公开(公告)号：US20180057514A1

公开(公告)日：2018-03-01

申请号：US15804275

申请日：2017-11-06

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： ANTON TOUTOV ,  KERRY BETZ ,  ALEXEY FEDOROV ,  BRIAN M. STOLTZ ,  WENBO LIU ,  ROBERT H. GRUBBS

IPC: C07F7/08 ,  C07D209/12

CPC classification number: C07F7/0801 ,  C07D209/12 ,  C07F7/0827 ,  C07F7/0832

Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including hydroxide, especially KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.

公开(公告)号：US20170096434A1

公开(公告)日：2017-04-06

申请号：US15286983

申请日：2016-10-06

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： MELANIE A. YEN ,  HARRY B. GRAY ,  ROBERT H. GRUBBS ,  JOSHUA Palmer

IPC: C07D487/22 ,  C07F5/00

CPC classification number: C07D487/22 ,  C07F5/003

Abstract: The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the corroles are compounds having a Structure (I-H) and (I-M): where R1, R2, R3, and R4 are independently —F or —N(H)—(CH2)m—Y, provided that at least one of R1, R2, R3, and R4 is —N(H)—(CH2)m—Y, and m and Y are described herein.

公开(公告)号：US20170088562A1

公开(公告)日：2017-03-30

申请号：US15375747

申请日：2016-12-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： ANTON TOUTOV ,  WENBO LIU ,  BRIAN M. STOLTZ ,  ROBERT H. GRUBBS ,  KERRY BETZ ,  DAVID P. SCHUMAN

IPC: C07F5/04 ,  C07F7/08

CPC classification number: C07B47/00 ,  C07D209/12 ,  C07F5/04 ,  C07F7/0827

Abstract: The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates using at least alkoxide base, preferably a potassium alkoxide base and at least one organodisilane and (b) at least one alkoxide base. Both methods and compositions for affecting these transformations are disclosed.

公开(公告)号：US20170029447A1

公开(公告)日：2017-02-02

申请号：US15219710

申请日：2016-07-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： ANTON TOUTOV ,  KERRY BETZ ,  ANDREW M. ROMINE ,  ROBERT H. GRUBBS

IPC: C07F7/18 ,  C07D235/08 ,  C07F7/21

CPC classification number: C07F7/1804 ,  C07D235/08 ,  C07F7/0896 ,  C07F7/21

Abstract: The present disclosure is directed to methods for dehydrogenatively coupled hydrosilanes and alcohols, the methods comprising contacting an organic substrate having at least one organic alcohol moiety with a mixture of at least one hydrosilane and sodium and/or potassium hydroxide, the contacting resulting in the formation of a dehydrogenatively coupled silyl ether. The disclosure further described associated compositions and methods of using the formed products.

Abstract translation: 本公开涉及脱氢偶联的氢硅烷和醇的方法，所述方法包括使具有至少一个有机醇部分的有机底物与至少一种氢硅烷和钠和/或氢氧化钾的混合物接触，导致形成 的脱氢偶联甲硅烷基醚。 本公开进一步描述了使用成形产品的相关组合物和方法。

公开(公告)号：US20160176772A1

公开(公告)日：2016-06-23

申请号：US14972653

申请日：2015-12-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： ANTON TOUTOV ,  WENBO LIU ,  BRIAN M. STOLTZ ,  ROBERT H. GRUBBS ,  KERRY BETZ ,  DAVID P. SCHUMAN

IPC: C07B47/00 ,  C07D209/12 ,  B01J31/22 ,  C07F7/08

CPC classification number: C07B47/00 ,  C07D209/12 ,  C07F5/04 ,  C07F7/0827

Abstract: The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates, said system consisting essentially of a mixture of (a) at least one organodisilane and (b) at least alkoxide base, preferably a potassium alkoxide base, and said methods comprising contacting a quantity of the organic substrate with a mixture consisting essentially of (a) at least one organodisilane and (b) at least one alkoxide base, preferably a potassium alkoxide, under conditions sufficient to silylate the heteroaromatic substrate.

Abstract translation: 本发明描述了用于甲硅烷基化杂芳族有机底物的化学系统和方法，所述系统基本上由（a）至少一种有机硅烷和（b）至少烷氧基，优选烷醇钾碱的混合物组成，所述方法包括使 基本上由（a）至少一种有机硅烷和（b）至少一种醇盐碱，优选烷氧基钾，在足以使所述杂芳族底物甲硅烷基化的条件下混合的混合物的有机底物的量。

公开(公告)号：US20160068669A1

公开(公告)日：2016-03-10

申请号：US14850178

申请日：2015-09-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： ROBERT J. MACFARLANE ,  ROBERT H. GRUBBS

IPC: C08L25/06 ,  C08L53/00 ,  C09D153/00 ,  C09D125/06

CPC classification number: C08L25/06 ,  C08F8/00 ,  C08G81/024 ,  C08G2261/136 ,  C08G2261/3324 ,  C08G2261/35 ,  C08G2261/418 ,  C08G2261/90 ,  C08L53/00 ,  C09D5/004 ,  C09D125/06 ,  C09D153/00 ,  C08L65/00 ,  C08L25/04 ,  C09D165/00

Abstract: The present invention is directed to brush block copolymer compositions comprising first and second homopolymers or random copolymers whose presence provides access to photonic bandgaps in the infrared frequency range, their use in this capacity, and methods of making the same. The specific parameters associated with these compositions are described within the specification.

Abstract translation: 本发明涉及包含第一和第二均聚物或无规共聚物的刷塞共聚物组合物，其存在提供了在红外频率范围内的光子带隙的访问，其在该能力下的用途及其制备方法。 在本说明书中描述了与这些组合物相关的具体参数。

公开(公告)号：US20150166579A1

公开(公告)日：2015-06-18

申请号：US14628641

申请日：2015-02-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： ROBERT H. GRUBBS ,  ALEXEY FEDEROV ,  ANTON TOUTOV ,  KERRY BETZ

IPC: C07F7/08

CPC classification number: C07F7/0829 ,  C07F7/081 ,  C07F7/0812 ,  C07F7/0814 ,  C07F7/0816 ,  C07F7/0896

Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate; wherein said system is substantially free of a transition-metal compound.

Abstract translation: 本发明描述了用于甲硅烷基化芳族有机基质的化学体系和方法，所述体系包含（a）至少一种有机硅烷和（b）至少一种强碱的混合物，所述体系基本上不含过渡金属化合物， 所述方法包括在足以使芳族底物甲硅烷基化的条件下使一定量的有机底物与（a）至少一种有机硅烷和（b）至少一种强碱的混合物接触; 其中所述体系基本上不含过渡金属化合物。

公开(公告)号：US20140128494A1

公开(公告)日：2014-05-08

申请号：US14071947

申请日：2013-11-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： ANDREW J. BOYDSTON ,  ROBERT H. GRUBBS ,  CHRIS DAEFFLER ,  NEBOJSA MOMCILOVIC

IPC: A61K9/00 ,  C08F120/14 ,  C08G77/38 ,  C08F22/14

CPC classification number: A61K9/0051 ,  A61F2/14 ,  A61F2/1624 ,  A61F2/1627 ,  C08F22/14 ,  C08F120/14 ,  C08G77/38 ,  C08J3/24 ,  C08J3/28 ,  C08J2333/00 ,  G02B1/043 ,  G02C7/022 ,  C08L83/04 ,  C08L33/08 ,  C08L33/10

Abstract: Compositions and methods for adjustable lenses are provided. In some embodiments, the lenses contain a lens matrix material, a masking compound, and a prepolymer. The lens matrix material provides structure to the lens. The masking compound is capable of blocking polymerization or crosslinking of the prepolymer, until photoisomerization of the compound is triggered, and the compound is converted from a first isomer to a second isomer having a different absorption profile. The prepolymer is a composition that can undergo a polymerization or crosslinking reaction upon photoinitiation to alter one or more of the properties of the lenses.

Abstract translation: 提供可调透镜的组成和方法。 在一些实施方案中，透镜含有透镜基质材料，掩蔽化合物和预聚物。 透镜基体材料为透镜提供结构。 掩蔽化合物能够阻断预聚物的聚合或交联，直到触发化合物的光异构化，并且化合物从第一异构体转变为具有不同吸收曲线的第二异构体。 预聚物是一种组合物，其可以在光引发时经历聚合或交联反应以改变透镜的一种或多种性质。

公开(公告)号：US20140091256A1

公开(公告)日：2014-04-03

申请号：US14043917

申请日：2013-10-02

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： ROBERT H. GRUBBS ,  ALEXEY FEDOROV ,  ANTON TOUTOV ,  NICHOLAS A. SWISHER

IPC: C07C209/28 ,  C07C1/22 ,  C07C37/50

CPC classification number: C07C209/28 ,  C07B2200/05 ,  C07C1/22 ,  C07C37/055 ,  C07C37/50 ,  C07C209/62 ,  C07C319/06 ,  C07F7/081 ,  C07F7/0814 ,  C07C39/15 ,  C07C15/06 ,  C07C15/16 ,  C07C15/18 ,  C07C15/14 ,  C07C15/04 ,  C07C15/02 ,  C07C15/24 ,  C07C211/48 ,  C07C321/26

Abstract: The present invention describes chemical systems and methods for reducing C—O, C—N, and C—S bonds, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said system optionally comprising at least one molecular hydrogen donor compound, molecular hydrogen, or both.

Abstract translation: 本发明描述了用于还原C-O，C-N和C-S键的化学体系和方法，所述体系包含（a）至少一种有机硅烷和（b）至少一种强碱的混合物，所述体系是 基本上不含过渡金属化合物，并且所述体系任选地包含至少一种分子给氢化合物，分子氢或两者。

公开(公告)号：US20130231499A1

公开(公告)日：2013-09-05

申请号：US13785101

申请日：2013-03-05

Applicant: California Institute of Technology

Inventor： ROBERT H. GRUBBS ,  MYLES B. HERBERT ,  ZACHARY K. WICKENS ,  VANESSA M. MARX

IPC: C07C29/00 ,  C07C45/30 ,  C07C67/08 ,  C07C67/28

CPC classification number: C07C29/00 ,  C07C29/32 ,  C07C45/30 ,  C07C67/08 ,  C07C67/28 ,  C07C67/293 ,  C07C67/343 ,  C07C33/025 ,  C07C47/21 ,  C07C69/145 ,  C07C33/02 ,  C07C49/203

Abstract: The present invention is directed to methods of synthesizing insect pheromones, particularly lepidopteran insect pheromones, their precursors and derivatives from inexpensive, readily available starting materials using olefin metathesis catalysis.

Abstract translation: 本发明涉及使用烯烃复分解催化合成昆虫信息素，特别是鳞翅目昆虫信息素，它们的前体和廉价，易得的原料的衍生物的方法。