flowed outside the flow path through temperature adjustment of a liquid holding section of the liquid feeder.