公开(公告)号：US20240319079A1

公开(公告)日：2024-09-26

申请号：US18581378

申请日：2024-02-20

Applicant: InnoSpectra Corporation

Inventor： Fei-Peng Chang ,  Kuo-Sheng Huang ,  Cheng-Hsiung Chen ,  Hsi-Pin Li

IPC: G01N21/25 ,  G01N21/27

CPC classification number: G01N21/255 ,  G01N21/27 ,  G01N2201/0637 ,  G01N2201/0638 ,  G01N2201/0664 ,  G01N2201/0668 ,  G01N2201/08

Abstract: A detecting system using a spectrum measurement device and detecting an object is provided. The system includes: a sampling module and spectrum measurement devices assembled to the sampling module. The sampling module provides an illumination beam to the object and collects measurement beams reflected by the object to the spectrum measurement devices. The illumination beam has an illumination light waveband. The measurement beams have the illumination light waveband. The spectrum measurement devices include first and second spectrum measurement devices. The first spectrum measurement device includes a digital micromirror device. The measurement beams include first and second measurement beams transmitted to the first and second spectrum measurement devices respectively. The first spectrum measurement device detects a portion of the illumination light waveband of the first measurement beam, and at the same time the second spectrum measurement device detects another portion of the illumination light waveband of the second measurement beam.

公开(公告)号：US12092572B2

公开(公告)日：2024-09-17

申请号：US18067216

申请日：2022-12-16

Applicant: VIAVI Solutions Inc.

Inventor： Curtis R. Hruska ,  William D. Houck ,  Valton Smith ,  Marc K. Von Gunten ,  Chuck Demilo

IPC: G01N21/359 ,  G02B19/00

CPC classification number: G01N21/359 ,  G02B19/0066 ,  G02B19/0076 ,  G01N2201/0625 ,  G01N2201/063 ,  G01N2201/08

Abstract: An optical sensor system may include a light source. The optical sensor system may include a concentrator component proximate to the light source and configured to concentrate light from the light source with respect to a measurement target. The optical sensor system may include a collection component that includes an array of at least two components configured to receive light reflected or transmitted from the measurement target. The optical sensor system may include may a sensor. The optical sensor system may include a filter provided between the collection component and the sensor.

公开(公告)号：US12092521B2

公开(公告)日：2024-09-17

申请号：US17685595

申请日：2022-03-03

Applicant: Finesse Solutions, Inc.

Inventor： Mark Selker ,  Barbara Paldus

IPC: G01J3/44 ,  G01J3/02 ,  G01N21/65 ,  G02B6/02

CPC classification number: G01J3/44 ,  G01J3/0218 ,  G01N21/65 ,  G02B6/02385 ,  G01N2201/08 ,  G01N2201/129 ,  G02B6/02328

Abstract: A method of determining the identity and concentration of a target analyte present in a biological sample includes: introducing a first target analyte into a hollow core of an optical fiber; introducing a first reference calibrant into the hollow core of the optical fiber; transmitting light from a laser light source through the hollow core of the optical fiber and the first target analyte to generate a first Raman anti-Stokes analyte emission corresponding to the first target analyte; receiving the first Raman anti-Stokes analyte emission at a spectral analysis system optically coupled to the optical fiber; and deriving Raman anti-Stokes spectral peaks or spectra of the first target analyte at the spectral analysis system based on the first Raman anti-Stokes analyte emission.

公开(公告)号：US20240240171A1

公开(公告)日：2024-07-18

申请号：US18560380

申请日：2021-12-24

Applicant: AUTOBIO LABTEC INSTRUMENTS CO., LTD.

Inventor： Chao WANG ,  Zhenkun LI ,  Long SUN ,  Peng ZHAO ,  Yaoji LIU ,  Haoran WEN ,  Weiye GAO ,  Chaohui ZHANG ,  Cong LIU

IPC: C12N15/10 ,  B01L7/00 ,  G01N21/64 ,  G01N35/00 ,  G01N35/10

CPC classification number: C12N15/1013 ,  B01L7/52 ,  G01N21/6428 ,  G01N35/00732 ,  G01N35/0099 ,  G01N35/1002 ,  G01N35/1079 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/041 ,  B01L2300/0663 ,  B01L2300/1805 ,  B01L2300/1894 ,  G01N2021/6439 ,  G01N2035/00752 ,  G01N2201/08

Abstract: A DNA and RNA nucleic acid co-extraction and detection system includes a nucleic acid extraction system, a sealing, transferring and mixing system, a nucleic acid detection system and a control system, wherein the nucleic acid extraction system, the sealing, transferring and mixing system and the nucleic acid detection system are all connected to the control system; the nucleic acid extraction system comprises a carry basket for loading an extraction reagent strip and a sample tube, a consumable-material supply module, a reagent kit loading module, a barcode scanning device for automatically inputting barcode information, a magnetic absorption incubation device, and an automatic sample addition device for transferring a liquid to a reaction chamber of the extraction reagent strip or a PCR tube and sealing the PCR tube; the sealing and transferring system comprises a PCR transferring device for grabbing and driving a PCR tube to move, and a high-speed mixing device.

公开(公告)号：US12025565B2

公开(公告)日：2024-07-02

申请号：US17653779

申请日：2022-03-07

Applicant: The Boeing Company

Inventor： Fei Cai ,  Richard Calawa

IPC: G01N21/88 ,  B23K26/70

CPC classification number: G01N21/8851 ,  B23K26/707 ,  G01N2021/8887 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/08

Abstract: The present disclosure provides an inspection system and method for inspecting an optical surface of a laser scanner, the system including a directional optical source and an optical detector. The method includes moving one of the laser scanner or the inspection system to a position in which a beam axis of the directional optical source extends across but does not intersect the optical surface, between the optical surface of and the optical detector. The method further includes emitting a light beam from the directional optical source, across the optical surface so that light from the light beam is incident on debris disposed on the optical surface. The method further includes collecting the light at the optical detector to form an image that indicates presence of the debris on the optical surface of the laser scanner; and generating feedback to alert a user of the presence of the debris.

公开(公告)号：US20240210323A1

公开(公告)日：2024-06-27

申请号：US18682657

申请日：2021-07-09

Applicant: Ayna Analytics GmbH

Inventor： Laura RODRÍGUEZ GARCÍA ,  David MAINKA

IPC: G01N21/65 ,  G01N21/3577 ,  G01N21/359

CPC classification number: G01N21/65 ,  G01N21/3577 ,  G01N21/359 ,  G01N2201/0636 ,  G01N2201/08

Abstract: A measurement chamber extension for a spectrophotometric characterization with a NIR-spectrophotometer of a Raman-spectrophotometer of a liquid in a polymer container, wherein a measurement chamber extension comprises: an adapter plate having an adapter opening; a container holder, and an optical element, selected from a mirror and a waveguide. The adapter is configured to cover in a light-tight manner the measurement chamber of the NIR-spectrophotometer or of the Raman-spectrophotometer. The container holder is configured to allow a close placement of the optical element adjacent to the polymer container containing the liquid providing a loss-free transmission or transflection of the measurement light beam from the optical element to a detector of the NIR-spectrophotometer or Raman-spectrophotometer.

公开(公告)号：US20240183655A1

公开(公告)日：2024-06-06

申请号：US18279030

申请日：2022-03-03

Applicant: ASML NETHERLANDS B.V.

Inventor： Alexander VON FINCK ,  Simon HALM ,  Ingo Juergen MARKEL ,  Maciej NEUMANN-RÖBISCH

IPC: G01B11/30 ,  G01N21/47 ,  G01N21/88 ,  G01N21/94

CPC classification number: G01B11/303 ,  G01N21/474 ,  G01N21/8806 ,  G01N21/94 ,  G01N2021/4742 ,  G01N2021/4783 ,  G01N2021/8835 ,  G01N2021/8845 ,  G01N2021/8848 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/08

Abstract: A measuring apparatus has at least two radiation sources arranged to illuminate a measuring region of a surface of a sample, the at least two sources configured to illuminate the measuring region along at least two illumination beam paths at different angles of incidence relative to a surface normal of the surface, a detector device configured to detect at least two scattered radiation images of surface sections in the illuminated measuring region at a predetermined viewing angle relative to the surface normal of the surface, portions of the scattered radiation received by the detector device, which portions are formed in each case by the illumination in one of the illumination beam paths, in each case having a common spatial frequency, and an evaluation device configured to determine at least one roughness feature of the surface sections from the at least two scattered radiation images.

公开(公告)号：US12000824B2

公开(公告)日：2024-06-04

申请号：US18206356

申请日：2023-06-06

Applicant: InViDx Corp.

Inventor： James Samsoondar ,  Michael Licht

IPC: G01N33/48 ,  B01L3/00 ,  G01N21/25 ,  G01N21/33 ,  G01N33/49

CPC classification number: G01N33/492 ,  B01L3/502715 ,  G01N21/255 ,  G01N21/33 ,  B01L2200/04 ,  B01L2200/16 ,  B01L2300/0654 ,  G01N2201/062 ,  G01N2201/08

Abstract: Described are various embodiments of a point-of-care testing (POCT) system, analyzer and method for measuring quantities of at least two analytes in a blood sample, for example bilirubin and hemoglobin. The system comprises an analyzer and a removable cartridge. The removable cartridge comprises an optical chamber configured for receiving the blood sample. The analyzer comprises a receptor for receiving the removable cartridge, a first and second set of incident electromagnetic radiation (EMR) for example two broadband LEDs, an EMR dispersive element for example a reflective grating, a photo diode array detector, and a processor. The two EMR sources are implemented in such a way so that the spectral wavelength range of EMR emerging from the blood is expanded, and the effect of stray EMR is mitigated. The expanded wavelength range and the mitigation of stray EMR allows the analyzer to measure quantities of the analytes in lysed or unlysed blood.

公开(公告)号：US11959853B2

公开(公告)日：2024-04-16

申请号：US17497835

申请日：2021-10-08

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Lawrence C. West ,  Keith G. Fife ,  Benjamin Cipriany ,  Farshid Ghasemi

IPC: G01N21/64 ,  C12Q1/6869 ,  C12Q1/6874

CPC classification number: G01N21/6408 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2201/0696 ,  G01N2201/08 ,  G01N2201/12

Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.

公开(公告)号：US20240118197A1

公开(公告)日：2024-04-11

申请号：US18390121

申请日：2023-12-20

Applicant: Simple Labs, Inc.

Inventor： Michael Slone

IPC: G01N21/3504 ,  G01N33/14

CPC classification number: G01N21/3504 ,  G01N33/146 ,  G01N2201/08

Abstract: A plug for a container for storing liquid includes a housing having a longitudinal axis. A first sensor bank is inside the housing, the first sensor bank comprising a first printed circuit board (PCB) and a first sensor mounted on the first PCB. A first sensor chamber is inside the housing, where the first PCB forms a lateral side of the first sensor chamber. An input chamber is at an input end of the housing, wherein the input chamber is partially enclosed by a side wall of the housing and is open at the input end. A cutout is in the side wall, the cutout adjacent to the input end. A flow pathway is between the input chamber and the first sensor chamber.