-
公开(公告)号：US20220364143A1
公开(公告)日：2022-11-17
申请号：US17741518
申请日：2022-05-11
Inventor： Degeng Wang , Leaf Huang , Hongjun Liang , Fengqian Chen , Weimin Gao
Abstract: The present invention includes method and system for detecting kinase activity in vivo, comprising: providing a cell that comprises one or more mutated kinases, wherein the one or more mutated kinases comprise a mutation that enlarges an ATP binding pocket of the kinase; contacting the cell with an ATP analog-nanoparticle conjugate capable of intracellular delivery of the ATP analog-nanoparticle conjugate, wherein the ATP analog comprises a detectable label; culturing the cells under conditions in which the ATP analog-nanoparticle conjugate contacts the one or more mutated kinases in cellulo, wherein the detectable label is transferred from the ATP analog-nanoparticle conjugate to a substrate of the one or more mutated kinases, wherein the one or more kinases react to transfer the detectable label to the substrate.
-
公开(公告)号：US20220339145A1
公开(公告)日：2022-10-27
申请号：US17740624
申请日：2022-05-10
Applicant: Texas Tech University System
Inventor： Sanjay K. Srivastava , Sharavan Ramachandran
IPC: A61K31/4468 , A61K31/506 , A61K45/06 , A61P35/00
Abstract: The present invention includes composition and methods for treating cancers comprising administering to a subject a pharmaceutical composition comprising Pimavanserin, active polymorphs, or salts thereof in an amount sufficient to treat the cancer in the subject and a pharmaceutically acceptable carrier.
-
23.发明申请公开(公告)号：US20220334057A1
公开(公告)日：2022-10-20
申请号：US17762899
申请日：2020-09-30
Applicant: Texas Tech University System
Inventor： David C. Weindorf , Somsubhra Chakraborty
IPC: G01N21/359 , G01N21/3554 , G01N23/223
Abstract: An apparatus or method determines a content of the one or more elements of a solid matrix by scanning the solid matrix using a PXRF spectrometer and a color sensor, receiving a PXRF spectra from the PXRF spectrometer and a numerical color data from the color sensor, extracting a value for each of the one or more elements the PXRF spectra, determining the content of the one or more elements of the solid matrix using one or more processors and a predictive model that relates the value of each of the one or more elements and the numerical color data to the content of the one or more elements of the solid matrix, and providing the content of the one or more elements of the solid matrix to one or more input/output interfaces.
-
公开(公告)号：US20220327140A1
公开(公告)日：2022-10-13
申请号：US17641911
申请日：2020-09-11
Applicant: Texas Tech University System
Inventor： Van Vung Pham , David C. Weindorf , Tommy Dang
IPC: G06F16/26 , G06F3/038 , G06F3/0484
Abstract: An apparatus and method include: receiving a data set having two or more variables; receiving a selection of at least one of the two or more variables, an abstraction level and a visual feature; automatically generating and displaying a set of visual representations of the data set on the display; receiving a change in the selected variables, selected abstraction level, the selected visual feature, or a selection from various views; determining a visual representation recommendation based on the selected variable(s), selected abstraction level and the selected visual feature, the change in the selected variables, selected abstraction level, the selected visual feature, or the selected views; and automatically updating and displaying the set of visual representations of the data set on the display based the visual representation recommendation, and the change in the selected variables, selected abstraction level, the selected visual feature, or the selected views.
-
25.发明申请公开(公告)号：US20220291211A1
公开(公告)日：2022-09-15
申请号：US17691972
申请日：2022-03-10
Inventor： Jungkyu KIM , Ali Khodayari BAVIL
IPC: G01N33/543 , B01L3/00 , G01N27/12
Abstract: Described herein are devices and methods for improved detection and quantitation of biomolecules. Devices and methods may include a microfluidic biosensing platform for measuring electrical impedance changes in the presence of target analytes from sinusoidal input voltages to improve the sensitivity of immunoassays. In one embodiment, the described devices and methods may provide a point-of-care immunoassay platform for quantitative diagnostics using signal-enhancing microparticles to improve sensitivity and the limit-of-detection.
-
Patent Agency Ranking
公开(公告)号：US11357766B2
公开(公告)日：2022-06-14
申请号：US16762525
申请日：2018-11-13
Applicant: Texas Tech University System
Inventor： Sanjay K. Srivastava , Sharavan Ramachandran
IPC: A61K31/4468 , A61P35/00
Abstract: The present invention includes composition and methods for treating cancers comprising administering to a subject a pharmaceutical composition comprising Pimavanserin or derivatives thereof in an amount sufficient to treat the reproductive cancer in the subject and a pharmaceutically acceptable carrier.
-
公开(公告)号：US11286502B2
公开(公告)日：2022-03-29
申请号：US16620581
申请日：2018-06-20
Applicant: Texas Tech University System
Inventor： Himanshu Garg , Anjali Joshi
Abstract: The present invention includes compositions, methods, vectors, vaccines, cell lines and other constructs for making and used Zika virus Reporter Virus Particles (RVPs) and/or Virus Like Particles (VLPs) that are safe for handling and manufacturing and are able to generate an effective immune response against Zika virus and can be readily scaled up for cost-effective production.
-
公开(公告)号：US11271497B2
公开(公告)日：2022-03-08
申请号：US15976113
申请日：2018-05-10
Applicant: Texas Tech University System
Inventor： Burak Aksak , Robert Koven , Serdar Gorumlu
Abstract: An energy harvester apparatus, system and method. A cantilevered beam resonator includes a cantilever beam and a base defined by the ends of the cantilever beam. The cantilevered beam resonator further includes a piezoelectric transducer composed of one or more piezoelectric components. The piezoelectric transducer is generally mounted beneath the base of the cantilevered beam resonator. In some example embodiments, the piezoelectric component can be configured in a split electrode configuration composed of a single split arrangement or more than one split (e.g., two splits, three splits, four splits, and so on).
-
公开(公告)号：US20220018797A1
公开(公告)日：2022-01-20
申请号：US17373515
申请日：2021-07-12
Applicant: Texas Tech University System
Inventor： Gerardine G. Botte , Ashwin Ramanujam
IPC: G01N27/327 , G01N27/407
Abstract: The present invention provides for a device and method for the rapid detection (within seconds) of viruses and virions (proteins and nucleic acids) found in novel coronavirus (SARS-CoV-2) and other viruses through testing of an air sample. The device can be used at front line, hospitals, clinical laboratories, airports, groceries, homes, and the like. The device can be used as a single probe for single use or home use for fast detection of multiple samples simultaneously. The present invention would facilitate multiple testing at times of pandemics caused by airborne viruses when a large number of samples have to be tested in short periods of time.
-
公开(公告)号：US20210401410A1
公开(公告)日：2021-12-30
申请号：US17364792
申请日：2021-06-30
Applicant: Texas Tech University System , RSI Technology Group, LLC
Inventor： Samuel D. Prien , Lindsay L. Penrose , Diana M. Peninger
Abstract: The present invention relates in general to the improved containment of biological fluids. In particular, a method and apparatus for collection and preservation of fluid samples in accordance with the present invention results in collection of semen having improved viability both at the time of collection and after storage. The disclosed methods and apparatuses methods support a wide variety of applications for containment of biological fluids related to human and veterinary medicine including, but not limited to, human reproductive medicine and animal husbandry.
-
-
-
-
-
-
-
-
-
Search Results
437
records
(took 0.031 seconds)
