公开(公告)号：US4851426A

公开(公告)日：1989-07-25

申请号：US810393

申请日：1986-02-12

Applicant: David Ladkani ,  Haim Yellin ,  Ben Z. Weiner ,  David Avnir

Inventor： David Ladkani ,  Haim Yellin ,  Ben Z. Weiner ,  David Avnir

IPC: A61K31/22 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61P25/04 ,  A61P29/00 ,  C07C67/00 ,  C07C68/06 ,  C07C69/96 ,  C07C209/74 ,  C07C211/56 ,  C07C229/38 ,  C07C229/58 ,  C07C313/00 ,  C07C317/44 ,  C07D207/32 ,  C07D207/337 ,  C07D209/26 ,  C07D209/28

CPC classification number: C07C68/06 ,  A61K31/22 ,  C07C229/38 ,  C07C229/58 ,  C07C69/96 ,  C07D207/337 ,  C07D209/26 ,  C07D209/28

Abstract: Novel esters of the general formula ##STR1## in which ##STR2## is the acyl residue of a non-steroidal anti-inflammatory compound containing a carboxylic acid function. The novel esters are prepared by reacting an acide R--COOH when R is as above, with 1-haloethyl ethyl carbonate. There are also provided pharmaceutical compositions containing any of the said novel esters.

Abstract translation: 新颖的通式（I）的酯，其中是含有羧酸官能团的非甾族抗炎化合物的酰基残基。 当R如上所述时，通过使酰基R-COOH与1-卤代乙基碳酸乙酯反应来制备新的酯。 还提供含有任何所述新型酯的药物组合物。

公开(公告)号：US09643168B2

公开(公告)日：2017-05-09

申请号：US12783916

申请日：2010-05-20

Applicant: David Avnir ,  Raed Abu-Reziq ,  Rachael Ben Knaz ,  Itzik Yosef ,  Guy Nesher ,  Gad Marom

Inventor： David Avnir ,  Raed Abu-Reziq ,  Rachael Ben Knaz ,  Itzik Yosef ,  Guy Nesher ,  Gad Marom

IPC: C12N11/14 ,  B01J31/00 ,  B01J23/50 ,  B01J31/06 ,  B01J31/22 ,  B01J31/24 ,  C07C5/03

CPC classification number: B01J31/003 ,  B01J23/50 ,  B01J31/06 ,  B01J31/2269 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/2295 ,  B01J31/2404 ,  B01J31/2409 ,  B01J2231/645 ,  B01J2531/0252 ,  B01J2531/0263 ,  B01J2531/0266 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  C07C5/03 ,  C12N11/14 ,  C07C15/073

Abstract: The present invention provides a composite comprising at least one hydrophobic organic compound and a matrix of at least one metal; wherein said at least one hydrophobic compound is entrapped within said matrix, compositions comprising at least one composite and methods of its preparation.

公开(公告)号：US09289402B2

公开(公告)日：2016-03-22

申请号：US13643247

申请日：2011-04-26

Applicant: David Avnir ,  Rachel Ben-Knaz ,  Rami Pedahzur

Inventor： David Avnir ,  Rachel Ben-Knaz ,  Rami Pedahzur

IPC: A61K31/155 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06 ,  A61L2/00 ,  B01J31/12 ,  C02F1/50 ,  C08K9/10

CPC classification number: A61K31/155 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06 ,  A61L2/00 ,  B01J31/12 ,  C02F1/50 ,  C02F1/505 ,  C08K9/10 ,  A61K2300/00

Abstract: The present invention provides composites comprising at least one bioactive agent entrapped within a matrix of at least one metal; wherein said composite controllably releases at least one of said bioactive agent and metal or ion thereof, processes for the preparation of composites of the invention, compositions and products comprising composites of the invention and various uses thereof.

Abstract translation: 本发明提供复合材料，其包含截留在至少一种金属的基体内的至少一种生物活性剂; 其中所述复合物可控地释放所述生物活性剂和金属或其离子中的至少一种，制备本发明复合材料的方法，包含本发明复合材料的组合物和产品及其各种用途。

公开(公告)号：US08449918B2

公开(公告)日：2013-05-28

申请号：US13243189

申请日：2011-09-23

Applicant: Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudi Rottman ,  Orit Gans ,  Alon Seri-Levy

Inventor： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudi Rottman ,  Orit Gans ,  Alon Seri-Levy

IPC: A61K9/14 ,  A61K9/00 ,  A61K31/07 ,  A61K31/19 ,  A61K31/327

CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/37 ,  A61K8/38 ,  A61K8/602 ,  A61K8/671 ,  A61K9/501 ,  A61K9/5031 ,  A61K9/5115 ,  A61K9/5138 ,  A61K2800/412 ,  A61K2800/75 ,  A61Q1/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/945

Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.

Abstract translation: 一种用于局部施用的治疗性，化妆品或药妆组合物，其能够稳定活性成分并递送活性成分，其包含多个具有核 - 壳结构的微胶囊。 微胶囊的直径约为0.1至100微米。 每个微胶囊的核心包含至少一种活性成分，并被包封在微胶囊壳内。 该壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且外壳在局部施用之前保护活性成分，并且被设计成在施用后从微胶囊中释放活性成分。 该组合物可用于包封在其它制剂中不稳定或对皮肤有刺激性的活性成分，例如过氧化苯甲酰。

公开(公告)号：US20100297724A1

公开(公告)日：2010-11-25

申请号：US12783916

申请日：2010-05-20

Applicant: David AVNIR ,  Raed ABU-REZIQ ,  Rachael BEN KNAZ ,  Itzik YOSEF ,  Guy NESHER ,  Gad MAROM

Inventor： David AVNIR ,  Raed ABU-REZIQ ,  Rachael BEN KNAZ ,  Itzik YOSEF ,  Guy NESHER ,  Gad MAROM

IPC: C12N11/14 ,  B01J31/12 ,  B01J37/36

CPC classification number: B01J31/003 ,  B01J23/50 ,  B01J31/06 ,  B01J31/2269 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/2295 ,  B01J31/2404 ,  B01J31/2409 ,  B01J2231/645 ,  B01J2531/0252 ,  B01J2531/0263 ,  B01J2531/0266 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  C07C5/03 ,  C12N11/14 ,  C07C15/073

Abstract: The present invention provides a composite comprising at least one hydrophobic organic compound and a matrix of at least one metal; wherein said at least one hydrophobic compound is entrapped within said matrix, compositions comprising at least one composite and methods of its preparation.

Abstract translation: 本发明提供了包含至少一种疏水性有机化合物和至少一种金属的基质的复合材料; 其中所述至少一种疏水化合物被包埋在所述基质内，包含至少一种复合物的组合物及其制备方法。

公开(公告)号：US20100078328A1

公开(公告)日：2010-04-01

申请号：US12311332

申请日：2007-10-07

Applicant: Daniel Mandler ,  David Avnir ,  Ronen Shacham

Inventor： Daniel Mandler ,  David Avnir ,  Ronen Shacham

IPC: C25D7/00 ,  C25D5/00 ,  C25D11/00 ,  C25D7/04

CPC classification number: C25D9/04 ,  C25D9/06

Abstract: A method for the co-deposition of sol-gel and one or more additives selected from a great variety of agents including monomers, oligomers, polymers, metals and others is provided. The method affords continuous films of high stability and precision. Also provided is a surface coated with a film of sol-gel and at least one additive electrodeposited according to the presently described methods.

Abstract translation: 提供了一种用于共沉积溶胶 - 凝胶和一种或多种添加剂的方法，所述添加剂选自多种试剂，包括单体，低聚物，聚合物，金属等。 该方法提供了高稳定性和精度的连续薄膜。 还提供了涂覆有溶胶 - 凝胶膜和至少一种根据目前描述的方法电沉积的添加剂的表面。

公开(公告)号：US20090061226A1

公开(公告)日：2009-03-05

申请号：US11792496

申请日：2005-12-07

Applicant: Uri Banin ,  David Avnir ,  Taleb Mokari ,  Hanan Sertchook

Inventor： Uri Banin ,  David Avnir ,  Taleb Mokari ,  Hanan Sertchook

IPC: B32B1/00 ,  C08K3/22

CPC classification number: C08K3/22 ,  C08K9/10 ,  Y10T428/2982

Abstract: Novel nanoparticles-entrapping spherical composites, composed of a metal oxide or semi-metal oxide and a hydrophobic polymer, are disclosed. The spherical composites are characterized by well-defined spherical shape, a narrow size distribution and high compatibility with various types of nanoparticles. Further disclosed are processes for preparing the nanoparticles-entrapping spherical composites and uses thereof.

Abstract translation: 公开了由金属氧化物或半金属氧化物和疏水性聚合物组成的新型纳米颗粒捕获球形复合材料。 球形复合材料的特征在于明确的球形形状，窄尺寸分布和与各种类型的纳米颗粒的高相容性。 进一步公开的是制备纳米颗粒截留的球形复合材料的方法及其用途。

公开(公告)号：US06797773B1

公开(公告)日：2004-09-28

申请号：US09646346

申请日：2000-11-15

Applicant: Mario Pagliaro ,  David Avnir ,  Giulio Deganello ,  Jochanan Blum

Inventor： Mario Pagliaro ,  David Avnir ,  Giulio Deganello ,  Jochanan Blum

IPC: C08G6348

CPC classification number: B01J37/036 ,  B01J37/033 ,  C07C51/235 ,  C07H3/02

Abstract: A versatile methodology to obtain efficient catalytic materials suitable for selective, liquid-phase oxidations of alcohols is described. Solid inorganic membranes were prepared by the sol-gel procedure by adding a solution of stable organic nitroxyl radicals at the onset of the polymerization of silicon alkoxide monomers. In this way, micro- and mesoporous materials can be obtained that axe effective and recyclable catalytic mediators for highly selective oxidations of a vast class of primary and secondary alcohols carried out with several primary oxidants. Delicate substrates such as carbohydrates and allylic alcohols can selectively be oxidized with these novel catalytic materials.

Abstract translation: 描述了获得适用于醇的选择性，液相氧化的有效催化材料的通用方法。 在硅烷醇单体聚合开始时，通过溶胶 - 凝胶法制备固体无机膜，通过加入稳定的有机硝酰自由基溶液。 以这种方式，可以获得微孔和介孔材料，该材料可以有效和可回收的催化介质用于高级选择性氧化大量的初级和次级醇，它们与几种主要氧化剂一起进行。 这些新型催化材料可以选择性地氧化诸如碳水化合物和烯丙醇之类的精细底物。

公开(公告)号：US6159453A

公开(公告)日：2000-12-12

申请号：US341647

申请日：1999-07-15

Applicant: David Avnir ,  Levy David Cohen

Inventor： David Avnir ,  Levy David Cohen

IPC: A61K8/04 ,  A61K8/11 ,  A61K8/25 ,  A61K8/37 ,  A61K8/44 ,  A61Q17/04 ,  A61K7/42 ,  A61K7/00 ,  A61K7/44 ,  A61K9/48 ,  A61K9/66

CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/37 ,  A61K8/445 ,  A61Q17/04 ,  A61K2800/412

Abstract: The present invention relates to sunscreen-doped sol-gel materials useful r protecting body tissues, such as skin, nails and hair and other surfaces from sunlight radiation. The sol-gel matrices are transparent to the UV radiation in the range above 250 nm and the doped sunscreen agents are either chemical or physical sunscreens capable of absorbing the UV radiation in the range above 250 nm. Any sunscreen molecule, moiety or particle may be used in the present invention. The sol-gel matrices may be particles in any shape, 0.01-100 microns in diameter, or they may be thin films, thin coatings or in the form of a monolith. The present invention also relates to a method for the preparation of sunscreen-doped sol-gel materials comprising condensation-polymerizing of at least one monomer selected from metal alkoxides, semi metal alkoxides, metal esters, semi metal esters and from monomers of the formula M(R)n(P)m, wherein M is a metallic or semi metallic element, R is a hydrolyzable substituent, n is an integer from 2 to 6, P is a non polymerizable substituent or a sunscreening moiety or derivative and m is an integer from 0 to 6, in the presence of at least one sunscreen ingredient, resulting in the entrapment of the sunscreen ingredients within the formed sol-gel matrix.

Abstract translation: PCT No.PCT / IL98 / 00021 Sec。 371日期：1999年7月15日 102（e）日期1999年7月15日PCT提交1998年1月15日PCT公布。 公开号WO98 / 31333 日期：1998年7月23日本发明涉及用于保护身体组织如皮肤，指甲和头发等阳光辐射的其他表面的防晒剂掺杂溶胶凝胶材料。 溶胶 - 凝胶基质对250nm以上范围内的UV辐射是透明的，并且掺杂的防晒剂是能够吸收在250nm以上范围内的紫外线辐射的化学或物理防晒剂。 任何防晒分子，部分或颗粒可用于本发明。 溶胶 - 凝胶基质可以是直径为0.01-100微米的任何形状的颗粒，或者它们可以是薄膜，薄涂层或整体形式。 本发明还涉及一种制备防晒剂掺杂溶胶凝胶材料的方法，其包括至少一种选自金属醇盐，半金属醇盐，金属酯，半金属酯和式M的单体的单体的缩聚 （R）n（P）m，其中M是金属或半金属元素，R是可水解取代基，n是2-6的整数，P是不可聚合取代基或防晒部分或衍生物，m是 在0至6的整数中，在存在至少一种防晒成分的情况下，导致防晒成分在形成的溶胶 - 凝胶基质内的捕获。