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    Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
    1.
    发明申请
    Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system 审中-公开
    使用方法和包含选择性细胞因子抑制药物的组合物用于治疗和控制中枢神经系统疾病

    公开(公告)号：US20070190070A1

    公开(公告)日：2007-08-16

    申请号：US10590575

    申请日：2004-09-03

    Applicant: Jerome Zeldis ,  Peter Schafer

    Inventor： Jerome Zeldis ,  Peter Schafer

    IPC: A61K31/4704 ,  A61K31/425 ,  A61K31/4035

    CPC classification number: A61K31/4035 ,  A61K31/425 ,  A61K31/4704

    Abstract: Methods of treating, preventing and/or managing central nervous system disorders, such as Parkinson disease, Alzheimer disease, mild cognitive impairment, Huntington disease, Amytophic Lateral Sclerosis, depression and defective long-term memory, and related syndromes are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active ingredient. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

    Abstract translation: 公开了治疗，预防和/或控制中枢神经系统疾病如帕金森病，阿尔茨海默病，轻度认知障碍，亨廷顿舞蹈症，扁桃腺侧索硬化，抑郁症和有缺陷的长期记忆的方法和相关综合征。 具体方法包括单独或与第二活性成分组合施用选择性细胞因子抑制药物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

    Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases
    2.
    发明申请
    Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases 审中-公开
    使用方法和包含选择性细胞因子抑制药物的组合物用于治疗和治疗骨髓增生性疾病

    公开(公告)号：US20060165649A1

    公开(公告)日：2006-07-27

    申请号：US10534324

    申请日：2003-04-13

    Applicant: Jerome Zeldis

    Inventor： Jerome Zeldis

    IPC: A61K38/19 ,  A61K38/21 ,  A61K35/14 ,  A61K31/704 ,  A61K31/724 ,  A61K31/573

    CPC classification number: A61K38/212 ,  A61K31/573 ,  A61K31/704 ,  A61K31/724 ,  A61K2300/00

    Abstract: Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, and/or the transplantation of blood or cells. Particular second active agent is capable of suppressing the overproduction of hematopoietic stem cells or ameliorating one or more of the symptoms of MPD. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

    Abstract translation: 公开了治疗，预防和/或治疗骨髓增生性疾病的方法。 具体方法包括单独或与第二活性剂组合施用选择性细胞因子抑制药物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药，和/或移植血液或细胞。 特别的第二活性剂能够抑制造血干细胞的过量产生或改善一种或多种MPD症状。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

    Methods and compositions for the prevention and treatment of atherosclerosis, restenosis and related disorders
    4.
    发明申请
    Methods and compositions for the prevention and treatment of atherosclerosis, restenosis and related disorders 失效
    用于预防和治疗动脉粥样硬化，再狭窄和相关疾病的方法和组合物

    公开(公告)号：US20060004054A1

    公开(公告)日：2006-01-05

    申请号：US11216950

    申请日：2005-08-30

    Applicant: Jerome Zeldis

    Inventor： Jerome Zeldis

    IPC: A61K31/454 ,  A61K31/277

    CPC classification number: A61K31/445 ,  A61K9/0024 ,  A61K31/16 ,  A61K31/165 ,  A61K31/195 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/44 ,  A61K31/454

    Abstract: Methods and compositions for the prevention and treatment of all forms of atherosclerosis are described. Administration of compounds such as thalidomide, its analogs, hydrolysis products, metabolites, derivatives and precursors as well as additional compounds capable of inhibiting tumor necrosis factor α(TNF-α) are used in the invention. Also disclosed is the coating of prosthetic devices, such as stents, with the compounds of the invention for the prevention and/or treatment of restenosis.

    Abstract translation: 描述了用于预防和治疗所有形式的动脉粥样硬化的方法和组合物。 在本发明中使用诸如沙利度胺，其类似物，水解产物，代谢产物，衍生物和前体的化合物以及能够抑制肿瘤坏死因子α（TNF-α）的其它化合物的给药。 还公开了将假体装置（例如支架）与本发明的化合物一起涂覆以预防和/或治疗再狭窄。

    Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
    5.
    发明申请
    Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases 审中-公开
    使用免疫调节化合物治疗和治疗中枢神经系统疾病或疾病的方法和组合物

    公开(公告)号：US20050143344A1

    公开(公告)日：2005-06-30

    申请号：US11022075

    申请日：2004-12-23

    Applicant: Jerome Zeldis ,  Herbert Faleck ,  Peter Schafer

    Inventor： Jerome Zeldis ,  Herbert Faleck ,  Peter Schafer

    IPC: A61K31/00 ,  A61K31/454 ,  A61K31/724

    CPC classification number: A61K31/454 ,  A61K31/00

    Abstract: Methods of treating, preventing and/or managing central nervous system disorders, such as Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease) and related syndromes are disclosed. Specific methods encompass the administration of an immunomodulatory compound of the invention, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active ingredient. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

    Abstract translation: 公开了治疗，预防和/或控制中枢神经系统疾病如肌萎缩性侧索硬化症（ALS或Lou Gehrig's disease）及相关综合征的方法。 具体方法包括单独或与第二活性成分组合施用本发明的免疫调节化合物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

    Drug-coated stents and methods of use therefor
    6.
    发明申请
    Drug-coated stents and methods of use therefor 审中-公开
    药物涂层支架及其使用方法

    公开(公告)号：US20050019366A1

    公开(公告)日：2005-01-27

    申请号：US10749344

    申请日：2003-12-30

    Applicant: Jerome Zeldis

    Inventor： Jerome Zeldis

    IPC: A61K31/415 ,  A61L31/16 ,  A61F2/00

    CPC classification number: A61L31/16 ,  A61K31/415 ,  A61L2300/434

    Abstract: This invention relates to stents comprising an effective amount of a c-Jun N-terminal kinase (“JNK”) Inhibitor, the stents being useful for treating or preventing a cardiovascular or renal disease. The invention also relates to the treatment or prevention of cardiovascular or renal disease, such as atherosclerosis or restenosis, comprising implanting into a patient in need thereof of a stent comprising an effective amount of a JNK Inhibitor.

    Abstract translation: 本发明涉及包含有效量的c-Jun N-末端激酶（“JNK”）抑制剂的支架，该支架可用于治疗或预防心血管或肾脏疾病。 本发明还涉及治疗或预防心血管或肾脏疾病，例如动脉粥样硬化或再狭窄，其包括向有需要的患者植入含有有效量的JNK抑制剂的支架。

    Methods using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of mantle cell lymphomas
    7.
    发明申请
    Methods using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of mantle cell lymphomas 审中-公开
    使用3-（4-氨基-1-氧代-1,3-二氢 - 异吲哚-2-基） - 哌啶-2,6-二酮处理套细胞淋巴瘤的方法

    公开(公告)号：US20080038263A1

    公开(公告)日：2008-02-14

    申请号：US11888881

    申请日：2007-08-01

    Applicant: Jerome Zeldis

    Inventor： Jerome Zeldis

    IPC: A61K31/496 ,  A61K39/395 ,  A61P35/00

    CPC classification number: A61K31/454 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/573 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2300/00

    Abstract: Methods of treating, preventing or managing mantle cell lymphomas are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as Revlimid® or lenalidomide. The invention further relates to methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods of the invention are also disclosed.

    Abstract translation: 公开了治疗，预防或治疗外套细胞淋巴瘤的方法。 所述方法包括施用称为Revlimid或来那度胺的本发明的免疫调节化合物。 本发明还涉及使用该化合物与化学疗法，放射疗法，激素疗法，生物疗法或免疫治疗方法。 还公开了适用于本发明方法的药物组合物和单一单位剂型。

    Methods And Compositions Using Thalidomide For The Treatment And Management Of Cancers And Other Diseases
    9.
    发明申请
    Methods And Compositions Using Thalidomide For The Treatment And Management Of Cancers And Other Diseases 审中-公开
    方法和组合使用沙利度胺治疗和治疗癌症和其他疾病

    公开(公告)号：US20070208057A1

    公开(公告)日：2007-09-06

    申请号：US10576138

    申请日：2004-11-04

    Applicant: Jerome Zeldis

    Inventor： Jerome Zeldis

    IPC: A61K31/454

    CPC classification number: A61K31/454 ,  A61K31/00 ,  A61K45/06 ,  A61K2300/00

    Abstract: Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of thalidomide alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of thalidomide. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

    Abstract translation: 公开了治疗，预防和/或控制癌症以及与不期望的血管发生相关或特征在于不期望的血管生成的疾病和病症的方法。 具体方法包括单独或与第二活性成分组合施用沙利度胺。 本发明还涉及减少或避免与化疗，放射疗法，激素治疗，生物治疗或免疫治疗相关的不利副作用的方法，其包括施用沙利度胺。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

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