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公开(公告)号：US09988371B2
公开(公告)日：2018-06-05
申请号：US15315490
申请日：2015-06-03
Applicant: The Arizona Board of Regents, on Behalf of the University of Arizona , Universita' Federico II
Inventor： Hong-yu Li , Brendan Frett , Massimo Santoro , Francesca Carlomagno
IPC: C07D413/12 , C07D413/14 , A61K31/422 , A61K45/06 , A61K31/4439 , A61K31/5377 , A61K31/506 , C12N9/12
CPC classification number: C07D413/14 , A61K31/422 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/12 , C12N9/12 , C12Y207/10002
Abstract: The invention relates to compounds of the formula (VIII) wherein the moieties R1, R2, R3, R4, and R5 are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.
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公开(公告)号：US20180140677A1
公开(公告)日：2018-05-24
申请号：US15574794
申请日：2016-05-18
Inventor： Victor J. Hruby , Minying Cai
CPC classification number: A61K38/34 , A61K8/64 , A61K38/00 , A61K38/10 , A61Q19/04 , C07K7/08 , C07K14/685 , C07K14/69
Abstract: A gamma-melanocyte stimulating hormone (γ-MSH) derivative having improved stability, selectivity and bioavailabilty. The γ-MSH derivative is selective for the melanocortin-1 receptor (MC1 R) and is deliverable to skin cells via topical or transdermal delivery. The γ-MSH derivative is made up of naturally occurring amino acids for stimulating melanin from within for photoprotection of human skin against ultraviolet radiation damage.
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公开(公告)号：US09962256B2
公开(公告)日：2018-05-08
申请号：US14421731
申请日：2013-08-15
Inventor： Sean J. McCafferty
IPC: A61F2/16
CPC classification number: A61F2/16 , A61F2/1624 , A61F2/1635 , A61F2002/1681 , A61F2002/1682 , A61F2002/1689 , A61F2002/169 , A61F2210/0014
Abstract: A haptic supporting an intraocular lens (IOL) in the eye permits radial tension from ciliary muscle relaxation rather than contraction to alter the lens power. The IOL is supported by the overlying tissue in the eye such as iris root, sclera and ciliary process, so that anterior and posterior forces on IOL are balanced, and buckling or displacement of lens in the eye or haptic is reduced or prevented. The haptic is of a thickness so as to increase stiffness and to reduce or prevent IOL buckling or displacement.
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公开(公告)号：US09927225B2
公开(公告)日：2018-03-27
申请号：US15168976
申请日：2016-05-31
Inventor： Jaehong Min , Nikolas Jorge Gelo , Hongki Jo
CPC classification number: G01B11/14 , G01B11/002 , G06T7/20 , G06T7/90 , G06T2207/10016
Abstract: Disclosed are methods of measuring dynamic displacement of an object. The methods include capturing a plurality of images of a dynamically moving object. The object may include one or two color-patterned target(s) that include two rows and two columns of two contrasting colors (e.g., colors with a difference in hue values of approximately 180). The methods include identifying a reference point of the object (e.g., a center of a color-patterned target or a midpoint between the centers of two color-patterned targets) and measuring the dynamic movement (displacement) of the reference point over time. The images may be captured by a smartphone camera and the smartphone may identify and measure the dynamic movement of the reference point. In view of the constraints of smartphone hardware capabilities, the images may be cropped and/or not displayed to enable the smartphone to process the images and measure the dynamic displacement in real time.
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公开(公告)号：US20180051055A1
公开(公告)日：2018-02-22
申请号：US15561230
申请日：2016-03-25
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INTITUTE, INC. , THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , UNIVERSITY OF SOUTH FLORIDA
Inventor： David L. Morse , Josef Vagner , Mark McLaughlin , Robert Gillies , Amanda Huynh , Michael Doligalski
CPC classification number: C07K5/081 , A61K49/0019 , A61K49/0032 , A61K49/0052 , A61K51/0497
Abstract: Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.
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Patent Agency Ranking
26.发明申请公开(公告)号：US20170360820A1
公开(公告)日：2017-12-21
申请号：US15535019
申请日：2015-12-18
Inventor： Andrew P. Capaldi , James E. Hughes Hallett
IPC: A61K31/7056 , A61K39/395 , A61K31/155 , A61K45/06 , C07K16/18
CPC classification number: A61K31/7056 , A61K31/155 , A61K31/60 , A61K39/3955 , A61K45/06 , C07K16/18 , C07K2317/76 , G01N2500/10 , Y02A50/409 , Y02A50/411
Abstract: Methods and compositions for activating TORC1 aggregate formation in a fungi or a parasite, wherein TORC1 aggregate formation inhibits growth of the fungi or parasite. TORC1 aggregate formation may be activated using small molecules or other agents, and said agents may be used to treat or prevent a disease or condition associated with the fungi and parasite. The agent may target Kog1 of TORC1, e.g., the agent may directly or indirectly inhibit Kog1 leading to aggregation of the TORC1 complex.
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公开(公告)号：US09796759B2
公开(公告)日：2017-10-24
申请号：US14801557
申请日：2015-07-16
Inventor： Meredith Hay , John Konhilas , Robin L. Polt , Evan Jones
Abstract: The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.
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公开(公告)号：US09779865B2
公开(公告)日：2017-10-03
申请号：US14885609
申请日：2015-10-16
Inventor： Weigang Wang , Chong Bi
CPC classification number: H01F7/04 , G11C11/15 , G11C11/161 , G11C11/1675 , H01F21/08 , H01F27/2804 , H01Q7/06
Abstract: Voltage controlled magnetic components are described. The magnetic components include a thin layer of ferromagnet adjacent to an oxide layer. The magnetic properties of the ferromagnet may be controlled in a reversible manner via application of an external electric field and voltage-induced reversible oxidation of the ferromagnet.
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公开(公告)号：US09774931B2
公开(公告)日：2017-09-26
申请号：US14873555
申请日：2015-10-02
Applicant: Futurewei Technologies, Inc. , the Arizona Board of Regents on Behalf of the University of Arizona
Inventor： Jiafeng Zhu , Jun He , Likun Lin , Weiyang Mo , Saied Agahi , John Wissinger
IPC: H04B17/00 , H04Q11/00 , H04J14/02 , H04B10/079
CPC classification number: H04Q11/0066 , H04B10/0793 , H04J14/021 , H04J14/0212 , H04J14/0257 , H04J14/0267 , H04J14/0271 , H04L45/62 , H04Q2011/0016 , H04Q2011/0073 , H04Q2011/0083 , H04Q2011/0086
Abstract: An embodiment method for managing connections on a communications network having an optical network portion includes receiving a request for a first connection at a controller in signal communication with one or more reconfigurable optical add-drop multiplexers (ROADMs) controlling an optical network portion of a communications network, wherein the controller is connected to the communications network. The controller determines a route on the communications network for the first connection according to conditions of the communications network, with the route comprising one or more first links of the optical network. The controller determines one or more first ROADMs controlling the one or more first links and sends commands from the controller to the one or more first ROADMs to allocate bandwidth on the one or more first links.
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公开(公告)号：US20170221645A1
公开(公告)日：2017-08-03
申请号：US15502480
申请日：2015-08-11
Inventor： Palash GANGOPADHYAY , Scott H. TAN
IPC: H01G11/38 , H01M4/587 , H01M4/36 , G01N27/30 , H01M4/485 , A61B5/1468 , H01G11/24 , H01G11/36 , H01G11/26 , H01G11/58 , H01G11/86 , A61B5/145 , H01M10/0525 , H01M4/58
CPC classification number: H01G11/38 , A61B5/14532 , A61B5/1468 , A61B2562/0285 , A61B2562/125 , B82Y30/00 , B82Y40/00 , C01B32/15 , C01B32/168 , C01B32/194 , C01B2202/02 , C01B2202/08 , C01B2204/02 , C01B2204/04 , G01N27/308 , H01G11/24 , H01G11/26 , H01G11/32 , H01G11/36 , H01G11/58 , H01G11/86 , H01M4/133 , H01M4/1393 , H01M4/362 , H01M4/364 , H01M4/485 , H01M4/5825 , H01M4/583 , H01M4/587 , H01M10/0525 , H01M2300/0045 , Y02E60/13 , Y10S977/734 , Y10S977/75 , Y10S977/753 , Y10S977/842 , Y10S977/892 , Y10S977/948
Abstract: Embodiments of the present disclosure are directed to carbon-containing composites which are suitable for use as electrodes in electrochemical systems. The composites are formed from a scaffold of graphene and carbon nanotubes. Graphene flakes form a plurality of generally planar sheets (e.g., extending in an x-y plane) separated in the direction of a composite axis (e.g., along a z-axis) and approximately parallel to one another. The carbon nanotubes extend between the graphene sheets and at least a portion of the carbon nanotubes are aligned in approximately the same direction, at a defined angle with respect to the composite axis. At least a portion of the scaffold is embedded within a porous carbon matrix (e.g., an activated carbon, a polymer derived graphitic carbon, etc.).
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