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公开(公告)号：US20190275327A1
公开(公告)日：2019-09-12
申请号：US16356639
申请日：2019-03-18
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
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公开(公告)号：US12179012B2
公开(公告)日：2024-12-31
申请号：US17713832
申请日：2022-04-05
Applicant: electroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods, wherein each burst period includes 2 to 20 pulses and has a duration of less than 20,000 microseconds.
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公开(公告)号：US12070593B2
公开(公告)日：2024-08-27
申请号：US18117542
申请日：2023-03-06
Applicant: ELECTROCORE, INC
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC classification number: A61N1/0456 , A61N1/36014 , A61N1/36021 , A61N1/36034 , A61N1/36053 , A61N1/40 , A61N2/008 , A61N2/02 , H04R25/305 , H04R25/505 , H04R25/70 , A61N1/36075 , A61N2/006
Abstract: Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US20240278012A1
公开(公告)日：2024-08-22
申请号：US18653888
申请日：2024-05-02
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC classification number: A61N1/36014 , A61N1/0456 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
Abstract: Devices and methods are described to produce therapeutic effects in a patient by utilizing an energy source that transmits energy non-invasively to nervous tissue. A device for modulating a nerve within a body of a patient comprises a housing comprising a power supply and a signal generator for generating an electrical impulse. The electrical impulse comprises bursts of 2 to 20 pulses, wherein each of the bursts has a frequency of 15 to 50 Hz. The device further comprises first and second electrodes coupled to the housing and having a contact surface configured for contacting an outer skin surface of a neck of a user. The energy source is configured to transmit the electrical impulse from the first and second electrodes through the outer skin surface of the user to a vagus nerve.
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公开(公告)号：US20240139508A1
公开(公告)日：2024-05-02
申请号：US18405000
申请日：2024-01-05
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC classification number: A61N1/36025 , A61N1/40 , A61N2/002 , A61N2/006 , A61N2/02 , A61N1/36114
Abstract: Methods and devices are provided for the non-invasive treatment of diseases or disorders, such as Alzheimer's disease, Parkinson's disease, rheumatoid arthritis (RA), multiple sclerosis, postoperative cognitive dysfunction, or postoperative delirium. A method for comprises positioning an electrode in contact with an outer skin surface of a neck of the patient and transmitting, via the electrode, an electric current transcutaneously and non-invasively through the outer skin surface of the neck of the patient to generate an electrical impulse at or near a vagus nerve within the patient. The electrical impulse comprises bursts of 2 to 20 pulses with each of the bursts comprising a frequency from about 15 Hz to about 50 Hz and with each of the pulses comprising a duration from about 20 microseconds to about 1000 microseconds.
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Patent Agency Ranking
公开(公告)号：US11623080B2
公开(公告)日：2023-04-11
申请号：US17702051
申请日：2022-03-23
Applicant: ELECTROCORE, INC
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US11623079B2
公开(公告)日：2023-04-11
申请号：US17461886
申请日：2021-08-30
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US11623078B2
公开(公告)日：2023-04-11
申请号：US17072392
申请日：2020-10-16
Applicant: ELECTROCORE, INC.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices and methods for non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode spaced from the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is positioned within the housing and operably coupled to the electrode, either wirelessly or via a lead or other wired connection. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises bursts each with a frequency from about 1 Hz to about 100 Hz, wherein each of the bursts comprises 2 pulses to 20 pulses.
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公开(公告)号：US11517742B2
公开(公告)日：2022-12-06
申请号：US16540476
申请日：2019-08-14
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
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公开(公告)号：US11439818B2
公开(公告)日：2022-09-13
申请号：US16599285
申请日：2019-10-11
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The devices comprise a housing and an energy source for generating an electric current and transmitting the electric current from the electrode through an interface and the outer skin surface of the patient to a selected nerve fiber within the patient as the interface contacts the outer skin surface. The electric current is sufficient to modulate the selected nerve fiber to at least one of treat or prevent at least one of gastroparesis, functional dyspepsia, or ileus in the patient.
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