公开(公告)号：US20120179010A1

公开(公告)日：2012-07-12

申请号：US13343867

申请日：2012-01-05

Applicant: John D. Maynard ,  Marwood Neal Ediger ,  Robert D. Johnson ,  M. Ries Robinson

Inventor： John D. Maynard ,  Marwood Neal Ediger ,  Robert D. Johnson ,  M. Ries Robinson

IPC: A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/0071 ,  A61B5/1455

Abstract: Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue. An illumination system communicates light at a plurality of broadband ranges to an optical probe, which can comprise a flexible probe. Light homogenizers and mode scramblers can be employed in some embodiments. The optical probe can physically contact the tissue, or can be maintained separate from the tissue. The optical probe receives light from the illumination system and transmits it to tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe can communicate the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties.

Abstract translation: 本发明的实施方案提供了适合于确定体内组织的性质的装置。 照明系统将多个宽带范围的光传送到可以包括柔性探针的光学探针。 在一些实施例中可以采用光匀化器和模式加扰器。 光学探针可以物理接触组织，或者可以与组织保持分离。 光学探针从照明系统接收光并将其传输到组织，并且响应于宽带光或其组合而接收从体内组织发出的响应于通过其荧光发射的宽带光而漫反射的光。 光学探针可以将光传送到产生表示光的光谱特性的信号的光谱仪。 分析系统根据光谱性质确定体内组织的性质。

公开(公告)号：US20120078075A1

公开(公告)日：2012-03-29

申请号：US13311282

申请日：2011-12-05

Applicant: John D. Maynard ,  Edward Hull

Inventor： John D. Maynard ,  Edward Hull

IPC: A61B5/145 ,  A61B6/00

CPC classification number: A61B5/443 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/14546

Abstract: The present invention provides a method of determining disease state in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical in the tissue responsive to the excitation light is detected. The HbA1c or FPG measurement of the individual (or other secondary indication of disease state) can also be determined. A model combining the tissue fluorescence and one or more of the secondary indications can be used to determine the disease state of the individual. In some embodiments, the tissue fluorescence can be used as an initial screen, and the combination with secondary indications only made for those individuals for whom the fluorescence screen indicates an increased likelihood of disease.

Abstract translation: 本发明提供一种确定个体疾病状态的方法。 用激发光照射个体的组织的一部分，然后检测由于激发光对组织中的化学物质的荧光而由组织发出的光。 也可以确定个体的HbA1c或FPG测量（或疾病状态的其他二次指示）。 可以使用组合荧光和一种或多种次要适应症的模型来确定个体的疾病状态。 在一些实施方案中，组织荧光可以用作初始屏幕，并且与次要指示的组合仅针对荧光屏显示增加的疾病可能性的那些个体进行。

公开(公告)号：US08121671B2

公开(公告)日：2012-02-21

申请号：US11417463

申请日：2006-05-03

Applicant: Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

Inventor： Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

IPC: A61B5/00 ,  A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

Abstract translation: 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

公开(公告)号：US07889349B2

公开(公告)日：2011-02-15

申请号：US11560362

申请日：2006-11-16

Applicant: Trent Ridder ,  Ben ver Steeg ,  Michael Haass ,  John D. Maynard ,  Zachary Benz

Inventor： Trent Ridder ,  Ben ver Steeg ,  Michael Haass ,  John D. Maynard ,  Zachary Benz

IPC: G01B9/02 ,  G01J3/45

CPC classification number: G01J3/45

Abstract: The present invention provides improved methods and apparatuses for accurate measurements using interferometers. A functional relationship between the optical path difference and time is determined from a reference signal from an interferometer. The times at which the interferometer had specific optical path differences can be determined from the functional relationship. Those times can then be used to select times at which the spectroscopic signal from the interferometer was produced at the specific optical path differences. The invention can be applied, as examples, to maintain instrument calibration, and to transfer or compare calibrations or measurements across different interferometers.

Abstract translation: 本发明提供了使用干涉仪精确测量的改进的方法和装置。 从干涉仪的参考信号确定光程差和时间之间的功能关系。 干涉仪具有特定光程差的时间可以从功能关系确定。 然后可以使用那些时间选择在特定光程差处产生来自干涉仪的分光信号的时间。 作为示例，本发明可以应用于维持仪器校准，以及传送或比较不同干涉仪之间的校准或测量。

公开(公告)号：US07616123B2

公开(公告)日：2009-11-10

申请号：US11515565

申请日：2006-09-05

Applicant: Trent Ridder ,  Ben ver Steeg ,  James McNally ,  John D. Maynard ,  Russell E. Abbink

Inventor： Trent Ridder ,  Ben ver Steeg ,  James McNally ,  John D. Maynard ,  Russell E. Abbink

IPC: G08B13/14

CPC classification number: G01J3/02 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/117 ,  A61B5/14546 ,  A61B5/7264 ,  G01J3/0218 ,  G01J3/0291 ,  G01N21/274 ,  G01N21/359 ,  G01N21/474 ,  G01N2201/129

Abstract: The present invention relates generally to non-invasive methods and apparatuses for determining analyte properties of a subject and identity characteristics of a subject. Embodiments of the present invention provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely that in systems that include separate analyte and identity determinations. The invention can be used to control and monitor individuals accessing controlled environments.

Abstract translation: 本发明一般涉及用于确定受试者的分析物特性和受试者身份特征的非侵入性方法和装置。 本发明的实施方案提供了来自相同光谱信息的分析物质性质确定和鉴别确认或验证，使得在包括单独的分析物和身份确定的系统中不太可能使用未经授权的使用或误导结果。 本发明可用于控制和监视访问受控环境的个人。

公开(公告)号：US07403804B2

公开(公告)日：2008-07-22

申请号：US10852415

申请日：2004-05-24

Applicant: Trent D. Ridder ,  John D. Maynard ,  Russell E. Abbink ,  Robert D. Johnson ,  Edward L. Hull ,  Andrew D. Meigs ,  Alan Ross ,  Dashiell A. Birnkrant

Inventor： Trent D. Ridder ,  John D. Maynard ,  Russell E. Abbink ,  Robert D. Johnson ,  Edward L. Hull ,  Andrew D. Meigs ,  Alan Ross ,  Dashiell A. Birnkrant

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14546

Abstract: An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination subsystem, a tissue sampling subsystem, a spectrometer subsystem, a data acquisition subsystem, and a processing subsystem. The invention is applicable, as examples, to determining the concentration or change of concentration of alcohol in human tissue.

Abstract translation: 一种用于通过定量红外光谱非侵入式确定人体组织属性的装置和方法。 该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。 子系统包括照明子系统，组织采样子系统，光谱仪子系统，数据采集子系统和处理子系统。 作为实例，本发明可用于确定人体组织中酒精浓度或浓度的变化。

公开(公告)号：US20080117405A1

公开(公告)日：2008-05-22

申请号：US11560362

申请日：2006-11-16

Applicant: Trent Ridder ,  Ben ver Steeg ,  John D. Maynard ,  Michael Haass ,  Zachary Benz

Inventor： Trent Ridder ,  Ben ver Steeg ,  John D. Maynard ,  Michael Haass ,  Zachary Benz

IPC: G01C3/08

CPC classification number: G01J3/45

Abstract: The present invention provides improved methods and apparatuses for accurate measurements using interferometers. A functional relationship between the optical path difference and time is determined from a reference signal from an interferometer. The times at which the interferometer had specific optical path differences can be determined from the functional relationship. Those times can then be used to select times at which the spectroscopic signal from the interferometer was produced at the specific optical path differences. The invention can be applied, as examples, to maintain instrument calibration, and to transfer or compare calibrations or measurements across different interferometers.

Abstract translation: 本发明提供了使用干涉仪精确测量的改进的方法和装置。 从干涉仪的参考信号确定光程差和时间之间的功能关系。 干涉仪具有特定光程差的时间可以从功能关系确定。 然后可以使用那些时间选择在特定光程差处产生来自干涉仪的分光信号的时间。 作为示例，本发明可以应用于维持仪器校准，以及传送或比较不同干涉仪之间的校准或测量。

公开(公告)号：US06944487B2

公开(公告)日：2005-09-13

申请号：US10786662

申请日：2004-02-25

Applicant: John D. Maynard ,  Shonn P. Hendee ,  Mark R. Rohrscheib ,  David Nunez ,  M. Kathleen Alam ,  James E. Franke ,  Gabor J. Kemeny

Inventor： John D. Maynard ,  Shonn P. Hendee ,  Mark R. Rohrscheib ,  David Nunez ,  M. Kathleen Alam ,  James E. Franke ,  Gabor J. Kemeny

IPC: A61B20060101 ,  A61B5/00 ,  G01N21/35

CPC classification number: A61B5/14539 ,  A61B5/14557 ,  G01N21/359

Abstract: Methods and apparatuses of determining the pH of a sample. A method can comprise determining an infrared spectrum of the sample, and determining the hemoglobin concentration of the sample. The hemoglobin concentration and the infrared spectrum can then be used to determine the pH of the sample. In some embodiments, the hemoglobin concentration can be used to select an model relating infrared spectra to pH that is applicable at the determined hemoglobin concentration. In other embodiments, a model relating hemoglobin concentration and infrared spectra to pH can be used. An apparatus according to the present invention can comprise an illumination system, adapted to supply radiation to a sample; a collection system, adapted to collect radiation expressed from the sample responsive to the incident radiation; and an analysis system, adapted to relate information about the incident radiation, the expressed radiation, and the hemoglobin concentration of the sample to pH.

Abstract translation: 测定样品pH值的方法和装置。 方法可以包括确定样品的红外光谱，以及确定样品的血红蛋白浓度。 然后可以使用血红蛋白浓度和红外光谱来确定样品的pH。 在一些实施方案中，可以使用血红蛋白浓度来选择将红外光谱与可确定的血红蛋白浓度适用的pH相关联的模型。 在其他实施方案中，可以使用将血红蛋白浓度和红外光谱与pH相关联的模型。 根据本发明的装置可以包括适于向样品提供辐射的照明系统; 收集系统，适于响应于入射辐射收集从样本表达的辐射; 以及分析系统，其适于将有关入射辐射，表达的辐射和样品的血红蛋白浓度的信息与pH相关联。

公开(公告)号：US06654125B2

公开(公告)日：2003-11-25

申请号：US10116267

申请日：2002-04-04

Applicant: John D. Maynard ,  Trent Ridder

Inventor： John D. Maynard ,  Trent Ridder

IPC: G01B902

CPC classification number: G01J3/453

Abstract: A vertical cavity surface-emitting laser (VCSEL) package utilized as a laser reference for use in interferometry. The primary disadvantage of VCSELs, in terms of interferometry, has been found to be the relatively poor wavenumber stability of the beam. The present invention is a method and apparatus that makes viable a VCSEL package suitable for use as a reference in interferometry. The VCSEL package incorporates current control, temperature control and an algorithm for correcting wavenumber drift. The algorithm is derived from spectroscopic analysis of a reference sample having a known spectrum and comparing the generated spectrum to the known spectrum.

Abstract translation: 垂直腔表面发射激光器（VCSEL）封装，用作激光参考，用于干涉测量。 已经发现VCSEL在干涉测量方面的主要缺点是光束的波数相对较差。 本发明是一种可行的VCSEL封装的方法和装置，适用于干涉测量中的参考。 VCSEL封装包含电流控制，温度控制和用于校正波数漂移的算法。 该算法来源于具有已知光谱的参考样品的光谱分析，并将生成的光谱与已知光谱进行比较。