公开(公告)号：US08785693B2

公开(公告)日：2014-07-22

申请号：US13415412

申请日：2012-03-08

Applicant: Thomas Schaub ,  Boris Buschhaus ,  Marion Kristina Brinks ,  Mathias Schelwies ,  Rocco Paciello ,  Johann-Peter Melder ,  Martin Merger

Inventor： Thomas Schaub ,  Boris Buschhaus ,  Marion Kristina Brinks ,  Mathias Schelwies ,  Rocco Paciello ,  Johann-Peter Melder ,  Martin Merger

IPC: C07C209/16 ,  C07C209/18 ,  C07D265/30 ,  C07D241/04 ,  C07D295/00 ,  C07D207/18 ,  C07D207/06 ,  C07D295/02 ,  C07D317/00

CPC classification number: C07C209/16 ,  C07C213/02 ,  C07D207/04 ,  C07D207/20 ,  C07D295/023 ,  C07D307/52 ,  C07C211/07 ,  C07C211/09 ,  C07C215/08 ,  C07C217/08

Abstract: Process for the preparation of primary amines which have at least one functional group of the formula (—CH2—NH2) by alcohol amination of starting materials which have at least one functional group of the formula (—CH2—OH), with ammonia, with the elimination of water, where the alcohol amination is carried out under homogeneous catalysis in the presence of at least one complex catalyst which comprises at least one element selected from groups 8 and 9 of the Periodic Table of the Elements, and also at least one phosphorus donor ligand of the general formula (I).

Abstract translation: 具有至少一个式（-CH 2 -NH 2）官能团的伯胺的方法，其通过具有至少一个式（-CH 2 -OH）官能团的起始原料与氨进行醇胺化反应，与 消除水，其中在均相催化下，在至少一种包含至少一种选自元素周期表第8和9族的元素的复合催化剂存在下进行醇胺化，以及至少一种磷 通式（I）的供体配体。

公开(公告)号：US20120232294A1

公开(公告)日：2012-09-13

申请号：US13415409

申请日：2012-03-08

Applicant: Thomas SCHAUB ,  Boris Buschhaus ,  Marion Kristina Brinks ,  Mathias Schelwies ,  Rocco Paciello ,  Johann-Peter Melder ,  Martin Merger

Inventor： Thomas SCHAUB ,  Boris Buschhaus ,  Marion Kristina Brinks ,  Mathias Schelwies ,  Rocco Paciello ,  Johann-Peter Melder ,  Martin Merger

IPC: C07C213/02 ,  C07D307/52

CPC classification number: C07C209/16 ,  C07C213/02 ,  C07D207/02 ,  C07D207/20 ,  C07D295/027 ,  C07D307/52 ,  C07C211/09 ,  C07C215/08 ,  C07C217/08 ,  C07C211/10 ,  C07C211/12

Abstract: Process for preparing alkanolamines which have a primary amino group (—NH2) and a hydroxyl group (—OH) by alcohol amination of diols having two hydroxyl groups (—OH) by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.

Abstract translation: 制备具有伯氨基（-NH 2）和羟基（-OH）的链烷醇胺的方法，其通过用氨除去水而具有两个羟基（-OH）的二醇醇胺化，其中反应进行 在包含至少一种选自元素周期表第8,9和10族的元素的复合催化剂的存在下，以及至少一种供体配体均匀催化。

公开(公告)号：US20120232293A1

公开(公告)日：2012-09-13

申请号：US13415466

申请日：2012-03-08

Applicant: Thomas SCHAUB ,  Boris Buschhaus ,  Marion Kristina Brinks ,  Mathias Schelwies ,  Rocco Paciello ,  Johann-Peter Melder ,  Martin Merger

Inventor： Thomas SCHAUB ,  Boris Buschhaus ,  Marion Kristina Brinks ,  Mathias Schelwies ,  Rocco Paciello ,  Johann-Peter Melder ,  Martin Merger

IPC: C07C213/02 ,  C07C209/16 ,  C07D307/52

CPC classification number: C07C213/02 ,  C07C209/16 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/02 ,  C07D207/20 ,  C07D211/06 ,  C07D223/04 ,  C07D295/027 ,  C07D307/52 ,  C07C217/08 ,  C07C215/08 ,  C07C211/09 ,  C07C211/10 ,  C07C211/18 ,  C07C215/20 ,  C07C211/12

Abstract: Process for preparing primary amines which have at least one functional group of the formula (—CH2—NH2) and at least one further primary amino group by alcohol amination of starting materials having at least one functional group of the formula (—CH2—OH) and at least one further functional group (—X), where (—X) is selected from among hydroxyl groups and primary amino groups, by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.

Abstract translation: 具有至少一个式（-CH 2 -NH 2）官能团和至少一个另外的伯氨基的伯胺的方法，其通过具有至少一个式（-CH 2 -OH）官能团的原料醇醇胺化， 和至少一个另外的官能团（-X），其中（-X）选自羟基和伯氨基，通过氨除去水，其中反应在存在下进行均匀催化 至少一种复合催化剂，其包含至少一种选自元素周期表第8,9和10族的元素，以及至少一种供体配体。

公开(公告)号：US20060149084A1

公开(公告)日：2006-07-06

申请号：US10539960

申请日：2003-12-13

Applicant: Thomas Domschke ,  Martin Merger ,  Petra Deckert ,  Friedrich Sauer

Inventor： Thomas Domschke ,  Martin Merger ,  Petra Deckert ,  Friedrich Sauer

IPC: C07D307/62 ,  C07C51/245

CPC classification number: C07H1/06 ,  C07H7/027

Abstract: The present invention relates to a process for extracting 2-keto-L-gulonic acid (KGA) from a polar, preferably aqueous, solvent, preferably from a solvent which comprises a mixture of ascorbic acid and 2-keto-L-gulonic acid, by means of liquid/liquid extraction using an extractant which comprises a tertiary amine and a polar organic diluent. The process of the invention preferably also comprises steps for back-extraction of the KGA and recycling of the extractant. The present invention likewise relates to a process for preparing ascorbic acid from KGA and isolating the prepared ascorbic acid.

Abstract translation: 本发明涉及一种从极性，优选含水溶剂，优选由包含抗坏血酸和2-酮-L-古洛糖酸的混合物的溶剂中提取2-酮-L-古洛糖酸（KGA）的方法， 通过使用包含叔胺和极性有机稀释剂的萃取剂的液/液萃取。 本发明的方法优选还包括用于反萃取KGA和回收萃取剂的步骤。 本发明同样涉及从KGA制备抗坏血酸并分离制备的抗坏血酸的方法。

公开(公告)号：US20050197504A1

公开(公告)日：2005-09-08

申请号：US10515625

申请日：2003-07-07

Applicant: Gerd Kaibel ,  Martin Merger ,  Thomas Domschke ,  Petra Deckert ,  Friedrich Sauer

Inventor： Gerd Kaibel ,  Martin Merger ,  Thomas Domschke ,  Petra Deckert ,  Friedrich Sauer

IPC: C07D307/62 ,  C07D305/12

CPC classification number: C07D307/62 ,  Y02P20/582

Abstract: The invention relates to a method for the separation of ascorbic acid from a mixture containing ascorbic acid and 2-keto-L-gulonic acid in a polar, preferably aqueous solvent, by means of liquid/liquid extraction using an amide. The method preferably also comprises steps for the back-extraction of the ascorbic acid, recycling of the extraction solvent and/or the back extraction solvent and for isolation of the ascorbic acid from the back extraction solvent. The invention further relates to a method for the production of ascorbic acid from KGA and isolation of the ascorbic acid so produced.

Abstract translation: 本发明涉及通过使用酰胺的液/液萃取从抗坏血酸和2-酮-L-古洛糖酸的混合物中分离抗坏血酸在极性，优选水性溶剂中的方法。 该方法优选还包括用于反萃取抗坏血酸的步骤，提取溶剂和/或反萃取溶剂的再循环以及用于从反萃取溶剂中分离抗坏血酸的步骤。 本发明还涉及从KGA生产抗坏血酸并分离如此生产的抗坏血酸的方法。

公开(公告)号：US06278023B1

公开(公告)日：2001-08-21

申请号：US09622774

申请日：2000-08-23

Applicant: Guido Voit ,  Rolf Fischer ,  Peter Bassler ,  Andreas Ansmann ,  Hermann Luyken ,  Martin Merger ,  Frank Ohlbach ,  Alwin Rehfinger

Inventor： Guido Voit ,  Rolf Fischer ,  Peter Bassler ,  Andreas Ansmann ,  Hermann Luyken ,  Martin Merger ,  Frank Ohlbach ,  Alwin Rehfinger

IPC: C07C20900

CPC classification number: C07C211/12 ,  B01J23/745 ,  C07C209/48

Abstract: A process for preparing aliphatic alpha, omega-diamines by hydrogenation of aliphatic alpha, omega-dinitriles in the presence of a catalyst comprises using a hydrogenation catalyst comprising (a) iron or a compound based on iron or mixtures thereof, (b) from 0.001 to 0.3% by weight based on (a) of a promoter based on 2, 3, 4 or 5 elements selected from the group consisting of aluminum, silicon, zirconium, titanium and vanadium, and also (c) from 0 to 0.3% by weight based on (a) of a compound based on an alkali and/or alkaline earth metal.

Abstract translation: 通过在催化剂存在下通过氢化脂肪族α，ω-二腈制备脂肪族α，ω-二胺的方法包括使用包含（a）铁或基于铁或其混合物的化合物的氢化催化剂，（b）0.001 至（c）基于（a）基于选自铝，硅，锆，钛和钒的2,3,4或5种元素的助催化剂，并且（c）0至0.3％ 基于（a）基于碱金属和/或碱土金属的化合物的重量。

公开(公告)号：US06852669B2

公开(公告)日：2005-02-08

申请号：US09851214

申请日：2001-05-08

Applicant: Guido Voit ,  Rolf Fischer ,  Peter Bassler ,  Andreas Ansmann ,  Hermann Luyken ,  Martin Merger ,  Frank Ohlbach ,  Alwin Rehfinger

Inventor： Guido Voit ,  Rolf Fischer ,  Peter Bassler ,  Andreas Ansmann ,  Hermann Luyken ,  Martin Merger ,  Frank Ohlbach ,  Alwin Rehfinger

IPC: B01J23/889 ,  C07B61/00 ,  C07C209/48 ,  C07C211/12 ,  C07C253/30 ,  C07C255/24 ,  B01J23/74

CPC classification number: C07C253/30 ,  B01J23/8892 ,  C07C209/48 ,  C07C211/12 ,  C07C255/24

Abstract: A material useful as catalyst for the hydrogenation of alpha, omega-dinitriles comprises(a) iron or a compound based on iron or mixtures thereof,(b) from 0.001 to 0.3% by weight based on (a) of a promoter based on 2, 3, 4 or 5 elements selected from the group consisting of aluminum, silicon, zirconium, titanium and vanadium,(c) from 0 to 0.3% by weight based on (a) of a compound based on an alkali and/or alkaline earth metal, and also(d) from 0.001 to 1% by weight based on (a) of manganese.

Abstract translation: 可用作α，ω-二腈的氢化催化剂的材料包括（a）铁或基于铁或其混合物的铁或其混合物，（b）基于（a）基于2的促进剂的0.001至0.3重量％ ，选自铝，硅，锆，钛和钒的3,4或5种元素，（c）基于（a）基于碱和/或碱土金属的化合物，0至0.3重量％ 金属，以及（d）以（a）锰计为0.001〜1重量％。

公开(公告)号：US06469211B2

公开(公告)日：2002-10-22

申请号：US09987243

申请日：2001-11-14

Applicant: Andreas Ansmann ,  Christoph Benisch ,  Frank Funke ,  Frank Ohlbach ,  Martin Merger

Inventor： Andreas Ansmann ,  Christoph Benisch ,  Frank Funke ,  Frank Ohlbach ,  Martin Merger

IPC: C07C20948

CPC classification number: C07C209/48 ,  C07C211/14

Abstract: In a process for the continuous hydrogenation of nitrites to primary amines in the liquid phase over a suspended, activated Raney catalyst based on an alloy of aluminum and at least one transition metal selected from the group consisting of iron, cobalt and nickel, and, if desired, one or more further transition metals selected from the group consisting of titanium, zirconium, chromium and manganese, the hydrogenation is carried out in the absence of ammonia and basic alkali metal compounds or alkaline earth metal compounds.

Abstract translation: 在一种基于铝合金和至少一种选自铁，钴和镍的过渡金属的悬浮活性阮内催化剂上，在液相中将亚硝酸盐连续氢化成伯胺的方法中，如果 所需的一种或多种选自钛，锆，铬和锰的过渡金属，氢化在不存在氨和碱性碱金属化合物或碱土金属化合物的情况下进行。

公开(公告)号：US06362333B1

公开(公告)日：2002-03-26

申请号：US09786940

申请日：2001-03-12

Applicant: Martin Merger ,  Rolf Fischer ,  Andreas Ansmann

Inventor： Martin Merger ,  Rolf Fischer ,  Andreas Ansmann

IPC: C07D20108

CPC classification number: C07D201/02 ,  C07D201/08 ,  C07D295/023

Abstract: A cyclic lactam and a cyclic amine are coproduced by coreacting an aliphatic alpha, omega-diamine and an aliphatic alpha, omega-aminonitrile with water in the gas phase in the presence of a heterogeneous catalyst.

Abstract translation: 通过在非均相催化剂的存在下，在气相中与脂肪族α，ω-二胺和脂族α，ω-氨基腈与水共核反应来共同制备环状内酰胺和环胺。

公开(公告)号：US06255521B1

公开(公告)日：2001-07-03

申请号：US09508965

申请日：2000-03-20

Applicant: Guido Voit ,  Andreas Bohnsack ,  Rolf Fischer ,  Peter Bassler ,  Hermann Luyken ,  Martin Merger ,  Klemens Flick

Inventor： Guido Voit ,  Andreas Bohnsack ,  Rolf Fischer ,  Peter Bassler ,  Hermann Luyken ,  Martin Merger ,  Klemens Flick

IPC: C07C25303

CPC classification number: B01J23/745 ,  C07C253/30 ,  C07C255/24

Abstract: The invention relates to a method for producing aliphatic alpha-omega amino nitriles in the presence of a catalyst composed of (a) iron or an iron based compound or a mixture thereof (b) 0.01 to 5 wt. %, in relation to (a), a promoter based on 2, 3, 4, or 5 elements selected from the group comprising aluminum, silicon, zirconium, titanium, and vanadium, and © to 0.5 wt. % in relation to (a) a compound based on an alkaline metal or alkaline-earth metal. The inventive method is characterized in that the aliphatic alpha-omega dinitrile contains 1.0 ppm or more phosphorus. Catalysts are obtainable through the reductive and optional successive passivation of magnetite, whereby the catalysts have a BET surface of 3 to 10 m2/g, a total pore volume of 0.05 to 0.2 ml/g, an average pore diameter of 0.03 to 0.1 mm and a pore volume portion in the range of 0.01 to 0.1 mm of 50 to 70%.

Abstract translation: 本发明涉及在由（a）铁或铁基化合物或其混合物（b）组成的催化剂存在下，生产脂族α-ω氨基腈的方法（b）0.01至5wt。 ％，关于（a），基于选自铝，硅，锆，钛和钒的2,3,4或5种元素的促进剂，和（C）至0.5重量％ 相对于（a）基于碱金属或碱土金属的化合物的％。 本发明的方法的特征在于脂族α-ω二腈含有1.0ppm或更多的磷。 催化剂可以通过磁铁矿的还原和任选的连续钝化获得，其中催化剂的BET表面积为3至10m 2 / g，总孔体积为0.05至0.2ml / g，平均孔径为0.03至0.1mm， 0.01〜0.1mm的孔体积部分为50〜70％。