公开(公告)号：US20250127635A1

公开(公告)日：2025-04-24

申请号：US18991192

申请日：2024-12-20

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Tommaso LENZI ,  Lukas R. GABERT ,  Minh TRAN

IPC: A61F2/66 ,  A61F2/50 ,  A61F2/68 ,  A61F2/70 ,  A61F2/76

Abstract: Disclosed herein is a robotic ankle foot prosthesis that replicates the key biomechanical functions of the biological ankle and toe joints while matching the weight, size, and battery life of passive microprocessor-controlled prostheses. A single actuator powers the ankle and toe joints. The mechanism maximizes the mechanical energy regeneration during walking while imitating the physiological features of energy injection by way of the ankle joint and energy dissipation by way of the toe joint.

公开(公告)号：US20250120755A1

公开(公告)日：2025-04-17

申请号：US18991840

申请日：2024-12-23

Applicant: University of Utah Research Foundation

Inventor： Colin S. GREGERSEN ,  T. Wade FALLIN ,  Charles L. SALTZMAN ,  Chase HAGMAN

IPC: A61B17/72 ,  A61B17/68

Abstract: A dynamic compression implant may be insertable into a bone, and may have a distal member with distal bone-engaging threads, a proximal member that slidably engages the distal member, and a tension member with a proximal end coupled to the proximal member, and a distal end coupled to the distal member such that, in response to motion of the distal member distally away from the proximal member, the tension member elongates and urges the distal member to move proximally toward the proximal member. The bone screw may further have an interpositional member, formed separately from the proximal member and the distal member, that cooperates with the proximal member and the distal member to form a torque transmission feature that transmits torque between the proximal member and the distal member. The dynamic compression implant may be a bone screw, intramedullary implant, or other implant that applies compression across two bone portions.

公开(公告)号：US20250107905A1

公开(公告)日：2025-04-03

申请号：US18898320

申请日：2024-09-26

Applicant: University of Utah Research Foundation

Inventor： Tommaso LENZI ,  Lukas R. GABERT ,  Liam SULLIVAN ,  Marissa Ann COWAN

IPC: A61F2/64 ,  A61F2/70

Abstract: Disclosed are prosthetic systems comprising a powered knee prosthesis and a volitional controller configured to provide control of the prosthesis to the user. The prosthetic system may be configured to enable a user to walk on smooth and/or uneven terrain and to ascend and/or descend stairs. The volitional controller may be configured in a contact state when the prosthesis is in contact with a ground surface and a no contact state when the prosthesis is lifted from the ground surface. When in the contact state, the controller may output a knee torque signal for controlling the powered knee of the prosthesis. The knee torque signal may be based on a target knee torque determined by the knee orientation and the torque measured at the ankle of a prosthetic foot. When in the no contact state, the controller may output a knee torque signal based on a desired knee position.

公开(公告)号：US20250102872A1

公开(公告)日：2025-03-27

申请号：US18759640

申请日：2024-06-28

Applicant: The Regents of the University of Colorado, a body corporate ,  University of Utah Research Foundation

Inventor： Noel A. Clark ,  Xi Chen ,  Matthew A. Glaser ,  Joseph E. Maclennan ,  Degnpan Dong ,  Dimitry Bedrov

IPC: G02F1/141 ,  G02F1/00 ,  G02F1/01 ,  G02F1/135 ,  G16C10/00 ,  G16C20/20 ,  G21K1/00

Abstract: Devices including nematic liquid crystal-forming molecules are disclosed. The molecules include one or more dipoles and exist in a ferroelectric nematic state. Exemplary devices can further include an electrode for applying an electric field in, for example, and in-plane direction.

公开(公告)号：US12253523B2

公开(公告)日：2025-03-18

申请号：US18453745

申请日：2023-08-22

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Andrew S. Dixon ,  Shawn Owen

IPC: G01N33/574 ,  C07K16/24 ,  C12Q1/66 ,  C12Q1/6804 ,  G01N33/542 ,  G01N33/58

Abstract: Split enzyme reporter systems are disclosed for detecting an analyte in a mixture. Fragments of the split enzyme may be covalently bound to targeting domains that bind to target regions of an analyte, thereby causing formation of an active complex. Some split enzyme reporter systems can be used to detect an analyte without the use of analyte immobilization, blocking, or wash steps. Some reporter systems also enable rapid detection of the analyte of interest.

公开(公告)号：US20250072940A1

公开(公告)日：2025-03-06

申请号：US18950105

申请日：2024-11-17

Applicant: University of Utah Research Foundation

Inventor： John HEFLIN ,  T. Wade FALLIN ,  Zackery EVANS

IPC: A61B17/70 ,  A61M5/168 ,  F04B43/04

Abstract: A bone implant system may include a plurality of bone anchors, a superior rod attachable to a superior portion of a bone via the bone anchors, and an inferior rod attachable to an inferior portion of the bone via the bone anchors. The superior rod may have a superior end, and the inferior rod may have an inferior end. The superior rod may telescopically engage the inferior rod such that a cavity is present within at least one of the superior rod and the inferior rod and such that a length of the combined superior and inferior rods, measured between the superior end and the inferior end, is adjustable. The cavity may contain a micropump and a chamber. The micropump may be configured to expel fluid into the chamber to urge the length to increase.

公开(公告)号：US20250069700A1

公开(公告)日：2025-02-27

申请号：US18949394

申请日：2024-11-15

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Carson Hinton Holt ,  Mark D. Yandell

IPC: G16B30/10 ,  G06F16/176 ,  G16B50/50

Abstract: A method for facilitating rapid genome sequence analysis includes accessing an output stream of an alignment process that includes aligned reads of a biological sequence that are aligned to a reference genome. The method also includes distributing the aligned reads to a plurality of computing nodes based on genomic position. Each of the plurality of computing nodes is assigned to a separate data bin of a plurality of data bins associated with genomic position. The method also includes, for at least one aligned read determined to overlap separate data bins of the plurality of data bins, duplicating the at least one aligned read and distributing the at least one aligned read to separate computing nodes of the plurality of computing nodes that are assigned to the separate data bins.

公开(公告)号：US12227512B2

公开(公告)日：2025-02-18

申请号：US18388765

申请日：2023-11-10

Applicant: University of Utah Research Foundation

Inventor： Darrell Davis ,  Shuanghu Liu

IPC: C07D491/147 ,  C07D235/30 ,  C07D487/04 ,  C07D491/048 ,  C07D491/052 ,  C07D495/14

Abstract: The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus, respiratory syntactical virus (RSV), Rift Valley fever, Influenza virus, Tacaribe virus, Mayaro virus, West Nile virus, yellow fever virus, and coronavirus), and disorders of uncontrolled cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20250052755A1

公开(公告)日：2025-02-13

申请号：US18448632

申请日：2023-08-11

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Katharine L. Diehl ,  Joseph J. Smith

IPC: G01N33/573 ,  C07K14/00

Abstract: Disclosed herein are a polypeptide biosensor and compositions comprising the polypeptide biosensor that detects acetyl coenzyme A (acetyl-CoA). The polypeptide comprises an acetyl-CoA binding protein and a fluorescent protein. Further described herein are methods of using the biosensor to detect acetyl-CoA and expression vectors comprising the biosensor.

公开(公告)号：US20250025219A1

公开(公告)日：2025-01-23

申请号：US18707298

申请日：2022-10-03

Applicant: University of Utah Research Foundation

Inventor： Zackery EVANS ,  T. Wade FALLIN ,  Peter M. STEVENS

IPC: A61B17/80 ,  A61B17/56 ,  A61B17/70 ,  A61B17/86

Abstract: A tether assembly may be attached to a bone to correct a rotational deformity. The bone may have a growth plate that separates a first section of the bone from a second section of the bone. The tether assembly may have a tether member with a first end, a second end, and a central portion extending between the first end and the second end. The first end may have a closed outer wall that defines and fully bounds a first aperture. The second end may have an open outer wall that defines and partially bounds a second aperture. The open outer wall may define a slot in communication with the second aperture. The first and second ends may be securable to the first and second sections of the bone via coupling members inserted through the first and second apertures and anchored in the first and second sections, respectively.