公开(公告)号：US20200060542A1

公开(公告)日：2020-02-27

申请号：US16533133

申请日：2019-08-06

Applicant: HI LLC

Inventor： Jamu Alford ,  Adam Marblestone ,  Ivo Vellekoop ,  Daniel Sobek ,  Michael Henninger ,  Brian Robinson ,  Yuecheng Shen ,  Roarke Horstmeyer

IPC: A61B5/00

Abstract: An optical measurement system comprising an optical source configured for delivering sample light in an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, an optical detector configured for detecting the physiological-encoded signal light, and a processor configured for acquiring a TOF profile derived from the physiological-encoded signal light, the initial TOF profile having an initial contrast-to-noise ratio (CNR) between a plurality of states of a physiological activity in the anatomical structure. The processor is further configured for applying one or more weighting functions to the initial TOF profile to generate a weighted TOF profile having a subsequent CNR greater than the initial CNR between the plurality of states of the physiological activity. The processor is further configured for processing the weighted TOF profile, and identifying one of the plurality of states of the physiological activity.

公开(公告)号：US20190336007A1

公开(公告)日：2019-11-07

申请号：US16393002

申请日：2019-04-24

Applicant: HI LLC

Inventor： Haowen Ruan ,  Adam Marblestone ,  Roarke Horstmeyer ,  Yuecheng Shen ,  Haojiang Zhou ,  Jamu Alford

IPC: A61B5/00

Abstract: An optical source sweeps a source light over an optical wavelength range. An interferometer splits the source light into sample light and reference light, delivers the sample light into an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, and combines the signal light and the reference light into an interference light pattern having an array of spatial components and a plurality of oscillation frequency components. An optical detector array detects intensity values of the array of spatial components. A processor derives an array of intensity values of each oscillation frequency component from the detected spatial component intensity value array, reduces each derived oscillation frequency component intensity value array to a single frequency component intensity value, and determines a depth of a physiological event in the anatomical structure based on the reduced frequency component intensity values.

公开(公告)号：US20190336005A1

公开(公告)日：2019-11-07

申请号：US16379090

申请日：2019-04-09

Applicant: HI LLC

Inventor： Jamu Alford ,  Roarke Horstmeyer ,  Adam Marblestone

IPC: A61B5/00

Abstract: An optical measurement system comprises an optical source assembly configured for intensity modulating sample light at multiple frequencies within a frequency range, and delivering the intensity modulated sample light along an optical path of an anatomical structure during a single measurement period, such that the intensity modulated sample light is scattered by the anatomical structure, resulting in signal light that exits the anatomical structure. The optical measurement system further comprises an optical detection assembly configured for detecting the signal light over the frequency range within the measurement period. The optical measurement system further comprises a processor configured for analyzing the detected signal light, and, based on this analysis, determining an occurrence and spatial depth of a physiological event in the anatomical structure.

公开(公告)号：US10420469B2

公开(公告)日：2019-09-24

申请号：US15844411

申请日：2017-12-15

Applicant: HI LLC

Inventor： Daniel Sobek ,  Changhuei Yang ,  Adam Marblestone ,  Jamu Alford

IPC: A61B5/00 ,  G01N21/17 ,  G01N21/45 ,  A61B5/1455 ,  G01B9/02 ,  G01N29/24

Abstract: A non-invasive system and method. Sample light is delivered into an anatomical structure, such that a portion of the sample light passes through a target voxel comprising brain matter in the head and is scattered by the head as signal light. The signal light is detected, changes in the level of water concentration or relative water concentration of the target voxel are detected based on the detected signal light, and a level of neural activity is determined within the target voxel based on the determined changes level of the water concentration or relative water concentration of the target voxel.

公开(公告)号：US10368752B1

公开(公告)日：2019-08-06

申请号：US15988799

申请日：2018-05-24

Applicant: HI LLC

Inventor： Jamu Alford ,  Adam Marblestone

IPC: A61B5/00 ,  G06T11/00 ,  G06K9/58 ,  G06K9/76 ,  G16H30/40 ,  G06K9/32 ,  A61B5/145

Abstract: Disclosed herein are devices and methods for modifying a conventional imager to have functional features similar to that of a lock-in camera. Optical mask devices are configured to be coupled to conventional imager sensors and the configuration of the mask devices can be adjusted to acquire image data in rapid succession. One variation of an optical mask device comprises a substrate comprising a pattern of light-blocking and light-transmitting regions and an attachment structure for coupling the optical mask device to the imager. The substrate is configured to adjust the position of the light-blocking regions and light-transmitting regions relative to the light-sensing region of the imager based on a set of one or more predetermined substrate configurations. In some variations, the mask device and/or the imager sensor may be mechanically moved relative to each other based on the set of one or more predetermined substrate configurations.

公开(公告)号：US10219700B1

公开(公告)日：2019-03-05

申请号：US15853538

申请日：2017-12-22

Applicant: HI LLC

Inventor： Changhuei Yang ,  Adam Marblestone ,  Jamu Alford

IPC: A61B5/00 ,  G01N21/45 ,  H04N5/349 ,  G02B26/06 ,  G01N21/47 ,  G02B21/00

Abstract: Described herein are systems and methods for noninvasive functional brain imaging using low-coherence interferometry (e.g., for the purpose of creating a brain computer interface with higher spatiotemporal resolution). One variation of a system and method comprises optical interference components and techniques using a lock-in camera. The system comprises a light source and a processor configured to rapidly phase-shift the reference light beam across a pre-selected set of phase shifts or offsets, to store a set of interference patterns associated with each of these pre-selected phase shifts, and to process these stored interference patterns to compute an estimate of the number of photons traveling between a light source and the lock-in camera detector for which the path length falls within a user-defined path length range.