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    SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING WITH PULSED LIGHT
    1.
    发明申请
    SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING WITH PULSED LIGHT 审中-公开
    用脉冲光束进行角度交叉连接的系统和方法

    公开(公告)号：US20130245536A1

    公开(公告)日：2013-09-19

    申请号：US13841617

    申请日：2013-03-15

    Applicant: AVEDRO, INC.

    Inventor： Marc D. Friedman ,  Evan Sherr ,  Pavel Kamaev ,  William Eddington ,  David Muller ,  David Usher ,  Radha Pertaub ,  Satish Herekar

    IPC: A61N5/06

    CPC classification number: A61N5/062 ,  A61F9/0008 ,  A61F9/0079 ,  A61F9/013 ,  A61F2009/00872 ,  A61F2210/0085 ,  A61K31/14 ,  A61K41/00 ,  A61K41/0042

    Abstract: A method for controlling activation of a cross-linking agent applied to an eye includes applying the cross-linking agent to a selected region of a cornea of the eye and initiating cross-linking activity in the selected region by activating the cross-linking agent with pulsed light illumination. The pulsed light illumination has a selectable wavelength, irradiance, dose, and on/off duty cycle. The wavelength, the irradiance, the dose, and the on/off duty cycle are adjusted in response to a determination of photochemical kinetic pathways for cross-linking activity and to control photochemical efficiency, depth of cross-linking, and density of cross-linking.

    Abstract translation: 用于控制施用于眼睛的交联剂的活化的方法包括将交联剂施加到眼睛的角膜的选定区域，并通过使所述交联剂与 脉冲光照。 脉冲光照明具有可选择的波长，辐照度，剂量和开/关占空比。 波长，辐照度，剂量和开/关占空比响应于光化学动力学途径对交联活性的测定和控制光化学效率，交联深度和交联密度的调节 。

    SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY
    2.
    发明申请
    SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY 有权

    公开(公告)号：US20210101020A1

    公开(公告)日：2021-04-08

    申请号：US17123089

    申请日：2020-12-15

    Applicant: Avedro, Inc.

    Inventor： David Muller ,  John Marshall ,  Marc D. Friedman ,  Stephen Blinn ,  Ronald Scharf ,  Pavel Kamaev ,  Radha Pertaub

    IPC: A61N5/06 ,  A61B3/10 ,  A61B3/107 ,  A61F9/008 ,  A61F9/00

    Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

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