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公开(公告)号：US10379052B2
公开(公告)日：2019-08-13
申请号：US16210311
申请日：2018-12-05
Applicant: THE UNIVERSITY OF TOKYO
Inventor： Yuichi Wakamoto , Koseki Kobayashi
IPC: G01J3/44 , G01N21/65 , C12Q1/6816 , G01L1/24 , G01N21/01
Abstract: An objective cell is irradiated with laser beam of a predetermined wavelength. Only Stokes light is selected out of detected light including reflected light and scattered light of the laser beam, and a Raman scattering spectrum is obtained by dispersion of the selected Stokes light. A transcriptome of the objective cells is estimated, based on the Raman scattering spectrum. It is preferable to estimate the transcriptome of the objective cells, based on N-dimensional Raman data obtained by dimensional reduction of the Raman scattering spectrum. This configuration only needs to irradiate the objective cell with the laser beam and does not require to destroy the objective cell. As a result, this enables the transcriptome of the cell to be estimated in a short time period without destroying the cell.
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公开(公告)号：US20190212761A1
公开(公告)日：2019-07-11
申请号：US15868521
申请日：2018-01-11
Applicant: Eric Swanson , OFS Fitel, LLC
Inventor： Eric Swanson , Tristan Kremp , Paul S. Westbrook , David DiGiovanni
CPC classification number: G05D25/02 , A61B1/06 , G01J3/4406 , G02B6/04
Abstract: An optical probe includes an optical source that generates an optical beam that propagates from a proximal end to a distal end of an optical fiber that imparts a transformation of a spatial profile of the optical beam. An optical control device imparts a compensating spatial profile on the optical beam that at least partially compensates for the transformation of the spatial profile of the optical beam imparted by the optical fiber in response to a control signal from a signal processor. A distal optical source generates a calibration light that propagates through the one or more optical waveguides from the distal end to the proximal end of the optical fiber. An optical detector detects the calibration light and generates electrical signals in response to the detected calibration light. The signal processor generates the control signal to instruct the optical control device to impart the compensating spatial profile on the optical beam that at least partially compensates for the transformation of the spatial profile of the optical beam imparted by the optical fiber.
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公开(公告)号：US10330688B2
公开(公告)日：2019-06-25
申请号：US15371692
申请日：2016-12-07
Inventor： Gabriela Gebrin Cezar , Alan M. Smith
Abstract: This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present or secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein. The individual metabolites or a pattern of secreted metabolites provides metabolic signatures of autism, which can be used to provide a diagnosis thereof.
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公开(公告)号：US10317388B2
公开(公告)日：2019-06-11
申请号：US16056020
申请日：2018-08-06
Applicant: Saudi Arabian Oil Company
Inventor： Ezzat Hegazi , Vincent Cunningham , Maha Nour
Abstract: Methods, systems, and apparatus to diagnose lubrication oil deterioration. In one aspect, a method includes irradiating a lubrication oil sample with a light beam to emit a light-induced fluorescence, detecting and processing the light-induced fluorescence signal to determine a temporal variation of a fluorescence intensity, identifying a steady state of the light-induced fluorescence signal, processing the temporal variation of the fluorescence intensity to determine a lubrication oil parameter, and correlating the oil parameter to a calibration curve to diagnose the lubrication oil deterioration.
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公开(公告)号：US10302561B2
公开(公告)日：2019-05-28
申请号：US15698443
申请日：2017-09-07
Applicant: CANON KABUSHIKI KAISHA
Inventor： Yukihiro Inoue , Takefumi Ota
Abstract: A center wavelength of first pulsed light (exciting pulsed light) is variable, and a pulse rate of the first pulsed light coincides with an integer multiple of a free spectral interval of an optical oscillator at a center wavelength of second pulsed light (signal pulsed light or idler pulsed light). A center wavelength of a nonlinear gain generated by a nonlinear optical medium is made approximately coincident with the center wavelength of the second pulsed light.
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Patent Agency Ranking
公开(公告)号：US10302487B2
公开(公告)日：2019-05-28
申请号：US16151013
申请日：2018-10-03
Applicant: CANON KABUSHIKI KAISHA
Inventor： Naoki Kohara
Abstract: A noise reduction apparatus includes a first delaying/combining unit configured to output first and second pulse light beams, and a second delaying/combining unit configured to branch the first pulse light beam into two pulse light beams to output third and fourth pulse light beams and branch the second pulse light beam into two pulse light beams to output fifth and sixth pulse light beams.
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公开(公告)号：US10281402B2
公开(公告)日：2019-05-07
申请号：US15880531
申请日：2018-01-26
Applicant: Azure Biosystems, Inc.
Inventor： Diping Che , Zhefu Zhang
Abstract: The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest.
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238.发明授权公开(公告)号：US10267681B2
公开(公告)日：2019-04-23
申请号：US15951885
申请日：2018-04-12
Applicant: SHIMADZU CORPORATION
Inventor： Yasuyuki Watanabe
Abstract: A quantum yield calculation method uses a quantum yield calculation program for a spectrophotofluorometer. When a quantum yield is calculated using a spectrophotofluorometer 1, a calibration processing unit executes the processing to calibrate a photon number A2 that is a photon number of the fluorescence in a blank measurement state based on a photon number A1 that is the photon number of an excitation light in the blank measurement state and a photon number B1 that is the photon number of an excitation light in the sample measurement state. A quantum yield calculation processing unit calculates a first quantum yield based on a background photon number A2′ after a calibration in addition to the photon number A1 of the excitation light in the blank measurement state and the photon number B2 of the fluorescence in the sample measurement state.
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公开(公告)号：US10261216B2
公开(公告)日：2019-04-16
申请号：US16163813
申请日：2018-10-18
Applicant: Saudi Arabian Oil Company
Inventor： Sehoon Chang , Wei Wang , Shannon L. Eichmann
Abstract: The present disclosure describes methods and systems for detecting a tracer in a hydrocarbon reservoir. One method includes injecting a tracer at a first location in a reservoir, wherein the tracer mixes with subsurface fluid in the reservoir; collecting fluid samples at a second location in the reservoir; mixing a magnetic surface-enhanced Raman scattering (SERS) particle with the fluid samples; applying a magnetic field to the mixed fluid samples; and analyzing the fluid samples to detect a presence of the tracer in the fluid samples.
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240.发明授权公开(公告)号：US10260948B2
公开(公告)日：2019-04-16
申请号：US14648010
申请日：2013-11-26
Inventor： Josef Hoeffner
Abstract: The invention relates to a device (1) and a method (20) for determining a spectrum (X) of scattered radiation (S). The invention further relates to a method (70) for calculating the spectrum (X) and a method for compressing unstructured data (60) of known distribution. To be able to determine the spectrum (X) as precisely as possible and to derive from this the characteristics of materials that scatter laser pulses (P), the invention proposes that at least one characteristic of the laser pulse (P) is determined and that a spectrum analyzer (5) is used for this. Frequencies (F) of laser pulses (P) and volumes (M) of backscattered radiation (S) are combined into frequency and volume values (F′, M′) to calculate the spectrum (X). The most frequent data values are deleted from the data to compress the data (60).
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