公开(公告)号：US10106545B2

公开(公告)日：2018-10-23

申请号：US15434275

申请日：2017-02-16

Applicant: University Health Network

Inventor： Yong Liu ,  Heinz W. Pauls ,  Radoslaw Laufer ,  Sze-Wan Li ,  Peter Brent Sampson ,  Miklos Feher ,  Grace Ng ,  Narendra Kumar B. Patel ,  Yunhui Lang

IPC: C07D487/04

Abstract: The present teachings provide a compound represented by structural formula (I-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20170320881A1

公开(公告)日：2017-11-09

申请号：US15598402

申请日：2017-05-18

Applicant: University Health Network

Inventor： Radoslaw Laufer ,  Grace Ng ,  Sze-Wan Li ,  Heinz W. Pauls ,  Yong Liu ,  Narendra Kumar B. Patel

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：US09657025B2

公开(公告)日：2017-05-23

申请号：US14926977

申请日：2015-10-29

Applicant: University Health Network

Inventor： Radoslaw Laufer ,  Grace Ng ,  Sze-Wan Li ,  Heinz W. Pauls ,  Yong Liu ,  Narendra Kumar B. Patel

IPC: A61K31/519 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20190322669A1

公开(公告)日：2019-10-24

申请号：US16225970

申请日：2018-12-19

Applicant: University Health Network

Inventor： Radoslaw Laufer ,  Grace Ng ,  Sze-Wan Li ,  Heinz W. Pauls ,  Yong Liu ,  Narendra Kumar B. Patel

IPC: C07D487/04 ,  C07D519/00

Abstract: The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20190040074A1

公开(公告)日：2019-02-07

申请号：US16155846

申请日：2018-10-09

Applicant: University Health Network

Inventor： Yong Liu ,  Heinz W. Pauls ,  Radoslaw Laufer ,  Sze-Wan Li ,  Peter Brent Sampson ,  Miklos Feher ,  Grace Ng ,  Narendra Kumar B. Patel ,  Yunhui Lang

IPC: C07D487/04 ,  C07D519/00

Abstract: The present teachings provide a compound represented by structural formula (I-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：US10167289B2

公开(公告)日：2019-01-01

申请号：US15598402

申请日：2017-05-18

Applicant: University Health Network

Inventor： Radoslaw Laufer ,  Grace Ng ,  Sze-Wan Li ,  Heinz W. Pauls ,  Yong Liu ,  Narendra Kumar B. Patel

IPC: C07D487/04 ,  C07D519/00

Abstract: The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20180282335A1

公开(公告)日：2018-10-04

申请号：US15521895

申请日：2015-10-09

Applicant: University Health Network

Inventor： Radoslaw Laufer ,  Grace Ng ,  Richard Brokx ,  Heinz W. Pauls ,  Sze-wan Li ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: C07D487/04 ,  A61P35/00 ,  A61P29/00 ,  A61P37/06

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06

Abstract: The invention is a compound represented by Structural Formula (I): (I); or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).

公开(公告)号：US20220204511A1

公开(公告)日：2022-06-30

申请号：US17521255

申请日：2021-11-08

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Radoslaw Laufer ,  Grace Ng ,  Sze-Wan Li ,  Heinz W. Pauls ,  Yong Liu ,  Narendra Kumar B. Patel

IPC: C07D487/04 ,  C07D519/00

Abstract: The present teachings provide a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：US10239881B2

公开(公告)日：2019-03-26

申请号：US15521895

申请日：2015-10-09

Applicant: University Health Network

Inventor： Radoslaw Laufer ,  Grace Ng ,  Richard Brokx ,  Heinz W. Pauls ,  Sze-wan Li ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P37/06 ,  A61P29/00 ,  A61P35/00

Abstract: The invention is a compound represented by Structural Formula (I): (I); or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).

公开(公告)号：US09573954B2

公开(公告)日：2017-02-21

申请号：US14443072

申请日：2013-11-15

Applicant: University Health Network

Inventor： Yong Liu ,  Heinz W. Pauls ,  Radoslaw Laufer ,  Sze-Wan Li ,  Peter Brent Sampson ,  Miklos Feher ,  Grace Ng ,  Narendra Kumar B. Patel ,  Yunhui Lang

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present teachings provide a compound represented by structural formula (1-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

Abstract translation: 本发明提供由结构式（1-0）表示的化合物或其药学上可接受的盐。 还描述了药物组合物及其使用方法。