公开(公告)号：US20160161410A1

公开(公告)日：2016-06-09

申请号：US15040545

申请日：2016-02-10

Applicant: Howard Hughes Medical Institute

Inventor： Philipp Johannes Keller

IPC: G01N21/64 ,  G02B21/16 ,  G02B27/10 ,  G02B21/00 ,  G02B21/36 ,  G01N33/483 ,  G02B21/06

CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B2503/42 ,  G01N21/64 ,  G01N33/4833 ,  G01N2021/1736 ,  G01N2201/06193 ,  G01N2201/064 ,  G02B21/0004 ,  G02B21/0048 ,  G02B21/06 ,  G02B21/16 ,  G02B21/361 ,  G02B21/362 ,  G02B21/367 ,  G02B27/1013

Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.

Abstract translation: 通过生成多个光片对活体生物样本进行成像; 沿着照明轴线引导多个光片通过生物样本，使得光片沿着图像平面在空间和时间上在生物样本内重叠，并与图像平面内的生物样本光学相互作用; 并且在多个视图的每一个处，由于光片和生物样本之间的光学相互作用，沿着检测轴从生物样本记录荧光的图像。 时间重叠在时间偏移之内，其小于对应于显微镜的空间分辨率极限的分辨率时间。

公开(公告)号：US20160131579A1

公开(公告)日：2016-05-12

申请号：US14924815

申请日：2015-10-28

Applicant: Hiroyoshi SEKIGUCHI ,  Shintaroh KIDA ,  Kohji OSHIKIRI ,  Izumi ITOH

Inventor： Hiroyoshi SEKIGUCHI ,  Shintaroh KIDA ,  Kohji OSHIKIRI ,  Izumi ITOH

IPC: G01N21/55 ,  B60Q1/08 ,  B60S1/08 ,  B60R16/023

CPC classification number: G01N21/55 ,  B60Q1/085 ,  B60R16/023 ,  B60S1/0844 ,  G01N21/552 ,  G01N21/94 ,  G01N2021/945 ,  G01N2021/9586 ,  G01N2201/061 ,  G01N2201/063 ,  G01N2201/064

Abstract: An adhering detection apparatus includes a light source to emit probe light to a light translucent object during an emission period, and to stop an emission of the probe light to the light translucent object during a non-emission period, a light receiver to receive light coming from the light translucent object during the emission period and the non-emission period of the light source, and an adhering detection processor to perform an adhering detection processing for detecting a substance adhering to the light translucent object based on light quantity of the light coming from the light translucent object and received by the light receiver, and to output a detection result of the adhering detection processing. The adhering detection processor selectively performs one or more processes depending on the light quantity of the light received by the light receiver during the non-emission period of the light source.

Abstract translation: 附着检测装置包括在发光期间将探测光发射到光半透明物体的光源，并且在非发光期间停止将探测光发射到光半透明物体;光接收器，用于接收光 在光源的发光期间和非发光期间的光半透明物体，以及附着检测处理器，其基于来自光源的光的光量进行用于检测附着在所述光半透明物体上的物质的附着检测处理 该光半透明物体并由光接收器接收，并输出粘附检测处理的检测结果。 粘附检测处理器根据在光源的非发光时段期间由光接收器接收的光的光量来选择性地执行一个或多个处理。

公开(公告)号：US20160123875A1

公开(公告)日：2016-05-05

申请号：US14893858

申请日：2014-05-30

Applicant: DURAG GMBH

Inventor： -Ing. Sven Cierullies

IPC: G01N21/49

CPC classification number: G01N21/49 ,  G01N15/0211 ,  G01N21/53 ,  G01N2021/4709 ,  G01N2021/473 ,  G01N2021/536 ,  G01N2201/064

Abstract: A device for measuring scattered light from a measurement volume with compensation for background signals, includes a light sensor having separately evaluable light-sensitive elements, a single imaging optical system, wherein the light-sensitive elements are arranged in the image plane and the measurement volume is arranged in the corresponding object plane of the optical system, a light transmitter with a collimated light beam, this light-sensitive element detects scattered light from the measurement volume and background light from the overlapping visual ranges behind the subject plane, and the other light-sensitive element detects no or significantly less scattered light from the measurement volume and background light from the overlapping visual areas behind the object plane, and a diaphragm that restricts the visual ranges of the light-sensitive elements behind the object plane.

Abstract translation: 一种用于测量来自测量体积的散射光的装置，用于补偿背景信号，包括具有单独可评估的感光元件的光传感器，单个成像光学系统，其中光敏元件布置在图像平面中，并且测量体积 被布置在光学系统的相应物体平面中，具有准直光束的光发射器，该感光元件检测来自测量体积的散射光和来自对象平面后面的重叠视觉范围的背景光，另一个光 敏感元件检测来自测量体积和来自物平面后面的重叠视觉区域的背景光的散射光以及限制光敏元件在物平面后面的视觉范围的光阑。

公开(公告)号：US09291551B2

公开(公告)日：2016-03-22

申请号：US14314603

申请日：2014-06-25

Applicant: DAINIPPON SCREEN MFG. CO., LTD.

Inventor： Sanzo Moriwaki ,  Hiroki Fujimoto

IPC: G01N21/25 ,  G01N21/47

CPC classification number: G01N21/255 ,  G01N21/47 ,  G01N2201/064 ,  G01N2201/0668

Abstract: An imaging apparatus for imaging a two-dimensional image of an imaging object comprises a holder which holds a sample container carrying a biological sample as the imaging object on a carrying surface, a light emitting part which emits light toward the carrying surface, an imager which includes a strip-like light receiving part, receives the light incident on the light receiving part and thereby images an image of a strip-like region of the carrying surface, a strip-like light shield which shields a part of light emitted from the illuminator toward the strip-like region, and a mover which integrally and relatively moves the light emitting part, the light receiving part and the light shield with respect to the sample container.

Abstract translation: 用于对成像对象的二维图像进行成像的成像装置包括：保持器，其将携带作为成像对象的生物样本的样本容器保持在承载表面上;发光部件，朝着承载表面发射光;成像器， 包括条状光接收部分，接收入射在光接收部分上的光，从而对承载表面的条状区域的图像进行成像;带状遮光罩，其屏蔽从照射器发出的光的一部分 朝向条状区域，以及使发光部，光接收部和遮光板相对于样本容器一体地移动的动子。

公开(公告)号：US20160025637A1

公开(公告)日：2016-01-28

申请号：US14877411

申请日：2015-10-07

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kurt J. Halverson ,  Raymond J. Kenney ,  Olester Benson, JR. ,  Raymond P. Johnston ,  Guoping Mao ,  Patrick R. Fleming ,  George Van Dyke Tiers ,  Naiyong Jing

IPC: G01N21/75 ,  G01N21/64 ,  G01N21/55 ,  G01N21/31

CPC classification number: G01N21/75 ,  B01L3/50853 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0851 ,  B01L2300/0887 ,  B29C35/0888 ,  B29C59/046 ,  B29C59/08 ,  B29C59/10 ,  B29C59/14 ,  B29C59/16 ,  B29C2035/0827 ,  B29C2059/023 ,  G01N21/03 ,  G01N21/253 ,  G01N21/31 ,  G01N21/55 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/064 ,  G01N2201/08

Abstract: The disclosure provides microstructured articles and methods useful for detecting an analyte in a sample. The articles include microwell arrays. The articles can be used with an optical system component in methods to detect or characterize an analyte.

Abstract translation: 本公开提供了用于检测样品中的分析物的微结构化制品和方法。 文章包括微孔阵列。 在用于检测或表征分析物的方法中，物品可以与光学系统组件一起使用。

公开(公告)号：US09013702B2

公开(公告)日：2015-04-21

申请号：US13456467

申请日：2012-04-26

Applicant: Robert Freese ,  Christopher Michael Jones ,  David Perkins ,  Michael Simcock ,  William Soltmann

Inventor： Robert Freese ,  Christopher Michael Jones ,  David Perkins ,  Michael Simcock ,  William Soltmann

IPC: G01N21/00 ,  G01N21/59 ,  G06E3/00 ,  G01N21/31 ,  G01N21/85

CPC classification number: G01N21/59 ,  G01N21/31 ,  G01N21/85 ,  G01N2201/064 ,  G06E3/00 ,  G06E3/001

Abstract: Optical computing devices are disclosed. One optical computing device includes an electromagnetic radiation source that emits electromagnetic radiation into an optical train to optically interact with a sample and at least one integrated computational element, the sample being configured to generate optically interacted radiation. A sampling window is arranged adjacent the sample and configured to allow transmission of the electromagnetic radiation therethrough and has one or more surfaces that generate one or more stray signals. A first focal lens is arranged to receive the optically interacted radiation and the one or more stray signals and generate a primary focal point from the optically interacted radiation. A structural element defines a spatial aperture aligned with the primary focal point such that the optically interacted radiation is able to pass therethrough while transmission of the one or more stray signals is substantially blocked by the structural element.

公开(公告)号：US20150069223A1

公开(公告)日：2015-03-12

申请号：US14467199

申请日：2014-08-25

Applicant: Kenichi Yoshimura

Inventor： Kenichi Yoshimura

IPC: G01S17/02 ,  B60S1/08 ,  G02B6/26

CPC classification number: G01S17/026 ,  B60S1/0833 ,  B60S1/0837 ,  B60S1/0844 ,  G01N21/3554 ,  G01N21/43 ,  G01N21/4738 ,  G01N21/552 ,  G01N2021/3155 ,  G01N2021/9586 ,  G01N2201/0626 ,  G01N2201/0631 ,  G01N2201/0636 ,  G01N2201/064 ,  G02B5/04 ,  G02B6/26

Abstract: A light guide member for an object detection apparatus for detecting an object adhered on a light translucent member based on change of quantity of reflection light received from the light translucent member includes a detection face where light exits to the light translucent member and reflection light reflected from the light translucent member enters, the detection face including a detection area where a part of the reflection light to enter the detection unit passes through, and a non-detection area where remaining part of the reflection light not to enter the detection unit passes through; a first intervening member disposed on the detection face attachable to the light translucent member via the first intervening member; and a second intervening member disposed on the detection face attachable to the light translucent member via the second intervening member. The first intervening member has flexibility greater than flexibility of the second intervening member.

Abstract translation: 一种用于物体检测装置的导光部件，用于根据从光透光部件接收到的反射光量的变化来检测粘附在透光性部件上的物体，包括：光从光透过部件射出的检测面， 光透过部件进入检测面，检测面包括进入检测部的反射光的一部分的检测区域，以及不进入检测部的反射光的剩余部分的非检测区域通过; 第一中间构件，其经由所述第一居间构件设置在所述检测面上，所述第一居间构件可附接到所述光半透明构件; 以及第二中间构件，其经由所述第二居间构件设置在所述检测面上，所述检测面可附着到所述光半透明构件。 第一个居间成员的灵活性大于第二个居间成员的灵活性。

公开(公告)号：US08724107B2

公开(公告)日：2014-05-13

申请号：US13964802

申请日：2013-08-12

Applicant: Hach Company

Inventor： Perry A. Palumbo

IPC: G01N21/00

CPC classification number: G02B19/0076 ,  G01N15/06 ,  G01N21/01 ,  G01N21/53 ,  G01N33/18 ,  G01N2015/0693 ,  G01N2201/064 ,  G02B3/04 ,  G02B5/001 ,  G02B13/18 ,  G02B19/0028 ,  G02B19/008 ,  G02B26/0808 ,  G02B2003/0093 ,  Y10T29/49826

Abstract: One embodiment provides an annular optical device (100), comprising: an annular meso-optic (1) including an annulus (11) centered about an axis of revolution (A); and a secondary optical structure (2) substantially coaxial within the annulus (11) of the annular meso-optic (1), wherein the secondary optical structure (2) and the annular meso-optic (1) are separated by a media (12) comprising a media refractive index that is lower than a secondary optical structure refractive index, with the secondary optical structure (2) being configured to hold a specimen to be radiated by impinging electromagnetic radiation directed into the secondary optical structure (2) substantially along the axis of revolution (A), wherein re-directed radiation from the specimen is allowed into the annular meso-optic (1) by the secondary optical structure (2) if an angle of incidence of the re-directed radiation exceeds the angle of Total Internal Reflectance. Other embodiments are descried and claimed.

Abstract translation: 一个实施例提供了一种环形光学装置（100），包括：环形介质光学元件（1），其包括以旋转轴线（A）为中心的环形部分（11）; 以及在所述环形中视光学器件（1）的所述环形空间（11）内基本上同轴的次级光学结构（2），其中所述次级光学结构（2）和所述环形中视镜（1）由介质（12） ）包括低于二次光学结构折射率的介质折射率，其中所述次级光学结构（2）构造成通过基本上沿着所述第二光学结构（2）的入射入射到所述次级光学结构（2）中的电磁辐射来保持待辐射的样本 旋转轴（A），其中如果重新引导的辐射的入射角超过总和的角度，则来自试样的重新定向的辐射被第二光学结构（2）允许进入环形介质光学器件（1） 内部反射。 描述并要求保护其他实施例。

公开(公告)号：US08436320B2

公开(公告)日：2013-05-07

申请号：US12319924

申请日：2009-01-14

Applicant: Masayuki Yamada

Inventor： Masayuki Yamada

IPC: F21V9/16

CPC classification number: G01N21/474 ,  G01N21/01 ,  G01N21/6456 ,  G01N2021/6484 ,  G01N2201/064

Abstract: A fluorescence detecting apparatus includes: an excitation light emitter for emitting excitation light exciting a fluorescent material onto a measurement object; an illumination light emitter for emitting illumination light onto the measurement object; an image pickup device for sensing light from the measurement object; and a controller for controlling the image pickup device, the excitation light emitter, and the illumination light emitter. The excitation light is emitted from the excitation light emitter onto the measurement object to define an image pickup condition of the image pickup device, based on an image pickup result to be obtained by sensing light from the measurement object by the image pickup device. A light amount of the illumination light to be emitted from the illumination light emitter is set depending on the image pickup condition. The excitation light, and the illumination light of the set light amount are simultaneously emitted from the excitation light emitter and the illumination light emitter, to cause the image pickup device to sense light from the measurement object.

公开(公告)号：US20130100433A1

公开(公告)日：2013-04-25

申请号：US13654747

申请日：2012-10-18

Applicant: Postnova Analytics GmbH

Inventor： Diethelm Frose ,  Roland Welz

IPC: G01N21/51

CPC classification number: G01N21/51 ,  G01N21/53 ,  G01N30/74 ,  G01N2021/4711 ,  G01N2201/064

Abstract: An apparatus for measuring the light scattering properties of a sample in a liquid medium, wherein the liquid medium with the sample is illuminated by a laser beam in a measuring cell transversely to the direction of filling the liquid medium in the measuring cell or transversely to the flow direction of the liquid medium within the measuring cell, comprising a laser, a cylindrical measuring cell, a first inner aperture system, a second outer aperture system and at least two detectors, wherein the detectors are arranged outside of the second outer aperture system so that they collect the light scattered on the sample within set, different angle ranges, wherein the first inner aperture system and the second outer aperture system are formed and arranged circularly and concentrically around the axis of the measuring cell. Use of the apparatus and a method that makes use of the apparatus are also disclosed.

Abstract translation: 一种用于测量液体介质中的样品的光散射性质的装置，其中具有样品的液体介质通过横向于在测量池中填充液体介质的方向的横向于横向于测量单元的测量单元中的激光束照射 测量单元内的液体介质的流动方向，包括激光器，圆柱形测量单元，第一内孔系统，第二外孔系统和至少两个检测器，其中检测器布置在第二外孔系统的外侧，因此 它们收集在集合的不同角度范围内散射在样品上的光，其中第一内孔系统和第二外孔系统被形成并围绕测量池的轴线圆周且同心地布置。 还公开了使用该装置和使用该装置的方法。