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    Method of making a tissue shaping device
    23.
    发明授权
    Method of making a tissue shaping device 有权
    制作组织整形装置的方法

    公开(公告)号：US07814635B2

    公开(公告)日：2010-10-19

    申请号：US11383115

    申请日：2006-05-12

    Applicant: Lucas Gordon ,  Mark L. Mathis ,  Nathan Aronson

    Inventor： Lucas Gordon ,  Mark L. Mathis ,  Nathan Aronson

    IPC: B23P11/00 ,  A61F2/24

    CPC classification number: A61F2/2451 ,  Y10T29/49609 ,  Y10T29/49826 ,  Y10T29/49947 ,  Y10T29/49995

    Abstract: A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.

    Abstract translation: 一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。 在一些实施例中，该装置包括第一和第二锚定器以及设置在第一和第二锚固件之间的连接器，其中连接器与第一锚固件的至少一部分成一体。 本发明还是一种制造组织成形装置的方法，包括以下步骤：从坯料上去除材料以形成连接器和一体的锚定部分; 以及将非整体锚定部分附接到所述整体锚定部分。

    Mitral valve device using conditioned shape memory alloy
    24.
    发明授权
    Mitral valve device using conditioned shape memory alloy 有权
    二尖瓣装置采用条状形状记忆合金

    公开(公告)号：US07758639B2

    公开(公告)日：2010-07-20

    申请号：US11655710

    申请日：2007-01-18

    Applicant: Mark L. Mathis

    Inventor： Mark L. Mathis

    IPC: A61F2/24

    CPC classification number: A61F2/2451 ,  A61F2210/0023

    Abstract: A mitral valve annulus reshaping device includes at least a portion that is formed of a biocompatible shape memory alloy SMA having a characteristic temperature, Af, that is preferably below body temperature. The device is constrained in an unstable martensite (UM) state while being introduced through a catheter that passes through the venous system and into the coronary sinus of the heart. The reshaping device is deployed adjacent to the mitral valve annulus of the heart as it is forced from the catheter. When released from the constraint of the catheter, the SMA of the device at least partially converts from the UM state to an austenitic state and attempts to change to a programmed shape that exerts a force on the adjacent tissue and modifies the shape of the annulus. The strain of the SMA can be varied when the device is within the coronary sinus.

    Abstract translation: 二尖瓣环重塑装置至少包括由具有特征温度Af的生物相容性形状记忆合金SMA形成的部分，其优选低于体温。 该装置被限制在不稳定的马氏体（UM）状态，同时通过导管穿过静脉系统并进入心脏的冠状窦。 当从导管被迫时，整形装置邻近心脏的二尖瓣环部署。 当从导管的约束释放时，该装置的SMA至少部分地从UM状态转变为奥氏体状态，并尝试改变为在相邻组织上施加力并且修改环形的形状的编程形状。 当器件在冠状窦内时，SMA的应变可以变化。

    Focused compression mitral valve device and method
    25.
    发明授权
    Focused compression mitral valve device and method 有权
    聚焦压缩二尖瓣装置及方法

    公开(公告)号：US07608102B2

    公开(公告)日：2009-10-27

    申请号：US10813354

    申请日：2004-03-29

    Applicant: John M. Adams ,  David G. Reuter ,  Mark L. Mathis ,  Scott J. Wolf

    Inventor： John M. Adams ,  David G. Reuter ,  Mark L. Mathis ,  Scott J. Wolf

    IPC: A61F2/24

    CPC classification number: A61F2/2451 ,  A61M25/1006

    Abstract: A mitral valve therapy device and method treats dilated cardiomyopathy. The device is configured to be placed in the coronary sinus of a heart adjacent to the mitral valve annulus. The device includes a force distributor that distributes an applied force along a pericardial wall of the coronary sinus, and a force applier that applies the applied force to one or more discrete portions of a wall of the coronary sinus adjacent to the mitral valve annulus to reshape the mitral valve annulus in a localized manner.

    Abstract translation: 二尖瓣治疗装置和方法治疗扩张型心肌病。 该装置被配置成放置在与二尖瓣环相邻的心脏的冠状窦中。 该装置包括力分配器，其沿着冠状窦的心包壁分布施加的力，以及施加力施加器，其将所施加的力施加到邻近二尖瓣环的冠状窦的壁的一个或多个离散部分，以重塑 二尖瓣环以局部方式。

    Devices and Methods for Perfusing an Organ
    26.
    发明申请
    Devices and Methods for Perfusing an Organ 审中-公开
    用于灌注器官的装置和方法

    公开(公告)号：US20090018526A1

    公开(公告)日：2009-01-15

    申请号：US11996416

    申请日：2006-08-25

    Applicant: John Melmouth Power ,  Mark L. Mathis ,  David Martin Kaye ,  Adam Lucas Bilney

    Inventor： John Melmouth Power ,  Mark L. Mathis ,  David Martin Kaye ,  Adam Lucas Bilney

    IPC: A61M25/01 ,  A61F2/84

    CPC classification number: A61M25/01 ,  A61F2/82 ,  A61M25/09 ,  A61M25/10 ,  A61M29/02 ,  A61M2025/09183 ,  A61M2025/1052

    Abstract: The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region.

    Abstract translation: 本发明提供了用于器官和解剖区域灌注中的装置和方法。 在一个方面，本方法提供了一种用于在人或动物对象中支撑血管的经皮递送装置，包括用于在输送流体或从其收集流体的过程中支撑血管的装置。 在另一方面，本发明提供了一种用于将流体递送或收集于人或动物受试者中的器官或解剖区域的方法，所述方法包括支撑与器官或解剖区域相关联的血管的步骤。 所述装置和方法可用于递送，移除或再循环治疗剂至器官或解剖区域。

    System and method to effect the mitral valve annulus of a heart
    27.
    发明授权
    System and method to effect the mitral valve annulus of a heart 有权
    影响心脏二尖瓣环的系统和方法

    公开(公告)号：US06964683B2

    公开(公告)日：2005-11-15

    申请号：US10798728

    申请日：2004-03-10

    Applicant: Leonard Kowalsky ,  Gregory D. Nieminen ,  Ryan H. Braxtan ,  Mark L. Mathis

    Inventor： Leonard Kowalsky ,  Gregory D. Nieminen ,  Ryan H. Braxtan ,  Mark L. Mathis

    IPC: A61F2/24

    CPC classification number: A61F2/2451

    Abstract: An assembly for effecting the condition of a mitral valve annulus includes a mitral valve therapy device, a coupling structure carried by the device, a catheter, a second coupling structure, and a locking member. To implant the device, the device is first releasably locked to a pushing member by the coupling structures and the locking member. When the device is positioned within the coronary sinus adjacent the mitral valve annulus and deployed, the coupling structures may be released from each other by the release of the locking member.

    Abstract translation: 用于实现二尖瓣环的状态的组件包括二尖瓣治疗装置，由装置承载的联接结构，导管，第二联接结构和锁定构件。 为了植入装置，装置首先通过联接结构和锁定构件可释放地锁定到推动构件。 当装置定位在邻近二尖瓣环并展开的冠状窦内时，联接结构可以通过释放锁定构件而相互释放。

    Device, assembly and method for mitral valve repair
    28.
    发明授权
    Device, assembly and method for mitral valve repair 有权
    二尖瓣修复的装置，装配和方法

    公开(公告)号：US06797001B2

    公开(公告)日：2004-09-28

    申请号：US10095507

    申请日：2002-03-11

    Applicant: Mark L. Mathis ,  Gregory D. Nieminen

    Inventor： Mark L. Mathis ,  Gregory D. Nieminen

    IPC: A61F206

    CPC classification number: A61F2/2451 ,  Y10S623/904

    Abstract: A mitral valve therapy device effects the condition of a mitral valve annulus of a heart. The device includes an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent the mitral valve annulus. The elongated member is flexible when placed in the heart in a first orientation to position the device in the coronary sinus adjacent the mitral valve annulus and relatively inflexible when rotated into a second orientation after the device is positioned in the coronary sinus adjacent to the mitral valve annulus to substantially straighten and increase the radius of curvature of the mitral valve annulus.

    Abstract translation: 二尖瓣治疗装置影响心脏二尖瓣环的状况。 该装置包括细长构件，其尺寸设置为放置在邻近二尖瓣环的心脏的冠状窦内。 细长构件在以第一取向放置在心脏中时是柔性的，以将装置定位在邻近二尖瓣环的冠状窦中，并且在将装置定位在与二尖瓣邻近的冠状窦内的第二取向时相对不灵活 环形件以基本上拉直并增加二尖瓣环的曲率半径。

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