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公开(公告)号：US20250164379A1
公开(公告)日：2025-05-22
申请号：US18880001
申请日：2024-05-03
Applicant: Beckman Coulter, Inc.
Inventor： Ihor BEREZHNYY
IPC: G01N15/1434 , G01N15/10 , G01N15/149
Abstract: A method of characterizing particles in flow cytometry includes determining a first pulse width value of a particle using a first technique. The method includes determining a second pulse width value of the particle using a second technique. The method further includes comparing the first and second pulse width values, and characterizing the particle as a concatenated particle when a difference between the first and second pulse width values exceeds a threshold.
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公开(公告)号：US12300363B2
公开(公告)日：2025-05-13
申请号：US16758325
申请日：2018-10-23
Applicant: Beckman Coulter, Inc.
Inventor： Wido Menhardt , Christoph Moellers , Santosh Kookal
Abstract: Disclosed herein are methods and systems for automatically generating processing rules to be used for automated decision-making when operating instruments to analyze and process biological samples (e.g., for the presence, absence, or concentration of analytes). For example, some automatically generated processing rules may set forth conditions and criteria in which some test results obtained from the biological samples can be automatically validated and sent out, while other test results are flagged for additional review. The processing rules can be generated based on patterns observed with the actions taken for historical test results associated with similar biological samples.
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公开(公告)号：US20250130141A1
公开(公告)日：2025-04-24
申请号：US19005851
申请日：2024-12-30
Applicant: Beckman Coulter, Inc.
Inventor： Michael Eberhardt , Charles Martinez , Kathleen Payne , Christoph Welte , Bernd Wiedemann
Abstract: One embodiment of the invention is directed to a method comprising receiving instruction data relating to a sample in a sample container. The method includes generating, by at least one processor using a workflow management layer, a process plan for the sample, and providing the process plan to a process control layer. The process plan comprises a plurality of possible routes. The method also comprises selecting, by the at least one processor using the process control layer, an optimized route within the plurality of possible routes in the process plan, and providing the optimized route to a middleware control layer. The at least one processor and middleware control layer are operable to cause a transport system to proceed along the selected route.
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公开(公告)号：US20250093336A1
公开(公告)日：2025-03-20
申请号：US18967195
申请日：2024-12-03
Applicant: Beckman Coulter, Inc.
Inventor： Jun Yang , Jon Tindel
IPC: G01N33/50 , G01N15/10 , G01N15/1404 , G01N15/1433 , G01N15/1434 , G01N33/96 , G06F3/048 , G06F16/50 , G06F18/22 , G06F18/40 , G06T5/77 , G06T7/00 , G06T11/00 , G06V10/44 , G06V10/75 , G06V10/94 , G06V20/69
Abstract: In some embodiments, a process and system are provided for generating a user interface for classification of a sample image of a cell that includes receiving a sample image of a sample particle from a biological sample and selecting reference images that each portray a reference particle of a biological sample. The reference images can be ordered based on similarity and the reference images can be selected based on the order. The first selected reference image can be aligned with the sample image and expanded such that the adjacent edges of the reference image and sample image are the same. The expanded image can be dynamically filled. The sample image and the expanded reference image can be displayed in a user interface.
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公开(公告)号：US20250084396A1
公开(公告)日：2025-03-13
申请号：US18547925
申请日：2022-02-24
Applicant: Beckman Coulter, Inc.
Inventor： Thomas Marshall , Evan Farthing , Jeffrey J. Corpstein , Thomas G. Keen , Abraham Olson , Asmita Patel , Amy Yoder , Sahana Mallya , Joseph Dominic Olechno
IPC: C12N15/10
Abstract: According to various aspects of the instant disclosure, a rapidly-sedimenting magnetic particle can include a core or inner layer. The core or inner layer can include a ferrimagnetic material and have at least one of a maximum field strength ranging from about 20 emu/g to about 250 emu/g, and a remanence ranging from about 0 cmu/g to about 20 emu/g. The rapidly-sedimenting magnetic particle can further include a coating layer overlaying at least a portion of the core or inner layer. The particle can further include an outer coating layer overlaying at least a portion of the core coating.
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Patent Agency Ranking
公开(公告)号：US20250035539A1
公开(公告)日：2025-01-30
申请号：US18919157
申请日：2024-10-17
Applicant: BECKMAN COULTER, INC.
Inventor： Michael KAPINSKY
IPC: G01N21/25 , G01N15/01 , G01N15/10 , G01N15/14 , G01N15/1434
Abstract: Embodiments of the present invention encompass systems and methods for determining detection limits for various antibody-dye conjugates for flow cytometry. Exemplary techniques involve a linear superpositioning approach of spillover-induced enlargements of normally distributed measurement errors.
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公开(公告)号：US12210027B2
公开(公告)日：2025-01-28
申请号：US17671308
申请日：2022-02-14
Applicant: Beckman Coulter, Inc.
Inventor： Andras Guttman , Clarence Lew , Marton Szigeti , Csaba Varadi
Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method using magnetic beads containing negatively charged carboxyl groups extending from the surface of the magnetic beads.
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公开(公告)号：US12196745B2
公开(公告)日：2025-01-14
申请号：US17898910
申请日：2022-08-30
Applicant: Beckman Coulter, Inc.
Inventor： Jun Yang , Jon Tindel
IPC: G01N33/50 , G01N15/10 , G01N15/1404 , G01N15/1433 , G01N15/1434 , G01N33/96 , G06F3/048 , G06F16/50 , G06F18/22 , G06F18/40 , G06T5/77 , G06T7/00 , G06T11/00 , G06V10/44 , G06V10/75 , G06V10/94 , G06V20/69
Abstract: In some embodiments, a process and system are provided for generating a user interface for classification of a sample image of a cell that includes receiving a sample image of a sample particle from a biological sample and selecting reference images that each portray a reference particle of a biological sample. The reference images can be ordered based on similarity and the reference images can be selected based on the order. The first selected reference image can be aligned with the sample image and expanded such that the adjacent edges of the reference image and sample image are the same. The expanded image can be dynamically filled. The sample image and the expanded reference image can be displayed in a user interface.
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公开(公告)号：US20250003524A1
公开(公告)日：2025-01-02
申请号：US18697864
申请日：2022-10-13
Applicant: Beckman Coulter, Inc.
Inventor： Masayuki Osako , Noriyuki Ito
Abstract: Disclosed are systems and methods for detecting a malfunction in an automated analyzer. The systems and methods may include receiving a signal from a sensor (116), such as a Hall effect sensor located proximate a coil (104) of a solenoid valve (100). The signal from the sensor may be correlated to a magnetic flux or change in the magnetic flux generated as a plunger (102) of the solenoid valve is drawn into the coil when the coil is energized. Deviations in the signal from a reference may indicated a malfunction of the solenoid valve. Upon detecting a malfunction, a pre-failure status may be determined.
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10.发明申请公开(公告)号：US20240418737A1
公开(公告)日：2024-12-19
申请号：US18817182
申请日：2024-08-27
Applicant: Beckman Coulter, Inc.
Inventor： Eric VARLET , Roland REICHLE
IPC: G01N35/00
Abstract: A computer-implemented method is provided. The method comprises: accessing, by a first computing device, sample-processing data, wherein the sample-processing data comprise information indicative of a set of procedures to be carried out on a biological sample, wherein each procedure comprises one or more actions; obtaining, by the first computing device, ALS1 state data, wherein the ALS1 state data comprise information indicative of a state of a first automated laboratory system-ALS1; obtaining, by the first computing device, ALS2 operation data, wherein the ALS2 operation data comprise information indicative of an ALS2 set of actions of at least a first procedure, wherein the ALS2 set of actions either has been carried out or is scheduled to be carried out by a second automated laboratory system-ALS2-on the biological sample; generating, by the first computing device, ALS1 processing data by using the sample-processing data, the ALS1 state data and the ALS2 operation data, wherein the ALS1 processing data comprise information indicative of an ALS1 set of actions of at least a second procedure of the sets of procedures; and initiating, by the first computing device, the generation of an ALS1 route plan for the first automated laboratory system, the ALS1 route plan being based on the ALS1 processing data.
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