公开(公告)号：US10591418B2

公开(公告)日：2020-03-17

申请号：US15837597

申请日：2017-12-11

Applicant: The Curators of the University of Missouri ,  Clemson University

Inventor： Yinfa Ma ,  Honglan Shi ,  Qingbo Yang ,  Hai Xiao

IPC: G01N21/77 ,  G01N21/64 ,  G01N31/22 ,  G01N21/76 ,  G01N21/80

Abstract: A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmuting an input light signal and a tip for inserting into a cell or other substance for measuring pH, temperature, and/or antigens. The pH micro-probe and the temperature micro-probe each include a luminescent material positioned on the tip of the micro-probe. The light signal excites the luminescent material so that the luminescent material emits a luminescent light signal. The luminescent light signal has a property value dependent on the pH or temperature being measured and reflects back through the shaft for being measured by a light signal measuring device. The immuno-based micro-probe includes a reflective material that has an effective refractive index dependent on the number of antigen-antibody bonds present on the reflective material.

公开(公告)号：US10465033B2

公开(公告)日：2019-11-05

申请号：US15807712

申请日：2017-11-09

Applicant: Clemson University

Inventor： Marek W. Urban

IPC: C08F293/00 ,  C08F297/02

Abstract: Single-step synthesis processes for production of ultrahigh molecular weight block copolymers are described. The ultrahigh molecular weight copolymers can have a molecular weight of about 106 or greater and can be formed within a few hours in a surfactant-free environment. The formation process is controlled by initiator-starvation conditions in a sequential polymerization of monomers exhibiting different solubility in the solvent.

公开(公告)号：US20190313593A1

公开(公告)日：2019-10-17

申请号：US16266537

申请日：2019-02-04

Applicant: Syngenta Participations AG ,  Clemson University

Inventor： Richard Hassell ,  James Brusca ,  Xingping Zhang ,  Shawna Daley

IPC: A01H5/08 ,  A01N31/02 ,  A01G2/30

Abstract: The invention provides methods of inhibiting the growth of a shoot apical meristem of a cucurbit rootstock plant, comprising contacting a shoot apical meristem of the cucurbit rootstock plant with an effective amount of a composition comprising one or more fatty alcohols, thereby inhibiting the growth of the shoot apical meristem of the cucurbit rootstock plant. The present invention further provides methods for preparing and producing cucurbit rootstock plants for grafting and methods for grafting. Additionally provided are cucurbit rootstock plants and plant parts and grafted cucurbit plants produced by the methods of the invention.

公开(公告)号：US20190290439A1

公开(公告)日：2019-09-26

申请号：US16292386

申请日：2019-03-05

Applicant: CLEMSON UNIVERSITY

Inventor： ALAN M. MARIONNEAUX ,  Jeremy J. Mercuri ,  Joshua D. Walters

IPC: A61F2/30 ,  A61L27/24 ,  A61L27/38

Abstract: Subchondral bone analog materials and osteochondral constructs that incorporate the subchondral bone analogs are described. The subchondral bone analog materials include a biodegradable matrix, calcium phosphate particles (e.g., hydroxy apatite) and bioactive glass particles. The materials can exhibit sufficient mechanical strength and biochemical properties such that the materials can support boney integration and healing. Osteochondral constructs can include a first layer of the subchondral bone analog material, a second layer of a calcified cartilage analog material, and a third layer of a cartilage analog material.

公开(公告)号：US20190177498A1

公开(公告)日：2019-06-13

申请号：US16272308

申请日：2019-02-11

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  CLEMSON UNIVERSITY

Inventor： MICHAEL VAN TOOREN ,  IGOR LUZINOV

IPC: C08J5/12 ,  C08J7/16 ,  B29C71/02 ,  B29C65/48

Abstract: Disclosed are thermoset/thermoplastic composites that include a thermoset component directly or indirectly bonded to a thermoplastic component via a crosslinked binding layer between the two. The crosslinked binding layer is bonded to the thermoplastic component via epoxy linkages and is either directly or indirectly bonded to the thermoset component via epoxy linkages. The composite can be a laminate and can provide a route for addition of a thermoplastic implant to a thermoset structure.

公开(公告)号：US10283759B2

公开(公告)日：2019-05-07

申请号：US15401841

申请日：2017-01-09

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION ,  GEORGIA TECH RESEARCH CORPORATION

Inventor： Gleb Nikolayevich Yushin ,  Igor Luzinov ,  Bogdan Zdyrko ,  Alexandre Magasinski

IPC: H01M4/1395 ,  H01M4/04 ,  H01M4/62 ,  H01M4/38 ,  H01M4/36 ,  H01M4/02

Abstract: A silicon-based anode comprising silicon, a carbon coating that coats the surface of the silicon, a polyvinyl acid that binds to at least a portion of the silicon, and vinylene carbonate that seals the interface between the silicon and the polyvinyl acid. Because of its properties, polyvinyl acid binders offer improved anode stability, tunable properties, and many other attractive attributes for silicon-based anodes, which enable the anode to withstand silicon cycles of expansion and contraction during charging and discharging.

公开(公告)号：US10281405B2

公开(公告)日：2019-05-07

申请号：US15399916

申请日：2017-01-06

Applicant: CLEMSON UNIVERSITY

Inventor： Richard Kenneth Marcus ,  Htoo Wai Paing ,  Xinyan Zhang

IPC: G01N21/67 ,  G01N21/69

Abstract: Described is an elemental analysis system and methods for use thereof that can be utilized in examination of samples in their native state. The systems utilize a liquid sampling—atmospheric pressure glow discharge (LS-APGD) device for ambient desorption sampling and excitation of a solid sample in combination with optical emission detection. This approach can find application across a broad spectrum of analytical challenges including metals, soils, and volume-limited samples.

公开(公告)号：US10280194B2

公开(公告)日：2019-05-07

申请号：US15317208

申请日：2015-06-08

Applicant: Clemson University

Inventor： Modi Wetzler ,  Paris Lamont Hamilton

IPC: C07C229/26 ,  C07K2/00 ,  C07K1/00 ,  C07K1/06 ,  C07C271/22 ,  C07C237/12

Abstract: Novel synthesized amino acids of glutamine and lysine that are directly PEGylated with small, monodisperse PEGs, and a novel process for creating novel amino acid monomers using PEGylation. These amino acids are readily incorporated into peptides for a range of different applications.

公开(公告)号：US10077378B2

公开(公告)日：2018-09-18

申请号：US15037214

申请日：2014-08-06

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： Marek W. Urban ,  Ying Yang

IPC: C09D175/08 ,  C08B11/02 ,  C08B37/00 ,  C08B37/08 ,  C08G18/48 ,  C08G18/64 ,  C09D175/04 ,  C08G18/32 ,  C08G18/40 ,  C08G18/24 ,  C08G18/72 ,  C09D5/00

CPC classification number: C09D175/08 ,  C08B11/02 ,  C08B37/00 ,  C08B37/003 ,  C08B37/0045 ,  C08B37/0075 ,  C08G18/242 ,  C08G18/3215 ,  C08G18/4081 ,  C08G18/4833 ,  C08G18/6484 ,  C08G18/72 ,  C09D5/00 ,  C09D175/04

Abstract: The present invention provides alkyl substituted polysaccharide compositions and methods of repairing substrates involving use of the alkyl substituted polysaccharide compositions.

公开(公告)号：US20180228938A1

公开(公告)日：2018-08-16

申请号：US15758528

申请日：2016-09-08

Applicant: Clemson University

Inventor： Rachel McGuire ,  Ryan Borem ,  Jeremy Mercuri

IPC: A61L27/36 ,  A61L27/52 ,  A61F2/44 ,  A61F2/08

Abstract: Biocompatible biomimetic materials that exhibit desirable mechanical properties while also encouraging cell ingrowth and proliferation are described. The biomaterials include a multi-layer laminate of three or more decellularized aligned collagen tissues. The individual layers are aligned with one another in an angle-ply arrangement, with the collagen of each layer aligned at an angle to the collagen of the adjacent layer. The biomaterials are useful as collagenous graft materials such as a patch for a hernia in an annulus fibrosus or grafting materials for repair of tendons, ligaments, cartilage and other musculoskeletal tissues.