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公开(公告)号：US11955230B2
公开(公告)日：2024-04-09
申请号：US17539440
申请日：2021-12-01
Applicant: Beckman Coulter, Inc.
Inventor： Martha C. Davis
CPC classification number: G16H40/40 , G06F8/65 , G06F16/24578 , G16H10/40 , G16H40/67 , G06F21/6245 , H04L63/029 , H04L63/0428
Abstract: Described herein are database systems including one or more remote analytical instruments operably connected to one or more servers. The instruments can transmit rich data to the servers, and the one or more servers can compile a database of the rich data. One or more processors associated with the servers can be configured to execute a data analytics program on the database to identify a stochastic phenomenon or to process the data and present in real-time at a location of the one or more instruments comparison information about the instruments.
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公开(公告)号：US11954925B2
公开(公告)日：2024-04-09
申请号：US17682809
申请日：2022-02-28
Applicant: Beckman Coulter, Inc.
Inventor： Takayuki Mizutani , Katsuhiro Seo , Shigeru Fujii , Kazuki Umebara
CPC classification number: G06V20/69 , C12M41/46 , G06T7/62 , G06V10/50 , G06V20/50 , G06T2207/10024 , G06T2207/30072
Abstract: Automatic substance preparation and evaluation systems and methods are provided for preparing and evaluating a fluidic substance, such as e.g. a sample with bodily fluid, in a container and/or in a dispense tip. The systems and methods can detect volumes, evaluate integrities, and check particle concentrations in the container and/or the dispense tip.
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公开(公告)号：US20240094187A1
公开(公告)日：2024-03-21
申请号：US18259727
申请日：2021-12-29
Applicant: Beckman Coulter, Inc. , Johns Hopkins University
Inventor： Ishan Barman , Peng Zheng , Taka Mizutani
IPC: G01N33/487 , G01N21/65 , G01N33/543
CPC classification number: G01N33/487 , G01N21/658 , G01N33/543 , B82Y30/00
Abstract: The disclosure relates to a substrate comprising a micro- or nanostructured periodic array comprised of a plurality of anisotropic metallic micro- or nanostructures, wherein each of the plurality of nanostructures induce an average maximum and substantially uniform plasmonic field greater than 108 across the substrate; a plurality of Raman-active linker molecules directly bound to the metallic micro- or nanostructures; and a plurality of capture molecules directly bound to the Raman-active linker molecules. The disclosure also relates to systems, devices, and methods that use the substrates to determine the concentration of various analytes.
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公开(公告)号：US20240085305A1
公开(公告)日：2024-03-14
申请号：US18262359
申请日：2021-12-28
Inventor： Jeff DEGEAL , Robert BURR , John TYKSINSKI , Jingzhe ZHAO , Sheng YU , Xuewen QIAO
IPC: G01N15/14
CPC classification number: G01N15/1427 , G01N15/147 , G01N2015/149 , G01N2015/1493
Abstract: The present application discloses a system and a method for calculating a droplet delay time in a liquid flow of a sorting device, and a sorting device. The system includes: a first laser source configured to emit a first laser beam to a liquid flow of a sorting device, the first laser beam and the liquid flow intersecting at a first laser interrogation point located in a nozzle system of the sorting device; a second laser source configured to emit a second laser beam to the liquid flow, the second laser beam and the liquid flow intersecting at a second laser interrogation point located outside the nozzle system; a first detector and a second detector which are respectively used for detecting emission, in response to the first laser beam and the second laser beam, of a particle in the liquid flow; and a droplet delay time calculation unit configured to calculate, on the basis of the time when the particle in the liquid flow passes through the first laser interrogation point and the time when the particle passes through the second laser interrogation point, a first delay time for the liquid flow flowing from the first laser interrogation point to the second laser interrogation point, and calculate, on the basis of the first delay time, a droplet delay time.
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公开(公告)号：US20240044931A1
公开(公告)日：2024-02-08
申请号：US18231355
申请日：2023-08-08
Applicant: BECKMAN COULTER, INC.
Inventor： Jozef SOFKA
CPC classification number: G01N35/1095 , F04B43/12
Abstract: A biological analyzer system includes a biological analyzer, a fluid routing system, and a first linear peristaltic pump. The biological analyzer is configured to analyze a biological sample. The fluid routing system is configured to direct the biological sample into the biological analyzer. The first linear peristaltic pump is configured to move the biological sample in the fluid routing system. The first linear peristaltic pump includes a first hollow flexible tubing, a first actuation assembly, and a first tubing compression member. The first hollow flexible tubing extends along a first longitudinal axis. The first hollow flexible tubing is in fluid communication with the fluid routing system. The first tubing compression member is configured to move relative to the first hollow flexible tubing along a predetermined path in response to an input from the first actuation assembly to advance fluid within the first hollow flexible tubing along the first longitudinal axis.
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Patent Agency Ranking
公开(公告)号：US20240044929A1
公开(公告)日：2024-02-08
申请号：US18038518
申请日：2021-11-30
Applicant: Beckman Coulter, Inc.
Inventor： Noriyuki Ito , Yuichi Hasegawa
IPC: G01N35/10
CPC classification number: G01N35/10 , G01N2035/00534
Abstract: A chemistry analysis machine and method for using the machine include adding heating functionality to provide faster test specimen heating times or comparable specimen heating times while using containers or cuvettes made of materials such as plastic that have lower thermal conductivity. In one example, a mixing bar is heated prior to contacting the test specimen within the container to provide the additional heating capability to the system. In one example where the mixing bar is heated, a heater is added to the system to heat the rinse water used to rinse the mixing bar after it is washed and prior to its next use in contacting a test specimen.
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公开(公告)号：US20240024867A1
公开(公告)日：2024-01-25
申请号：US18224953
申请日：2023-07-21
Applicant: BECKMAN COULTER, INC.
Inventor： Francisco BOLANOS , Bart WANDERS , Eduardo DELGADO , Sarah GORFINKEL
CPC classification number: B01L3/502715 , G02B21/06 , G02B21/36 , G01N1/31 , G01N1/30 , B01L2300/0654 , B01L2300/0883 , B01L2400/082 , B01L2300/0609 , B01L2200/025
Abstract: A biological imaging analyzer comprises a flowcell configured to flow biological cells therethrough, the flowcell including an imaging region where images of the biological cells are captured. The analyzer also comprises a lighting module configured to generate a light, the lighting module comprising a light guide configured to convey the light to an imaging region of the flowcell. The analyzer further comprises an imaging module configured to capture images of the biological cells at the imaging region of the flowcell. The analyzer also comprises a flowcell holder in operable connection with the flowcell. A method of positioning a flowcell for biological analysis comprises providing the flowcell configured to flow a biological sample for analysis, and operably connecting the flowcell holder with the flowcell.
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公开(公告)号：US11867708B2
公开(公告)日：2024-01-09
申请号：US16534296
申请日：2019-08-07
Applicant: Beckman Coulter, Inc.
Inventor： Madhuri La Barrie , Scott Lendzian , Joanna Selinsky
CPC classification number: G01N35/00623 , G01N35/00693 , G01N35/00732 , G01N33/48 , G01N35/00 , G01N35/00871 , G01N2035/00752
Abstract: Systems and methods for calibrating laboratory instruments. In an example, a laboratory instrument for testing patient specimens includes a testing apparatus configured to receive a cassette that includes a patient specimen or a quality control specimen. In response to determining that a quality control specimen is present, the instrument obtains a first measurement of a parameter. If the first parameter is outside an expected tolerance, the instrument ceases performing tests on all specimens, the instrument re-tests the quality control specimen to obtain a second measurement of the parameter. If the second measurement is within the expected tolerance, instrument resumes processing of the cassette. If the second measurement is outside the expected tolerance, the instrument indicates that recalibration or service is required.
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公开(公告)号：US20230420088A1
公开(公告)日：2023-12-28
申请号：US18367672
申请日：2023-09-13
Applicant: Beckman Coulter, Inc.
Inventor： Carola SCHMIDT
Abstract: A middleware device or software may be placed in communication with one or more testing instruments and a lab information system. As samples are collected from patients and tested with the testing instruments, test results pass through the middleware and are analyzed in context with other data, such as patient history, testing instrument history, and test results from other tests of the sample, in order to determine whether a particular result is acceptable, whether retesting is needed, whether additional sample collection or testing is needed, and whether currently ordered testing is still necessary. When the middleware determines a need for additional testing or retesting it may automatically create orders for such testing in order to reduce delays in manual review of testing results.
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公开(公告)号：US20230417731A1
公开(公告)日：2023-12-28
申请号：US18190438
申请日：2023-03-27
Inventor： Aaron HUDSON , Takayuki MIZUTANI , Subhasish PURKAYASTHA , Thomas ROSCOE
IPC: G01N33/487 , G01N35/00
CPC classification number: G01N33/48792 , G01N35/1095 , G01N35/00871
Abstract: One embodiment of the invention is directed to a sample processing system for analyzing a biological sample from a patient. The sample processing system comprises: a plurality of analyzers comprising at least one mass spectrometer, wherein each analyzer in the plurality of analyzers is configured to acquire at least one measurement value corresponding to at least one characteristic of the biological sample; at least one data storage component which stores (i) a list of parameters for the plurality of analyzers, and (ii) at least two condition sets, which contain data associated with completing one or more test orders. The condition sets contain data which differ by at least one variable; and a control system operatively coupled to the plurality of analyzers, and the at least one data storage component. The control system is configured to (i) determine which condition set of the at least two condition sets to use based on the determined condition set, (ii) determine which analyzer or analyzers of the plurality of analyzers to use to process each test order based on the determined condition set and one or more parameters from the list of parameters, and (iii) cause the determined analyzer or analyzers to acquire one or more measurement values for the biological sample.
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