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21.发明申请Methods and compositions using JNK inhibitors for treatment and management of central nervous system injury 审中-公开使用JNK抑制剂治疗和治疗中枢神经系统损伤的方法和组合公开(公告)号：US20060122179A1
公开(公告)日：2006-06-08
申请号：US11286128
申请日：2005-11-22
Applicant: Jerome Zeldis , Herbert Faleck , Donald Manning
Inventor： Jerome Zeldis , Herbert Faleck , Donald Manning
IPC: A61K31/5377 , A61K31/4245 , A61K31/454 , A61K31/4196 , A61K31/416
CPC classification number: A61K31/416 , A61K31/4196 , A61K31/423 , A61K31/4245 , A61K31/428 , A61K31/4453 , A61K31/454 , A61K31/506 , A61K31/5377
Abstract: Methods of treating, preventing and/or managing a central nervous system injury/damage and related syndromes are disclosed. Specific methods encompass the administration of a JNK inhibitor alone or in combination with a second active agent. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Abstract translation: 公开了治疗，预防和/或治疗中枢神经系统损伤/损伤及相关综合征的方法。 具体方法包括单独或与第二活性剂组合施用JNK抑制剂。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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22.发明申请公开(公告)号：US20060105993A1
公开(公告)日：2006-05-18
申请号：US11325954
申请日：2006-01-04
Applicant: Jerome Zeldis
Inventor： Jerome Zeldis
IPC: A61K31/724 , A61K31/454 , A61K38/18 , A61K38/19 , A61K31/704 , A61K31/522
CPC classification number: A61K31/454 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/00 , A61K31/198 , A61K31/40 , A61K31/4035 , A61K31/425 , A61K31/4439 , A61K31/445 , A61K31/475 , A61K31/515 , A61K31/573 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K35/12 , A61K39/0011 , A61K39/3955 , A61K45/06 , A61K2300/00
Abstract: Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
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23.发明申请Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases 审中-公开使用免疫调节化合物治疗和治疗癌症和其他疾病的方法和组合物公开(公告)号：US20060069065A1
公开(公告)日：2006-03-30
申请号：US11267896
申请日：2005-11-04
Applicant: Jerome Zeldis
Inventor： Jerome Zeldis
IPC: A61K31/724 , A61K31/454 , A61K38/19 , A61K31/4745 , A61K31/56 , A61K31/522
CPC classification number: A61K31/454 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/00 , A61K31/198 , A61K31/40 , A61K31/4035 , A61K31/425 , A61K31/4439 , A61K31/445 , A61K31/475 , A61K31/515 , A61K31/573 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K35/12 , A61K39/0011 , A61K39/3955 , A61K45/06 , A61K2300/00
Abstract: Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Abstract translation: 公开了治疗，预防和/或控制癌症以及与不期望的血管发生相关或特征在于不期望的血管生成的疾病和病症的方法。 具体方法包括单独或与第二活性成分组合施用免疫调节化合物。 本发明还涉及减少或避免与包括施用免疫调节化合物的化学疗法，放射疗法，激素疗法，生物疗法或免疫疗法相关的不良副作用的方法。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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24.发明申请Methods of using and compositions comprising PDE4 modulators for the treatment and management of pulmonary hypertension 审中-公开使用的方法和包含PDE4调节剂的组合物用于治疗和治疗肺动脉高压公开(公告)号：US20050239867A1
公开(公告)日：2005-10-27
申请号：US11111187
申请日：2005-04-21
Applicant: Jerome Zeldis
Inventor： Jerome Zeldis
IPC: A61K31/366 , A61K31/397 , A61K31/40 , A61K31/4035 , A61K31/519 , A61K31/704 , A61K45/06
CPC classification number: A61K45/06 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/4035 , A61K31/519 , A61K31/704 , A61K31/7048 , A61K2300/00
Abstract: Methods of treating, preventing and managing pulmonary hypertension are disclosed. Specific methods encompass the administration of a PDE4 modulator, or a pharmaceutically acceptable salt, solvate (e.g., hydrate), stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, surgery and/or lung transplantation. Specific second active agents are capable of reducing pulmonary artery pressure. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Abstract translation: 公开了治疗，预防和治疗肺动脉高压的方法。 具体方法包括单独使用PDE4调节剂或其药学上可接受的盐，溶剂合物（例如水合物），立体异构体，包合物或前药，或与第二活性剂，外科手术和/或肺移植相结合。 特定的第二活性剂能够降低肺动脉压。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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25.发明申请Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders 审中-公开使用方法和包含免疫调节化合物的组合物用于治疗和管理石棉相关疾病和病症公开(公告)号：US20050100529A1
公开(公告)日：2005-05-12
申请号：US10981189
申请日：2004-11-03
Applicant: Jerome Zeldis
Inventor： Jerome Zeldis
IPC: A61K31/00 , A61K31/4525 , A61K31/454 , A61K38/19 , A61K38/20 , A61K38/21 , A61K45/06 , A61K31/138 , A61K31/337 , A61K31/4745 , A61K31/57 , A61K31/7048 , A61K38/12
CPC classification number: A61K31/454 , A61K31/00 , A61K31/4525 , A61K38/193 , A61K38/2013 , A61K38/21 , A61K45/06 , A61K2300/00
Abstract: Methods of treating, preventing and managing an asbestos-related disease or disorder are disclosed. Specific embodiments encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or chemotherapy, surgery, or radiation therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in the methods of the invention are also disclosed.
Abstract translation: 公开了治疗，预防和治疗石棉相关疾病或病症的方法。 具体实施方案包括单独或与第二活性剂和/或化学疗法，手术或放射治疗组合施用免疫调节化合物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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Patent Agency Ranking
26.发明申请Methods for treatment of ovarian, colorectal or pancreatic cancer using 4-(aminno)-2(2,6-dioxo(3-piperidyl)-isoindoline-1,3-dione 审中-公开使用4-（氨基）-2（2,6-二氧代（3-哌啶基） - 异吲哚啉-1,3-二酮来治疗卵巢癌，结肠直肠癌或胰腺癌的方法公开(公告)号：US20070299020A1
公开(公告)日：2007-12-27
申请号：US11881756
申请日：2007-07-27
Applicant: Jerome Zeldis
Inventor： Jerome Zeldis
IPC: A61K31/704 , A61K31/4353 , A61K31/445 , A61K31/7115 , A61P35/00 , A61K31/706 , A61K31/573
CPC classification number: A61K31/454 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/00 , A61K31/198 , A61K31/40 , A61K31/4035 , A61K31/425 , A61K31/4439 , A61K31/445 , A61K31/475 , A61K31/515 , A61K31/573 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K35/12 , A61K39/0011 , A61K39/3955 , A61K45/06 , A61K2300/00
Abstract: Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Abstract translation: 公开了治疗，预防和/或控制癌症以及与不期望的血管发生相关或特征在于不期望的血管生成的疾病和病症的方法。 具体方法包括单独或与第二活性成分组合施用免疫调节化合物。 本发明还涉及减少或避免与包括施用免疫调节化合物的化学疗法，放射疗法，激素疗法，生物疗法或免疫疗法相关的不良副作用的方法。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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27.发明申请Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline 失效使用1-氧代-2-（2,6-二氧代哌啶-3-基）-4-甲基异吲哚啉处理和治疗脑癌的方法公开(公告)号：US20060199843A1
公开(公告)日：2006-09-07
申请号：US10704237
申请日：2003-11-06
Applicant: Jerome Zeldis
Inventor： Jerome Zeldis
IPC: A61K31/454 , A61K38/19 , A61K38/20 , A61K38/18 , A61K31/704 , A61K31/522 , A61K31/496 , A61K31/4745 , A61K31/573 , A61K31/203 , A61K31/415
CPC classification number: A61K31/00 , A61K31/203 , A61K31/404 , A61K31/415 , A61K31/454 , A61K31/4745 , A61K31/496 , A61K31/522 , A61K31/573 , A61K31/704 , A61K38/1816 , A61K38/193 , A61K38/2013 , A61K38/21 , A61K41/00 , A61K45/06 , A61K2300/00
Abstract: Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Abstract translation: 公开了治疗，预防和/或控制癌症以及与不期望的血管发生相关或特征在于不期望的血管生成的疾病和病症的方法。 具体方法包括单独或与第二活性成分组合施用免疫调节化合物。 本发明还涉及减少或避免与包括施用免疫调节化合物的化学疗法，放射疗法，激素疗法，生物疗法或免疫疗法相关的不良副作用的方法。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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28.发明申请Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate 审中-公开用D-threo哌甲酯治疗认知和绝经障碍的方法公开(公告)号：US20060183774A1
公开(公告)日：2006-08-17
申请号：US11402385
申请日：2006-04-11
Applicant: Jerome Zeldis , Andrew Zeitlin , Herbert Faleck , Vikram Khetani , Maghsoud Dariani , David Sterling
Inventor： Jerome Zeldis , Andrew Zeitlin , Herbert Faleck , Vikram Khetani , Maghsoud Dariani , David Sterling
IPC: A61K31/445
CPC classification number: C07D211/34 , A61K31/4458 , A61K45/06 , C12P17/12 , C12P41/006 , A61K2300/00
Abstract: In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invention is directed to methods for treating disorders related to menopause, including executive function defects. The methods involve the administration of a composition comprising D-threo methylphenidate that is substantially free of L-threo methylphenidate and of erythro forms of methylphenidate.
Abstract translation: 一方面，本发明涉及用于治疗疲劳，神经行为减缓以及由于与癌症相关的癌症和治疗以及类似病症引起的其他认知障碍和缺陷的方法。 在另一方面，本发明涉及治疗与绝经相关的疾病的方法，包括执行功能缺陷。 所述方法包括施用包含基本上不含有哌甲酯和类似哌甲酯的红霉素的基本上不含哌甲酯的组合物。
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29.发明申请Methods for treatment and management of lung cancer using 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione 审中-公开使用4-（氨基）-2-（2,6-二氧代（3-哌啶基）） - 异吲哚啉-1,3-二酮治疗和治疗肺癌的方法公开(公告)号：US20060172970A1
公开(公告)日：2006-08-03
申请号：US11370560
申请日：2006-03-07
Applicant: Jerome Zeldis
Inventor： Jerome Zeldis
IPC: A61K31/724 , A61K31/454
CPC classification number: A61K31/454 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/00 , A61K31/198 , A61K31/40 , A61K31/4035 , A61K31/425 , A61K31/4439 , A61K31/445 , A61K31/475 , A61K31/515 , A61K31/573 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K35/12 , A61K39/0011 , A61K39/3955 , A61K45/06 , A61K2300/00
Abstract: Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Abstract translation: 公开了治疗，预防和/或控制癌症以及与不期望的血管发生相关或特征在于不期望的血管生成的疾病和病症的方法。 具体方法包括单独或与第二活性成分组合施用免疫调节化合物。 本发明还涉及减少或避免与包括施用免疫调节化合物的化学疗法，放射疗法，激素疗法，生物疗法或免疫疗法相关的不良副作用的方法。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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30.发明申请Methods of using and compositions comprising PDE4 modulators for treatment, prevention and management airway inflammation 审中-公开使用方法和包含PDE4调节剂的治疗，预防和管理气道炎症的组合物公开(公告)号：US20060148882A1
公开(公告)日：2006-07-06
申请号：US11299702
申请日：2005-12-13
Applicant: Jerome Zeldis , Patricia Rohane , Peter Schafer
Inventor： Jerome Zeldis , Patricia Rohane , Peter Schafer
IPC: A61K31/4035 , A61K31/522 , A61K31/557
CPC classification number: A61K31/4245 , A61K31/00 , A61K31/403 , A61K31/4035 , A61K31/522 , A61K31/557 , A61K45/06 , A61K2300/00
Abstract: Methods of treating, preventing, and managing airway inflammation and other airway or pulmonary diseases and disorders are disclosed. Specific methods comprise the administration of a PDE4 modulator, or a pharmaceutically acceptable salt, solvate, stereoisomer, or prodrug thereof, alone or in combination with a second active agent and/or other conventional therapies. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Abstract translation: 公开了治疗，预防和管理气道炎症和其它气道或肺部疾病和病症的方法。 具体方法包括单独或与第二活性剂和/或其它常规疗法组合施用PDE4调节剂或其药学上可接受的盐，溶剂合物，立体异构体或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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