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公开(公告)号:US11466316B2
公开(公告)日:2022-10-11
申请号:US16277113
申请日:2019-02-15
Applicant: Quantum-Si Incorporated
Inventor: Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife
IPC: C12Q1/6869 , G01N21/64 , H01L27/146 , H01S3/00 , H01S3/081 , H01S3/0941 , H01S3/10 , H01S3/101 , H01S3/105 , H01S3/11 , H01S3/13 , H01S3/16 , G01S7/481 , H01S3/04
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.
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公开(公告)号:US20210354133A1
公开(公告)日:2021-11-18
申请号:US17236804
申请日:2021-04-21
Applicant: Quantum-Si Incorporated
Inventor: Jonathan M. Rothberg , John H. Leamon , Jonathan C. Schultz , Michele Millham , Caixia Lv , Haidong Huang , Roger Nani , Omer Ad , Brian Reed , Matthew Dyer , Robert E. Boer
IPC: B01L3/00 , C12Q1/6806
Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).
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公开(公告)号:US20190211389A1
公开(公告)日:2019-07-11
申请号:US16239789
申请日:2019-01-04
Applicant: Quantum-Si Incorporated
Inventor: Guojun CHEN , Jeremy Lackey , Alex Goryanyov , Gerard Schmid , Ali Kabiri , Jonathan M. Rothberg , Todd Rearick , Jonathan C. Schultz , Farshid Ghasemi , Keith G. Fife
IPC: C12Q1/6869 , C12Q1/6806 , B01L3/00 , C08L1/02 , G01N21/64 , G01N27/447
CPC classification number: C12Q1/6869 , B01L3/502761 , B01L3/50857 , B01L2200/0647 , B01L2300/0645 , B01L2300/0829 , B01L2300/0864 , B01L2400/0415 , B01L2400/0421 , C08L1/02 , C12Q1/6806 , G01N21/6428 , G01N27/44743 , G01N27/44782
Abstract: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.
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公开(公告)号:US20180173000A1
公开(公告)日:2018-06-21
申请号:US15842720
申请日:2017-12-14
Applicant: Quantum-Si Incorporated
Inventor: Jonathan M. Rothberg , Paul E. Glenn , Jonathan C. Schultz , Benjamin Cipriany
Abstract: Apparatus and methods for coupling an optical beam from an optical source to a hi-tech system are described. A compact, low-cost beam-shaping and steering assembly may be located between the optical source and hi-tech system and provide automated adjustments to beam parameters such as beam position, beam rotation, and beam incident angles. The beam-shaping and steering assembly may be used to couple an elongated beam to a plurality of optical waveguides.
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公开(公告)号:US09617594B2
公开(公告)日:2017-04-11
申请号:US15255624
申请日:2016-09-02
Applicant: Quantum-Si Incorporated
Inventor: Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife
IPC: G01N21/00 , H01S3/105 , C12Q1/68 , H01S3/11 , H01S3/00 , H01S3/101 , H01S3/13 , H01S3/10 , G01N21/64 , H01L27/146 , H01S3/081 , H01S3/0941 , H01S3/04 , H01S3/16 , G01S7/481
CPC classification number: C12Q1/6869 , G01N21/6408 , G01N21/645 , G01N21/6458 , G01N2021/6439 , G01N2021/6441 , G01S7/4814 , H01L27/14603 , H01S3/0071 , H01S3/0405 , H01S3/0817 , H01S3/0941 , H01S3/10061 , H01S3/101 , H01S3/105 , H01S3/1115 , H01S3/1118 , H01S3/1305 , H01S3/1611 , H01S3/1673
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.
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公开(公告)号:US12235463B2
公开(公告)日:2025-02-25
申请号:US17566765
申请日:2021-12-31
Applicant: Quantum-Si Incorporated
Inventor: Jonathan M. Rothberg , Paul E. Glenn , Jonathan C. Schultz , Benjamin Cipriany
Abstract: Apparatus and methods for coupling an optical beam from an optical source to a hi-tech system are described. A compact, low-cost beam-shaping and steering assembly may be located between the optical source and hi-tech system and provide automated adjustments to beam parameters such as beam position, beam rotation, and beam incident angles. The beam-shaping and steering assembly may be used to couple an elongated beam to a plurality of optical waveguides.
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公开(公告)号:US20240110871A1
公开(公告)日:2024-04-04
申请号:US18465965
申请日:2023-09-12
Applicant: Quantum-Si Incorporated
Inventor: Jonathan C. Schultz
IPC: G01N21/64
CPC classification number: G01N21/6428 , G01N21/6402 , G01N21/645 , G01N2021/6439 , G01N2201/06113 , G01N2201/0636
Abstract: Disclosed herein are embodiments of a sensor chip package that comprises a cap that engages the sensor chip and serving as a helmet that covers some or all of a top surface of the sensor chip. Aspects of the present disclosure provide a cap design that has an optical component to deflect an excitation light signal towards the top surface of sensor chip to excite samples within the sample wells. In some embodiments, the optical component may be a mirror or prism that provides a right angle coupling of excitation light signal to the sensor chip. Some embodiments are directed to a cap design in which a mirror is supported by multiple support surfaces of the cap body such that a mirror of a different length will provide a different tilt angle when supported by the same support surfaces.
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公开(公告)号:US11932906B2
公开(公告)日:2024-03-19
申请号:US17350509
申请日:2021-06-17
Applicant: Quantum-Si Incorporated
Inventor: Guojun Chen , Jeremy Lackey , Alexander Goryaynov , Gerard Schmid , Ali Kabiri , Jonathan M. Rothberg , Todd Rearick , Jonathan C. Schultz , Farshid Ghasemi , Keith G. Fife
IPC: C12Q1/6869 , B01L3/00 , C08L1/02 , C12Q1/6806 , G01N21/64 , G01N27/447 , G01N30/86 , G01N30/88
CPC classification number: C12Q1/6869 , B01L3/502761 , B01L3/50857 , C08L1/02 , C12Q1/6806 , G01N21/6428 , G01N21/6454 , G01N27/44743 , G01N27/44782 , G01N30/86 , B01L2200/0647 , B01L2300/0645 , B01L2300/0829 , B01L2300/0864 , B01L2400/0415 , B01L2400/0421 , G01N27/447 , G01N30/88
Abstract: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.
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公开(公告)号:US20220339627A1
公开(公告)日:2022-10-27
申请号:US17725155
申请日:2022-04-20
Applicant: Quantum-Si Incorporated
Inventor: Xiaoxiao Ma , Jonathan C. Schultz , Caixia Lv , Brittany Lathrop
Abstract: Aspects of this disclosure relate to systems, devices, and methods for the transfer of fluid to fluidic receptacles. In some embodiments, the fluid contains one or more molecules (e.g., one or more peptides, proteins, and/or nucleic acids) of interest, and the fluidic receptacle includes an integrated device. In certain embodiments, the one or more molecules can be immobilized on the integrated device for subsequent analysis (e.g., sequencing). Certain aspects of the present disclosure are directed towards systems and methods that can, in some instances, enhance the immobilization of the one or more molecules on the integrated device, e.g., by improving a rate of sample interaction with the integrated device. Through the use of systems, devices, and methods of the instant disclosure, target molecules may be more readily sequenced or prepared for sequencing. For example, in some embodiments, systems, devices, and methods of the instant disclosure allow automated loading of the fluidic receptacle using a fluidic device.
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公开(公告)号:US20220128828A1
公开(公告)日:2022-04-28
申请号:US17566765
申请日:2021-12-31
Applicant: Quantum-Si Incorporated
Inventor: Jonathan M. Rothberg , Paul E. Glenn , Jonathan C. Schultz , Benjamin Cipriany
Abstract: Apparatus and methods for coupling an optical beam from an optical source to a hi-tech system are described. A compact, low-cost beam-shaping and steering assembly may be located between the optical source and hi-tech system and provide automated adjustments to beam parameters such as beam position, beam rotation, and beam incident angles. The beam-shaping and steering assembly may be used to couple an elongated beam to a plurality of optical waveguides.
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