公开(公告)号：US20210145759A1

公开(公告)日：2021-05-20

申请号：US17045127

申请日：2019-03-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Matthias Alexander Oberli ,  Owen O'Connor ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Paul Kevin Wotton

IPC: A61K9/50 ,  A61K35/28 ,  A61K35/30 ,  C07K14/755 ,  C07K14/62 ,  C12N9/64

Abstract: Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.

公开(公告)号：US12161760B2

公开(公告)日：2024-12-10

申请号：US17045127

申请日：2019-03-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Matthias Alexander Oberli ,  Owen O'Connor ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Paul Kevin Wotton

IPC: A61K9/50 ,  A61K35/28 ,  A61K35/30 ,  C07K14/62 ,  C07K14/755 ,  C12N9/64

Abstract: Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.

公开(公告)号：US20230008121A1

公开(公告)日：2023-01-12

申请号：US17782368

申请日：2020-12-04

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Michael Beauregard ,  Faith C. David-Hegerich ,  John Patrick Golden ,  Joseph Gordon ,  Erika Ellen Johnston ,  Robert James Miller ,  Justin David Morse ,  Peter Calvin Costello

IPC: G01N1/31 ,  B01D43/00 ,  B01J2/04 ,  B01J13/08

Abstract: Described herein are apparatuses and methods for conditioning particles. In some embodiments, the apparatuses and methods are configured for first-in-first-out transit of particles through a chamber containing a conditioning fluid.

公开(公告)号：US20230123802A1

公开(公告)日：2023-04-20

申请号：US17598154

申请日：2020-03-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Owen O'Connor ,  Matthias Alexander Oberli ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Paul Kevin Wotton ,  Zoe Yin

IPC: A61K35/30 ,  A61K9/48 ,  C12N9/64 ,  C12N15/52 ,  C12N5/079

Abstract: Described herein are RPE cells engineered to secrete a FVII protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating a patient with hemophilia or FVII deficiency.

公开(公告)号：US20220267794A1

公开(公告)日：2022-08-25

申请号：US17598176

申请日：2020-03-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Owen O'Connor ,  Matthias Alexander Oberli ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Jeffrey Charles Way ,  Paul Kevin Wotton ,  Zoe Yin ,  Elina Makino ,  Brian Richard Fluharty ,  Marianthi Papakosta

IPC: C12N15/85 ,  A61K38/47 ,  A61K47/22 ,  A61K9/50 ,  C08L5/04

Abstract: Described herein are RPE cells engineered to secrete a GLA protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating Fabry disease.

公开(公告)号：US20220000789A1

公开(公告)日：2022-01-06

申请号：US17280802

申请日：2019-09-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Owen O'Connor ,  Matthias Alexander Oberli ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Paul Kevin Wotton ,  Zoe Yin

IPC: A61K9/50 ,  A61K35/30 ,  A61K38/37

Abstract: Described herein are implantable devices comprising means for mitigating the foreign body response (FBR) and at least one cell-containing compartment which comprises a plurality of cells (e.g., live cells) encapsulated in a polymer composition comprising a cell-binding substance (CBS), as well as compositions and methods of making and using the same. The cells are capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.