公开(公告)号：US20240011969A1

公开(公告)日：2024-01-11

申请号：US18271023

申请日：2022-01-05

Applicant: CytoVeris Inc.

Inventor： Rishikesh Pandey ,  David Fournier ,  Patrick Curry ,  Alan Kersey

IPC: G01N33/483 ,  G01N21/64

CPC classification number: G01N33/4833 ,  G01N21/6486 ,  A61B10/00

Abstract: A system and method for analyzing bladder tissue sample is provided that includes an excitation light source, a photodetector, an optical filter, and a system controller. The excitation light source produces excitation lights centered on a distinct wavelengths. At least one of the wavelengths produces autofluorescence emissions from one or more biomolecules, and at least one of the wavelengths produces diffuse reflectance signals. The photodetector detects at least one of the autofluorescence emissions or diffuse reflectance signals and produces signals representative thereof. The optical filter filters at least one of autofluorescence emissions or the diffuse reflectance signals. The system controller communicates with the system components and a memory storing instructions. The instructions cause the system controller to control the excitation light unit, receive and process the photodetector signals, produce a signal image, and analyze the tissue sample to determine the presence of detrusor muscle tissue.

公开(公告)号：US20230366821A1

公开(公告)日：2023-11-16

申请号：US18027022

申请日：2021-09-17

Applicant: CytoVeris Inc.

Inventor： David Fournier ,  Rishikesh Pandey

IPC: G01N21/64 ,  G01N21/47

CPC classification number: G01N21/6456 ,  G01N21/6486 ,  G01N21/4738 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2223/401 ,  G01N2800/7028

Abstract: A method and system for analyzing a tissue sample is provided. The method includes: a) sequentially interrogating a tissue sample with excitation lights, wherein at least one of the excitation lights is configured to produce autofluorescence emissions from one or more biomolecules of interest, and diffuse reflectance signals from the tissue sample; b) using a photodetector to detect the autofluorescence emissions and/or the diffuse reflectance signals from the tissue sample, and to produce photodetector signals representative of the detected said autofluorescence emissions and/or the detected said diffuse reflectance signals; c) filtering the light emitted or reflected from the tissue sample; d) processing the photodetector signals for each sequential application of excitation light, including producing an image representative of the photodetector signals produced by each sequential application of excitation light; and e) analyzing the tissue sample using each image to identify the presence of diseased tissue within the tissue sample.

公开(公告)号：US20220317046A1

公开(公告)日：2022-10-06

申请号：US17627287

申请日：2020-07-16

Applicant: CytoVeris Inc.

Inventor： Alan Kersey ,  Rishikesh Pandey

IPC: G01N21/65 ,  G02B26/10 ,  G02B26/08 ,  G01N33/483

Abstract: A system and method for mapping a tissue sample is provided. The system includes a light source, a scanner, a digital mirror device (DMD), a light detector, and an analyzer. The DMD has an array of micromirrors. The analyzer controls the light source, controls the scanner, controls the DMD to have on-state micromirrors aligned with a light beam, and other micromirrors in an off-state. The on-state micromirrors direct the light beam to a tissue sample. The analyzer assigns one or more location codes to the on-state micromirrors, controls the light detector to receive Raman light emitted from the tissue sample, correlates the location codes of the on-state micromirrors with light detector signals representative of the Raman emitted light, and produces a spatial map of the Raman emitted light.

公开(公告)号：US11441949B2

公开(公告)日：2022-09-13

申请号：US17222858

申请日：2021-04-05

Applicant: CytoVeris Inc.

Inventor： Gary Root ,  David Fournier ,  Rishikesh Pandey

IPC: G01N15/02 ,  G01J3/44 ,  A61B5/00 ,  G06N3/04

Abstract: A method and system for identifying a Raman spectrum component of an observed spectrum is provided. The observed spectrum is produced by interrogating a material such as a tissue sample with light at the one or more predetermined wavelengths, and the observed spectrum includes a background fluorescence component representative of fluorescent emissions resulting from the light interrogation and a Raman spectrum component representative of a Raman scattering resulting from the light interrogation. The method includes a) creating a reconstructed fluorescence spectrum representative of the background fluorescence component of the observed spectrum using one or more empirically determined fluorescent spectral profiles; and b) identifying the Raman spectrum of the observed spectrum using the reconstructed fluorescence spectrum.

公开(公告)号：US20220128477A1

公开(公告)日：2022-04-28

申请号：US17513824

申请日：2021-10-28

Applicant: CytoVeris Inc.

Inventor： David Fournier ,  Rishikesh Pandey

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/543 ,  A61B5/00

Abstract: A system and method for assaying high and low abundant biomolecules within a biological fluid sample is provided. The method includes: a) placing a biological fluid sample in contact with a first nanostructure surface; b) interrogating the sample with a light source, the sample in contact with the first nanostructure surface, the interrogation using a SERS technique; c) detecting an enhanced Raman scattering from at least one high abundant biomolecule type and producing first signals representative thereof; d) placing the sample in contact with a second nanostructure surface having a targeting agent that targets a low abundant biomolecule; e) interrogating the sample with the light source using the SERS technique; f) detecting the enhanced Raman scattering from the low abundant biomolecules and producing second signals representative thereof; and g) assaying the biological fluid sample using the first signals and the second signals.