公开(公告)号：US20150254849A1

公开(公告)日：2015-09-10

申请号：US14404162

申请日：2013-05-28

Applicant: Optos PLC

Inventor： David Clifton

IPC: G06T7/00 ,  A61B3/12 ,  G06K9/46 ,  G06T3/00 ,  G06K9/00

CPC classification number: G06T7/0014 ,  A61B3/1225 ,  G06K9/0061 ,  G06K9/4628 ,  G06K2009/00932 ,  G06T3/0068 ,  G06T3/0093 ,  G06T7/0016 ,  G06T7/42 ,  G06T2207/10004 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/20016 ,  G06T2207/20032 ,  G06T2207/20036 ,  G06T2207/20064 ,  G06T2207/30041 ,  G06T2207/30201

Abstract: A laser scanning ophthalmoscope obtains images of a retina. An image is processed by (i) mapping an image along a one dimensional slice; (ii) computing a wavelet scalogram of the slice; (iii) mapping ridge features from the wavelet scalogram; repeating steps (i), (ii) and (iii) for one or more mapped image slices. The mapped ridge features from the slices are superimposed. Textural information is derived from the superimposed mapped ridge features. The analysis can be tuned to detect various textural features, for example to detect image artefacts, or for retinal pathology classification.

Abstract translation: 激光扫描检眼镜获得视网膜的图像。 通过（i）沿着一维切片映射图像来处理图像; （ii）计算切片的小波缩放图; （iii）从小波图示中绘制脊特征; 对于一个或多个映射的图像切片重复步骤（i），（ii）和（iii）。 来自切片的映射脊特征被叠加。 纹理信息是从叠加的映射脊特征导出的。 可以调整分析以检测各种纹理特征，例如检测图像伪影或视网膜病理学分类。

公开(公告)号：US20140327877A1

公开(公告)日：2014-11-06

申请号：US14267642

申请日：2014-05-01

Applicant: Optos PLC

Inventor： Jano Van Hemert ,  Michael Verhoek

IPC: A61B3/14

CPC classification number: A61B3/0025 ,  A61B3/1005 ,  A61B3/1025 ,  A61B3/12 ,  A61B3/14 ,  G06T7/0012 ,  G06T7/64 ,  G06T2207/30041

Abstract: A method of determining a geometrical measurement of a retina of an eye, comprising obtaining a two dimensional representation of at least a portion of the retina of the eye (34), deriving a geometrical remapping which converts the two dimensional representation of the retinal portion to a three dimensional representation of the retinal portion (36), using one or more coordinates of the two dimensional representation of the retinal portion to define the geometrical measurement to be taken of the retina on the two dimensional representation (38), using the geometrical remapping to convert the or each coordinate of the two dimensional representation of the retinal portion to an equivalent coordinate of the three dimensional representation of the retinal portion (40), and using the or each equivalent coordinate of the three dimensional representation of the retinal portion to determine the geometrical measurement of the retina of the eye (42).

Abstract translation: 一种确定眼睛视网膜的几何测量的方法，包括获得眼睛（34）的视网膜的至少一部分的二维表示，导出几何重新映射，其将视网膜部分的二维表示转换为 使用视网膜部分的二维表示的一个或多个坐标来定义视网膜部分（36）的三维表示，以使用几何重新映射来限定在二维表示（38）上对视网膜进行的几何测量 将视网膜部分的二维表示的或每个坐标转换为视网膜部分（40）的三维表示的等效坐标，并且使用视网膜部分的三维表示的或每个等效坐标来确定 眼睛视网膜的几何测量（42）。

公开(公告)号：US12274499B2

公开(公告)日：2025-04-15

申请号：US17205501

申请日：2021-03-18

Applicant: OPTOS PLC

Inventor： Praveen Ashok ,  Alan Anderson

IPC: A61B3/10 ,  A61B3/12 ,  A61B3/14

Abstract: A multimode optical coherence tomography (OCT) imaging system comprises a light source arranged to emit coherent light in a path to scan a sample. An optical parameter unit is arranged in the path and is operable in at least one selected mode from among a plurality of available operating modes, including at least a first mode, a second mode and a third mode. A detector is arranged to detect reflected light, the reflected light being light reflected in the path as a result of the coherence light scanning the sample. A controller is arranged to control at least one of the light source or the optical parameter unit. The first, second and third modes include a retina mode, anterior segment mode, and biometry mode, respectively. Also provided are a method for operating a multimode OCT imaging system, and a computer-readable storage medium storing a program for performing the method.

公开(公告)号：US20250082199A1

公开(公告)日：2025-03-13

申请号：US18884958

申请日：2024-09-13

Applicant: Optos plc

Inventor： Miguel Preciado ,  Paul McCool ,  Margaret Normand ,  Ewan Rycroft ,  Alan Anderson

IPC: A61B3/12 ,  A61B3/00 ,  A61B3/10

Abstract: A Fourier-domain OCT apparatus for acquiring optoretinography data, comprising: an optical system which applies an optical stimulus to a retina of an eye; an OCT imaging system which acquires OCT data from the retina; and a controller which: controls the OCT imaging system to acquire OCT data of a plurality of portions of the retina such that, for each portion, at least some of the OCT data from the portion is acquired after a respective optical stimulus has been applied to the portion; generates, based on the OCT data, respective ORG data for each portion which indicates the response of the portion to the optical stimulus; and stores respective ORG data generated for each portion in association with a respective position in a visual field of the eye that is optically conjugate with a position of the portion on the retina.

公开(公告)号：US20240415385A1

公开(公告)日：2024-12-19

申请号：US18743202

申请日：2024-06-14

Applicant: Optos plc

Inventor： David Clifton

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/14 ,  G06T7/00

Abstract: Aspects of the present invention relate to a method of suppressing a banding artefact in an ophthalmic image of a patient's eye. The method comprises: partitioning the ophthalmic image into a plurality of segments that partially overlap each other, applying an image correction algorithm, which computes a discrete cosine transform of each segment of the plurality of segments to suppress the banding artefact in the plurality of segments removing at least part of the one or more overlapping regions from each segment to remove an artefact introduced by the image correction algorithm to generate a respective corrected segment; and combining the corrected segments to generate a corrected ophthalmic image that comprises less of the banding artefact than the ophthalmic image.

公开(公告)号：US12137976B2

公开(公告)日：2024-11-12

申请号：US17200800

申请日：2021-03-13

Applicant: OPTOS PLC

Inventor： Praveen Ashok ,  David Evans

IPC: A61B3/10 ,  A61B3/00 ,  G01B9/02091

Abstract: An ophthalmic optical coherence tomography instrument, method, and computer-readable medium. The instrument includes a scanner defining an apparent point source for scanning sample light across a subject position and an objective having a posterior imaging configuration to project the apparent point source onto a pivot point between the objective and the subject position. The objective is settable between the posterior imaging configuration for scanning the sample light across a retina of an eye at the subject position and an anterior imaging configuration for scanning the sample light across a pivot plane. An axial region from which an interferogram is detectable extends across the pivot plane while the objective is in the anterior imaging configuration. A pupil alignment method uses the anterior imaging modality to obtain a structure position of a structure of an eye's anterior segment and then an offset between the structure position and a reference position.

公开(公告)号：US12059210B2

公开(公告)日：2024-08-13

申请号：US17035152

申请日：2020-09-28

Applicant: NIKON CORPORATION ,  OPTOS PLC

Inventor： Gonzalo Muyo ,  Alistair Gorman ,  David M. Williamson ,  Makoto Fujimoto ,  Yasufumi Nishi ,  Azuna Nonaka ,  Katsuya Watanabe ,  Miwako Yoshida ,  Kyoya Tokunaga ,  Masahiro Mizuta

IPC: A61B3/14 ,  A61B3/00

CPC classification number: A61B3/14 ,  A61B3/0008 ,  A61B3/0041

Abstract: The ophthalmic optical system is configured to apply an angular scanning light ray to an eye. M=|ωout/ωin| is defined, where ωin represents an angle between an incident light ray to the ophthalmic optical system and an optical axis of the ophthalmic optical system, and ωout represents an angle between an exiting light ray exiting from the ophthalmic optical system toward the eye and the optical axis. The ophthalmic optical system satisfies a conditional expression Mpar

公开(公告)号：US12048481B2

公开(公告)日：2024-07-30

申请号：US17207077

申请日：2021-03-19

Applicant: OPTOS PLC

Inventor： Praveen Cheriyan Ashok ,  Michael Verhoek ,  Sriram Vikraman Sithalakshmi Amma

IPC: A61B3/00 ,  A61B3/10 ,  G16H30/40

CPC classification number: A61B3/0025 ,  A61B3/1005 ,  A61B3/102 ,  G16H30/40

Abstract: A technique for generating a mapping relating values of a scan parameter of an ocular imaging apparatus that are indicative of scan locations in an eye at which the apparatus acquires digital images of imaged regions of the eye, to respective values of a conversion factor for calculating a distance between designated ocular features in the imaged regions, by: simulating light ray propagation to relate each value of the scan parameter in a sequence of scan parameter values to a corresponding location in a model eye; calculating, for each scan parameter value, a distance between the corresponding location in the model eye and a location in the model eye corresponding to an adjacent value in the sequence; and using the calculated distances to generate a respective value of the conversion factor for each scan parameter value.

公开(公告)号：US20240188822A1

公开(公告)日：2024-06-13

申请号：US18527639

申请日：2023-12-04

Applicant: Optos plc

Inventor： Brian Laffoley ,  Alan Williams

IPC: A61B3/14 ,  A61B3/00

CPC classification number: A61B3/14 ,  A61B3/0033

Abstract: There is provided a control system for controlling two or more illuminates of a multi-modality ophthalmic imaging system that are arranged to generate light for imaging an eye, the control system comprising: a processor which selects, from the illuminates and based on a selected imaging modality of the ophthalmic imaging system, one or more illuminates that are to be used to image the eye, and to generate an input signal identifying the selected one or more illuminates. The control system further comprises a logic block, which receives the input signal and comprises logic that determines a respective operating power for each illuminate of the selected one or more illuminates, based on the received input signal. The logic block also generates a respective control signal for each illuminate of the selected one or more illuminates, each control signal indicating the respective operating power determined for the respective illuminate.

公开(公告)号：US20230186683A1

公开(公告)日：2023-06-15

申请号：US17924993

申请日：2020-05-14

Applicant: OPTOS PLC

Inventor： Peter Robert Wakeford ,  Enrico Pellegrini

IPC: G06V40/18 ,  G06V10/764

CPC classification number: G06V40/197 ,  G06V10/764 ,  G06V2201/07

Abstract: An apparatus for generating an alert indicating an unreliability in a location of a landmark feature in a retinal image predicted by a machine learning algorithm, comprising: a receiver module which receives the predicted location; a probability indication determining module which uses the predicted location and a mixture model, which comprises a probability distribution of a landmark feature location and is based on determined locations of the landmark feature in retinal images having a plurality of retinal image classes, to determine, for each class, a respective probability indication indicating a probability that the retinal image belongs to the class; an outlier detector module which uses the probability indications to determine whether the retinal image is an outlier belonging to none of the classes; and an alert generator module which generates, when the retinal image belongs to none of the classes, an alert indicating unreliability of the predicted location.