公开(公告)号：US11299778B2

公开(公告)日：2022-04-12

申请号：US16277113

申请日：2019-02-15

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Jason W. Sickler ,  Lawrence C. West ,  Faisal R. Ahmad ,  Paul E. Glenn ,  Jack Jewell ,  John Glenn ,  Jose Camara ,  Jeremy Christopher Jordan ,  Todd Rearick ,  Farshid Ghasemi ,  Jonathan C. Schultz ,  Keith G. Fife

IPC: C12Q1/6869 ,  G01N21/64 ,  H01L27/146 ,  H01S3/101 ,  H01S3/13 ,  H01S3/105 ,  H01S3/081 ,  H01S3/11 ,  H01S3/0941 ,  H01S3/10 ,  H01S3/00 ,  H01S3/16 ,  G01S7/481 ,  H01S3/04

Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.

公开(公告)号：US20210384696A1

公开(公告)日：2021-12-09

申请号：US17412154

申请日：2021-08-25

Applicant: Quantum-Si Incorporated

Inventor： Jonathan C. Schultz ,  Andrey V. Okishev ,  Craig Wenger ,  Brittany Lathrop ,  Faisal R. Ahmad

IPC: H01S3/11 ,  G01J11/00 ,  H01S3/00 ,  H01S3/08 ,  H01S3/086 ,  H01S3/105 ,  H01S3/16

Abstract: A method and apparatus for characterizing an optical element. The optical element is part of a laser and is mounted on a translation stage to scan the optical element transverse to an intracavity laser beam. A performance characteristic of the laser is recorded as a function of position of the optical element.

公开(公告)号：US20210164035A1

公开(公告)日：2021-06-03

申请号：US17082226

申请日：2020-10-28

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  John H. Leamon ,  Jonathan C. Schultz ,  Michele Millham ,  Caixia Lv ,  Xiaxiao Ma

IPC: C12Q1/6869 ,  B01L3/00

Abstract: Methods and devices for enriching and analyzing target molecules from a sample are provided herein. In some embodiments, methods and devices involve enrichment of target molecules (e.g., using SCODA) and subsequent detection and analysis using sequencing.

公开(公告)号：US20210121875A1

公开(公告)日：2021-04-29

申请号：US17083126

申请日：2020-10-28

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Jonathan C. Schultz ,  John H. Leamon ,  Todd Roswech ,  Xiaxiao Ma

IPC: B01L3/00

Abstract: Embodiments described herein generally relate to apparatuses, cartridges, and pumps for peristaltic pumping of fluids and associated methods, systems, and devices. The pumping of fluids is, in certain cases, an important aspect of a variety of applications, such as bioanalytical applications (e.g., biological sample analysis, sequencing, identification). The inventive features described herein may, in some embodiments, provide an ability to pump fluids in ways that combine certain advantages of robotic fluid handling systems (e.g., automation, programmability, configurability, flexibility) with certain advantages of microfluidics (e.g., small fluid volumes with high fluid resolution, precision, monolithic consumables, limiting of the wetting of components to consumables).

公开(公告)号：US20180175582A1

公开(公告)日：2018-06-21

申请号：US15844469

申请日：2017-12-15

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Jason W. Sickler ,  Lawrence C. West ,  Faisal R. Ahmad ,  Paul E. Glenn ,  Jack Jewell ,  John Glenn ,  Jose Camara ,  Jeremy Christopher Jordan ,  Todd Rearick ,  Farshid Ghasemi ,  Jonathan C. Schultz ,  Keith G. Fife ,  Benjamin Cipriany

IPC: H01S3/11 ,  H01S3/08 ,  H01S3/0941 ,  H01S3/042 ,  H01S3/16 ,  G02F1/37 ,  H01S3/00

CPC classification number: H01S3/1115 ,  G02F1/37 ,  H01S3/0092 ,  H01S3/042 ,  H01S3/08072 ,  H01S3/0941 ,  H01S3/10046 ,  H01S3/1611 ,  H01S3/1673

Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.

公开(公告)号：US20240023285A1

公开(公告)日：2024-01-18

申请号：US17864370

申请日：2022-07-13

Applicant: Quantum-Si Incorporated

Inventor： Todd Rearick ,  Kyle Rearick ,  Jonathan C. Schultz ,  Philip Trioli

IPC: H05K7/20

CPC classification number: H05K7/20509 ,  H05K7/2049 ,  G01N33/53

Abstract: Heat transfer systems and methods are generally described. A bioanalytical instrument may employ a variety of heat-generating optoelectronic chips to perform biochemical assays. In some embodiments, the instrument may include a heat transfer system configured to cool the chips by thermally coupling them to a heat sink. The heat transfer system may include an elastically deformable flexible plate to conform to the differently-sized chips, withstand numerous cycles of chip insertion/removal, and respond to pressures exerted by supporting structures of the instrument. The heat transfer system may include a thermally conductive material indirectly but thermally coupled to the chip via the flexible plate, which may be positioned between the heat sink and the flexible plate.

公开(公告)号：US20230184678A1

公开(公告)日：2023-06-15

申请号：US18080671

申请日：2022-12-13

Applicant: Quantum-Si Incorporated

Inventor： Gerard Schmid ,  Todd Rearick ,  Brian Brian ,  Jonathan C. Schultz

IPC: G01N21/64 ,  C12Q1/6869

CPC classification number: G01N21/6408 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N21/6454

Abstract: Provided herein, in some embodiments, are methods of loading an integrated device and/or chip for detection (e.g., sequencing) and methods of sequencing a target molecule.

公开(公告)号：US11567006B2

公开(公告)日：2023-01-31

申请号：US16751135

申请日：2020-01-23

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Jason W. Sickler ,  Lawrence C. West ,  Faisal R. Ahmad ,  Brendan Huang ,  Paul E. Glenn ,  Jonathan C. Schultz ,  Jose Camara

IPC: H05B45/335 ,  H05B47/16 ,  G01N21/64 ,  H01S5/042 ,  H01L27/146 ,  G01S7/484 ,  G01S7/4863

Abstract: Compact optical sources and methods for producing short and ultrashort optical pulses are described. A semiconductor laser or LED may be driven with a bipolar waveform to generate optical pulses with FWHM durations as short as approximately 85 ps having suppressed tail emission. The pulsed optical sources may be used for fluorescent lifetime analysis of biological samples and time-of-flight imaging, among other applications.

公开(公告)号：US11249318B2

公开(公告)日：2022-02-15

申请号：US16721611

申请日：2019-12-19

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Paul E. Glenn ,  Jonathan C. Schultz ,  Benjamin Cipriany

IPC: G02B27/09 ,  G02B6/34 ,  G02B7/00 ,  G02B19/00 ,  G01N21/64

Abstract: Apparatus and methods for coupling an optical beam from an optical source to a hi-tech system are described. A compact, low-cost beam-shaping and steering assembly may be located between the optical source and hi-tech system and provide automated adjustments to beam parameters such as beam position, beam rotation, and beam incident angles. The beam-shaping and steering assembly may be used to couple an elongated beam to a plurality of optical waveguides.

公开(公告)号：US20210310066A1

公开(公告)日：2021-10-07

申请号：US17350509

申请日：2021-06-17

Applicant: Quantum-Si Incorporated

Inventor： Guojun Chen ,  Jeremy Lackey ,  Alexander Goryaynov ,  Gerard Schmid ,  Ali Kabiri ,  Jonathan M. Rothberg ,  Todd Rearick ,  Jonathan C. Schultz ,  Farshid Ghasemi ,  Keith G. Fife

IPC: C12Q1/6869 ,  G01N21/64 ,  B01L3/00 ,  G01N30/86 ,  C08L1/02 ,  C12Q1/6806 ,  G01N27/447

Abstract: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.