公开(公告)号：US10952656B2

公开(公告)日：2021-03-23

申请号：US17000820

申请日：2020-08-24

Applicant: MediBeacon Inc.

Inventor： Kimberly Shultz ,  Kate Bechtel ,  Martin P. Debreczeny

IPC: G06F11/30 ,  A61B5/1455 ,  G01J1/44 ,  A61B5/00 ,  G01J1/04 ,  A61B5/20

Abstract: A sensor head is provided. In any of the various aspects of the invention, the sensor head has a housing enclosing at least two light sources configured to deliver light to a patient and comprising a blue LED first light source that delivers light at an excitatory wavelength and a green LED second light source, and at least one light detector configured to detect light at an emission wavelength from the patient. The sensor is useful for non-invasive monitoring of fluorescent tracers agents.

公开(公告)号：US11602570B2

公开(公告)日：2023-03-14

申请号：US16171689

申请日：2018-10-26

Applicant: MediBeacon Inc.

Inventor： Martin P. Debreczeny ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers

IPC: A61K49/00 ,  C07D241/26 ,  A61B5/20 ,  A61B5/00 ,  C09B57/00 ,  A61B5/1495 ,  A61P13/12

Abstract: The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

公开(公告)号：US20230173111A1

公开(公告)日：2023-06-08

申请号：US18162163

申请日：2023-01-31

Applicant: MediBeacon Inc.

Inventor： Martin P. Debreczeny ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers

IPC: A61K49/00 ,  C07D241/26 ,  A61B5/20 ,  A61B5/00 ,  C09B57/00

CPC classification number: A61K49/0021 ,  C07D241/26 ,  A61B5/201 ,  A61B5/7203 ,  A61B5/6815 ,  A61B5/0071 ,  A61K49/0054 ,  C09B57/00 ,  A61K49/0004 ,  A61B5/1495

Abstract: The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

公开(公告)号：US11590244B2

公开(公告)日：2023-02-28

申请号：US16171695

申请日：2018-10-26

Applicant: MediBeacon Inc.

Inventor： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers ,  Martin P. Debreczeny

IPC: A61K51/00 ,  A61K49/00 ,  A61M5/00 ,  A61B5/00 ,  A61B5/20 ,  C09B57/00 ,  A61P13/12 ,  C09K11/06 ,  C07D241/26

Abstract: The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The method includes administering a pyrazine compound of Formula I to a patient and monitoring the rate in which the kidneys of the patient eliminate the pyrazine from the systemic circulation of the patient. The pyrazine compound fluoresces when exposed to electromagnetic radiation which is detected using one or more sensors. The rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

公开(公告)号：US20230158175A1

公开(公告)日：2023-05-25

申请号：US18159253

申请日：2023-01-25

Applicant: MediBeacon Inc.

Inventor： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers ,  Martin P. Debreczeny

IPC: A61K49/00 ,  A61M5/00 ,  A61B5/00 ,  A61B5/20 ,  C09B57/00 ,  A61P13/12 ,  C09K11/06

CPC classification number: A61K49/0021 ,  A61M5/007 ,  A61B5/0071 ,  A61B5/201 ,  A61K49/0054 ,  A61K49/0004 ,  C09B57/00 ,  A61P13/12 ,  C09K11/06 ,  C07D241/26

Abstract: A method for determining a glomerular filtration rate (GFR) in a patient includes administering to said patient a compound of Formula I and transdermally measuring spectral energy emitted by the compound of Formula I over a measurement time window. The spectral energy is emitted by the compound of Formula I in response to electromagnetic radiation delivered to the compound of Formula I. The method also includes determining the GFR in said patient based on the measured spectral energy emitted by the compound of Formula I over the measurement time window by fitting an exponential function to the spectral energy as a function of time or a linear function to the log of the spectral energy as a function of time to calculate a rate constant associated with renal clearance over the measurement time window and directly related to the GFR normalized to a body size metric of the patient.

公开(公告)号：US20190125901A1

公开(公告)日：2019-05-02

申请号：US16171689

申请日：2018-10-26

Applicant: MediBeacon Inc.

Inventor： Martin P. Debreczeny ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers

IPC: A61K49/00 ,  C07D241/26 ,  A61B5/00 ,  A61B5/20

Abstract: The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.