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公开(公告)号：US20220217479A1
公开(公告)日：2022-07-07
申请号：US17702051
申请日：2022-03-23
Applicant: ELECTROCORE, INC
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US20220079502A1
公开(公告)日：2022-03-17
申请号：US17514551
申请日：2021-10-29
Applicant: electroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico
Abstract: Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.
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公开(公告)号：US20210353943A1
公开(公告)日：2021-11-18
申请号：US17390747
申请日：2021-07-30
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Methods and devices are disclosed for the non-invasive treatment of Parkinson's disease through the delivery of energy to target nervous tissue, particularly the vagus nerve. The methods and devices transmit an electrical impulse transcutaneously through an outer skin surface of the patient to modulate activity of the vagus nerve to treat one or more symptoms of Parkinson's disease. This modulation may inhibit neuroinflammation and/or increase levels of at least one neurotrophic factor to promote the survival of dopamine producing cells in patients suffering from the conditions of Parkinson's disease.
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公开(公告)号：US20210299435A1
公开(公告)日：2021-09-30
申请号：US17346265
申请日：2021-06-13
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico
Abstract: Devices, systems and methods are disclosed for reducing inflammation associated with an aneurysm in a patient. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in the vagus nerve. Vagus nerve stimulation is used to modulate the release of neurotransmitters in the brain and to reduce inflammation that may lead to the formation, growth, rupture or hemorrhage of an aneurysm.
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公开(公告)号：US11123545B2
公开(公告)日：2021-09-21
申请号：US16837818
申请日：2020-04-01
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a target nerve within the patient. The electrical signal comprises bursts of about 2 to about 20 pulses and the pulses oscillate between a positive voltage and a negative voltage within each burst.
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Patent Agency Ranking
公开(公告)号：US20210283396A1
公开(公告)日：2021-09-16
申请号：US17315883
申请日：2021-05-10
Applicant: ElectroCore, Inc.
Inventor： Joseph P. Errico , Steven Mendez , Bruce J. Simon
Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A nerve stimulator is configured for coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The stimulator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.
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17.发明申请公开(公告)号：US20200230408A1
公开(公告)日：2020-07-23
申请号：US16838953
申请日：2020-04-02
Applicant: ElectroCore, Inc.
Inventor： Joseph P. Errico , Bruce J. Simon , Peter Staats , Thomas Errico
Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient. The systems and methods of the present invention reduce the expression of inflammatory mediators that are elevated in ARDS and other inflammatory or allergic disorders, thereby ameliorating the overactivity of the immune reaction in patient's suffering from certain disorders, such as the coronavirus. This therapy may include a feedback mechanism to provide potent anti-inflammatory benefits without the negative side effects of conventional immune suppression techniques and drugs, such as steroids and other nebulized drugs.
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公开(公告)号：US20200078589A1
公开(公告)日：2020-03-12
申请号：US16662295
申请日：2019-10-24
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
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19.发明申请公开(公告)号：US20200038655A1
公开(公告)日：2020-02-06
申请号：US16597188
申请日：2019-10-09
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: A method for modulating a nerve within a body of a patient includes generating a single signal comprising an electrical impulse, contacting an interface with an outer skin surface of a patient and delivering the electrical impulse from an electrode through the interface and the outer skin surface of the patient to a vagus nerve, thereby modulating the vagus nerve. The electrical impulse may comprise bursts of pulses with a silent intra-burst interval between each of the bursts based on the single signal, wherein each of the bursts has a frequency of about 5 Hz to about 100 Hz and each of the pulses has a duration from about 50 microseconds to about 1000 microseconds. The electrode may be spaced from the interface by a distance of about 0.25 to about 4 times an outer dimension of the interface.
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20.发明申请公开(公告)号：US20190336764A1
公开(公告)日：2019-11-07
申请号：US16511953
申请日：2019-07-15
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico
IPC: A61N1/36 , A61B5/00 , A61N1/04 , A61B5/0488
Abstract: Devices, systems and methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by noninvasive electrical stimulation of a vagus nerve, used in conjunction with the measurement of evoked potentials (EPs). The system comprises a stimulator that is applied to the surface of the patient's neck to apply electrical impulses sufficient to stimulate a cervical vagus nerve, scalp electrodes that are used to measure EPs that are evoked by that stimulation, feedback or biofeedback circuits to vary the stimulation based upon EP characteristics, and other sensory stimulation modalities that produce EPs. The system is preferably used to optimize the placement of the stimulator, to test whether a patient is a suitable candidate for treatment using vagus nerve stimulation, and to select the stimulation parameters that optimized acute or chronic treatment, e.g., by correcting an EP habituation deficit.
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