公开(公告)号：US07902196B2

公开(公告)日：2011-03-08

申请号：US11908901

申请日：2006-03-17

Applicant: Andrew G. Myers ,  Seth B. Herzon ,  Jeremy Earle Wulff ,  Romain Siegrist ,  Jakub Svenda ,  Matthew Allen Zajac

Inventor： Andrew G. Myers ,  Seth B. Herzon ,  Jeremy Earle Wulff ,  Romain Siegrist ,  Jakub Svenda ,  Matthew Allen Zajac

IPC: A61K31/4355 ,  A61K31/4985 ,  A61K31/424 ,  A61K31/403 ,  A61K31/407 ,  C07D221/18 ,  C07D241/00 ,  C07D498/22 ,  C07D209/58 ,  C07D487/04

CPC classification number: C07D209/88 ,  C07D471/22 ,  C07D491/052 ,  C07D491/22 ,  C07D495/22

Abstract: The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enzyme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.

Abstract translation: 提供了天然产物，维生素A和抗抑郁素B的合成。 显示出avrainvillamide及其3-亚烷基-3H-吲哚-1-氧化物核心的α和bgr-不饱和硝酮官能团共价和可逆地键合到基于杂原子的亲核试剂。 这种能力可以允许这些分子结合活性位点亲核试剂，并且可以为设计有效和选择性酶抑制剂提供依据。 已经报道了丙氨酰维他命和其二聚杀生物素蛋白B都具有抗增殖活性，据报道，抗谷氨酰胺具有抗多药耐药细菌的抗微生物活性。 已经发现Avrainvillamide靶向细胞骨架连接膜蛋白（CLIMP-63），从而防止细胞发生有丝分裂。 本发明提供这些天然产物以及这些天然产物及其功能核心的类似物的合成。 本发明的化合物可用于治疗诸如癌症，自身免疫性疾病和细菌感染等疾病。

公开(公告)号：US07655809B2

公开(公告)日：2010-02-02

申请号：US11130190

申请日：2005-05-17

Applicant: Alexander Graham Fallis ,  Matthew Allen Heuft ,  Christophe Bénard

Inventor： Alexander Graham Fallis ,  Matthew Allen Heuft ,  Christophe Bénard

IPC: C09B3/50 ,  H01L51/10

CPC classification number: H01L51/0055 ,  C07B37/12 ,  Y02E10/549 ,  Y02P70/521

Abstract: The present application discloses methods for the production of organic compounds comprising a linear series of five fused carbon rings. Such compounds are useful in the production of electronic components, devices and materials. For example the methods disclosed permit the production of 2,9- and 2,10-disubstituted pentacene compounds that present particularly advantageous properties for the manufacture of semiconductor materials, and may be used in devices such as for example thin film transistors and solar cells. Also disclosed are compounds that are excellent candidates for use in the manufacture of semiconductor materials, and other components of electronic systems, by virtue of their solubility, crystal packing geometries, and electronic properties.

Abstract translation: 本申请公开了生产包含线性系列的五个稠合碳环的有机化合物的方法。 这些化合物可用于生产电子元件，器件和材料。 例如，所公开的方法允许制备出具有用于制造半导体材料的特别有利性质的2,9-和2,10-二取代并五苯化合物，并可用于例如薄膜晶体管和太阳能电池的器件中。 还公开了通过其溶解度，晶体填充几何形状和电子性质，用于制造半导体材料和电子系统的其它组分的优异候选物。

公开(公告)号：USD595788S1

公开(公告)日：2009-07-07

申请号：US29294365

申请日：2008-01-07

Applicant: Steve Jaqua ,  Matthew Allen Perry ,  Beth Balogh

Designer： Steve Jaqua ,  Matthew Allen Perry ,  Beth Balogh

公开(公告)号：US20090142736A1

公开(公告)日：2009-06-04

申请号：US12274943

申请日：2008-11-20

Applicant: Eren Tolga Rosenfeld ,  Ekpedeme Mfon Bassey ,  Beth Elyse Zadik ,  Martha Torrey O'Connor ,  Alexander Han Leung Poon ,  Eric Jeffrey Lannert ,  Tracey Andrea Solomon ,  Jonathan Christian Conant ,  Alexander Zorba ,  Carl Michael Puccio ,  Timothy John Gobran ,  James Andrew Gilchrist ,  Mark Stewart Nichols ,  Brandon Denning Fleisher ,  Craig William Friedman ,  Adebisi Detoro Lipede ,  Matthew Allen Bailey

Inventor： Eren Tolga Rosenfeld ,  Ekpedeme Mfon Bassey ,  Beth Elyse Zadik ,  Martha Torrey O'Connor ,  Alexander Han Leung Poon ,  Eric Jeffrey Lannert ,  Tracey Andrea Solomon ,  Jonathan Christian Conant ,  Alexander Zorba ,  Carl Michael Puccio ,  Timothy John Gobran ,  James Andrew Gilchrist ,  Mark Stewart Nichols ,  Brandon Denning Fleisher ,  Craig William Friedman ,  Adebisi Detoro Lipede ,  Matthew Allen Bailey

IPC: G09B19/00 ,  G06N5/02 ,  G09B7/00 ,  G06F17/00

CPC classification number: G09B7/04 ,  Y10S706/927

Abstract: A system is disclosed that provides a goal based learning system utilizing a rule based expert training system to provide a cognitive educational experience. The system provides the user with a simulated environment that presents a business opportunity to understand and solve optimally. Mistakes are noted and remedial educational material presented dynamically to build the necessary skills that a user requires for success in the business endeavor. The system utilizes an artificial intelligence engine driving individualized and dynamic feedback with synchronized video and graphics used to simulate real-world environment and interactions. A robust business model provides support for realistic activities and allows a user to experience real world consequences for their actions and decisions and entails realtime decision-making and synthesis of the educational material. The system is architectured around a table of components to manage and control the system.

Abstract translation: 公开了一种系统，其提供基于目标的学习系统，其利用基于规则的专家训练系统来提供认知教育经验。 该系统为用户提供了一个模拟环境，为您提供了理解和最佳解决方案的商机。 注意到错误，并动态呈现补救性教材，以建立用户在业务活动中获得成功所需的必要技能。 该系统利用人造智能引擎，驱动具有同步视频和图形的个性化和动态反馈，用于模拟现实环境和交互。 强大的商业模式提供对现实活动的支持，并允许用户体验现实世界对他们的行为和决策的后果，并需要实时决策和综合教材。 系统围绕组件表构建，以管理和控制系统。

公开(公告)号：US20090087012A1

公开(公告)日：2009-04-02

申请号：US11863952

申请日：2007-09-28

Applicant: Matthew Allen Merzbacher ,  Todd Gable

Inventor： Matthew Allen Merzbacher ,  Todd Gable

IPC: G06K9/00 ,  G08B23/00

CPC classification number: G06T7/0004 ,  G06T2207/10081 ,  G06T2207/30112

Abstract: Systems and methods for classifying targets within a container are provided. In one aspect, a method for resolving an alarm raised by an imaging system is provided, the imaging system alarm triggered by an alarm target including a plurality of objects. The method includes receiving a plurality of images from the imaging system, calculating at least one feature value for each object of the plurality of objects, determining whether each object is part of the alarm target, and rendering a decision on the alarm target.

Abstract translation: 提供了用于对容器内的目标进行分类的系统和方法。 一方面，提供了一种用于解决由成像系统引起的警报的方法，所述成像系统警报由包括多个对象的警报目标触发。 所述方法包括从所述成像系统接收多个图像，为所述多个对象中的每个对象计算至少一个特征值，确定每个对象是否是所述报警目标的一部分，并且对所述报警目标进行判定。

公开(公告)号：US20090006214A1

公开(公告)日：2009-01-01

申请号：US12209126

申请日：2008-09-11

Applicant: David Ross Lerman ,  Troy William Young ,  Matthew Allen Sanchez ,  Nicholas Sanchez

Inventor： David Ross Lerman ,  Troy William Young ,  Matthew Allen Sanchez ,  Nicholas Sanchez

IPC: G06Q30/00

CPC classification number: G06Q30/00 ,  G06Q30/0277

Abstract: Systems and methods for dynamically sizing, structuring and operating advertisements that include a variety of content, including interaction prompts and other elements, which enable an engagement-based revenue generation model. According to one embodiment, a computer implemented method comprises storing advertising content, serving an XML file from an advertising server to an advertisement manager in order to control a player on a user computer, dynamically generating the advertisement through the player based on directions from the advertisement manager and the stored content, and tracking and reporting a user's engagement with the advertisement in order to determine compensation for the publisher.

Abstract translation: 用于动态调整，构建和操作广告的系统和方法，包括各种内容，包括交互提示和其他元素，从而实现基于参与的收入生成模型。 根据一个实施例，一种计算机实现的方法包括：存储广告内容，从广告服务器向广告管理器提供XML文件，以便控制用户计算机上的玩家，基于来自广告的指示通过播放器动态生成广告 经理和存储的内容，并跟踪和报告用户与广告的互动，以确定对发布者的赔偿。

公开(公告)号：US07417331B2

公开(公告)日：2008-08-26

申请号：US11429712

申请日：2006-05-08

Applicant: Roger A. de la Torre ,  Matthew P. LaConte ,  Matthew Allen Adam

Inventor： Roger A. de la Torre ,  Matthew P. LaConte ,  Matthew Allen Adam

IPC: F02B63/04 ,  F03G7/08 ,  H02K7/18 ,  F01C13/00 ,  F01D15/10 ,  F02C6/00

CPC classification number: H02K7/075 ,  H02K7/1876

Abstract: An engine drive electric generator apparatus converts the reciprocating movements of a pushrod of an internal combustion engine to electricity. Each generator apparatus has an electric coil surrounding a combustion engine pushrod, and a magnet on the pushrod that reciprocates with the pushrod through the coil. The relative reciprocating movement between the magnet and coil generates an electric current in the coil that is communicated with a battery of the vehicle to charge the battery.

Abstract translation: 发动机驱动发电机装置将内燃机的推杆的往复运动转换为电。 每个发电机装置具有围绕内燃发动机推杆的电线圈，以及推杆上的磁铁，其中推杆通过线圈往复运动。 磁体和线圈之间的相对往复运动产生线圈中的电流，该电流与车辆的电池连通以对电池充电。

公开(公告)号：US20080162238A1

公开(公告)日：2008-07-03

申请号：US11647120

申请日：2006-12-28

Applicant: Rajesh Venkat subbu ,  Kete Chalermkraivuth ,  Jose R. Celaya ,  James G. Russo ,  John Andrew Ellis ,  Hoai-Hai Doan ,  Melissa Ialeggio ,  Matthew Allen

Inventor： Rajesh Venkat subbu ,  Kete Chalermkraivuth ,  Jose R. Celaya ,  James G. Russo ,  John Andrew Ellis ,  Hoai-Hai Doan ,  Melissa Ialeggio ,  Matthew Allen

IPC: G06F9/46

CPC classification number: G06Q10/00 ,  G06Q10/063 ,  G06Q10/06315 ,  G06Q10/0637 ,  G06Q20/10 ,  G06Q30/0278 ,  G06Q30/0641 ,  G06Q40/00 ,  G06Q40/04 ,  G06Q40/06 ,  G06Q40/10 ,  G06Q50/16

Abstract: A visual interactive multi-criteria decision-making method and computer-based apparatus for portfolio management. The method/apparatus supports partitioning of a portfolio of physical or other assets into two mutually exclusive categories, such as assets recommended for sale and assets recommended for retention. The method/apparatus utilizes one or more coupled 2-D projections of the portfolio in criteria space. The user interacts with the projections to express and record preferences.

Abstract translation: 视觉交互式多标准决策方法和基于计算机的投资组合管理设备。 方法/设备支持将物理或其他资产组合划分为两个相互排斥的类别，例如推荐出售的资产和建议保留的资产。 该方法/装置在标准空间中利用组合的一个或多个耦合的2-D投影。 用户与投影进行交互以表达和记录偏好。

公开(公告)号：US20080097725A1

公开(公告)日：2008-04-24

申请号：US11552009

申请日：2006-10-23

Applicant: Chad Eric Knodle ,  Matthew Allen Nelson ,  Stephen Robert Schmid ,  Marc Steven Tompkins

Inventor： Chad Eric Knodle ,  Matthew Allen Nelson ,  Stephen Robert Schmid ,  Marc Steven Tompkins

IPC: G06F19/00 ,  G06F17/40

CPC classification number: G05B23/0221

Abstract: Disclosed is a monitoring system implementing a network. The system includes at least one source of dynamic data, the at least one source configured to be in signal communication with a machine, a monitoring module configured for communication with the at least one source, configured for receiving the dynamic data, and configured for converting the dynamic data to output data for transmittal over the network, a controller configured for communication with the monitoring module and the network, and configured for receiving the output data, a computing resource configured for communication with the network, and configured for receiving the output data, and a rule implementer in the monitoring module, the rule implementer configured to implement at least one system rule.

Abstract translation: 披露了实现网络的监控系统。 所述系统包括至少一个动态数据源，所述至少一个源被配置为与机器进行信号通信;被配置为与所述至少一个源进行通信的监视模块，被配置为用于接收所述动态数据，并且被配置为用于转换 所述动态数据输出用于通过所述网络发送的数据;控制器，被配置为与所述监控模块和所述网络通信，并且被配置为用于接收所述输出数据;计算资源，被配置为与所述网络进行通信，并且被配置为用于接收所述输出数据 以及监视模块中的规则实现者，所述规则实现器被配置为实现至少一个系统规则。

公开(公告)号：US20080063602A1

公开(公告)日：2008-03-13

申请号：US11743740

申请日：2007-05-03

Applicant: Laura Kiessling ,  Ronald Raines ,  Matthew Allen

Inventor： Laura Kiessling ,  Ronald Raines ,  Matthew Allen

IPC: A61K49/06 ,  A61B5/055 ,  C08G73/00

CPC classification number: A61K49/128

Abstract: Polymeric chelating agents and metal chelates, particularly those of lanthanide metals and more specifically those of Gd(III), useful as contrast agents in magnetic resonance imaging (MRI) for therapeutic and diagnostic applications as well as clinical and biomedical research applications. The polymeric chelates are generated using ring-opening metathesis polymerization (ROMP). Polymers can have multiple sites for functionalization allowing for the synthesis of multimodal and targeted contrast agents. Hydroxypyridonate (HOPO)-based chelating moieties are integrated into a ROMP-derived polymer. More specifically, the HOPO-based chelating moiety is integrated into a benzonorbornadiene unit that constitutes the backbone of the polymer. The ROMP-derived polymer chelators can comprise multiple metal ions, particularly Gd(III) ions, in polymers of varying lengths to provide a series of agents with controlled relaxivites. Polymer chelates include those that are water-soluble.

Abstract translation: 聚合螯合剂和金属螯合物，特别是镧系元素金属螯合剂，更具体地，可用作Gd（III）的螯合剂，用作治疗和诊断应用以及临床和生物医学研究应用的磁共振成像（MRI）中的造影剂。 使用开环易位聚合（ROMP）产生聚合物螯合物。 聚合物可以具有多个用于官能化的位点，允许合成多峰和靶向造影剂。 将羟基吡啶酮（HOPO）基螯合部分整合到ROMP衍生的聚合物中。 更具体地，基于HOPO的螯合部分整合成构成聚合物主链的苯并降二烯单元。 ROMP衍生的聚合物螯合剂可以在不同长度的聚合物中包含多种金属离子，特别是Gd（III）离子，以提供具有受控弛豫物质的一系列试剂。 聚合物螯合物包括那些水溶性螯合物。