公开(公告)号：US4935106A

公开(公告)日：1990-06-19

申请号：US798791

申请日：1985-11-15

Applicant: Max D. Liston ,  Paul K. Hsei ,  David G. Dickinson ,  George M. Daffern ,  James G. Fetty

Inventor： Max D. Liston ,  Paul K. Hsei ,  David G. Dickinson ,  George M. Daffern ,  James G. Fetty

IPC: G01N27/26 ,  G01N27/28 ,  G01N33/487

CPC classification number: G01N27/3271

Abstract: A modular multi-channel automated medical analyzer device is disclosed, characterized by use of an ion selective electrode and/or enzymatic electrode/wash cell system which permits rapid analysis of various substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. The ion selective electrode and/or the enzymatic electrode are disposed upon a probe which automatically axially reciprocates downwardly in a simple manipulative motion between an open-ended reference wash cell and a sample cup bearing the body fluid specimen to be analyzed. The wash cell includes an inlet port and one or more outlet ports through which is circulated an aqueous solution bearing a known concentration of the substance to be measured to provide a reference calibration medium as well as a probe washing medium. The probe is lowered directly into the sample cup to physically contact the specimen to be measured and, after analysis, is lifted upwardly into the wash cell wherein any attendant portion of the specimen remaining on the probe is stripped off by suction and the aqueous solution flow through the wash cell is initiated to thoroughly wash the probe and establish a new calibration medium for subsequent specimen analysis. The wash cell/probe assembly is specifically designed to prevent any leakage or drooling of the aqueous solution from the wash cell into the sample cup throughout manipulation of the probe. Operation of each of the modules of the analyzer is facilitated through common processing and control electronics and test measurements are accomplished initially on a dual point calibration procedure and subsequently on a single point calibration procedure.

Abstract translation: 公开了一种模块化多通道自动医学分析仪装置，其特征在于使用离子选择性电极和/或酶电极/洗涤细胞系统，其允许快速分析未稀释体液中所含的各种感兴趣物质，例如全血，血清和 /或等离子体。 离子选择电极和/或酶电极设置在探针上，该探针在开放式参考洗涤池和承载待分析体液样品的样品杯之间的简单操作运动中向下自动轴向往复运动。 洗涤池包括入口端口和一个或多个出口端口，循环具有已知浓度待测量物质的水溶液以提供参考校准介质以及探针洗涤介质。 将探针直接放入样品杯中以物理接触要测量的样品，并且在分析之后，将其向上提升到洗涤池中，其中留在探针上的样品的任何附加部分通过抽吸被剥离，并且水溶液流 通过洗涤池开始彻底清洗探针并建立新的校准介质，用于随后的样品分析。 洗涤池/探针组件被专门设计成防止在操纵探针时水溶液从洗涤池中渗入或流出到样品杯中。 通过共同的处理和控制电子装置便于分析器的每个模块的操作，并且测试测量最初在双点校准程序上完成，随后在单点校准程序上完成。

公开(公告)号：US4528159A

公开(公告)日：1985-07-09

申请号：US400191

申请日：1982-07-20

Applicant: Max D. Liston

Inventor： Max D. Liston

IPC: B01L3/00 ,  G01N21/03 ,  G01N35/02 ,  G01N35/04

CPC classification number: B01L3/505 ,  G01N21/03 ,  G01N2035/023 ,  Y10S435/805

Abstract: An automated instrument system for analyzing constituents of a patient sample while reacting a reagent specific for the selected constituent within the sample. The analyzer includes: a continuous flexible cuvette belt having a series of parallel discrete reaction compartments thereon, a carousel for dispensing solid tabletted reagents into the compartments, a means for effecting ultrasonic dissolution of the tabletted reagent in the reaction compartment, means for dispensing sample from a source thereof into a reaction compartment, including a sample source transport carousel assembly, and means for transporting the cuvette belt through a plurality of analysis stations located in a linear relationship along the path of travel of the cuvette belt.

Abstract translation: 一种自动化仪器系统，用于分析患者样品的成分，同时使样品中所选组分特异的试剂反应。 分析仪包括：连续柔性比色杯带，其上具有一系列平行的离散反应室，用于将固体压片试剂分配到隔室中的转盘，用于将压片试剂超声溶解在反应室中的装置， 其来源进入反应室，包括样品源运输转盘组件，以及用于通过沿着比色皿带的行进路径以线性关系位置的多个分析台运送比色杯带的装置。

公开(公告)号：US4477190A

公开(公告)日：1984-10-16

申请号：US284841

申请日：1981-07-20

Applicant: Max D. Liston ,  David G. Dickinson ,  William A. Stark

Inventor： Max D. Liston ,  David G. Dickinson ,  William A. Stark

IPC: G01J3/08 ,  G01J3/10 ,  G01J3/42 ,  G01N21/25 ,  G01N21/27 ,  G01J3/50

CPC classification number: G01N21/253 ,  G01N2021/3174

Abstract: A multichannel spectrophotometer has a single radiant energy source formed into a multiplicity of radiant energy beams which are each simultaneously intercepted by segments of a rotary source filter wheel, the spectral radiant energy output selected by each filter segment being directed into a separate source radiant energy conduit and transmitted to a remote sample station where a cuvette containing a sample to be analyzed is located, the radiant energy outputs of each cuvette being directed into a separate detector radiant energy conduit where each conduit is intercepted by a filter segment of a second rotating detector filter wheel identical to the source filter wheel and rotated in aligned synchronism therewith, the spectral radiant energy outputs of each segment of the detector filter wheel being further directed into a separate radiant energy detector and signal processing electronics associated with that sample station or spectrophotometer channel from which the radiant energy signal being detected and analyzed has been received. Central control, timing and display electronics are shared by each channel and may be overall programmed and controlled by computer. In one application involving the measurement of fluorescence, the filters of the detector filter wheel will be different from the filters of the source filter wheel so as to excite the sample cuvette at one wavelength and to measure fluorescent response at another.

Abstract translation: 多通道分光光度计具有形成多个辐射能量束的单个辐射能量源，每个辐射能量束都被旋转源滤光轮的各个部分同时截取，由每个滤光片段选择的光谱辐射能输出被引导到单独的光源辐射能导管 并传输到远程采样站，其中包含要分析的样品的比色杯位于其中，每个比色杯的辐射能输出被引导到单独的检测器辐射能导管中，其中每个导管被第二旋转检测器滤光片的滤光片截取 车轮与源滤光轮相同并与其同步旋转，检测器滤光轮的每个部分的光谱辐射能输出被进一步导向到与该样品台或分光光度计通道相关联的单独的辐射能量检测器和信号处理电子器件 辐射能量 已经接收到检测和分析的点火。 中央控制，定时和显示电子设备由每个通道共享，可以由计算机进行整体编程和控制。 在涉及荧光测量的一个应用中，检测器滤光轮的滤光器将不同于源滤光轮的滤光片，以便在一个波长处激发样品比色皿并测量另一个波长的荧光响应。

公开(公告)号：US4891104A

公开(公告)日：1990-01-02

申请号：US42266

申请日：1987-04-24

Applicant: Max D. Liston ,  Paul K. Hsei ,  Christopher C. Feistel

Inventor： Max D. Liston ,  Paul K. Hsei ,  Christopher C. Feistel

IPC: G01N27/28 ,  C12Q1/00 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487

CPC classification number: C12Q1/001

Abstract: An improved enzymatic electrode and electrode module specifically adapted for use in a medical analyzer device is disclosed which permits rapid analysis of substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. The enzymatic electrode is in fluid communication with an axially reciprocating probe which selectively transports either a quantity of a buffer aqueous solution or a calibrant aqueous solution presented at a wash cell or a body fluid specimen disposed within a sample cup to an active enzyme bearing membrane positioned adjacent the enzymatic electrode. The membrane comprises a composite membrane structure having a protective membrane layer adapted to prevent the passage of blood cells and other particulate or cellular substances therethrough as well as adjust the diffusion rate of the substance of interest desired to be measured into the membrane, an active enzyme layer adapted to convert the desired substance of interest to be measured into a detectable substance and a limiting membrane formed to prevent the passage of interfering low molecular weight substance therethrough. The membrane/reagent chemistry kinetics of the enzymatic electrode are specifically defined to enable a novel pseudo-rate/created peak measurement technique to be utilized which reduces measurement inaccuracies as well as signal data processing requirements. The membrane/electrode support structure and membrane/electrode solution flow path are specifically formed to permit rapid replacement of the composite membrane and aqueous solutions by non-professional personnel.

Abstract translation: 公开了一种特别适用于医疗分析装置的改进的酶电极和电极模块，其允许快速分析未稀释的体液如全血，血清和/或血浆中所含的感兴趣物质。 酶电极与轴向往复式探针流体连通，该探针选择性地将一定量的缓冲水溶液或呈现在洗涤池的校准液水溶液或设置在样品杯内的体液样品输送到位于 邻近酶电极。 膜包括具有保护膜层的复合膜结构，其适于防止血细胞和其它颗粒或细胞物质通过其中，并且调节所需要测量的物质的扩散速率到膜中，活性酶 层，其适于将要测量的所需物质转化为可检测物质和形成以防止干扰低分子量物质通过的限制膜。 酶电极的膜/试剂化学动力学具体定义为使得能够利用新的伪速率/创建的峰值测量技术，其减少测量不准确度以及信号数据处理要求。 膜/电极支撑结构和膜/电极溶液流动路径是特别形成的，以允许非专业人员快速更换复合膜和水溶液。

公开(公告)号：US4600412A

公开(公告)日：1986-07-15

申请号：US659097

申请日：1984-10-09

Applicant: Max D. Liston ,  James R. Braig ,  Wayne Blackburn ,  Paul Hsei

Inventor： Max D. Liston ,  James R. Braig ,  Wayne Blackburn ,  Paul Hsei

IPC: G01N30/14 ,  B01D45/00

CPC classification number: G01N30/14

Abstract: A water separator adapted for use in a gas monitor includes a gas inlet port, a gas outlet port, a two-stage gas/water separator section, and a fluid reservoir. The two-stage gas/water separator section includes a first portion defining a first chamber which communicates with the gas inlet and gas outlet ports via a connecting conduit, a second portion defining a second chamber which communicates with the first chamber and the fluid reservoir, and an intermediate portion interposed between the first and second portions and defining a constricted passage between the first and second chambers. The second chamber has a frusto-conical shape in longitudinal cross section.

Abstract translation: 适用于气体监测器的水分离器包括气体入口，气体出口，两级气/水分离器部分和流体储存器。 两级气/水分离器部分包括限定通过连接导管与气体入口和气体出口连通的第一腔室的第一部分，限定与第一腔室和流体容器连通的第二腔室的第二部分， 以及介于所述第一和第二部分之间并且限定所述第一和第二腔室之间的收缩通道的中间部分。 第二腔室具有纵截面的截头圆锥形状。

公开(公告)号：US4595562A

公开(公告)日：1986-06-17

申请号：US551437

申请日：1983-11-14

Applicant: Max D. Liston ,  Paul K. Hsei

Inventor： Max D. Liston ,  Paul K. Hsei

IPC: G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/06

CPC classification number: G01N35/04 ,  G01N2035/00752 ,  G01N2035/00861 ,  G01N2035/0465 ,  G01N35/025

Abstract: The present invention relates to an assembly and method for introducing and transporting sample containers in a chemical analyzer, and in particular, to an assembly for organizing randomly loaded sample containers in a positively-identifiable fashion. The assembly additionally includes a means for sequencing the organization of sample containers and a novel means for dispensing measured amounts of sample therefrom.

Abstract translation: 本发明涉及一种用于在化学分析仪中引入和运送样品容器的装置和方法，特别涉及用于以可识别的方式组织随机装载的样品容器的组件。 该组件还包括用于对样品容器的组织进行排序的装置和用于从其中分配测量量的样品的新型装置。

公开(公告)号：US4586026A

公开(公告)日：1986-04-29

申请号：US549411

申请日：1983-11-07

Applicant: James R. Braig ,  Max D. Liston

Inventor： James R. Braig ,  Max D. Liston

IPC: G01N21/25 ,  G01N21/35

CPC classification number: H03M1/48 ,  G01N21/256 ,  G01N21/3504

Abstract: The percentage gas concentration within a sample as measured in a conventional optical bench is derived from the composite signal of the reference beam and sample beam transmitted through a sample cell in the optical bench. The primary source, which generates the reference beam and the secondary source which generates the sample beam are driven ninety degrees out of phase. The composite signal derived from the detector in the optical bench is digitized and then integrated according to the quadrature of the primary component of the composite signal derived from the reference beam, and is also integrated according to the quadrature of the secondary component of the composite signal derived from the sample beam. What is obtained is the integral of the absolute value of the secondary component and the integral of the absolute value of the primary component of the composite signal over one cycle of the reference beam and sample beam. The ratio of these component signals is computed to obtain a signal which is related to the percentage concentration of reference gas contained within the sample.

Abstract translation: 在常规光学平台中测量的样品中的气体浓度百分比是从参考光束和通过光学平台中的样品池传输的样品光束的复合信号导出的。 产生参考光束的主光源和产生采样光束的次光源相位驱动九十度。 从光台上的检测器导出的复合信号被数字化，然后根据从参考光束导出的复合信号的主分量的正交积分，并且还根据复合信号的次分量的正交积分 源自样品束。 获得的是二次分量的绝对值的积分和复合信号的主要分量的绝对值的积分在参考光束和样本光束的一个周期上。 计算这些分量信号的比率以获得与样品中包含的参考气体的浓度百分比相关的信号。

公开(公告)号：US4483616A

公开(公告)日：1984-11-20

申请号：US400192

申请日：1982-07-20

Applicant: Max D. Liston ,  Paul K. Hsei

Inventor： Max D. Liston ,  Paul K. Hsei

IPC: B01L3/00 ,  B01L3/14 ,  G01N1/00 ,  G01N1/10 ,  G01N35/02

CPC classification number: B01L3/5082 ,  B01L3/508 ,  B01L2200/023 ,  B01L2300/0854

Abstract: A container for holding a small quantity of liquid. The container comprises an elongated housing having a fluid receptacle disposed in the upper end thereof. The dimensions of the receptacle are substantially less than the overall dimensions of the housing, thereby facilitating the handling of the container and inhibiting evaporation of the liquid therein.

Abstract translation: 用于容纳少量液体的容器。 容器包括细长壳体，其具有设置在其上端中的流体容器。 容器的尺寸基本上小于外壳的整体尺寸，从而便于处理容器并阻止其中的液体的蒸发。

公开(公告)号：US4445012A

公开(公告)日：1984-04-24

申请号：US203119

申请日：1980-11-03

Applicant: Wayne E. Blackburn ,  Max D. Liston ,  William A. Stark

Inventor： Wayne E. Blackburn ,  Max D. Liston ,  William A. Stark

IPC: A61B5/08 ,  A61M1/00 ,  A61M16/00 ,  A61M16/16 ,  H01H29/00

CPC classification number: A61M16/00 ,  A61B5/08 ,  A61M1/00 ,  A61M16/161 ,  A61B5/082

Abstract: A moisture sensor detects the presence of foreign matter in a fluid conducting conduit and produces an electrical signal which activates a pump to purge the conduit of the foreign matter. The moisture sensor includes a pair of conduits that may be formed of an electrically conductive material and a coupling for placing the pair of conduits in fluid communication. A pair of electrodes are mounted in the coupling and are insulated from one another until electrically conductive foreign matter bridges a gap between the electrodes. Bridging the gap between the electrodes causes a signal to be sent to a source of gas that injects gas in the conduits to remove the foreign material therefrom.

Abstract translation: 湿度传感器检测流体导管中异物的存在并产生电信号，该电信号激活泵以清除异物的导管。 水分传感器包括可由导电材料形成的一对导管和用于将一对管道放置成流体连通的联接器。 一对电极安装在耦合器中并且彼此绝缘，直到导电异物桥接电极之间的间隙。 连接电极之间的间隙会导致信号发送到气体源，该气体源将管道中的气体注入，以从中除去异物。

公开(公告)号：USRE30391E

公开(公告)日：1980-09-02

申请号：US660258

申请日：1976-02-23

Applicant: Max D. Liston

Inventor： Max D. Liston

IPC: G01N21/03

CPC classification number: G01N21/03

Abstract: Improved components, such as a cuvette, are disclosed in the specification.