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    Cross-sectional modification during deployment of an elongate lung volume reduction device
    11.
    发明授权
    Cross-sectional modification during deployment of an elongate lung volume reduction device 有权
    在展开细长的肺容积减小装置期间的横截面修改

    公开(公告)号：US09474533B2

    公开(公告)日：2016-10-25

    申请号：US14225892

    申请日：2014-03-26

    Applicant: PneumRx, Inc.

    Inventor： Mark L. Mathis ,  Patrick Wu ,  David Lehrberg ,  Jaime Vasquez ,  Erin McGurk ,  Ronald Dieck ,  Andrew Stein

    IPC: A61F2/04 ,  A61B17/12 ,  A61B1/267 ,  A61B17/10 ,  A61B17/00

    CPC classification number: A61B17/12104 ,  A61B1/2676 ,  A61B17/10 ,  A61B17/12022 ,  A61B17/12031 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/1219 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61F2/04 ,  A61F2002/043

    Abstract: Elongate implant structures can be introduced into an airway system to a target airway axial region, often to apply lateral bending and/or compression forces against the lung tissue from within the airways for an extended period of time. Structures or features of the implants may inhibit tissue reactions that might otherwise allow portions of the device to eventually traverse through the wall of the airway. The devices may enhance the area bearing laterally on the tissue of a surrounding airway lumen wall. Embodiments may have features which increase the device friction with the airway to allow the device to grip the surrounding airway as the device is deployed. An appropriate adhesive may be introduced around the device in the lung. Hydrophilic material may inhibit biofilm formation, or features which induce some tissue ingrowth (stimulation of tissue growth) may enhance implanted device supported.

    Abstract translation: 细长的植入物结构可被引入到目标气道轴向区域的气道系统中，经常在气道内长时间施加横向弯曲和/或压缩力对肺组织。 植入物的结构或特征可以抑制组织反应，否则可能会使装置的部分最终穿过气道的壁。 这些装置可以增强在周围气道腔壁的组织上横向承受的面积。 实施例可以具有增加与气道的装置摩擦的特征，以允许装置在装置展开时夹紧周围气道。 可能在肺内的装置周围引入适当的粘合剂。 亲水材料可能抑制生物膜形成，或引起一些组织向内生长（刺激组织生长）的特征可以增强植入装置的支持。

    Genetically-Associated Chronic Obstructive Pulmonary Disease Treatment
    13.
    发明申请
    Genetically-Associated Chronic Obstructive Pulmonary Disease Treatment 审中-公开

    公开(公告)号：US20200155165A1

    公开(公告)日：2020-05-21

    申请号：US16708909

    申请日：2019-12-10

    Applicant: PneumRx, Inc.

    Inventor： Mark L. Mathis ,  Kara Andersen Reiter

    IPC: A61B17/12 ,  A61B90/00 ,  A61B50/30

    Abstract: A system for treating a genetically associated chronic obstructive pulmonary disease. The system includes a coil implant, wherein the coil implant is configured to increase tension of a lung having alveolar damage caused by a genetic disorder and thereby improve breathing function of the lung. The system includes a delivery system configured to deliver the coil implant into an airway of the lung, wherein the delivery system comprises a cartridge configured to retain the coil implant in a straight configuration. The coil implant is configured to recover to a non-straight, pre-determined shape upon deployment within the airway the lung of the patient.

    Cross-Sectional Modification During Deployment of an Elongate Lung Volume Reduction Device
    16.
    发明申请
    Cross-Sectional Modification During Deployment of an Elongate Lung Volume Reduction Device 审中-公开
    在延长肺容积减少装置的部署过程中的横断面修改

    公开(公告)号：US20170065282A1

    公开(公告)日：2017-03-09

    申请号：US15263195

    申请日：2016-09-12

    Applicant: PneumRx, Inc.

    Inventor： Mark L. Mathis ,  Patrick Wu ,  David Lehrberg ,  Jaime Vasquez ,  Erin McGurk ,  Ronald Dieck ,  Andrew Stein

    IPC: A61B17/12 ,  A61B1/267

    CPC classification number: A61B17/12104 ,  A61B1/2676 ,  A61B17/10 ,  A61B17/12022 ,  A61B17/12031 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/1219 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61F2/04 ,  A61F2002/043

    Abstract: Elongate implant structures can be introduced into an airway system to a target airway axial region, often to apply lateral bending and/or compression forces against the lung tissue from within the airways for an extended period of time. Structures or features of the implants may inhibit tissue reactions that might otherwise allow portions of the device to eventually traverse through the wall of the airway. The devices may enhance the area bearing laterally on the tissue of a surrounding airway lumen wall. Embodiments may have features which increase the device friction with the airway to allow the device to grip the surrounding airway as the device is deployed. An appropriate adhesive may be introduced around the device in the lung. Hydrophilic material may inhibit biofilm formation, or features which induce some tissue ingrowth (stimulation of tissue growth) may enhance implanted device supported.

    Abstract translation: 细长的植入物结构可被引入到目标气道轴向区域的气道系统中，经常在气道内长时间施加横向弯曲和/或压缩力对肺组织。 植入物的结构或特征可以抑制组织反应，否则可能会使装置的部分最终穿过气道的壁。 这些装置可以增强在周围气道腔壁的组织上横向承受的面积。 实施例可以具有增加与气道的装置摩擦的特征，以允许装置在装置展开时夹紧周围气道。 可能在肺内的装置周围引入适当的粘合剂。 亲水材料可能抑制生物膜形成，或引起一些组织向内生长（刺激组织生长）的特征可以增强植入装置的支持。

    Torque Alleviating Intra-Airway Lung Volume Reduction Compressive Implant Structures
    19.
    发明申请
    Torque Alleviating Intra-Airway Lung Volume Reduction Compressive Implant Structures 有权
    扭矩缓解气道内肺容积压缩植入物结构

    公开(公告)号：US20150051709A1

    公开(公告)日：2015-02-19

    申请号：US14209194

    申请日：2014-03-13

    Applicant: PneumRx, Inc.

    Inventor： Jaime Vasquez ,  Mark L. Mathis ,  Tim Machold ,  Andrew Stein

    IPC: A61B17/12 ,  A61L31/02 ,  A61L31/04

    CPC classification number: A61B17/12104 ,  A61B17/12036 ,  A61B17/12145 ,  A61B17/1215 ,  A61B2017/1205

    Abstract: A device for enhancing the breathing efficiency of a patient is provided. The implantable device may include a deployed configuration with one or more helical sections with proximal end in a stand-off proximal end configuration. The stand-off proximal end configuration may reduce migration of the deployed device and may preserve implant tissue compression. Alternative configurations may include two or more helical sections with a transition section disposed between the two or more helical sections. A device may include a right-handed helical section and a left-handed helical section and the transition section comprises a switchback transition section. The switchback section may provide greater control of the device during deployment by limiting recoiling forces of a device comprising a spring material. The deployed device may compress the lung to increase a gas filling resistance of the compressed portion of the lung, and/or increase tension and elastic recoil in other portions of the lung.

    Abstract translation: 提供了一种用于增强患者呼吸效率的装置。 可植入装置可以包括具有一个或多个螺旋部分的展开构造，其中近端处于支撑近端构型。 邻近的近端构型可以减少所展开的装置的移动并且可以保持植入物组织的压缩。 替代配置可以包括两个或多个螺旋部分，其中过渡部分设置在两个或多个螺旋部分之间。 设备可以包括右旋螺旋部分和左旋螺旋部分，并且过渡部分包括回转过渡部分。 回转部分可以通过限制包括弹簧材料的装置的反冲力来在展开期间提供对装置的更大的控制。 所展开的装置可以压缩肺以增加肺的压缩部分的气体填充阻力，和/或增加肺其他部分的张力和弹性反冲。

    Torque alleviating intra-airway lung volume reduction compressive implant structures
    20.
    发明授权
    Torque alleviating intra-airway lung volume reduction compressive implant structures 有权

    公开(公告)号：US10188397B2

    公开(公告)日：2019-01-29

    申请号：US15192085

    申请日：2016-06-24

    Applicant: PneumRx, Inc.

    Inventor： Jaime Vasquez ,  Mark L. Mathis ,  Timothy Machold ,  Andrew Stein

    IPC: A61B17/08 ,  A61B17/12

    Abstract: A device for enhancing the breathing efficiency of a patient is provided. The implantable device may include a deployed configuration with one or more helical sections with proximal end in a stand-off proximal end configuration. The stand-off proximal end configuration may reduce migration of the deployed device and may preserve implant tissue compression. Alternative configurations may include two or more helical sections with a transition section disposed between the two or more helical sections. A device may include a right-handed helical section and a left-handed helical section and the transition section comprises a switchback transition section. The switchback section may provide greater control of the device during deployment by limiting recoiling forces of a device comprising a spring material. The deployed device may compress the lung to increase a gas filling resistance of the compressed portion of the lung, and/or increase tension and elastic recoil in other portions of the lung.

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