公开(公告)号：US09958402B2

公开(公告)日：2018-05-01

申请号：US13775325

申请日：2013-02-25

Applicant: Steven M. Ebstein

Inventor： Steven M. Ebstein

IPC: G01J1/00 ,  G01N23/04 ,  A61N5/10

CPC classification number: G01N23/04 ,  A61N5/1075 ,  A61N2005/1076

Abstract: An apparatus and method are provided for performing Quality Assurance of complex beams of penetrating radiation inside a patient. A detector with a transverse scintillating screen images the radiation inside a tissue phantom with high spatial resolution. The scintillator is comprised of a mixture of two or more scintillators emitting different spectra of light and having different characteristic responses as a function of the beam LET value. The optics relaying the scintillation output have variable transmission with wavelength, further shaping the spectrum of light transmitted to the imaging sensor which also has spectrally varying sensitivity. Parameters of the scintillator construction, the optics, and the imaging sensor are chosen so the output of the composite detector is proportional to a characteristic of the input beam, for example the dose deposited as a function of depth inside the tissue phantom.

公开(公告)号：US07969570B2

公开(公告)日：2011-06-28

申请号：US12584574

申请日：2009-09-08

Applicant: Steven M. Ebstein

Inventor： Steven M. Ebstein

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/5088 ,  B01L2200/12 ,  B01L2300/165 ,  B81B1/006 ,  B81C1/00206 ,  B82Y15/00 ,  B82Y30/00

Abstract: A method for performing a diagnostic assay of an analyte, wherein the method comprises providing a base that has been structured using laser processing so as to provide a substrate with at least one patterned surface, wherein the laser processing comprises the selective application of pulsed laser energy to the base, whereby to melt a surface layer of the base which resolidifies, whereby to create the at least one patterned surface; applying a metal to the at least one patterned surface so as to provide at least one metalized patterned surface; positioning the analyte on the at least one metalized patterned surface; and performing a diagnostic assay of the analyte.

Abstract translation: 一种用于执行分析物的诊断测定的方法，其中所述方法包括提供已经使用激光处理构造的基底，以便为基底提供至少一个图案化表面，其中所述激光处理包括选择性地施加脉冲激光能量 从而使基体的表面层熔融，从而形成至少一个图案化的表面; 将金属施加到所述至少一个图案化表面，以便提供至少一个金属化图案化表面; 将分析物定位在至少一个金属化图案化表面上; 并进行分析物的诊断测定。

公开(公告)号：US20230119921A1

公开(公告)日：2023-04-20

申请号：US17970205

申请日：2022-10-20

Applicant: Steven M. Ebstein ,  VOTIS Subdermal Imaging Technologies, Ltd.

Inventor： Zeev Bomzon ,  Steven M. Ebstein ,  EliyahuShalom Kolet ,  Ori Kadosh ,  Amit Barak ,  Hagai Barak ,  Arie Oscar Holtz ,  Edan Kenig

IPC: A61B5/145 ,  A61B5/00

Abstract: An apparatus for performing diffuse optical imaging of blood circulation in a patient, said apparatus comprising: at least one sensor module comprising at least one optical source and at least one photodetector; an interface electronics module; and means for communicating at least one selected from the group consisting of control signals and measurement data between said sensor module and said interface electronics module; wherein said apparatus further comprises a membrane releasably secured to the skin of the patient, said membrane being configured to releasably secure said at least one sensor module to said membrane such that said at least one sensor module is disposed against the skin of the patient.

公开(公告)号：US20230118120A1

公开(公告)日：2023-04-20

申请号：US17970397

申请日：2022-10-20

Applicant: Steven M. Ebstein ,  VOTIS Subdermal Imaging Technologies, Ltd.

Inventor： Steven M. Ebstein ,  Jacques Aschkenasy ,  Ephraim Siegel ,  Zeev Bomzon ,  Ariel Rachminov

IPC: G01N21/47 ,  G01T7/00

Abstract: An apparatus for performing diffuse optical imaging of a patient, said apparatus comprising: a computer; at least one sensor module comprising at least one optical source, at least one photodetector, and calibration data specific to said at least one sensor module; means for communicating between said computer and said at least one sensor module; means for automatically accessing said calibration data; and means for adjusting said apparatus in order to produce calibrated measurements.

公开(公告)号：US11002688B2

公开(公告)日：2021-05-11

申请号：US16506241

申请日：2019-07-09

Applicant: Steven M. Ebstein

Inventor： Steven M. Ebstein

IPC: G06T7/00 ,  G01N21/95 ,  H04N5/225 ,  G02B21/00 ,  G02B5/18 ,  H01S3/09

Abstract: An apparatus and method are disclosed for actinic inspection of semiconductor masks intended for extended ultraviolet (EUV) lithography, or similar objects, with feature sizes less than 100 nm. The approach uses a coherent light source with wavelength less than 120 nm. Inside a vacuum system, an optical system directs the light to an object, i.e., the mask or mask blank, and directs the resulting reflected or transmitted light to an imaging sensor. A computational system processes the imaging sensor data to generate phase and amplitude images of the object. The preferred imaging modality, a form of digital holography, produces images of buried structures and phase objects, as well as amplitude or reflectance images, with nanometer resolution less than or equal to the feature size of the mask.

公开(公告)号：US09750958B2

公开(公告)日：2017-09-05

申请号：US14528079

申请日：2014-10-30

Applicant: Steven M. Ebstein

Inventor： Steven M. Ebstein

IPC: G01J1/00 ,  A61N5/10

CPC classification number: A61N5/1075 ,  A61N2005/1076

Abstract: An apparatus and method are provided for performing Quality Assurance of complex beams of penetrating radiation inside a patient. A detector with a transverse scintillating screen images the radiation inside a tissue phantom with high spatial resolution. The scintillator is comprised of a mixture of two or more scintillators emitting different spectra of light and having different characteristic responses as a function of the beam LET value. The optics relaying the scintillation output have variable transmission with wavelength, further shaping the spectrum of light transmitted to the imaging sensor which also has spectrally varying sensitivity. Parameters of the scintillator construction, the optics, and the imaging sensor are chosen so the output of the composite detector is proportional to a characteristic of the input beam, for example the dose deposited as a function of depth inside the tissue phantom.

公开(公告)号：US20130287170A1

公开(公告)日：2013-10-31

申请号：US13775325

申请日：2013-02-25

Applicant: Steven M. Ebstein

Inventor： Steven M. Ebstein

IPC: G01N23/04

CPC classification number: G01N23/04 ,  A61N5/1075 ,  A61N2005/1076

Abstract: An apparatus and method are provided for performing Quality Assurance of complex beams of penetrating radiation inside a patient. A detector with a transverse scintillating screen images the radiation inside a tissue phantom with high spatial resolution. The scintillator is comprised of a mixture of two or more scintillators emitting different spectra of light and having different characteristic responses as a function of the beam LET value. The optics relaying the scintillation output have variable transmission with wavelength, further shaping the spectrum of light transmitted to the imaging sensor which also has spectrally varying sensitivity. Parameters of the scintillator construction, the optics, and the imaging sensor are chosen so the output of the composite detector is proportional to a characteristic of the input beam, for example the dose deposited as a function of depth inside the tissue phantom.

Abstract translation: 提供了一种用于执行患者内的复杂的穿透辐射束的质量保证的装置和方法。 具有横向闪烁屏幕的检测器以高空间分辨率对组织体模内的辐射进行成像。 闪烁体由两个或更多个闪烁体的混合物组成，其发射不同光谱并且具有作为束LET值的函数的不同特征响应。 中继闪烁输出的光学器件具有波长可变的透射率，进一步使传输到成像传感器的光谱形成光谱变化的灵敏度。 选择闪烁体结构，光学器件和成像传感器的参数，使得复合检测器的输出与输入光束的特性成比例，例如作为组织体模内部深度的函数沉积的剂量。

公开(公告)号：US20120092661A1

公开(公告)日：2012-04-19

申请号：US13135197

申请日：2011-06-28

Applicant: Steven M. Ebstein

Inventor： Steven M. Ebstein

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/5088 ,  B01L2200/12 ,  B01L2300/165 ,  B81B1/006 ,  B81C1/00206 ,  B82Y15/00 ,  B82Y30/00

Abstract: Surface enhanced Raman Scattering (SERS) and related modalities offer greatly enhanced sensitivity and selectivity for detection of molecular species through the excitation of plasmon modes and their coupling to molecular vibrational modes. One of the chief obstacles to widespread application is the availability of suitable nanostructured materials that exhibit strong enhancement of Raman scattering, are inexpensive to fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other photonic sensing that use semiconductor and metal surfaces fabricated using femtosecond laser processing. A noble metal film (e.g., silver or gold) is evaporated onto the resulting nanostructured surfaces for use as a substrate for SERS. These surfaces are inexpensive to produce and can have their statistical properties precisely tailored by varying the laser processing. Surfaces can be readily micropatterned and both stochastic and self-organized structures can be fabricated. This material has application to a variety of genomic, proteomic, and biosensing applications including label free applications including binding detection. Using this material, monolithic or arrayed substrates can be designed. Substrates for cell culture and microlabs incorporating microfluidics and electrochemical processing can be fabricated as well. Laser processing can be used to form channels in the substrate or a material sandwiched onto it in order to introduce reagents and drive chemical reactions. The substrate can be fabricated so application of an electric potential enables separation of materials by electrophoresis or electro-osmosis.

Abstract translation: 表面增强拉曼散射（SERS）和相关模式通过激发等离子体模式及其与分子振动模式的耦合，为分子物质的检测提供了极大的增强的灵敏度和选择性。 广泛应用的主要障碍之一是具有显示拉曼散射强烈增强的合适的纳米结构材料的可用性，制造成本低且可再现。 我描述了使用飞秒激光加工制造的半导体和金属表面的SERS和其他光子传感的纳米结构表面。 将贵金属膜（例如银或金）蒸发到所得的纳米结构表面上，用作SERS的底物。 这些表面生产成本便宜，并且可以通过改变激光加工来精确地调整其统计特性。 表面可以容易地微图案化，并且可以制造随机和自组织结构。 该材料可应用于各种基因组，蛋白质组学和生物传感应用，包括无标签应用，包括结合检测。 使用这种材料，可以设计单片或阵列基板。 也可以制造用于细胞培养的底物和结合微流体学和电化学处理的微生物。 激光加工可用于在基材中形成通道或夹在其上的材料以引入试剂并驱动化学反应。 可以制造衬底，因此施加电势可以通过电泳或电渗透分离材料。

公开(公告)号：US07586601B2

公开(公告)日：2009-09-08

申请号：US11452729

申请日：2006-06-14

Applicant: Steven M. Ebstein

Inventor： Steven M. Ebstein

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/5088 ,  B01L2200/12 ,  B01L2300/165 ,  B81B1/006 ,  B81C1/00206 ,  B82Y15/00 ,  B82Y30/00

Abstract: Surface enhanced Raman Scattering (SERS) and related modalities offer greatly enhanced sensitivity and selectivity for detection of molecular species through the excitation of plasmon modes and their coupling to molecular vibrational modes. One of the chief obstacles to widespread application is the availability of suitable nanostructured materials that exhibit strong enhancement of Raman scattering, are inexpensive to fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other photonic sensing that use semiconductor and metal surfaces fabricated using femtosecond laser processing. A noble metal film (e.g., silver or gold) is evaporated onto the resulting nanostructured surfaces for use as a substrate for SERS. These surfaces are inexpensive to produce and can have their statistical properties precisely tailored by varying the laser processing. Surfaces can be readily micropatterned and both stochastic and self-organized structures can be fabricated. This material has application to a variety of genomic, proteomic, and biosensing applications including label free applications including binding detection. Using this material, monolithic or arrayed substrates can be designed. Substrates for cell culture and microlabs incorporating microfluidics and electrochemical processing can be fabricated as well. Laser processing can be used to form channels in the substrate or a material sandwiched onto it in order to introduce reagents and drive chemical reactions. The substrate can be fabricated so application of an electric potential enables separation of materials by electrophoresis or electro-osmosis.

Abstract translation: 表面增强拉曼散射（SERS）和相关模式通过激发等离子体模式及其与分子振动模式的耦合，为分子物质的检测提供了极大的增强的灵敏度和选择性。 广泛应用的主要障碍之一是具有显示拉曼散射强烈增强的合适的纳米结构材料的可用性，制造成本低且可再现。 我描述了使用飞秒激光加工制造的半导体和金属表面的SERS和其他光子传感的纳米结构表面。 将贵金属膜（例如银或金）蒸发到所得的纳米结构表面上，用作SERS的底物。 这些表面生产成本便宜，并且可以通过改变激光加工来精确地调整其统计特性。 表面可以容易地微图案化，并且可以制造随机和自组织结构。 该材料可应用于各种基因组，蛋白质组学和生物传感应用，包括无标签应用，包括结合检测。 使用这种材料，可以设计单片或阵列基板。 也可以制造用于细胞培养的底物和结合微流体学和电化学处理的微生物。 激光加工可用于在基材中形成通道或夹在其上的材料以引入试剂并驱动化学反应。 可以制造衬底，因此施加电势可以通过电泳或电渗透分离材料。

公开(公告)号：US07515681B2

公开(公告)日：2009-04-07

申请号：US11629380

申请日：2005-06-30

Applicant: Steven M. Ebstein

Inventor： Steven M. Ebstein

IPC: A61B6/00

CPC classification number: G01T1/02 ,  A61N5/1048 ,  A61N2005/1087 ,  G01T1/023 ,  G01T1/20 ,  G01T1/29 ,  G01T1/2914

Abstract: A method and apparatus for monitoring a scanning beam of penetrating radiation, such as a scanning proton beam used to irradiate tissue. The position of the beam is tracked in real time by interposing a scintillator film between a source and an object of irradiation. An imaging detector, in optical communication with the scintillator, provides an output that is indicative of the position of the radiation and its variation with time. The accumulated dose over a scan may also be monitored.

Abstract translation: 一种用于监测穿透辐射的扫描光束的方法和装置，例如用于照射组织的扫描质子束。 通过在源和照射对象之间插入闪烁体膜来实时跟踪光束的位置。 与闪烁体光学通信的成像检测器提供了指示辐射位置及其随时间变化的输出。 也可以监视扫描时的累积剂量。