公开(公告)号：US09957285B2

公开(公告)日：2018-05-01

申请号：US14906908

申请日：2014-07-01

Applicant: SHOWA DENKO K.K.

Inventor： Keisuke Kishida ,  Yoshihiro Watanabe ,  Yoshikuni Okumura

IPC: B01D53/02 ,  B01D53/22 ,  B01D69/14 ,  C07F3/06 ,  B01J20/22 ,  B01J20/28 ,  C07C7/12 ,  C07C201/12 ,  C07D213/06 ,  C07D213/68 ,  C07D213/70 ,  B01J20/34 ,  B01D53/04 ,  B01D53/047

CPC classification number: C07F3/06 ,  B01D53/02 ,  B01D53/0462 ,  B01D53/047 ,  B01D53/228 ,  B01D69/14 ,  B01D2253/112 ,  B01D2253/20 ,  B01D2256/24 ,  B01D2257/7022 ,  B01D2325/12 ,  B01J20/226 ,  B01J20/28035 ,  B01J20/3483 ,  C07C7/12 ,  C07C201/12 ,  C07D213/06 ,  C07D213/68 ,  C07D213/70 ,  Y02C10/08 ,  C07C11/167 ,  C07C205/57

Abstract: A separating material superior to conventional separating materials, and a separation method are provided, with which 1,3-butadiene is selectively separated and recovered from a mixed gas including 1,3-butadiene and C4 hydrocarbons other than 1,3-butadiene. A metal complex, which comprises a dicarboxylic acid compound (I) (see (I) below) represented by general formula (I), an ion of a metal such as beryllium, and a dipyridyl compound (II) represented by general formula (II), namely L-Z-L (II) (see L below), is characterized by including, as the dipyridyl compound (II), at least two different dipyridyl compounds (II). The metal complex is used as a 1,3-butadiene separating material. Formula (I) L is represented by any of the compounds below.

公开(公告)号：US09878970B1

公开(公告)日：2018-01-30

申请号：US15717327

申请日：2017-09-27

Applicant: Syngenta Crop Protection, LLC

Inventor： Denis Gribkov ,  Bjorn Antelmann ,  Fanny Bois ,  Harald Walter ,  Alain De Mesmaeker

IPC: C07C22/02 ,  C07C22/04 ,  C07C205/06 ,  C07C205/11 ,  C07C205/12 ,  C07C17/32 ,  C07C17/266 ,  C07C209/36 ,  C07C17/23 ,  C07C17/26 ,  C07C201/12

CPC classification number: C07C17/32 ,  C07C17/23 ,  C07C17/26 ,  C07C17/266 ,  C07C22/02 ,  C07C22/04 ,  C07C201/12 ,  C07C205/06 ,  C07C205/11 ,  C07C205/12 ,  C07C209/365 ,  C07C2601/10 ,  C07C2603/66 ,  C07C211/61

Abstract: The present invention relates to a novel a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCl3, wherein X is chloro or bromo, to a compound of formula I1, or aa) reacting cyclopentadiene with CXCl3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula I1, wherein X is chloro, b) reacting the compound of formula I1 with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst.

公开(公告)号：US20170369412A1

公开(公告)日：2017-12-28

申请号：US15532957

申请日：2015-09-25

Applicant: ZHEJIANG ZHUJI UNITED CHEMICALS CO., LTD

Inventor： Yehua Su ,  Jieping Shi ,  Jianxin Lu ,  Tianhao Zhang ,  Xiaohua Yu ,  Guoping Cai ,  Bangchi Chen

IPC: C07C51/285 ,  C07B41/08

CPC classification number: C07C51/285 ,  C07B41/08 ,  C07C53/08 ,  C07C201/12 ,  C07C205/58 ,  C07C253/30 ,  C07C315/04 ,  C07C317/44 ,  C07D213/60 ,  C07D213/79 ,  C07D213/803 ,  C07C205/56 ,  C07C205/11 ,  C07C255/41

Abstract: A preparative method for carboxylic acids is disclosed in the present invention. The method is characterized in that: compounds (II) are reacted in the presence of hydrogen peroxide and base to produce target products (I), as represented by the following reaction scheme: wherein R1 is aryl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, benzothienyl, benzofuranyl, quinolinyl, isoquinolinyl, thiadiazolyl, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl and hydrogen; R2 is alkoxycarbonyl, alkylaminocarbonyl, aminocarbonyl, alkylthiolcarbonyl, cyano, sulfonyl, sulfinyl, carbonyl, aldehyde, carboxyl, nitro, alkyl and hydrogen; R3 is alkoxycarbonyl, alkyl amido carbonyl, aminocarbonyl, cyano, sulfonyl, sulfinyl, carbonyl, carboxyl and nitro. The present invention has the following main benefits: cheap and readily available starting materials, safe processes, high yield, good quality, which facilitates industrial production.

公开(公告)号：US20170341069A1

公开(公告)日：2017-11-30

申请号：US15624400

申请日：2017-06-15

Applicant: The Regents of The University of California

Inventor： Bruce H. Lipshutz ,  Sachin Handa

IPC: B01J31/24 ,  C07D409/04 ,  B01J23/89 ,  B01J31/02 ,  B01J31/06 ,  B01J31/22 ,  B01J35/00 ,  B01J35/12 ,  B01J37/16 ,  C07B37/04 ,  C07C41/30 ,  C07D405/14 ,  C07D405/04 ,  C07D403/04 ,  C07D401/04 ,  C07D333/60 ,  C07D317/46 ,  C07D317/22 ,  C07D241/18 ,  C07D239/54 ,  C07D239/26 ,  C07D215/06 ,  C07D213/64 ,  C07D213/30 ,  C07D211/70 ,  C07C319/20 ,  C07C269/06 ,  C07C211/45 ,  C07C209/68 ,  C07C209/32 ,  C07C205/12 ,  C07C201/12 ,  C07C45/68 ,  C07D471/04 ,  C07C2603/24

CPC classification number: B01J31/2404 ,  B01J23/8906 ,  B01J31/0202 ,  B01J31/0209 ,  B01J31/068 ,  B01J31/22 ,  B01J35/0013 ,  B01J35/10 ,  B01J35/12 ,  B01J37/16 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4266 ,  B01J2231/64 ,  B01J2531/004 ,  B01J2531/007 ,  B01J2531/824 ,  B01J2531/842 ,  B01J2531/96 ,  B01J2531/985 ,  C07B37/04 ,  C07C37/18 ,  C07C41/30 ,  C07C45/68 ,  C07C201/12 ,  C07C205/12 ,  C07C209/325 ,  C07C209/68 ,  C07C211/45 ,  C07C269/06 ,  C07C269/08 ,  C07C319/20 ,  C07C2603/24 ,  C07D211/70 ,  C07D213/30 ,  C07D213/64 ,  C07D215/06 ,  C07D239/26 ,  C07D239/54 ,  C07D241/18 ,  C07D317/22 ,  C07D317/46 ,  C07D333/60 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D471/04 ,  C07F9/12 ,  C07C271/28 ,  C07C321/28 ,  C07C43/215 ,  C07C43/205 ,  C07C43/2055 ,  C07C47/546 ,  C07C47/575 ,  C07C39/21

Abstract: In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Ir, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt.

公开(公告)号：US09815757B2

公开(公告)日：2017-11-14

申请号：US15123252

申请日：2015-03-01

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ronny Neumann ,  Amir Rubinstein

IPC: C07C45/28 ,  C07C67/00 ,  B01J31/00 ,  C07C67/333 ,  C07C201/12 ,  B01J31/02

CPC classification number: C07C45/28 ,  B01J23/002 ,  B01J23/8993 ,  B01J27/188 ,  B01J31/0239 ,  B01J31/0271 ,  B01J2231/321 ,  B01J2531/002 ,  C07C67/333 ,  C07C201/12 ,  C07C47/54 ,  C07C49/78 ,  C07C49/786 ,  C07C49/84 ,  C07C47/02 ,  C07C69/716 ,  C07C205/44

Abstract: The present invention relates to a process for preparing aldehydes and ketones by carbon-carbon bond cleavage of alkenes, wherein the process is catalysed by first row transition metal nitro coordinated polyoxometalate catalyst. The catalyst can be prepared by pre-treatment of aqua coordinated polyoxometalates with NO2, or they are formed in situ when the reactions are carried in nitroalkanes under aerobic conditions, or they are formed in situ from nitrosyl (NO) compounds in the presence of O2.

公开(公告)号：US20170217865A1

公开(公告)日：2017-08-03

申请号：US15515271

申请日：2015-10-07

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Denis GRIBKOV

IPC: C07C45/63 ,  C07C201/08 ,  C07C205/45 ,  C07C45/46

CPC classification number: C07C45/63 ,  C07C45/46 ,  C07C201/08 ,  C07C201/12 ,  C07C205/45 ,  C07C49/80

Abstract: A process for the preparation of a compound of formula (I) wherein R1 is hydrogen, fluoro or chloro; which process comprises: a) reacting a compound of formula (II) wherein R1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III) wherein R1 is hydrogen, fluoro or chloro; b) reacting the compound of formula (III) with trichloroisocyanuric acid in the presence of sulfuric acid or fuming sulfuric acid to the compound of formula (IV) wherein R1 is hydrogen, fluoro or chloro; and c) reacting the compound of formula (III) with chlorine gas at a temperature from 180° C. to 250° C. to the compound of formula (I).

公开(公告)号：US09718763B2

公开(公告)日：2017-08-01

申请号：US14990308

申请日：2016-01-07

Applicant: Regents of the University of Minnesota

Inventor： William Baker Tolman ,  Marc A. Hillmyer ,  Alex John ,  Levi Thomas Hogan

IPC: C07C253/30 ,  C07C67/32 ,  B01J27/13 ,  C07C67/317 ,  C07C201/12 ,  C07C1/207 ,  C07C17/361

CPC classification number: C07C253/30 ,  B01J23/44 ,  B01J23/755 ,  B01J27/128 ,  B01J27/13 ,  B01J2531/824 ,  C07C1/207 ,  C07C17/361 ,  C07C67/317 ,  C07C67/32 ,  C07C201/12 ,  C07C2527/13 ,  C07C2531/24 ,  Y02P20/52 ,  C07C69/54 ,  C07C255/08 ,  C07C15/46 ,  C07C15/44 ,  C07C11/167 ,  C07C11/02 ,  C07C11/12 ,  C07C15/52 ,  C07C205/06 ,  C07C15/50 ,  C07C15/58 ,  C07C25/28

Abstract: A process of preparing olefins of the formula (I) is described herein: with R1 being a substituted or unsubstituted (C1-C30)hydrocarbyl, and R2 being a substituted or unsubstituted (C1-C20)hydrocarbyl. The process includes reacting a compound of formula (II) wherein Ar is chosen from in the presence of a palladium-based catalyst and an organic solvent. A process of preparing olefins of the formula (III) is also described: with R3 being a substituted or unsubstituted (C1-C30)hydrocarbyl, R4 being a substituted or unsubstituted (C1-C20)hydrocarbyl, and R5 being a substituted or unsubstituted (C1-C30) hydrocarbyl. The process includes reacting a compound of formula (IV) wherein Ar is chosen from with a compound of formula (V) wherein Ar is chosen from in the presence of a palladium-based catalyst and an organic solvent.

公开(公告)号：US20170197907A1

公开(公告)日：2017-07-13

申请号：US15313365

申请日：2015-05-29

Applicant: E I DU PONT DE NEMOURS AND COMPANY

Inventor： Stephen Ernest Jacobson ,  Donald J. Dumas ,  Rupert Spence ,  Sarah May Crawford ,  Venkateswara Rao Surisetty

IPC: C07C201/12 ,  C07C253/14 ,  C07C231/02

CPC classification number: C07C201/12 ,  C07C231/02 ,  C07C253/14 ,  C07C205/57

Abstract: A method for preparing 3-methyl-2-nitrobenzoic acid is disclosed wherein 1,3-dimethyl-2-nitrobenzene is combined with an oxidation catalyst in the presence of an oxygen source and an initiator, provided that less than 99% of the 1,3-dimethyl-2-nitrobenzene is oxidized.A method for preparing compounds of Formula 7 and Formula 11 is also disclosed wherein the method is characterized by using 3-methyl-2-nitrobenzoic acid as prepared by the method disclosed above. wherein R1 is C1-C7 alkyl, C3-C6 cycloalkyl or C4-C7 alkylcycloalkyl

公开(公告)号：US20170160636A1

公开(公告)日：2017-06-08

申请号：US15323043

申请日：2015-07-14

Applicant: TOKYO OHKA KOGYO CO., LTD.

Inventor： Yoshinori TADOKORO ,  Dai SHIOTA

IPC: G03F7/031 ,  C07C249/10 ,  C07C201/12 ,  G02B5/22 ,  C07D333/22 ,  G03F7/00 ,  G02F1/1335 ,  C07C251/66 ,  C07C45/46

CPC classification number: G03F7/031 ,  C07C45/46 ,  C07C201/12 ,  C07C249/10 ,  C07C251/40 ,  C07C251/66 ,  C07C255/40 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/18 ,  C07D333/22 ,  C08F2/48 ,  G02B5/20 ,  G02B5/223 ,  G02F1/1333 ,  G02F1/1335 ,  G02F1/133514 ,  G03F7/0007

Abstract: The purpose of the present invention is to provide a photosensitive composition having excellent sensitivity, an insulating film formed using said photosensitive composition, a color filter formed using said photosensitive composition, a display device provided with said insulating film or said color filter, and a compound suitable for incorporation as a photopolymerization initiator into said photosensitive composition. This photosensitive composition includes (A) a photopolymerizable compound and (B) a photopolymerization initiator, wherein the photopolymerization initiator (B) contains a compound represented by formula (1). In formula (1), R1 is a hydrogen atom, a nitro group, or a monovalent organic group; R2 and R3 are each an optionally substituted linear alkyl group, an optionally substituted cyclic organic group, or a hydrogen atom, and R2 and R3 may be bonded to one another to form a ring; R4 is a monovalent organic group; R5 is a hydrogen atom, an optionally substituted C1-11 alkyl group, or an optionally substituted aryl group; n is an integer from 0 to 4; and m is 0 or 1.

公开(公告)号：US09663475B2

公开(公告)日：2017-05-30

申请号：US14768252

申请日：2014-01-20

Applicant: Merck Patent GmbH

Inventor： Markus Klein ,  Christos Tsaklakidis

IPC: A61K31/517 ,  C07D239/84 ,  C07D403/06 ,  C07D413/06 ,  A61K31/5377 ,  A61K31/538 ,  C07C201/12 ,  C07C209/22 ,  C07C209/36 ,  C07C213/02 ,  C07C331/28 ,  C07D239/95

CPC classification number: C07D239/84 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/538 ,  C07C201/12 ,  C07C209/22 ,  C07C209/36 ,  C07C213/02 ,  C07C331/28 ,  C07D239/95 ,  C07D403/06 ,  C07D413/06

Abstract: The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.