公开(公告)号：US20120234393A1

公开(公告)日：2012-09-20

申请号：US13457199

申请日：2012-04-26

Applicant: George Maltezos ,  Jeremy Witzens ,  Axel Scherer

Inventor： George Maltezos ,  Jeremy Witzens ,  Axel Scherer

IPC: F03B11/00

CPC classification number: G01N21/6428 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/14 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/0683 ,  B81C1/00119 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/6456 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/0364 ,  G01N2201/024 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T137/1714 ,  Y10T137/2202 ,  Y10T137/8811

Abstract: An apparatus for analysis of a sample and in particular of a biological sample. The apparatus contains a microfluidic chip with dies, adapted to be selectively activated or deactivated by presence of target molecules in the biological sample. The apparatus further contains a light source to emit light for illumination of the microfluidic chip and an optical filter to allow passage of the light from the dies once activated or deactivated by the presence of the target molecules. A method for pressurizing a microfluidic chip is also disclosed, where a chamber is provided, the chamber is connected with the microfluidic chip and pressure is applied to the chamber.

Abstract translation: 用于分析样品，特别是生物样品的装置。 该装置包含具有管芯的微流体芯片，适于通过生物样品中目标分子的存在而被选择性地活化或失活。 该装置还包含用于发射微流芯片照明的光源和滤光器，以允许通过靶分子的存在激活或去激活来自模具的光的通过。 还公开了一种用于对微流体芯片加压的方法，其中设置有腔室，腔室与微流体芯片连接，并且将压力施加到腔室。

公开(公告)号：US08212217B2

公开(公告)日：2012-07-03

申请号：US12572234

申请日：2009-10-01

Applicant: Axel Scherer ,  Michael D. Henry ,  Harold Hager

Inventor： Axel Scherer ,  Michael D. Henry ,  Harold Hager

IPC: G01T1/24

CPC classification number: H01L31/09 ,  H01L27/1446 ,  H01L31/0216 ,  H01L31/0547 ,  Y02E10/52

Abstract: Photodetection devices and methods are described. The photodetection devices comprise semiconductor tapered pillars.

Abstract translation: 描述了光检测装置和方法。 光检测装置包括半导体锥形支柱。

公开(公告)号：US20120161207A1

公开(公告)日：2012-06-28

申请号：US12952181

申请日：2010-11-22

Applicant: Andrew P. HOMYK ,  Michael D. Henry ,  Axel Scherer ,  Sameer Walavalkar

Inventor： Andrew P. HOMYK ,  Michael D. Henry ,  Axel Scherer ,  Sameer Walavalkar

IPC: H01L29/772 ,  H01L21/336 ,  H01L29/02

CPC classification number: G01N27/4146 ,  B82Y10/00 ,  B82Y15/00 ,  H01L29/0676 ,  H01L29/66666 ,  H01L29/775

Abstract: Methods for fabricating silicon nanowire chemical sensing devices, devices thus obtained, and methods for utilizing devices for sensing and measuring chemical concentration of selected species in a fluid are described. Devices may comprise a metal-oxide-semiconductor field-effect transistor (MOSFET) structure.

Abstract translation: 描述了制造硅纳米线化学感测装置的方法，如此获得的装置，以及利用用于感测和测量流体中选定物种的化学浓度的装置的方法。 器件可以包括金属氧化物半导体场效应晶体管（MOSFET）结构。

公开(公告)号：US08201765B2

公开(公告)日：2012-06-19

申请号：US12554817

申请日：2009-09-04

Applicant: Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

IPC: B02C17/10

CPC classification number: C12N13/00 ,  C12M47/06 ,  C12N1/066

Abstract: Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.

Abstract translation: 描述了裂解生物样品的方法和布置。 该装置包括含有样品的裂解管，产生磁场的一个或多个电磁体和裂解管内的一个或多个永磁体。 当电磁铁产生磁场时，永久磁铁移动并裂开样品。

公开(公告)号：US08189204B2

公开(公告)日：2012-05-29

申请号：US12792059

申请日：2010-06-02

Applicant: Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer ,  Demetri Psaltis ,  Guoan Zheng

Inventor： Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer ,  Demetri Psaltis ,  Guoan Zheng

IPC: G01B9/02

CPC classification number: G02B21/0056 ,  B82Y20/00 ,  G01N21/554 ,  G02B6/1226 ,  G02B21/10 ,  G02B21/14 ,  G02B27/52

Abstract: Embodiments of the present invention relate to a surface wave enabled darkfield aperture structure comprising an aperture layer, a aperture in the aperture layer and a plurality of grooves around the aperture. The aperture layer has a first and second surface. The plurality of grooves is in the first surface. A surface wave propagates along at least the first surface. The plurality of grooves is configured to generate a darkfield at the aperture by modifying the surface wave to cancel out direct transmission of a uniform incident light field received by the aperture.

Abstract translation: 本发明的实施例涉及一种表面波使能暗场孔结构，其包括孔径层，孔径层中的孔和围绕孔的多个凹槽。 孔层具有第一和第二表面。 多个槽位于第一表面。 表面波沿着至少第一表面传播。 多个槽被配置为通过修改表面波来在孔处产生暗场，以消除由孔接收的均匀入射光场的直接透射。

公开(公告)号：US20120091235A1

公开(公告)日：2012-04-19

申请号：US13230933

申请日：2011-09-13

Applicant: Zhenyu Li ,  Axel Scherer

Inventor： Zhenyu Li ,  Axel Scherer

IPC: C12N1/06

CPC classification number: C12M47/06 ,  C12N1/066

Abstract: Apparatus and methods for mechanical cell lysis with single cell resolution which requires very low applied pressure. The device can be handheld, simple to operate, requires no external power except for hand-applied pressure via a syringe, and is applicable to all cell types including yeast and bacterial cells. The device is also capable of mechanically lysing a single cell. A single cell is selected from a biological sample of interest. The single cell is lysed by application of mechanical stress in a single cell lysing apparatus having a trap structure for deterministically capturing the cell and a stress raiser that cooperates with a source of mechanical stress so as to apply sufficient force to rupture a cell. The stress raiser can be a properly designed edge of the trap or it can be a lithographically produced structure such as a nanoblade or a nanopillar.

Abstract translation: 用于单细胞分辨率的机械细胞裂解的装置和方法，其需要非常低的施加压力。 该装置可以是手持式的，操作简单，除了通过注射器的手动施加的压力外，不需要外部功率，并且适用于包括酵母和细菌细胞在内的所有细胞类型。 该装置还能够机械裂解单个电池。 从感兴趣的生物样品中选择单个细胞。 单细胞通过在具有用于确定性捕获细胞的捕获结构的单细胞裂解装置中施加机械应力而裂解，并且应力提升器与机械应力源协作以施加足够的力使细胞破裂。 应力提升器可以是陷阱的适当设计的边缘，或者它可以是光刻产生的结构，例如纳米颗粒或纳米柱。

公开(公告)号：US20120024010A1

公开(公告)日：2012-02-02

申请号：US13253678

申请日：2011-10-05

Applicant: George Maltezos ,  Axel Scherer ,  Jeremy Witzens

Inventor： George Maltezos ,  Axel Scherer ,  Jeremy Witzens

IPC: A44C17/00 ,  C23F1/04

CPC classification number: A44C17/00 ,  A44C17/001 ,  A44C17/005 ,  G01N21/87 ,  G02B5/18 ,  G02B5/1857

Abstract: Various embodiments described herein comprise a gemstone or other piece of jewelry, which incorporates one or more diffractive optical elements to enhance the fire displayed by the gemstone. In certain embodiments, the diffractive optical element comprises a diffraction grating etched on one or more facets of the gemstone.

Abstract translation: 本文描述的各种实施例包括宝石或其他珠宝首饰，其包含一个或多个衍射光学元件以增强由宝石显示的火。 在某些实施例中，衍射光学元件包括在宝石的一个或多个刻面上刻蚀的衍射光栅。

公开(公告)号：US08104497B2

公开(公告)日：2012-01-31

申请号：US11685654

申请日：2007-03-13

Applicant: Marc Unger ,  Hou-Pu Chou ,  Todd Thorsen ,  Axel Scherer ,  Stephen Quake ,  Markus Enzelberger ,  Mark Adams ,  Carl Hansen

Inventor： Marc Unger ,  Hou-Pu Chou ,  Todd Thorsen ,  Axel Scherer ,  Stephen Quake ,  Markus Enzelberger ,  Mark Adams ,  Carl Hansen

IPC: B08B3/04

CPC classification number: B05D3/04 ,  B01J2219/00355 ,  B01J2219/00378 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00439 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/06 ,  B01L2400/0655 ,  B01L2400/0688 ,  B32B2037/1081 ,  B65B31/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  C12Q1/6832 ,  C12Q1/6874 ,  C30B29/54 ,  F04B43/043 ,  F15C1/06 ,  F15C3/00 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0324 ,  Y10T137/0379 ,  Y10T137/0424 ,  Y10T137/206 ,  Y10T137/2082 ,  Y10T137/2164 ,  Y10T137/2169 ,  Y10T137/2174 ,  Y10T137/2202 ,  Y10T137/2224 ,  Y10T137/3084 ,  Y10T137/7837 ,  Y10T137/86027 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US08012791B2

公开(公告)日：2011-09-06

申请号：US10570839

申请日：2004-09-01

Applicant: Theodor Doll ,  Susanne Scheinert ,  Axel Scherer ,  Gernot Paasch

Inventor： Theodor Doll ,  Susanne Scheinert ,  Axel Scherer ,  Gernot Paasch

IPC: H01L51/40

CPC classification number: H01L51/0545 ,  H01L21/0272 ,  H01L51/0023

Abstract: The invention relates to a method for producing electronic components comprising adjacent electrodes interspaced at distances ranging between 10 nanometers and several micrometers on a substrate of any type. According to the invention, the electrodes are structured by means of overlapping edges on the deposited layer or by undercutting the deposited layers. The electronic components are then produced either in the conventional manner or using a lithographic process from the underside of the transparent substrate and finally by means of a succession of known method steps for the production of electronic components.

Abstract translation: 本发明涉及一种用于制造电子部件的方法，所述电子部件包括在任何类型的基板上间隔10纳米至数微米之间的相邻电极。 根据本发明，电极通过沉积层上的重叠边缘或通过底切沉积的层而构成。 然后以常规方式或使用来自透明基板的下侧的光刻工艺，最后通过一系列用于生产电子部件的已知方法步骤来生产电子部件。

公开(公告)号：US20110075254A1

公开(公告)日：2011-03-31

申请号：US12792059

申请日：2010-06-02

Applicant: Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer ,  Demetri Psaltis ,  Guoan Zheng

Inventor： Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer ,  Demetri Psaltis ,  Guoan Zheng

IPC: G02B21/10 ,  G02B21/14

CPC classification number: G02B21/0056 ,  B82Y20/00 ,  G01N21/554 ,  G02B6/1226 ,  G02B21/10 ,  G02B21/14 ,  G02B27/52

Abstract: Embodiments of the present invention relate to a surface wave enabled darkfield aperture structure comprising an aperture layer, a aperture in the aperture layer and a plurality of grooves around the aperture. The aperture layer has a first and second surface. The plurality of grooves is in the first surface. A surface wave propagates along at least the first surface. The plurality of grooves is configured to generate a darkfield at the aperture by modifying the surface wave to cancel out direct transmission of a uniform incident light field received by the aperture.

Abstract translation: 本发明的实施例涉及一种表面波使能暗场孔结构，其包括孔径层，孔径层中的孔和围绕孔的多个凹槽。 孔层具有第一和第二表面。 多个槽位于第一表面。 表面波沿着至少第一表面传播。 多个槽被配置为通过修改表面波来在孔处产生暗场，以消除由孔接收的均匀入射光场的直接透射。