公开(公告)号：US11945786B2

公开(公告)日：2024-04-02

申请号：US16339285

申请日：2017-10-03

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Omid Veiseh ,  Richard Heidebrecht ,  Paul Kevin Wotton ,  Matthias Alexander Oberli ,  Robert James Miller

IPC: A61K31/4192 ,  A61K9/00 ,  A61K31/05 ,  A61K31/54 ,  A61K31/541 ,  A61K31/695 ,  A61K31/7056 ,  A61K35/30 ,  A61K38/47 ,  A61K39/395 ,  A61P3/00 ,  A61P7/02 ,  A61P7/04 ,  A61P37/00 ,  A61P37/04 ,  A61P37/06 ,  A61P43/00 ,  C07D249/04 ,  C07D249/06 ,  C07D295/088 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07F7/18 ,  C07H15/26 ,  C07K16/22 ,  C12N9/40

CPC classification number: C07D249/04 ,  A61K9/0019 ,  A61K31/4192 ,  A61K31/54 ,  A61K31/541 ,  A61K31/695 ,  A61K31/7056 ,  A61K35/30 ,  A61K38/47 ,  A61K39/3955 ,  A61P37/04 ,  A61P37/06 ,  C07D295/088 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07F7/1804 ,  C07F7/1892 ,  C07H15/26 ,  C07K16/22 ,  C12N9/2465 ,  C12Y302/01022

Abstract: The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.

公开(公告)号：US20220267794A1

公开(公告)日：2022-08-25

申请号：US17598176

申请日：2020-03-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Owen O'Connor ,  Matthias Alexander Oberli ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Jeffrey Charles Way ,  Paul Kevin Wotton ,  Zoe Yin ,  Elina Makino ,  Brian Richard Fluharty ,  Marianthi Papakosta

IPC: C12N15/85 ,  A61K38/47 ,  A61K47/22 ,  A61K9/50 ,  C08L5/04

Abstract: Described herein are RPE cells engineered to secrete a GLA protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating Fabry disease.

公开(公告)号：US20220000789A1

公开(公告)日：2022-01-06

申请号：US17280802

申请日：2019-09-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Owen O'Connor ,  Matthias Alexander Oberli ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Paul Kevin Wotton ,  Zoe Yin

IPC: A61K9/50 ,  A61K35/30 ,  A61K38/37

Abstract: Described herein are implantable devices comprising means for mitigating the foreign body response (FBR) and at least one cell-containing compartment which comprises a plurality of cells (e.g., live cells) encapsulated in a polymer composition comprising a cell-binding substance (CBS), as well as compositions and methods of making and using the same. The cells are capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.

公开(公告)号：US20210060205A1

公开(公告)日：2021-03-04

申请号：US16977724

申请日：2019-03-01

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Richard Heidebrecht ,  Robert James Miller ,  Omid Veiseh

IPC: A61L27/20 ,  C07D249/06 ,  C07D405/12 ,  C07D309/12 ,  C07D235/00 ,  C07D279/12 ,  C07D249/04 ,  C07D491/107 ,  C07D417/06 ,  A61K9/50 ,  A61K9/00 ,  A61L27/52 ,  C08B37/00 ,  A61L27/54

Abstract: Described herein are compounds of Formula (I), modified polymers and implantable elements comprising compounds of Formula (II), as well as compositions and methods of use thereof. In particular, the compounds, modified polymers, implantable elements and related compositions may be used in methods for the prevention and treatment of a disease, disorder or condition in a subject.

公开(公告)号：US20210002433A1

公开(公告)日：2021-01-07

申请号：US16977735

申请日：2019-03-01

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller

IPC: C08J3/075 ,  C08J3/24 ,  C08J3/20 ,  C08K3/16

Abstract: Described herein are compositions and methods for preparing hydrogel capsules using a cross-linking solution comprising a process additive. The process additive improves the quality of the resulting hydrogel capsules, such as increasing the number of defect-free capsules.