公开(公告)号：US20190325113A1

公开(公告)日：2019-10-24

申请号：US15960445

申请日：2018-04-23

Applicant: Michael H. Wigler ,  James Hicks ,  Alexander Krasnitz ,  Anders Zetterberg

Inventor： Michael H. Wigler ,  James Hicks ,  Alexander Krasnitz ,  Anders Zetterberg

IPC: G06F19/18 ,  C12Q1/6886 ,  G16H50/20 ,  G16H50/30 ,  G06F19/24 ,  G06F17/18

Abstract: The present invention provides methods and compositions related to genomic profiling, and in particular, to assigning probabilistic measure of clinical outcome for a patient having a disease or a tumor using segmented genomic profiles such as those produced by representational oligonucleotide microarray analysis (ROMA).

公开(公告)号：US20160251715A1

公开(公告)日：2016-09-01

申请号：US15063278

申请日：2016-03-07

Applicant: James Hicks ,  Nicholas Navin ,  Jennifer Troge ,  Zihua Wang ,  Michael Wigler

Inventor： James Hicks ,  Nicholas Navin ,  Jennifer Troge ,  Zihua Wang ,  Michael Wigler

IPC: C12Q1/68 ,  G06F19/20

CPC classification number: C12Q1/6874 ,  C12Q1/683 ,  C12Q1/6881 ,  C12Q1/6886 ,  C12Q2600/156 ,  G16B25/00 ,  C12Q2525/155 ,  C12Q2525/191 ,  C12Q2535/122 ,  C12Q2537/159 ,  C12Q2537/16

Abstract: A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to amplification by polymerase chain reaction (PCR), generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules having a different tag that have been assigned to the same location on the genome, thereby obtaining genomic copy number information unaffected by amplification distortion.

Abstract translation: 一种用于从基因组材料获得未受扩增变形影响的基因组拷贝数信息的方法，包括获得所述基因组材料的片段，用基本上唯一的标签标记片段以产生标记的核酸分子，使得每个标记的核酸分子包含 基因组材料和标签，通过聚合酶链反应（PCR）对标记的核酸分子进行扩增，通过测序PCR反应的产物产生标签相关序列读数，将每个标记的核酸分子分配到与 基因组材料通过将对应于基因组材料的片段读取的每个标签相关序列的子序列映射到基因组上的位置，并计数已经被分配到相同位置的具有不同标签的标记的核酸分子的数目 基因组，从而获得基因组拷贝数信息 由放大变形引起。

公开(公告)号：US20070207481A1

公开(公告)日：2007-09-06

申请号：US11639674

申请日：2006-12-14

Applicant: Michael Wigler ,  James Hicks ,  Larry Norton ,  Anders Zettenberg

Inventor： Michael Wigler ,  James Hicks ,  Larry Norton ,  Anders Zettenberg

IPC: C12Q1/68 ,  G06F19/00 ,  C07H21/04

CPC classification number: C12Q1/6886 ,  C12Q2600/106

Abstract: The present invention relates to methods and compositions for detecting genomic rearrangements (e.g., amplification) at one or more genetic loci and various applications of such methods and compositions. Examples of genetic loci include HER2, TOP2A and other loci on the human chromosome 17.

Abstract translation: 本发明涉及用于在一个或多个遗传基因座上检测基因组重排（例如扩增）的方法和组合物以及这些方法和组合物的各种应用。 遗传基因的实例包括人染色体17上的HER2，TOP2A和其他基因座。

公开(公告)号：US20060221265A1

公开(公告)日：2006-10-05

申请号：US11097399

申请日：2005-03-31

Applicant: Luan Chen ,  James Hicks ,  Jeffrey Whitelaw

Inventor： Luan Chen ,  James Hicks ,  Jeffrey Whitelaw

IPC: H04N5/645

CPC classification number: H04N5/65 ,  G03B21/56 ,  Y10S348/904

Abstract: An apparatus and methods that facilitate efficient and easy installation of a display screen and protective shield onto a cabinet of a display unit such as a projection TV (PTV) and the like. Preferably, a screen frame and bezel clip system includes a bezel clip having a latch arm releaseably coupleable to catch arm extending from or attached to a cabinet side wall of a display unit. The bezel clip further includes one or more receptacles sized and shaped to receive and retain a side or edge portion of one or more screens. The catch arm is preferably deformable under pressure and returns to a pre-stressed orientation when the pressure is removed. Alternatively, a screen frame and bezel mount system includes a stiffener member adapted to couple a bezel member to a cabinet side wall of a display unit. The bezel member includes one or more receptacles sized and shaped to receive and retain a side or edge portion of one or more screens.

Abstract translation: 有利于将显示屏和保护屏蔽件安装到诸如投影电视（PTV）等的显示单元的机柜上的便利性和方便性的装置和方法。 优选地，屏幕框架和边框夹系统包括具有可释放地联接到从显示单元的机柜侧壁延伸或附接到显示单元的机柜侧壁的止动臂的闩锁臂的挡板夹。 所述挡板夹进一步包括一个或多个容器，其尺寸和形状适于容纳和保持一个或多个屏幕的侧面或边缘部分。 夹臂优选地在压力下变形并且当压力被移除时返回到预应力取向。 或者，屏幕框架和边框安装系统包括适于将边框构件耦合到显示单元的机柜侧壁的加强构件。 边框构件包括一个或多个容器，其尺寸和形状适于容纳和保持一个或多个屏幕的侧面或边缘部分。

公开(公告)号：US20050219425A1

公开(公告)日：2005-10-06

申请号：US10817272

申请日：2004-04-01

Applicant: Brian Maxson ,  James Hicks

Inventor： Brian Maxson ,  James Hicks

IPC: H04N3/26 ,  H04N9/28 ,  H04N17/00

CPC classification number: H04N9/28

Abstract: Systems and methods are provided that facilitate automatic convergence and geometry alignment in projection systems. Preferably, an optical element such as a lens array is coupled to all areas of the projection system's screen and to a detector element such as a photocell array. In operation, each lens of the lens array is adapted to map an individual portion or region of the screen onto the photocell array. A microprocessor, controller or the like uses the data output from the photocells to instruct an alignment controller to center or steer the beams to compensate for convergence error at a particular location. In a center alignment mode, four (4) or more beacon dots located about the periphery of the screen are detected to determine screen size and position, which is used to center the video image and the centers of the mapped regions on the screen.

公开(公告)号：US20050143427A1

公开(公告)日：2005-06-30

申请号：US10822389

申请日：2004-04-12

Applicant: Nicole Barvian ,  Cleo Connolly ,  Peter Guzzo ,  James Hamby ,  James Hicks ,  Matthew Johnson ,  Van-Duc Le ,  Lorna Mitchell ,  William Roark

Inventor： Nicole Barvian ,  Cleo Connolly ,  Peter Guzzo ,  James Hamby ,  James Hicks ,  Matthew Johnson ,  Van-Duc Le ,  Lorna Mitchell ,  William Roark

IPC: A61P19/00 ,  C07D209/12 ,  C07D209/14 ,  C07D403/04 ,  C07D413/04 ,  C07D417/02 ,  C07D495/04 ,  A61K31/433 ,  A61K31/4245 ,  C07D413/02

CPC classification number: C07D495/04 ,  C07D209/12 ,  C07D209/14 ,  C07D403/04 ,  C07D413/04 ,  C07D417/02

Abstract: This invention relates to a compound which is [b]-fused bicyclic proline derivative, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the compound or the salt thereof, and methods of treating diseases, including, but not limited to, methods of preventing or inhibiting joint cartilage damage and preventing or treating diseases characterized by joint cartilage damage, joint inflammation, or joint pain. The [b]-fused bicyclic proline derivatives are compounds of Formula I as described above. Diseases characterized by joint cartilage damage or joint pain include, for example, osteoarthritis and rheumatoid arthritis. Rheumatoid arthritis is also characterized by joint inflammation. This invention also relates to methods of synthesizing and preparing the [b]-fused bicyclic proline derivatives, or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及[b]双环脯氨酸衍生物或其药学上可接受的盐的化合物; 包含该化合物或其盐的药物组合物和治疗疾病的方法，包括但不限于预防或抑制关节软骨损伤和预防或治疗以关节软骨损伤，关节炎症或关节疼痛为特征的疾病的方法。 [b]引发的双环脯氨酸衍生物是如上所述的式I化合物。 以关节软骨损伤或关节疼痛为特征的疾病包括例如骨关节炎和类风湿性关节炎。 类风湿性关节炎的特征还在于关节炎。 本发明还涉及合成和制备[b] - 双环脯氨酸衍生物或其药学上可接受的盐的方法。