公开(公告)号：US08516907B2

公开(公告)日：2013-08-27

申请号：US12825753

申请日：2010-06-29

Applicant: Marc Stein ,  James Ellis

Inventor： Marc Stein ,  James Ellis

IPC: G01L1/04

CPC classification number: A61B5/6878 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6846 ,  A61B5/7239 ,  A61B8/15 ,  Y10T307/615

Abstract: A load sensing platform (121) is disclosed for capturing a transit time, phase, or frequency of energy waves propagating through a medium that measures a parameter of the muscular-skeletal system. The load sensing platform (121) comprises a sensing assemblage (1), substrates (702, 704, and 706), springs (315), spring posts (708), and spring retainers (710). The sensing assemblage (1) comprises a stack of a transducer (5), waveguide (3), and transducer (6). A parameter is applied to the contact surfaces (8) of the load sensing platform (121). The sensing assemblage (1) measures changes in dimension due to the parameter. Position of the applied parameter can be measured by using more than one sensing assemblage (1). The springs (315) couple to the substrates (702, 704) providing mechanical support and to prevent cantilevering. The spring posts (708) and spring retainers (710) maintain the springs (315) at predetermined locations in the load sensing platform (121).

Abstract translation: 公开了负载感测平台（121），用于捕获通过测量肌肉 - 骨骼系统的参数的介质传播的能量波的渡越时间，相位或频率。 负载感测平台（121）包括感测组件（1），基底（702,704和706），弹簧（315），弹簧柱（708）和弹簧保持器（710）。 感测组件（1）包括传感器（5），波导（3）和换能器（6）的堆叠。 将参数应用于负载感测平台（121）的接触表面（8）。 感测组合（1）由于参数而测量尺寸变化。 应用参数的位置可以通过使用多个传感组件（1）来测量。 弹簧（315）耦合到提供机械支撑并防止悬臂的基板（702,704）。 弹簧柱（708）和弹簧保持器（710）将弹簧（315）保持在负载感测平台（121）中的预定位置处。

公开(公告)号：US20080153917A1

公开(公告)日：2008-06-26

申请号：US11574604

申请日：2005-09-09

Applicant: James Ellis ,  Doina Ene ,  Eric Schwartz ,  Nivedita Namdev ,  Claire Brown ,  Sophie Binet-Cross ,  David Meyers

Inventor： James Ellis ,  Doina Ene ,  Eric Schwartz ,  Nivedita Namdev ,  Claire Brown ,  Sophie Binet-Cross ,  David Meyers

IPC: A61K31/165 ,  C07C233/34 ,  A61P11/14 ,  A61P25/28 ,  A61P25/24 ,  A61P37/00 ,  A61P29/00

CPC classification number: C07D295/13 ,  C07C233/40 ,  C07C233/62 ,  C07D207/09 ,  C07D207/14 ,  C07D211/26 ,  C07D211/58

Abstract: The present invention concerns phenylcyclopentylacetamides and phenylcyclopropylcarboxamides and analogues thereof, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract translation: 本发明涉及苯基环戊基乙酰胺和苯基环丙基甲酰胺及其类似物，其制备方法，含有它们的药物组合物及其作为药物的用途。

公开(公告)号：US20060107313A1

公开(公告)日：2006-05-18

申请号：US10986070

申请日：2004-11-12

Applicant: John Crowley ,  Jerry Dowless ,  James Ellis

Inventor： John Crowley ,  Jerry Dowless ,  James Ellis

IPC: H04L9/32

CPC classification number: H04L63/20

Abstract: A method, system, and medium for performing a security analysis of a system, which is comprised of components and paths wherein a user identifies the components and paths of a system, associates a set of predetermined requirements to the components and paths of a system, and wherein the user selects security services to satisfy the requirements of the paths and components of the system. In at least some embodiments of the invention, the method comprises the publication of reports detailing the components, paths, requirements, and security services of a system as well as the rationale that a security service satisfies the requirements mapped to the components and paths of the system.

Abstract translation: 用于执行系统的安全分析的方法，系统和介质，其由用户识别系统的组件和路径的组件和路径组成，将一组预定要求与系统的组件和路径相关联， 并且其中用户选择安全服务以满足系统的路径和组件的要求。 在本发明的至少一些实施例中，该方法包括发布详细描述系统的组件，路径，要求和安全服务的报告，以及安全服务满足映射到组件和路径的组件和路径的要求的原理 系统。

公开(公告)号：US20060005847A1

公开(公告)日：2006-01-12

申请号：US11226571

申请日：2005-09-13

Applicant: Paul Chapman ,  Sara Williard ,  Charles Ashcraft ,  James Ellis ,  James Hutchens ,  Gregory Pierce ,  John Tomel ,  Mark Powell

Inventor： Paul Chapman ,  Sara Williard ,  Charles Ashcraft ,  James Ellis ,  James Hutchens ,  Gregory Pierce ,  John Tomel ,  Mark Powell

IPC: D21F11/00

CPC classification number: A24D1/025

Abstract: Smokable rods of cigarettes are manufactured using wrapping materials that incorporate at least one fibrous material (e.g., flax fibers, hardwood pulp fibers and/or softwood pulp fibers) at least one filler material (e.g., calcium carbonate in particulate form). The wrapping materials possess multi-layer coatings. The wrapping materials possess coatings in the form of series of spaced apart bands, each band possessing a series of layers. At least one of the coating layers can have a filler material dispersed or suspended within a film-forming material of that layer.

公开(公告)号：US06894059B1

公开(公告)日：2005-05-17

申请号：US09937667

申请日：2000-03-23

Applicant: Ralph Scannell ,  Pierre Chatelain ,  Anna Toy-Palmer ,  Edmund Differding ,  James Ellis ,  Marie-Agnes Lassoie ,  Michelle Young ,  Xiong Cai ,  Sajjat Hussoin ,  Gurmit Grewal ,  Timothy Lewis

Inventor： Ralph Scannell ,  Pierre Chatelain ,  Anna Toy-Palmer ,  Edmund Differding ,  James Ellis ,  Marie-Agnes Lassoie ,  Michelle Young ,  Xiong Cai ,  Sajjat Hussoin ,  Gurmit Grewal ,  Timothy Lewis

IPC: C07D295/084 ,  C07D295/088 ,  C07D295/092 ,  C07D295/096 ,  C07D295/125 ,  C07D295/13 ,  C07D295/135 ,  C07D295/15 ,  C07D307/52 ,  A61K31/44 ,  A61K31/445

CPC classification number: C07D295/096 ,  C07D295/084 ,  C07D295/088 ,  C07D295/125 ,  C07D295/13 ,  C07D295/135 ,  C07D295/15 ,  C07D307/52

Abstract: The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

Abstract translation: 本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。 本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。 本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。 这些病症优选包括哮喘，季节性和常年性过敏性鼻炎，窦炎，结膜炎，食物过敏，鲭鱼中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性损伤性肺病，血栓性疾病和中耳炎。 还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

公开(公告)号：US6110666A

公开(公告)日：2000-08-29

申请号：US488145

申请日：1995-06-07

Applicant: Franklin Gerardus Grosveld ,  James Ellis ,  Dimitris Kioussis

Inventor： Franklin Gerardus Grosveld ,  James Ellis ,  Dimitris Kioussis

IPC: A01K67/027 ,  A61K38/00 ,  A61K48/00 ,  C07K14/805 ,  C12N15/10 ,  C12N15/85 ,  C12N15/864 ,  C12Q1/68 ,  C12N15/63 ,  C12N15/64 ,  C12N15/90

CPC classification number: A01K67/0275 ,  A61K48/00 ,  C07K14/805 ,  C12N15/1034 ,  C12N15/85 ,  C12N15/86 ,  A01K2217/05 ,  A61K38/00 ,  C12N2750/14143

Abstract: The invention encompasses a locus control subregion that possesses chromatin opening domain activity, the activity conferring reproducible activation of tissue-specific expression on a linked transgene to a non-physiological level when the transgene is integrated in single copy in the genome of a host cell.

Abstract translation: 本发明包括具有染色质开放结构域活性的基因座控制亚区域，当转基因整合到宿主细胞的基因组中的单拷贝时，活性赋予连接的转基因上的组织特异性表达对非生理学水平的可重复的活化。