公开(公告)号：US12123834B2

公开(公告)日：2024-10-22

申请号：US16900008

申请日：2020-06-12

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid

IPC: B01L3/00 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/64 ,  G01N21/77

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/7743 ,  G01N21/7746 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/168 ,  C12Q2521/101 ,  C12Q2525/101 ,  C12Q2537/157 ,  C12Q2563/107 ,  C12Q2565/607 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/125 ,  Y10T29/49016 ,  C12Q1/6874 ,  C12Q2521/101 ,  C12Q2525/101 ,  C12Q2537/157 ,  C12Q2563/107 ,  C12Q2565/607

Abstract: An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that are analyzed to differentiate between and identify tags that are attached to, or associated with, the sample. Tag differentiation may be spectral and/or temporal based. Identification of the tags may be used to detect, analyze, and/or sequence the biomolecule.

公开(公告)号：US20240319617A1

公开(公告)日：2024-09-26

申请号：US18578168

申请日：2022-06-28

Applicant: ASML Holding N.V.

Inventor： Mohamed SWILLAM ,  Wei GUO ,  Stephen ROUX

IPC: G03F7/00 ,  G01N21/956 ,  G02F1/295

CPC classification number: G03F7/706849 ,  G01N21/956 ,  G02F1/2955 ,  G03F7/7065 ,  G03F7/706837 ,  G03F7/706845 ,  G03F7/706847 ,  G03F7/70925 ,  G01N2201/068

Abstract: A metrology system includes a radiation source (708), a phased array (722a,b;724a,b;726;734), a detector, and a comparator. The phased array includes optical elements (706), waveguides (704), and phase modulators (702). The phased array generates a beam of radiation and directs the beam toward a surface of an object. The optical elements radiate radiation waves. The waveguides guide radiation from the radiation source to the optical elements. The phase modulators adjust phases of the radiation waves such that the radiation waves combine to form the beam. The detector receives radiation scattered from the surface and generates a detection signal based on the received radiation. The comparator analyzes the detection signal and determines a location of a defect on the surface based on the analyzing.

公开(公告)号：US20240310781A1

公开(公告)日：2024-09-19

申请号：US18121063

申请日：2023-03-14

Applicant: BottleVin, Inc.

Inventor： Leslie Young Harvill

IPC: G03H1/00 ,  G01N21/33 ,  G01N21/359 ,  G03H1/04 ,  H04N23/55

CPC classification number: G03H1/0011 ,  G01N21/33 ,  G01N21/359 ,  G03H1/0443 ,  H04N23/55 ,  G01N2201/068 ,  G03H2001/0033 ,  G03H2001/0445 ,  G03H2223/15 ,  G03H2223/24 ,  G03H2226/11 ,  H04N23/56 ,  H04N25/10

Abstract: In some implementations, a method comprises: determining a set of characteristics of light spectra reflected or transmitted by a set of materials when the set of materials is illuminated by a plurality of light wavelengths; constructing one or more classifiers configured to classify each material of the set of materials based on the set of characteristics of the light spectra; using the classifiers, mapping each of the light spectra onto an area of an image sensor; wherein one or more optical elements filter and focus the light spectra onto one or more elements of a detector array; wherein each optical element focuses onto an area of the detector array; wherein the mapping is a 1:1 mapping; wherein each optical element uses a Bragg reflection condition to filter the light spectra and to focus the light spectra onto an element of the detector array.

公开(公告)号：US12071664B2

公开(公告)日：2024-08-27

申请号：US17939760

申请日：2022-09-07

Applicant: Pacific Biosciences of California, Inc.

Inventor： Adrian Fehr ,  Nathaniel Joseph McCaffrey ,  Stephen Turner

IPC: C12Q1/6874 ,  B01L3/00 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/05 ,  G01N21/64 ,  G01N21/75 ,  G01N21/77 ,  G01N33/543 ,  G02B6/122

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G02B6/1226 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  Y10T436/143333

Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

公开(公告)号：US20240167955A1

公开(公告)日：2024-05-23

申请号：US18420704

申请日：2024-01-23

Applicant: Gemological Institute of America, Inc. (GIA)

Inventor： Hiroshi TAKAHASHI

IPC: G01N21/64 ,  G01N21/87 ,  G01N33/38

CPC classification number: G01N21/6456 ,  G01N21/87 ,  G01N33/381 ,  G01N2021/6471 ,  G01N2201/062 ,  G01N2201/0634 ,  G01N2201/068 ,  G01N2201/12

Abstract: Provided herein is an apparatus for assessing a fluorescence characteristic of a gemstone. The apparatus comprises an optically opaque platform for supporting a gemstone to be assessed, one or more light source to provide uniform UV and non-UV illumination, an image capturing component, and a telecentric lens positioned to provide fluorescent images of the illuminated gemstone to the image capturing component. Also provided are methods of fluorescence analysis based on images collected using such an apparatus.

公开(公告)号：US11860103B2

公开(公告)日：2024-01-02

申请号：US17592721

申请日：2022-02-04

Applicant: K2R2 LLC

Inventor： Robert L Kay ,  Graham Ross

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01N2021/651 ,  G01N2201/022 ,  G01N2201/068

Abstract: A method of analyzing a sample is disclosed. The method includes the steps of measuring a spectral response of the sample, selecting a reference material having a Raman peak with a magnitude at a wave number, measuring a peak value in the spectral response at the wave number, and determining an amount of the reference material in the sample based in part on a ratio of the measured peak value to the magnitude of the Raman peak of the reference material.

公开(公告)号：US20230408415A1

公开(公告)日：2023-12-21

申请号：US18455983

申请日：2023-08-25

Applicant: Foss Analytical A/S

Inventor： Daniel ADEN ,  Ahmed FADIL

IPC: G01N21/71

CPC classification number: G01N21/718 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/126

Abstract: A LIBS analysis system comprises a focusing lens arrangement having a focal plane; a laser for propagating a laser beam through the focusing lens arrangement to be focused at the focal plane; a detector for generating an output that is proportional to an intensity of incident electromagnetic radiation that is incident on the detector; a translation mechanism configured to cause a relative movement of the sample holder and the focusing lens arrangement to vary a position of the focal plane along the optical path with respect to the sample holder; and a controller configured to automatically control the translation mechanism to cause the relative movement of the sample holder and the focusing lens arrangement to achieve an optimum position at which the focal plane and an analysis region of the upper surface intersecting the optical path are at or are close to coincidence.

公开(公告)号：US11787452B2

公开(公告)日：2023-10-17

申请号：US18104497

申请日：2023-02-01

Applicant: Ensco, Inc.

Inventor： Anthony Kim ,  David G. Ford ,  Jeffrey Bloom

IPC: B61K9/08 ,  B61L23/04 ,  E05F15/70 ,  G01N21/55 ,  G02B7/182 ,  G01N21/95

CPC classification number: B61K9/08 ,  B61L23/041 ,  B61L23/042 ,  E05F15/70 ,  G01N21/55 ,  G01N21/95 ,  G02B7/182 ,  E05Y2900/51 ,  G01N2201/0216 ,  G01N2201/068

Abstract: A deployable measurement system for analyzing a rail of a railroad track includes a housing, a reflecting assembly coupled to the housing, a movement assembly coupled to the housing, and an optical measurement system disposed within the housing. Both the housing and the reflecting assembly are moveable between a stored position and a deployed position. The movement assembly includes a deployment assembly that moves the reflecting assembly from the stored position to the deployed position, and a retraction assembly that moves the reflecting assembly from the deployed position to the stored position. The optical measurement system emits and receives light. The reflecting assembly reflects the emitted light toward the rail. The reflecting assembly reflects light reflected off of the rail toward the optical measurement system. The light received by the optical measurement system is used to measure parameters related to the rail.

公开(公告)号：US20230266118A1

公开(公告)日：2023-08-24

申请号：US18310314

申请日：2023-05-01

Applicant: OMRON Corporation

Inventor： Hisayasu Morino ,  Kenichi Matoba ,  Takahiro Suga

IPC: G01B11/24 ,  G01C3/06 ,  G01B11/06 ,  G01B11/14 ,  G01N21/27

CPC classification number: G01B11/24 ,  G01C3/06 ,  G01B11/0608 ,  G01B11/14 ,  G01N21/27 ,  G01B2210/50 ,  G01N2201/068

Abstract: A white light confocal optical measurement device capable of detecting abnormalities in a received light waveform; the optical measurement device includes: a light source; an optical system; a light receiving unit; and a processor configured to compute the distance from the optical system to the measurement object on the basis of a received light intensity of the wavelength components received in the light receiving unit. The processor compares a received light intensity of a wavelength component to a reference value for the wavelength component for a plurality of wavelength components in a waveform representing the light received, and detects an abnormality in the received light waveform when the amount of change in the received light intensity compared to the reference value therefor is greater than or equal to a predetermined threshold for any wavelength component in the plurality of wavelength components.
57544739

公开(公告)号：US20230168193A1

公开(公告)日：2023-06-01

申请号：US18070121

申请日：2022-11-28

Applicant: Lumileds LLC

Inventor： Florent Gregoire Monestier ,  Franklin Chiang ,  Hisashi Masui

IPC: G01N21/3504

CPC classification number: G01N21/3504 ,  G01N2201/0636 ,  G01N2201/068

Abstract: A gas sensing system measures a concentration of a gas sample having an absorption peak at a first wavelength. An emitter emits light having a spectrum that includes at least the first wavelength. A sensor detects at least some of the light emitted by the emitter. A porous scattering material is substantially transparent at the first wavelength and scatters at least some of the light. A surface of the porous scattering material opposing the emitter and the sensor has a depression. The emitter and the sensor are laterally and vertically separated by a separator filling the depression. The separator specularly or diffusively reflects the light emitted by the emitter.