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公开(公告)号：US20210378518A1
公开(公告)日：2021-12-09
申请号：US17408027
申请日：2021-08-20
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph S. Dacosta , Brian C. Wilson , Kai Zhang
Abstract: A method for fluorescence-based imaging of a target to detect contamination and/or pollutants is disclosed. The method includes labelling a pre-selected biomarker at the target, illuminating the target with excitation light emitted by an excitation light source and having at least one wavelength or wavelength band causing at least the pre-selected biomarker to fluoresce, detecting fluorescence emissions of at least the pre-selected biomarker with an image detector of a handheld imaging device, and determining the presence, location, and/or quantity of contamination and/or pollutants on and/or in the illuminated target based on the detected fluorescence emissions of at least the pre-selected biomarker.
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Patent Agency Ranking
公开(公告)号：US11154198B2
公开(公告)日：2021-10-26
申请号：US16027775
申请日：2018-07-05
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph S. Dacosta , Brian C. Wilson , Kai Zhang
Abstract: A system for fluorescence-based imaging of a target includes at least one excitation light source configured to emit a homogeneous field of excitation light and positioned to uniformly illuminate a target surface with the homogeneous field of excitation light during fluorescent imaging, a power source, and a portable housing configured to be held in a user's hand during imaging. The housing contains a lens, a filter, an image sensor, and a processor. The filter is configured to permit optical signals responsive to illumination of the target surface and having a wavelength corresponding to at least one of bacterial autofluorescence and tissue autofluorescence to pass through the filter to the image sensor. The at least one excitation light is adjacent to the housing so as to be positioned between the target surface and the image sensor during fluorescent imaging.
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公开(公告)号：US20250160648A1
公开(公告)日：2025-05-22
申请号：US19024995
申请日：2025-01-16
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph S. DaCosta , Brian C. Wilson , Kai Zhang
Abstract: A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.
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公开(公告)号：US12226186B2
公开(公告)日：2025-02-18
申请号：US17193318
申请日：2021-03-05
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph Sebastian Dacosta , Brian C. Wilson , Kai Zhang
Abstract: A system for acquiring data regarding a wound in tissue comprises at least one excitation light source configured to directly illuminate a wound with excitation light; a spectral filtering mechanism configured to permit passage of optical signals responsive to illumination of the wound and having at least one wavelength corresponding to bacterial, fungal, and/or other microorganism autofluorescence and/or bacterial, fungal, viral, and/or microbial fluorescence, the spectral filtering mechanism including a plurality of selectable filters respectively corresponding to different discrete spectral bandwidths; an optical sensor configured to detect the spectrally filtered signals; and a processor configured to receive the detected, filtered signals and to identify a fluorescent signature of bacteria in the wound based at least in part on the detected, filtered signals and to output data regarding the bacterial, fungal, viral, and/or microbial fluorescent signature.
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公开(公告)号：US20230000356A1
公开(公告)日：2023-01-05
申请号：US17856487
申请日：2022-07-01
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph Sebastian Dacosta , Brian C. Wilson , Kai Zhang
Abstract: A system for outputting a representation of a wound in tissue comprises a housing configured to removably receive at least a portion of a wireless communication device. At least one light source coupled to the housing is configured to emit excitation light to illuminate a target which includes at least a portion of the wound. A power supply contained in the housing is configured to provide power to the light source. A non-transitory computer-readable medium stores a program executable to cause the performance of operations comprising detecting signals responsive to illumination of the target, outputting the representation of the target based thereon, storing data relative to one or more target surface parameter based on the detected signals, and displaying the representation. The signals correspond to at least one of endogenous or exogeneous fluorescence, absorbance, and reflectance from at least one biological component in and/or on the target.
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16.发明申请公开(公告)号：US20250160651A1
公开(公告)日：2025-05-22
申请号：US19027622
申请日：2025-01-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph Sebastian Dacosta , Brian C. Wilson , Kai Zhang
Abstract: A system for acquiring data regarding a wound in tissue comprises at least one excitation light source configured to directly illuminate a wound with excitation light; a spectral filtering mechanism configured to permit passage of optical signals responsive to illumination of the wound and having at least one wavelength corresponding to bacterial, fungal, and/or other microorganism autofluorescence and/or bacterial, fungal, viral, and/or microbial fluorescence, the spectral filtering mechanism including a plurality of selectable filters respectively corresponding to different discrete spectral bandwidths; an optical sensor configured to detect the spectrally filtered signals; and a processor configured to receive the detected, filtered signals and to identify a fluorescent signature of bacteria in the wound based at least in part on the detected, filtered signals and to output data regarding the bacterial, fungal, viral, and/or microbial fluorescent signature.
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