公开(公告)号：US10525149B2

公开(公告)日：2020-01-07

申请号：US15572706

申请日：2016-05-12

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Thomas E. Rogers

IPC: A61K49/00 ,  C07D241/20 ,  A61B5/00 ,  C07K5/078 ,  A61B1/04 ,  A61B5/026

Abstract: Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.

公开(公告)号：US20240182430A1

公开(公告)日：2024-06-06

申请号：US18520826

申请日：2023-11-28

Applicant: MediBeacon Inc.

Inventor： Thomas E. Rogers ,  Eric Buck

IPC: C07D241/28

CPC classification number: C07D241/28

Abstract: Described herein are methods to form substituted pyrazines. Also described herein are methods to purify substituted pyrazines.

公开(公告)号：US20230132384A9

公开(公告)日：2023-04-27

申请号：US17492260

申请日：2021-10-01

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Thomas E. Rogers

IPC: A61K49/00 ,  C07D241/20 ,  C07K5/078 ,  A61B5/00

Abstract: Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.

公开(公告)号：US11602570B2

公开(公告)日：2023-03-14

申请号：US16171689

申请日：2018-10-26

Applicant: MediBeacon Inc.

Inventor： Martin P. Debreczeny ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers

IPC: A61K49/00 ,  C07D241/26 ,  A61B5/20 ,  A61B5/00 ,  C09B57/00 ,  A61B5/1495 ,  A61P13/12

Abstract: The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

公开(公告)号：US20220016269A1

公开(公告)日：2022-01-20

申请号：US17492260

申请日：2021-10-01

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Thomas E. Rogers

IPC: A61K49/00 ,  C07D241/20 ,  C07K5/078 ,  A61B5/00

Abstract: Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.

公开(公告)号：US11160880B2

公开(公告)日：2021-11-02

申请号：US16694982

申请日：2019-11-25

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Thomas E. Rogers

IPC: A61K49/00 ,  A61B5/00 ,  C07K5/06 ,  C07D241/20 ,  C07K5/078 ,  A61B1/04 ,  A61B5/026

Abstract: Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.

公开(公告)号：US20200155709A1

公开(公告)日：2020-05-21

申请号：US16694994

申请日：2019-11-25

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Thomas E. Rogers

IPC: A61K49/00 ,  A61B5/00 ,  C07K5/078 ,  C07D241/20

Abstract: Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.

公开(公告)号：US20200155708A1

公开(公告)日：2020-05-21

申请号：US16694982

申请日：2019-11-25

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Thomas E. Rogers

IPC: A61K49/00 ,  A61B5/00 ,  C07K5/078 ,  C07D241/20

Abstract: Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.

公开(公告)号：US20190192694A1

公开(公告)日：2019-06-27

申请号：US16289487

申请日：2019-02-28

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Thomas E. Rogers

IPC: A61K49/00 ,  C07K5/078 ,  A61B5/00 ,  C07D241/20

CPC classification number: A61K49/0021 ,  A61B1/042 ,  A61B5/0071 ,  A61B5/0082 ,  A61B5/0261 ,  C07D241/20 ,  C07K5/06139

Abstract: The present disclosure relates to compositions and methods for assessing blood vessels and organs of the body, more specifically to methods for assessing the vasculature of the eye.

公开(公告)号：US20190125902A1

公开(公告)日：2019-05-02

申请号：US16171695

申请日：2018-10-26

Applicant: MediBeacon Inc.

Inventor： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers

IPC: A61K49/00 ,  A61B5/20 ,  A61B5/00 ,  A61M5/00

Abstract: The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The method includes administering a pyrazine compound of Formula I to a patient and monitoring the rate in which the kidneys of the patient eliminate the pyrazine from the systemic circulation of the patient. The pyrazine compound fluoresces when exposed to electromagnetic radiation which is detected using one or more sensors. The rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.