公开(公告)号：US20160266143A1

公开(公告)日：2016-09-15

申请号：US14638770

申请日：2015-03-04

Applicant: HemCon Medical Technologies, Inc.

Inventor： Barbara McGrath ,  Simon McCarthy ,  Sam Kuhn ,  Alysha Wold ,  Michael Stolten ,  Amanda Bennett

IPC: G01N33/68 ,  A61K49/00

CPC classification number: A61L27/58 ,  A61K9/0024 ,  A61K47/36 ,  A61K49/0008 ,  A61L27/20 ,  A61L27/26 ,  A61L2400/04 ,  C08B37/003 ,  C08L5/08 ,  C08L89/06 ,  C08L2201/06 ,  G01N33/5014 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2400/28

Abstract: The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.

Abstract translation: 本发明涉及用于生物医学使用的1-乙基-3- [3-二甲基氨基丙基]碳二亚胺盐酸盐（EDC），任选地交联至明胶/胶原的生物相容性，生物可吸收的衍生的非交联壳聚糖组合物，以及制备和测试这些组合物的方法，包括 改良型急性全身毒性试验。 组合物包含重新乙酰化至约15％至40％的N-脱乙酰度（DDA）的衍生的壳聚糖。 组合物通常在约90天或更短时间内生物吸收，并且可以以不同的速度制成生物吸收。 组合物最初可溶于低于pH6.5的水溶液中。 组合物的酸含量可以在约0％（w / w）至约8％（w / w）之间调节，以定制需要和/或耐受不同水平的细胞毒性，粘附性，组成内聚力， 和细胞浸润到组合物中。

公开(公告)号：US09428744B2

公开(公告)日：2016-08-30

申请号：US14308526

申请日：2014-06-18

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS ,  UNIVERSITE DE POITIERS ,  VALAGRO CARBONE RENOUVELABLE POITOU—CHARENTES

Inventor： Thierry Ferreira ,  Frederic Bataille ,  Cedric Dever ,  Jacques Barbier

IPC: D06P1/52 ,  C08K5/00 ,  C12N11/08 ,  C12N9/14 ,  C12N11/04 ,  C08L67/04 ,  C08J3/00 ,  C08J3/20 ,  C12N9/20 ,  C12N9/58 ,  C12N11/18

CPC classification number: C08J3/005 ,  C08J3/201 ,  C08J3/203 ,  C08J2367/04 ,  C08J2489/00 ,  C08K5/0033 ,  C08L67/04 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2203/20 ,  C12N9/14 ,  C12N9/20 ,  C12N9/58 ,  C12N11/04 ,  C12N11/08 ,  C12N11/18 ,  C08L89/00

Abstract: The present invention relates to a process for preparing a polymer/biological entities alloy, comprising a step of mixing a polymer and biological entities that degrade it, during a heat treatment, said heat treatment being performed at a temperature T above room temperature and said biological entities being resistant to said temperature T, characterized in that said biological entities are chosen from enzymes that degrade said polymer and microorganisms that degrade said polymer.

Abstract translation: 本发明涉及一种制备聚合物/生物实体合金的方法，包括在热处理期间混合聚合物和降解其的生物实体的步骤，所述热处理在高于室温的温度T下进行，并且所述生物 实体对所述温度T具有抗性，其特征在于所述生物实体选自降解所述聚合物的酶和降解所述聚合物的微生物。

公开(公告)号：US20160185955A1

公开(公告)日：2016-06-30

申请号：US14903042

申请日：2014-07-04

Applicant: Solegear Bioplastics Inc.

Inventor： Richard CHEN ,  Michel LABONTE ,  Toby REID

IPC: C08L67/04 ,  B29C35/00 ,  B29C45/00 ,  C08J5/18

CPC classification number: C08L67/04 ,  B29C35/00 ,  B29C45/0013 ,  B29K2035/00 ,  B29K2509/00 ,  C08J5/18 ,  C08J2367/04 ,  C08J2467/02 ,  C08K3/26 ,  C08L67/00 ,  C08L67/02 ,  C08L2201/06

Abstract: The present disclosure provides, at least in part, a composition comprising polylactic acid (PLA), poly(butylene succinate) (PBS), and a compostable polyester such as poly(butylene adipate-co-terephthalate) (PBAT). The present compositions may comprises calcium carbonate. The present disclosure provides, at least in part, an article manufactured from present composition, such as a packaging.

Abstract translation: 本公开至少部分提供了包含聚乳酸（PLA），聚（丁二酸丁二醇酯）（PBS）和可堆肥聚酯如聚（己二酸丁二醇酯 - 共 - 对苯二甲酸酯）（PBAT）的组合物。 本发明的组合物可以包括碳酸钙。 本公开至少部分地提供由本发明组合物制成的制品，例如包装。

公开(公告)号：US20160024297A1

公开(公告)日：2016-01-28

申请号：US14620673

申请日：2015-02-12

Applicant: FUJI XEROX CO., LTD.

Inventor： Akira IMADA

IPC: C08L67/04 ,  C08L67/03

CPC classification number: C08L67/04 ,  C08K5/0025 ,  C08L67/02 ,  C08L2201/06

Abstract: A resin composition includes an aromatic polyester resin, a polylactic acid resin, and at least one compound selected from a carbodiimide compound, an epoxy compound, an oxazoline compound, an oxazine compound, and an aziridine compound, wherein the resin composition has only one peak of tan σ obtainable by a viscoelasticity measurement in a temperature range of 60° C. to 90° C.

Abstract translation: 树脂组合物包括芳族聚酯树脂，聚乳酸树脂和选自碳二亚胺化合物，环氧化合物，恶唑啉化合物，恶嗪化合物和氮丙啶化合物中的至少一种化合物，其中树脂组合物仅具有一个峰 的tan＆sgr 可以通过在60℃至90℃的温度范围内的粘弹性测量获得。

公开(公告)号：US09221972B2

公开(公告)日：2015-12-29

申请号：US14410895

申请日：2013-06-13

Applicant: KANEKA CORPORATION

Inventor： Tetsuya Minami ,  Kenichiro Nishiza ,  Noriyuki Suzuki

IPC: C08L67/04 ,  C08L31/04 ,  B29C47/00

CPC classification number: C08L67/04 ,  C08L2201/06 ,  C08L31/04

Abstract: A poly-3-hydroxyalkanoate resin composition having excellent ductility and transparency, and a molded article thereof. The poly-3-hydroxyalkanoate resin composition includes: a poly-3-hydroxyalkanoate resin (A); and an ethylene-vinyl acetate copolymer resin (B) having a vinyl acetate content of 65 to 95 wt %, wherein the resin (A) and the resin (B) are miscible and a ratio of resin (A)/resin (B) is 90/10 to 55/45 (wt/wt). The molded article is produced using such a poly-3-hydroxyalkanoate resin composition.

Abstract translation: 具有优异的延展性和透明性的聚-3-羟基链烷酸酯树脂组合物及其成型品。 聚-3-羟基链烷酸酯树脂组合物包括：聚-3-羟基链烷酸酯树脂（A）; 和乙酸乙烯酯含量为65〜95重量％的乙烯 - 乙酸乙烯酯共聚物树脂（B），其中树脂（A）和树脂（B）是可混溶的，树脂（A）/树脂（B）的比例 为90/10〜55/45（wt / wt）。 使用这种聚-3-羟基链烷酸酯树脂组合物制造模塑制品。

公开(公告)号：US09181412B2

公开(公告)日：2015-11-10

申请号：US14159075

申请日：2014-01-20

Applicant: Manuel Rendon

Inventor： Manuel Rendon

IPC: C08J11/16 ,  C08J11/20 ,  C08J11/24 ,  C08J11/10 ,  C08L1/02

CPC classification number: C08J11/105 ,  C08J3/226 ,  C08J11/16 ,  C08J11/20 ,  C08J11/24 ,  C08K5/0033 ,  C08L1/02 ,  C08L2201/06 ,  Y02W30/705

Abstract: A composition for the degradation of plastic in the form of an additive used during the manufacturing of plastic. The composition being comprised of a predetermined amount of heptane, cellulose, methyl rhenium trioxide, butylated hydroxytoluene, and polyphenol oxidase. The additive can be selectively programmed to cause the plastic to begin disintegrating at a predetermined time.

Abstract translation: 用于在塑料制造期间使用的添加剂形式的塑性降解的组合物。 该组合物由预定量的庚烷，纤维素，甲基铼三氧化物，丁基化羟基甲苯和多酚氧化酶组成。 可以选择性地编程添加剂以使塑料在预定时间开始分解。

公开(公告)号：US20150166735A1

公开(公告)日：2015-06-18

申请号：US14132410

申请日：2013-12-18

Applicant: Universite Cergy-Pontoise

Inventor： Laurent Bidault ,  Odile Fichet ,  Veronique Larreta Garde ,  Cedric Vancaeyzeele ,  Mathilde Hindie ,  Marie Deneufchatel

IPC: C08J3/075 ,  C08L51/00 ,  C08J3/24 ,  A61L15/40 ,  A61L15/24 ,  A61L15/64 ,  C08J3/28 ,  C08L89/00 ,  A61L15/32

CPC classification number: C08J3/075 ,  A61L15/24 ,  A61L15/32 ,  A61L15/40 ,  A61L15/64 ,  A61L26/0014 ,  A61L26/0042 ,  A61L26/0052 ,  A61L27/16 ,  A61L27/225 ,  A61L27/34 ,  A61L27/3633 ,  A61L27/54 ,  A61L29/041 ,  A61L29/047 ,  A61L29/049 ,  A61L29/085 ,  A61L29/16 ,  A61L31/046 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2400/04 ,  A61L2430/34 ,  C08G18/6212 ,  C08G18/8116 ,  C08H1/00 ,  C08J3/246 ,  C08J2329/04 ,  C08J2351/00 ,  C08J2389/00 ,  C08L51/00 ,  C08L89/00 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2205/04 ,  C08L2312/06 ,  C08L29/04

Abstract: The present invention relates to a material as interpenetrating polymer network (IPN) associating a gel with a co-network of functionalized synthetic polymer and functionalized protein as well as a method of the manufacture of such a material. In particular, the invention relates to a material as interpenetrating polymer network associating a fibrin gel with a co-network of polyvinylalcohol and albumin thank to methacrylate bridges, with improved biodegradability properties.

Abstract translation: 本发明涉及将凝胶与官能化合成聚合物和官能化蛋白质的共网络相结合的互穿聚合物网络（IPN）的材料以及制造这种材料的方法。 特别地，本发明涉及一种作为互穿聚合物网络的材料，其将纤维蛋白凝胶与感谢甲基丙烯酸桥接的聚乙烯醇和白蛋白的共网络相结合，具有改进的生物降解性质。

公开(公告)号：US20150159011A1

公开(公告)日：2015-06-11

申请号：US14533274

申请日：2014-11-05

Applicant: Ethicon, Inc.

Inventor： Dennis D. Jamiolkowski ,  Sasa Andjelic ,  Brian M. Kelly ,  Christopher DeFelice

IPC: C08L67/04 ,  A61L31/14 ,  A61L31/04

CPC classification number: C08L67/04 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00004 ,  A61B2017/00831 ,  A61L17/12 ,  A61L27/18 ,  A61L29/06 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148 ,  C08G63/664 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2205/02 ,  C08L2205/025

Abstract: Novel absorbable polymeric blends having bimodal molecular weight distribution are disclosed. The bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a bimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of unimodal or bimodal molecular weight distribution. Alternately, the bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a unimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of bimodal molecular weight distribution. The novel polymeric bimodal molecular weight blends provide medical devices having improved dimensional stability. Also disclosed are novel absorbable medical devices made from these novel bimodal polymer blends, as well as novel methods of manufacture.

Abstract translation: 公开了具有双峰分子量分布的新型可吸收聚合物共混物。 双峰共混物具有第一组分，其是聚丙交酯聚合物或具有双峰分子量分布的丙交酯和乙交酯的共聚物，以及作为单峰或双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 或者，双峰共混物具有第一组分，其是具有单峰分子量分布的聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及作为双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 新型聚合双峰分子量共混物提供具有改进的尺寸稳定性的医疗装置。 还公开了由这些新型双峰聚合物共混物制成的新型可吸收医疗装置，以及新颖的制造方法。

公开(公告)号：US09045630B2

公开(公告)日：2015-06-02

申请号：US13171819

申请日：2011-06-29

Applicant: Wei Wang ,  David K. Knoeppel ,  Fengkui Li ,  Jose M. Sosa

Inventor： Wei Wang ,  David K. Knoeppel ,  Fengkui Li ,  Jose M. Sosa

IPC: C08L25/06 ,  C08L35/06 ,  C08L101/00 ,  C08L29/04 ,  C08L67/00

CPC classification number: C08L25/14 ,  C08L25/06 ,  C08L29/04 ,  C08L35/06 ,  C08L67/00 ,  C08L101/00 ,  C08L2201/06

Abstract: Polystyrene blends and methods of making polystyrene blends including combining a styrene monomer and an epoxy-functional comonomer to form a combined mixture, subjecting the combined mixture to polymerization to obtain a polystyrene copolymer and combining the polystyrene copolymer with a biodegradable polymer to obtain a polystyrene blend.

Abstract translation: 聚苯乙烯共混物和制备聚苯乙烯共混物的方法，包括组合苯乙烯单体和环氧官能的共聚单体以形成组合的混合物，使合并的混合物进行聚合以获得聚苯乙烯共聚物并将聚苯乙烯共聚物与可生物降解的聚合物组合以获得聚苯乙烯共混物 。

公开(公告)号：US09034990B2

公开(公告)日：2015-05-19

申请号：US13956514

申请日：2013-08-01

Applicant: FINA TECHNOLOGY, INC.

Inventor： Fengkui Li ,  John Ashbaugh ,  Gabriel Desille ,  Caroline Schils

IPC: C08F10/06 ,  C08L23/14 ,  B29C45/72 ,  C08L51/06 ,  C08L67/04 ,  C08L23/10

CPC classification number: C08L23/142 ,  B29C45/72 ,  C08K3/34 ,  C08L23/06 ,  C08L23/10 ,  C08L23/14 ,  C08L23/16 ,  C08L51/06 ,  C08L67/04 ,  C08L2201/06 ,  C08L2205/025 ,  C08L2205/03 ,  C08L2205/08 ,  C08L2207/02 ,  C08L2207/04

Abstract: Injection molded articles and process of forming the same are described herein. The processes generally include providing a polyolefin including one or more propylene heterophasic copolymers, the polyolefin having an ethylene content of at least 10 wt. % based on the total weight of the polyolefin; contacting the polyolefin with a polylactic acid and a reactive modifier to form a compatiblized polymeric blend, wherein the reactive modifier is produced by contacting a polypropylene, a multifunctional acrylate comonomer, and an initiator under conditions suitable for the formation of a glycidyl methacrylate grafted polypropylene (PP-g-GMA) having a grafting yield in a range from 1 wt. % to 15 wt. %; and injection molding the compatibilized polymeric blend into an article.

Abstract translation: 本文描述了注塑制品及其制备方法。 该方法通常包括提供包含一种或多种丙烯异相共聚物的聚烯烃，所述聚烯烃的乙烯含量为至少10wt。 基于聚烯烃的总重量％; 使聚烯烃与聚乳酸和反应性改性剂接触以形成相容的聚合物共混物，其中反应性改性剂通过在适于形成甲基丙烯酸缩水甘油酯接枝聚丙烯的条件下使聚丙烯，多官能丙烯酸酯共聚单体和引发剂接触来制备 PP-g-GMA），其接枝收率在1wt。 ％至15wt。 ％; 并将相容的聚合物共混物注塑成制品。