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    Systems and methods for treating an eye with a mask device
    21.
    发明授权
    Systems and methods for treating an eye with a mask device 有权

    公开(公告)号：US10646372B2

    公开(公告)日：2020-05-12

    申请号：US15369647

    申请日：2016-12-05

    Applicant: Avedro, Inc.

    Inventor： Marc D. Friedman ,  Desmond Adler

    IPC: A61M37/00 ,  A61F9/00 ,  A61F9/04 ,  A61F9/008 ,  A61M13/00 ,  A61N5/06 ,  A61N5/067

    Abstract: An eye treatment positions a mask device over first and second eyes. A posterior side of the mask device is proximate to the face and the anterior side is distal from the face. The mask device includes an outer wall extending between the anterior and posterior sides and defining a chamber extending across the first and second eyes. The anterior side includes a first transmission region that allows a photoactivating light for the first eye to be delivered into a first section of the chamber positioned over the first eye. The anterior side includes a second transmission region that allows a photoactivating light for the second eye to be delivered into the second section positioned over the second eye. The system includes at least one gas source storing a gas that is different than ambient air. The system includes a gas delivery system that delivers the gas into the chamber.

    Systems and methods for photoactivating a photosensitizer applied to an eye
    23.
    发明授权
    Systems and methods for photoactivating a photosensitizer applied to an eye 有权

    公开(公告)号：US10258809B2

    公开(公告)日：2019-04-16

    申请号：US15137748

    申请日：2016-04-25

    Applicant: Avedro, Inc.

    Inventor： Marc D. Friedman ,  Mikhail Smirnov ,  Pavel Kamaev

    IPC: A61N5/06 ,  A61F9/02

    Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

    SYSTEMS AND METHODS FOR MONITORING CROSS-LINKING ACTIVITY FOR CORNEAL TREATMENTS
    24.
    发明申请
    SYSTEMS AND METHODS FOR MONITORING CROSS-LINKING ACTIVITY FOR CORNEAL TREATMENTS 审中-公开
    用于监测CORNEAL治疗的交联活动的系统和方法

    公开(公告)号：US20160338588A1

    公开(公告)日：2016-11-24

    申请号：US15161302

    申请日：2016-05-23

    Applicant: Avedro, Inc.

    Inventor： Marc D. Friedman

    IPC: A61B3/14 ,  A61N5/06 ,  A61B5/00 ,  A61K31/525

    CPC classification number: A61B3/145 ,  A61B5/004 ,  A61B5/0071 ,  A61B5/4836 ,  A61B5/4848 ,  A61F9/0079 ,  A61F9/008 ,  A61F2009/00872 ,  A61K31/525 ,  A61N5/062 ,  A61N2005/0643 ,  A61N2005/0661 ,  A61N2005/0662

    Abstract: A system for treatment of corneal tissue includes one or more light sources that generate excitation light delivered to corneal tissue treated with a cross-linking agent. The excitation light causes the cross-linking agent to fluoresce by emitting an emission light at a plurality of emission wavelengths. The system includes an image capture system that captures image(s) of the corneal tissue. The image(s) indicate at least two of the emission wavelengths. The system includes a controller that receives the image(s). The controller: identifies each of the at least two emission wavelengths in the image(s); determines, from the image(s), respective characteristics associated separately with each of the at least two emission wavelengths; and provides information relating to cross-linking activity generated by the cross-linking agent in the corneal tissue based on the respective characteristics associated with each of the at least two emission wavelengths.

    Abstract translation: 用于治疗角膜组织的系统包括产生激发光的一个或多个光源，所述光源传递给用交联剂处理的角膜组织。 通过发射多个发射波长的发射光，激发光使交联剂发荧光。 该系统包括捕获角膜组织的图像的图像捕获系统。 图像表示至少两个发射波长。 该系统包括接收图像的控制器。 控制器：识别图像中的至少两个发射波长中的每一个; 从所述图像确定与所述至少两个发射波长中的每一个分别相关联的各个特性; 并且基于与所述至少两个发射波长中的每一个相关联的相应特征，提供与所述交联剂在角膜组织中产生的交联活性有关的信息。

    SYSTEMS AND METHODS FOR DELIVERING LIGHT IN EYE TREATMENTS
    25.
    发明申请
    SYSTEMS AND METHODS FOR DELIVERING LIGHT IN EYE TREATMENTS 审中-公开
    用于在眼睛治疗中递送光的系统和方法

    公开(公告)号：US20140320819A1

    公开(公告)日：2014-10-30

    申请号：US14248966

    申请日：2014-04-09

    Applicant: Avedro, Inc

    Inventor： David Muller ,  Marc D. Friedman

    IPC: A61B3/00

    CPC classification number: A61B3/0008 ,  A61F9/0079 ,  A61N5/062 ,  A61N2005/0651 ,  A61N2005/0661

    Abstract: A system for applying a treatment to an eye includes a housing having a first end and a second end, a contact element having an open end and a closed end, and a light source disposed within the housing and configured to direct light toward the open end. The contact element is coupled to the first end of the housing at the closed end. The open end is configured to be positioned at an eye.

    Abstract translation: 用于对眼睛进行治疗的系统包括具有第一端和第二端的壳体，具有开口端和封闭端的接触元件，以及设置在壳体内并被配置为将光引向开口端的光源 。 接触元件在封闭端处联接到壳体的第一端。 开口端构造成定位在眼睛处。

    Eye Therapy System
    26.
    发明申请
    Eye Therapy System 有权
    眼科治疗系统

    公开(公告)号：US20140024997A1

    公开(公告)日：2014-01-23

    申请号：US14035528

    申请日：2013-09-24

    Applicant: Avedro Inc.

    Inventor： David Muller ,  John Marshall ,  Marc D. Friedman

    IPC: A61F9/00

    CPC classification number: A61N5/062 ,  A61F9/0008 ,  A61F9/013 ,  A61K31/14

    Abstract: Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes. For example, the cross-linking agent may be Riboflavin or Rose Bengal, and the initiating element may be photoactivating light, such as ultraviolet (UV) light. In these embodiments, the photoactivating light initiates cross-linking activity by irradiating the applied cross-linking agent to release reactive oxygen radicals in the corneal tissue. The cross-linking agent acts as a sensitizer to convert O2 into singlet oxygen which causes cross-linking within the corneal tissue. The rate of cross-linking in the cornea is related to the concentration of O2 present when the cross-linking agent is irradiated with photoactivating light. Accordingly, the embodiments control the concentration of O2 during irradiation to increase or decrease the rate of cross-linking and achieve a desired amount of cross-linking.

    Abstract translation: 实施例将交联剂应用于角膜组织的区域。 交联剂改善了角膜组织抵抗不良结构变化的能力。 例如，交联剂可以是核黄素或玫瑰红，起始元件可以是光活化的光，例如紫外（UV）光。 在这些实施方案中，光活化光通过照射施加的交联剂以释放角膜组织中的活性氧自由基引发交联活性。 交联剂作为敏化剂将O 2转化成单线态氧，导致角膜组织内的交联。 角膜中的交联速率与交联剂用光活化光照射时存在的O 2浓度有关。 因此，实施例控制照射期间的O 2浓度以增加或降低交联速率并达到所需量的交联。

    SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING WITH PULSED LIGHT
    27.
    发明申请
    SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING WITH PULSED LIGHT 审中-公开
    用脉冲光束进行角度交叉连接的系统和方法

    公开(公告)号：US20130245536A1

    公开(公告)日：2013-09-19

    申请号：US13841617

    申请日：2013-03-15

    Applicant: AVEDRO, INC.

    Inventor： Marc D. Friedman ,  Evan Sherr ,  Pavel Kamaev ,  William Eddington ,  David Muller ,  David Usher ,  Radha Pertaub ,  Satish Herekar

    IPC: A61N5/06

    CPC classification number: A61N5/062 ,  A61F9/0008 ,  A61F9/0079 ,  A61F9/013 ,  A61F2009/00872 ,  A61F2210/0085 ,  A61K31/14 ,  A61K41/00 ,  A61K41/0042

    Abstract: A method for controlling activation of a cross-linking agent applied to an eye includes applying the cross-linking agent to a selected region of a cornea of the eye and initiating cross-linking activity in the selected region by activating the cross-linking agent with pulsed light illumination. The pulsed light illumination has a selectable wavelength, irradiance, dose, and on/off duty cycle. The wavelength, the irradiance, the dose, and the on/off duty cycle are adjusted in response to a determination of photochemical kinetic pathways for cross-linking activity and to control photochemical efficiency, depth of cross-linking, and density of cross-linking.

    Abstract translation: 用于控制施用于眼睛的交联剂的活化的方法包括将交联剂施加到眼睛的角膜的选定区域，并通过使所述交联剂与 脉冲光照。 脉冲光照明具有可选择的波长，辐照度，剂量和开/关占空比。 波长，辐照度，剂量和开/关占空比响应于光化学动力学途径对交联活性的测定和控制光化学效率，交联深度和交联密度的调节 。

    SYSTEMS AND METHODS FOR PHOTOACTIVATING A PHOTOSENSITIZER APPLIED TO AN EYE
    29.
    发明申请
    SYSTEMS AND METHODS FOR PHOTOACTIVATING A PHOTOSENSITIZER APPLIED TO AN EYE 有权

    公开(公告)号：US20240366961A1

    公开(公告)日：2024-11-07

    申请号：US18775674

    申请日：2024-07-17

    Applicant: Avedro, Inc.

    Inventor： Marc D. Friedman ,  MIkhail Smirnov ,  Pavel Kamaev

    IPC: A61N5/06 ,  A61F9/007 ,  A61F9/02

    Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

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