公开(公告)号：US10197477B2

公开(公告)日：2019-02-05

申请号：US15408276

申请日：2017-01-17

Applicant: Pulse Health LLC

Inventor： Martin Krauss ,  Maura Mahon ,  Andrew King ,  Steve Cooper ,  James Ingle ,  Gerald Thomas ,  David Barsic ,  Neal Andrews ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC: G01N33/48 ,  G01D11/24 ,  G01N1/22 ,  G01N33/497 ,  G01N21/64 ,  G01N33/52 ,  G01N33/64 ,  A61B5/08 ,  G01N7/10 ,  A61B5/00 ,  A61B5/087

Abstract: An analysis cartridge the includes a main body portion and a filter assembly. The main body portion includes an upper portion that defines an upper chamber and a lower portion that defines a fluid chamber. The filter assembly is movable along a filter assembly path between a first position and a second position. The filter assembly has an opening defined therethrough. In the first position, the opening partially defines the upper chamber and in the second position the opening partially defines the fluid chamber.

公开(公告)号：US09797815B2

公开(公告)日：2017-10-24

申请号：US14754534

申请日：2015-06-29

Applicant: Pulse Health LLC

Inventor： Steve Cooper ,  Neal Andrews ,  Martin Krauss ,  Andrew E. King ,  Maura Mahon ,  Weston Myler ,  James Ingle ,  Gerald Thomas ,  Rachel Dreilinger ,  David Barsic ,  Rick Myers ,  Craig Carlsen ,  Scot Herbst ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC: G01N1/22 ,  G01N33/497 ,  G01D11/24 ,  G01N33/52 ,  G01N33/64 ,  G01N21/64

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.

公开(公告)号：US20170242018A1

公开(公告)日：2017-08-24

申请号：US15436103

申请日：2017-02-17

Applicant: Pulse Health, LLC

Inventor： Gerald Thomas ,  Juven Lara ,  Charles Noll ,  Brian Young ,  Craig Carlsen ,  Maura Mahon ,  James Ingle

IPC: G01N33/58 ,  G01N33/64

Abstract: Methods, systems and reagents are provided for detecting and quantifying carbonyl containing moieties in a variety of sample types. The amount of time elapsed from capturing of the carbonyl containing moieties from a sample to the detection of the carbonyl containing moieties is less than about 2 hours. Compounds are provided to facilitate labeling and detection of the carbonyl containing moieties.

公开(公告)号：US09404836B2

公开(公告)日：2016-08-02

申请号：US14754567

申请日：2015-06-29

Applicant: Pulse Health LLC

Inventor： Gerald Thomas ,  Brian Young ,  Juven Lara ,  Charles Noll ,  James Ingle

IPC: G01N33/497 ,  G01N33/48 ,  G01N33/58 ,  G01N1/22 ,  G01D11/24 ,  G01N33/52 ,  G01N21/64

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: Fluorescence chromophores such as phenylene diamine derivatives can undergo oxidative coupling and polymerization to form optical, colorimetric and fluorogenic, multimers and polymers. The presence of carbonyl containing moieties such as aldehydes and ketones under favorable environmental conditions can initiate, catalyze, accelerate and modulate this reaction which in turn provides a mechanism for the detection and quantitation of such moieties. Selected phenylene diamine derivatives can be used for the detection and quantitation of aldehyde and ketones via measurement of the reaction and the associated spectroscopic transformation. In particular, the use of meta-phenylene diamine (mPDA) and related compounds for aldehyde detection and quantitation is described. The method provides a convenient means for monitoring aldehyde and ketone levels without use of separation steps. The method is applicable to kinetic and quasi-endpoint detection assay formats.

Abstract translation: 荧光发色团如苯二胺衍生物可进行氧化偶联和聚合以形成光学，比色和荧光，多聚体和聚合物。 在有利的环境条件下，含有羰基的部分如醛和酮的存在可引发，催化，加速和调节该反应，而反应又提供了检测和定量这些部分的机理。 选择的苯二胺衍生物可用于通过测量反应和相关的光谱转化来检测和定量醛和酮。 特别地，描述了使用间苯二胺（mPDA）和相关化合物进行醛检测和定量。 该方法提供了在不使用分离步骤的情况下监测醛和酮水平的方便手段。 该方法适用于动力学和准终点检测测定方法。