公开(公告)号：US09744528B2

公开(公告)日：2017-08-29

申请号：US14775159

申请日：2014-03-11

Applicant: Rutgers, The State University Of New Jersey

Inventor： Xumu Zhang

IPC: C07C201/12 ,  B01J31/24 ,  C07D307/38 ,  C07F17/02 ,  C07C209/52 ,  C07C213/02 ,  C07B53/00 ,  C07F17/00

CPC classification number: B01J31/2409 ,  B01J31/2414 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0263 ,  B01J2531/16 ,  B01J2531/17 ,  B01J2531/18 ,  B01J2531/26 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/84 ,  B01J2531/842 ,  B01J2540/22 ,  B01J2540/225 ,  B01J2540/66 ,  B01J2540/68 ,  C07B53/00 ,  C07C201/12 ,  C07C209/52 ,  C07C213/02 ,  C07D307/38 ,  C07F17/00 ,  C07F17/02 ,  C07C205/04 ,  C07C205/09 ,  C07C205/32 ,  C07C211/30 ,  C07C211/29 ,  C07C211/27 ,  C07C217/58

Abstract: A ligand having the structure or its enantiomer; (I) wherein: each one of Ra, Rb, Rc and Rd is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH2NH; *CH(CH3)NH(C*,R); and the organocatalyst is an organic molecule catalyst covalently bound to the bridge group. Also, a catalyst having the structure or its enantiomer: (II) wherein: each one of Ra, Rb, Rc and Rd is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH2NH; *CH(CH3)NH(C*,R); and *CH(CH3)NH(C*,S); the organocatalyst is an organic molecule catalyst covalently bound to the bridge group; and M is selected from the group consisting of Rh, Pd, Cu, Ru, Ir, Ag, Au, Zn, Ni, Co, and Fe.

公开(公告)号：US09340519B2

公开(公告)日：2016-05-17

申请号：US14336603

申请日：2014-07-21

Applicant: Johnson Matthey Public Limited Company

Inventor： Jianliang Xiao ,  Jiwu Ruan

IPC: C07D295/14 ,  C07D295/033 ,  B01J31/24 ,  C07C25/22 ,  C07C41/30 ,  C07C45/68 ,  C07C209/10 ,  C07D295/096 ,  C07D295/155 ,  C07F9/50 ,  C07B53/00 ,  C07C253/30

CPC classification number: C07D295/033 ,  B01J31/2404 ,  B01J31/2447 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4283 ,  B01J2531/0263 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  C07B53/00 ,  C07C25/22 ,  C07C41/30 ,  C07C45/68 ,  C07C209/10 ,  C07C253/30 ,  C07C2603/92 ,  C07D295/096 ,  C07D295/155 ,  C07F9/5022 ,  C07C211/48 ,  C07C211/55 ,  C07C43/205 ,  C07C43/2055 ,  C07C43/202

Abstract: A substituted paracyclophane of formula (I) is provided wherein X1 and X2 are linking groups comprising between 2 to 4 carbon atoms, Y1 and Y2 are selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalkyl, aryl or heteroaryl and Z is a substituted or unsubstituted alkyl group, aryl group or heteroaryl group. The substituted paracyclophane provides transition metal catalysts that are useful in C—C and C—N bond formation and asymmetric hydrogenation reactions.

Abstract translation: 提供式（I）的取代的对环芳烷，其中X 1和X 2是包含2至4个碳原子的连接基团，Y 1和Y 2选自氢，卤素，氧，氮，烷基，环烷基，芳基或杂芳基 Z为取代或未取代的烷基，芳基或杂芳基。 取代的对环烷烃提供了可用于C-C和C-N键形成和不对称氢化反应的过渡金属催化剂。

公开(公告)号：US08822680B2

公开(公告)日：2014-09-02

申请号：US12675918

申请日：2008-08-21

Applicant: Jianliang Xiao ,  Jiwu Ruan

Inventor： Jianliang Xiao ,  Jiwu Ruan

IPC: C07D295/14 ,  C07C41/30 ,  C07F9/50 ,  C07C25/22 ,  B01J31/24 ,  C07D295/033 ,  C07C209/10 ,  C07C45/68 ,  C07D295/155 ,  C07D295/096

CPC classification number: C07D295/033 ,  B01J31/2404 ,  B01J31/2447 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4283 ,  B01J2531/0263 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  C07B53/00 ,  C07C25/22 ,  C07C41/30 ,  C07C45/68 ,  C07C209/10 ,  C07C253/30 ,  C07C2603/92 ,  C07D295/096 ,  C07D295/155 ,  C07F9/5022 ,  C07C211/48 ,  C07C211/55 ,  C07C43/205 ,  C07C43/2055 ,  C07C43/202

Abstract: A substituted paracyclophane is described of formula (I) wherein X1 and X2 are linking groups comprising between 2 to 4 carbon atoms, Y1 and Y2 are selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalkyl, aryl or heteroaryl and Z is a substituted or unsubstituted alkyl group, aryl group or heteroaryl group. Preferably X1 and X2 are —(C2H4)— and Z is a substituted aryl group. The substituted paracyclophane provides transition metal catalysts that are useful in C—C and C—N bond formation and asymmetric hydrogenation reactions.

Abstract translation: 描述了式（I）的取代的对环芳烷，其中X 1和X 2是包含2至4个碳原子的连接基团，Y 1和Y 2选自氢，卤素，氧，氮，烷基，环烷基，芳基或杂芳基 Z为取代或未取代的烷基，芳基或杂芳基。 优选X1和X2是 - （C2H4） - ，Z是取代的芳基。 取代的对环烷烃提供了可用于C-C和C-N键形成和不对称氢化反应的过渡金属催化剂。

公开(公告)号：US08754248B2

公开(公告)日：2014-06-17

申请号：US13132723

申请日：2009-12-03

Applicant: Alan Malcolm Dyke ,  Hans Guenter Nedden

Inventor： Alan Malcolm Dyke ,  Hans Guenter Nedden

IPC: C07F15/00 ,  B01J31/18

CPC classification number: C07F15/0046 ,  B01J31/2409 ,  B01J2531/0263 ,  B01J2531/0266 ,  B01J2531/821

Abstract: Ethereal solvents to precipitate [ruthenium (arene) (phosphorus ligand) (halogen)] complexes result in complexes having reduced stability. The stability of [ruthenium (arene) (phosphorus ligand) (halogen)] complexes is improved when the complexes are triturated or precipitated with at least one alkane. The at least one alkane can be pentane isomers, hexane isomers, heptane isomers, octane isomers and combinations thereof.

Abstract translation: [钌（芳烃）（磷配体）（卤素）]）络合物的沉淀溶剂沉淀导致复合物的稳定性降低。 当复合物用至少一种烷烃研磨或沉淀时，[钌（芳烃）（磷配体）（卤素）]）络合物的稳定性得到改善。 至少一种烷烃可以是戊烷异构体，己烷异构体，庚烷异构体，辛烷异构体及其组合。

公开(公告)号：US08318873B2

公开(公告)日：2012-11-27

申请号：US13020334

申请日：2011-02-03

Applicant: Kumudini C. Jayaratne ,  Michael D. Jensen ,  Qing Yang

Inventor： Kumudini C. Jayaratne ,  Michael D. Jensen ,  Qing Yang

IPC: C08F4/52 ,  C08F4/64 ,  C08F4/76

CPC classification number: B01J31/2295 ,  B01J31/143 ,  B01J2531/0263 ,  B01J2531/48 ,  B01J2531/49 ,  C08F4/65912 ,  C08F4/65925 ,  C08F4/65927 ,  C08F10/00 ,  C08F210/16 ,  Y10S526/941 ,  Y10S526/943 ,  C08F4/65904 ,  C08F210/14 ,  C08F2500/05 ,  C08F2500/07 ,  C08F2500/12

Abstract: Catalyst compositions comprising a first metallocene compound, a second metallocene compound, an activator-support, and an organoaluminum compound are provided. An improved method for preparing cyclopentadienyl complexes used to produce polyolefins is also provided.

Abstract translation: 提供了包含第一茂金属化合物，第二茂金属化合物，活化剂 - 载体和有机铝化合物的催化剂组合物。 还提供了用于制备用于制备聚烯烃的环戊二烯基络合物的改进方法。

公开(公告)号：US20090124804A1

公开(公告)日：2009-05-14

申请号：US12290438

申请日：2008-10-30

Applicant: William A. Kinney ,  Christopher A. Teleha ,  Shyamali Ghosh ,  Bruce E. Maryanoff

Inventor： William A. Kinney ,  Christopher A. Teleha ,  Shyamali Ghosh ,  Bruce E. Maryanoff

IPC: C07D401/14 ,  C07D401/02

CPC classification number: C07D401/06 ,  B01J31/2213 ,  B01J31/2409 ,  B01J31/2495 ,  B01J2231/645 ,  B01J2531/0263 ,  B01J2531/0266 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  C07D405/14 ,  C07D471/04

Abstract: The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.

Abstract translation: 本发明涉及对映选择性制备取代的哌啶链烷酸整联蛋白拮抗剂化合物的方法。

公开(公告)号：US07521572B2

公开(公告)日：2009-04-21

申请号：US11705695

申请日：2007-02-12

Applicant: Kumudini C. Jayaratne ,  Michael D. Jensen ,  Qing Yang

Inventor： Kumudini C. Jayaratne ,  Michael D. Jensen ,  Qing Yang

IPC: C07F17/00 ,  C08F4/76 ,  C08F4/64

CPC classification number: B01J31/2295 ,  B01J31/143 ,  B01J2531/0263 ,  B01J2531/48 ,  B01J2531/49 ,  C08F4/65912 ,  C08F4/65925 ,  C08F4/65927 ,  C08F10/00 ,  C08F210/16 ,  Y10S526/941 ,  Y10S526/943 ,  C08F4/65904 ,  C08F210/14 ,  C08F2500/05 ,  C08F2500/07 ,  C08F2500/12

Abstract: Catalyst compositions comprising a first metallocene compound, a second metallocene compound, an activator-support, and an organoaluminum compound are provided. An improved method for preparing cyclopentadienyl complexes used to produce polyolefins is also provided.

Abstract translation: 提供了包含第一茂金属化合物，第二茂金属化合物，活化剂 - 载体和有机铝化合物的催化剂组合物。 还提供了用于制备用于制备聚烯烃的环戊二烯基络合物的改进方法。

公开(公告)号：US20080269528A1

公开(公告)日：2008-10-30

申请号：US11577068

申请日：2005-10-08

Applicant: Christoph Jakel ,  Rocco Paciello

Inventor： Christoph Jakel ,  Rocco Paciello

IPC: C07C29/136 ,  C07C45/27

CPC classification number: B01J31/20 ,  B01J31/1845 ,  B01J31/189 ,  B01J31/2221 ,  B01J31/2409 ,  B01J31/2495 ,  B01J2231/643 ,  B01J2531/0205 ,  B01J2531/0255 ,  B01J2531/0263 ,  B01J2531/0266 ,  B01J2531/0272 ,  B01J2531/822 ,  B01J2531/827 ,  C07B53/00 ,  C07B2200/07 ,  C07C29/172 ,  C07C29/56 ,  C07C45/62 ,  C07C2601/14 ,  C07C49/395 ,  C07C49/21 ,  C07C35/12 ,  C07C35/17

Abstract: The present invention relates to a process for preparing optically active carbonyl compounds by asymmetrically hydrogenating α,β-unsaturated carbonyl compounds in the presence of optically active transition metal catalysts which are soluble in the reaction mixture and have at least one carbon monoxide ligand. The present invention especially relates to a process for preparing optically active aldehydes or ketones, in particular citronellal, by asymmetrically hydrogenating the corresponding optically active α,β-unsaturated aldehydes or ketones.

Abstract translation: 本发明涉及一种通过在光学活性的过渡金属催化剂存在下不溶性氢化α，β-不饱和羰基化合物来制备旋光性羰基化合物的方法，其可溶于反应混合物并具有至少一种一氧化碳配体。 本发明特别涉及通过不对称氢化相应的光学活性α，β-不饱和醛或酮而制备光学活性醛或酮，特别是香茅醛的方法。

公开(公告)号：US20080255355A1

公开(公告)日：2008-10-16

申请号：US11915924

申请日：2006-05-30

Applicant: Manfred T. Reetz ,  Xiaoguang Li

Inventor： Manfred T. Reetz ,  Xiaoguang Li

IPC: C07F15/00 ,  C07F9/6571 ,  C07C37/00

CPC classification number: C07C29/145 ,  B01J31/1865 ,  B01J31/187 ,  B01J31/26 ,  B01J2231/643 ,  B01J2531/0263 ,  B01J2531/0266 ,  B01J2531/821 ,  C07B53/00 ,  C07B2200/07 ,  C07C29/143 ,  C07C67/31 ,  C07C209/52 ,  C07C227/32 ,  C07C2601/08 ,  C07C2601/14 ,  C07F15/0046 ,  C07F15/0053 ,  C07F17/02 ,  C07C69/732 ,  C07C69/675 ,  C07C69/757 ,  C07C211/27 ,  C07C211/45 ,  C07C229/14 ,  C07C33/22 ,  C07C33/46 ,  C07C33/20 ,  C07C31/12 ,  C07C31/1355

Abstract: Chiral ruthenium complexes are disclosed, obtained by reaction of a ruthenium salt with a chiral diphosphonite. Chiral diols with the general structure given in scheme 1 are preferably used as chiral diphosphonites. Said ruthenium complexes can be simply and economically obtained and provide high enantioselectivity on reduction of ketones, β-ketoesters and ketimines.

Abstract translation: 公开了通过钌盐与手性二膦酸盐反应获得的手性钌络合物。 具有方案1中给出的一般结构的手性二醇优选用作手性二膦酸盐。 所述钌络合物可以简单和经济地获得，并且在还原酮，β-酮酯和酮亚胺时提供高对映体选择性。

公开(公告)号：US20080097053A1

公开(公告)日：2008-04-24

申请号：US11660465

申请日：2005-08-16

Applicant: Shahram Mihan ,  Markus Enders ,  Pablo Fernandez

Inventor： Shahram Mihan ,  Markus Enders ,  Pablo Fernandez

IPC: B01J31/12 ,  C07F17/00 ,  C08F4/42

CPC classification number: B01J31/1608 ,  B01J31/181 ,  B01J31/1825 ,  B01J31/2295 ,  B01J31/2419 ,  B01J2231/122 ,  B01J2231/20 ,  B01J2531/023 ,  B01J2531/0233 ,  B01J2531/0263 ,  B01J2531/60 ,  B01J2531/62 ,  C07F17/00 ,  C08F10/00 ,  C08F2420/01 ,  Y10S526/943 ,  C08F4/78 ,  C08F4/69 ,  C08F4/6392

Abstract: Cyclopentadienyl complexes of group 6 having at least one cyclopentadienyl system which is substituted by at least one silyl group which bears at least one halogen substituent and a catalyst system comprising at least one of the cyclopentadienyl complexes, and also a process for preparing them, the use of the catalyst system for the polymerization or copolymerization of olefins and a process for preparing polyolefins by polymerization or copolymerization of olefins in the presence of the catalyst system.

Abstract translation: 具有至少一个被至少一个含有至少一个卤素取代基的甲硅烷基取代的环戊二烯基系统的第6族环戊二烯基络合物和包含至少一种环戊二烯基络合物的催化剂体系，以及制备它们的方法， 用于烯烃聚合或共聚的催化剂体系和通过烯烃在催化剂体系存在下聚合或共聚制备聚烯烃的方法。