公开(公告)号：US20070263049A1

公开(公告)日：2007-11-15

申请号：US11804093

申请日：2007-05-17

Applicant: Tobias Preckel ,  Hans-Peter Zimmermann ,  Konstantin Choikhet

Inventor： Tobias Preckel ,  Hans-Peter Zimmermann ,  Konstantin Choikhet

IPC: B41J2/175

CPC classification number: B01L3/502715 ,  B01F5/0683 ,  B01F5/0689 ,  B01F11/0045 ,  B01F11/0071 ,  B01F15/0205 ,  B01F15/0212 ,  B01L3/502738 ,  B01L3/505 ,  B01L2200/0642 ,  B01L2400/0481 ,  B01L2400/0638

Abstract: A supply arrangement includes a supply reservoir element and a microfluidic device, wherein the supply reservoir element has a first reservoir unit having a prefilled liquid reagent therein, and the microfluidic device has a reception device adapted for receiving the liquid reagent from the first reservoir unit. The supply reservoir element is coupled to the microfluidic device. One of the supply reservoir element and the microfluidic device includes a puncturing element in order to cause fluid flow of the liquid reagent from the first reservoir unit to the reception device when the puncturing element is operated. The supply reservoir element has a basal plane, and the first reservoir unit has a first blister element arranged on the basal plane.

Abstract translation: 供应装置包括供应储存器元件和微流体装置，其中所述供应储存器元件具有其中具有预充式液体试剂的第一储存器单元，并且所述微流体装置具有适于从所述第一储存器单元接收所述液体试剂的接收装置。 供应储存器元件联接到微流体装置。 供应储存器元件和微流体装置中的一个包括穿刺元件，以便当穿刺元件操作时使液体试剂从第一储存器单元流体流向接收装置。 供给储存元件具有基面，第一储存器单元具有布置在基面上的第一泡罩元件。

公开(公告)号：US20100299079A1

公开(公告)日：2010-11-25

申请号：US12763806

申请日：2010-04-20

Applicant: Manfred Berndt ,  Konstantin Choikhet ,  Philip Herzog

Inventor： Manfred Berndt ,  Konstantin Choikhet ,  Philip Herzog

IPC: G01N30/02 ,  F04B49/10 ,  F04B49/00

CPC classification number: F04B23/06 ,  F04B11/0075 ,  F04B53/08 ,  F04B2205/10 ,  F04B2205/112 ,  G01N30/24 ,  G01N30/30

Abstract: A pump unit comprises a primary piston pump, a secondary piston pump, and a flow path adapted for fluidically connecting in series the primary piston pump and the secondary piston pump. The pump unit's duty cycle comprises a delivery-and-fill phase, in which the primary piston pump supplies a flow of liquid to the secondary piston pump, and during the delivery-and-fill phase, the flow of liquid supplied by the primary piston pump is partly used for filling up the secondary piston pump and partly used for maintaining another flow of liquid dispensed across the secondary piston pump. The flow path comprises a heat exchanger, wherein liquid supplied by the primary piston pump passes through the heat exchanger before being supplied to the secondary piston pump. The heat exchanger is adapted for reducing a temperature difference between a temperature of liquid supplied to heat exchanger and a temperature of the secondary piston pump, in that the heat exchanger is kept at a temperature of the secondary piston pump, so that after having passed the heat exchanger, liquid supplied to the secondary piston pump has substantially the same temperature as the secondary piston pump itself.

Abstract translation: 泵单元包括主活塞泵，次级活塞泵和适于串联流体连接主活塞泵和次级活塞泵的流路。 泵单元的占空比包括输送和填充阶段，其中主活塞泵将液体流供应到次级活塞泵，并且在输送和填充阶段期间，由主活塞泵供应的液体流 泵部分地用于填充次级活塞泵，并且部分地用于保持分配在次级活塞泵上的另外的液体流。 流路包括热交换器，其中由主活塞泵供应的液体在被供应到次级活塞泵之前通过热交换器。 热交换器适于减少供应到热交换器的液体的温度与次级活塞泵的温度之间的温度差，因为热交换器保持在次级活塞泵的温度，使得在通过 热交换器，供应到次级活塞泵的液体具有与次级活塞泵本身基本相同的温度。

公开(公告)号：US07685866B2

公开(公告)日：2010-03-30

申请号：US11221158

申请日：2005-09-07

Applicant: Alexander Bierbaum ,  Hans-Georg Weissgerber ,  Konstantin Choikhet

Inventor： Alexander Bierbaum ,  Hans-Georg Weissgerber ,  Konstantin Choikhet

IPC: G01M3/08

CPC classification number: G01N30/32 ,  F04B11/0075 ,  G01N2030/324 ,  G01N2030/326

Abstract: A liquid delivery system having at least one channel, at least one valve within that channel, at least one flow sensing device within that channel, and a pressure source downstream of the valve capable for generating variable pressures.

Abstract translation: 具有至少一个通道的液体输送系统，该通道内的至少一个阀，该通道内的至少一个流量感测装置，以及能够产生可变压力的阀下游的压力源。

公开(公告)号：US20070116609A1

公开(公告)日：2007-05-24

申请号：US11654210

申请日：2007-01-17

Applicant: Martin Baeuerle ,  Hans-Peter Zimmermann ,  Konstantin Choikhet ,  Tobias Preckel

Inventor： Martin Baeuerle ,  Hans-Peter Zimmermann ,  Konstantin Choikhet ,  Tobias Preckel

IPC: B01L3/02

CPC classification number: G01N30/74 ,  B01L3/502715 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0654 ,  B01L2300/0877 ,  B01L2300/168 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2030/746 ,  G01N30/6095

Abstract: A microfluidic arrangement (1) for the optical detection of fluids is provided, comprising a microfluidic device (2) having at least one first channel (3) with an opening (4) which is in fluid communication with an optical detection unit (6) of an optical device (5); the microfluidic device (2) being operatively detachably coupled with the optical device (5) whereby an extension of the part (7,7′) of relevance of the optical detection path (17) is provided. A method for detecting fluids using the arrangement of the present invention is provided.

Abstract translation: 提供了一种用于流体光学检测的微流体装置（1），包括具有至少一个具有与光学检测单元（6）流体连通的开口（4）的至少一个第一通道（3）的微流体装置（2） 的光学装置（5）; 所述微流体装置（2）可操作地与所述光学装置（5）耦合，由此提供所述光学检测路径（17）的相关部分（7,7'）的延伸。 提供了使用本发明的装置检测流体的方法。

公开(公告)号：US20050158875A1

公开(公告)日：2005-07-21

申请号：US11036616

申请日：2005-01-18

Applicant: Patrick Kaltenbach ,  Konstantin Choikhet ,  Gerhard Ple ,  Clemens Linowski

Inventor： Patrick Kaltenbach ,  Konstantin Choikhet ,  Gerhard Ple ,  Clemens Linowski

IPC: G01N35/10 ,  B01L3/00

CPC classification number: G01N35/1011 ,  Y10T436/2575

Abstract: A liquid transfer appliance and a well plate are moved towards each other and a current is detected that flows upon contact between the liquid transfer appliance and a first electrically conductive element of the well plate. The position of the well plate relative to the liquid transfer appliance is determined at the time of contact. The determined position is used as a reference position for further positioning at least one of the well plate and the liquid transfer appliance.

Abstract translation: 液体输送器具和孔板彼此相对移动，并且检测在液体转移器具和孔板的第一导电元件之间接触时流动的电流。 在接触时确定孔板相对于液体转移器具的位置。 确定的位置用作用于进一步定位井板和液体输送装置中的至少一个的参考位置。

公开(公告)号：US20070240773A1

公开(公告)日：2007-10-18

申请号：US11807242

申请日：2007-05-25

Applicant: Hans-Peter Zimmermann ,  Konstantin Choikhet ,  Tobias Preckel

Inventor： Hans-Peter Zimmermann ,  Konstantin Choikhet ,  Tobias Preckel

IPC: F16K37/00 ,  E03B7/07

CPC classification number: G01N21/05 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2400/0644 ,  F16K99/0001 ,  F16K99/0013 ,  F16K2099/0084 ,  G01N2021/0346 ,  Y10T137/8242 ,  Y10T137/8326

Abstract: Methods and devices for delivering fluids into microfluidic device body structures (112, 202, 316, 508) are described. The methods and devices include the use of fluid manifolds (200, 300, 400, 500) which are integrated or interchangeable with device body structures. Methods of fabricating manifolds are also provided.

Abstract translation: 描述了将流体输送到微流体装置主体结构（112,202,316,508）中的方法和装置。 所述方法和装置包括使用与装置主体结构集成或可互换的流体歧管（200,300,400,500）。 还提供了制造歧管的方法。

公开(公告)号：US06629775B2

公开(公告)日：2003-10-07

申请号：US09903963

申请日：2001-07-12

Applicant: Konstantin Choikhet ,  Gerard Rozing

Inventor： Konstantin Choikhet ,  Gerard Rozing

IPC: B01F506

CPC classification number: B01F5/0602 ,  B01F5/064

Abstract: Disclosed is a mixing apparatus where a fluid is progressing from an Inlet tubing to an Outlet tubing. Every segment of the liquid is part by part transferred to the Outlet channel via numerous restrictor channels. The distances between the restrictor channels determine a dispersion pattern for any segment of the flow, progressing from the inlet chamber in the form of a reservoir channel to the Outlet. The nearer the outlet channels are placed one to another, the higher is the permeability to the outlet collector at the respective location. Delaying partial flows of the fluid with different flow delays and providing different flow volumes for the partial flows results in a predetermined flow distribution function thus determining a dispersion pattern. This allows for a continuous dispersion of a fluid property which is intended to be mixed, in accordance with a predefined fluid distribution function.

Abstract translation: 公开了一种混合装置，其中流体从入口管道进入出口管道。 液体的每个部分通过许多限流器通道部分地部分转移到出口通道。 限流器通道之间的距离确定了流体的任何段的分散模式，从储存器通道形式的入口室进入出口。 出口通道越靠近放置，相应位置的出口收集器的渗透性越高。 延迟具有不同流动延迟的流体的部分流动并且为部分流提供不同的流量导致预定的流量分布函数，从而确定分散模式。 这允许根据预定的流体分配功能连续分散旨在混合的流体性质。

公开(公告)号：US06601439B2

公开(公告)日：2003-08-05

申请号：US09907365

申请日：2001-07-17

Applicant: Konstantin Choikhet

Inventor： Konstantin Choikhet

IPC: G01N3054

CPC classification number: G01N30/30 ,  G01N30/54 ,  G01N2030/027

Abstract: A method of reducing baseline instabilities in liquid chromatographic measurements is disclosed. A mobile phase comprising sample substances passes through a chromatographic column comprising a stationary phase, and subsequently through a detector. An additional solid body or liquid bath having a high heat capacity and heat conductance is coupled to the column and to an inlet capillary of the column such that the inlet capillary and the column are enclosed by said solid body or liquid bath. In that way temperature stabilization of the column and inlet capillaries is achieved and baseline variations due to temperature dependent adsorption of water at the stationary phase, in particular stationary phases with amino functional groups, are reduced.

Abstract translation: 公开了一种降低液相色谱测量中基线不稳定性的方法。 包含样品物质的流动相通过包含固定相的色谱柱，随后通过检测器。 具有高热容量和热导率的另外的固体或液体浴连接到塔和塔的入口毛细管，使得入口毛细管和塔被所述固体或液体浴包围。 以这种方式实现柱和入口毛细管的温度稳定性，并且由于在固定相，特别是具有氨基官能团的固定相的温度依赖性吸附而导致的基线变化减小。

公开(公告)号：US09671375B2

公开(公告)日：2017-06-06

申请号：US14344113

申请日：2011-09-15

Applicant: Martin Baeuerle ,  Konstantin Choikhet

Inventor： Martin Baeuerle ,  Konstantin Choikhet

IPC: G01N30/32 ,  B01L3/00 ,  B01D15/10 ,  B01D53/02 ,  B01D57/02 ,  G01L13/02 ,  G01L13/06 ,  G01L27/00 ,  G01N30/36 ,  G01N30/60

CPC classification number: G01N30/32 ,  B01D15/10 ,  B01D53/025 ,  B01D57/02 ,  B01L3/5027 ,  B01L2200/146 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/14 ,  B01L2400/0487 ,  G01L13/023 ,  G01L13/06 ,  G01L27/002 ,  G01N30/36 ,  G01N30/6095 ,  G01N2030/326

Abstract: A fluidic chip device configured for processing a fluid, wherein the fluidic chip device comprises a plurality of layers laminated to one another, wherein at least a part of the layers comprises a patterned section of an alternating sequence of bars and fluidic channels for conducting the fluid under pressure, the patterned section being configured for being displaceable in response to the pressure, and a pressure detector responding to the displacement of the patterned section by generating a detector signal being indicative of a value of the pressure.

公开(公告)号：US09417219B2

公开(公告)日：2016-08-16

申请号：US12619283

申请日：2009-11-16

Applicant: Konstantin Choikhet

Inventor： Konstantin Choikhet

IPC: G01N30/02 ,  G01N30/38 ,  G01N30/34 ,  G01N30/20

CPC classification number: G01N30/38 ,  G01N30/20 ,  G01N30/34 ,  G01N2030/347

Abstract: A sample separation device for separating a sample comprises a first fluid supply path for supplying a first fluid, a second fluid supply path for supplying a second fluid, a sample separation unit adapted for separating the sample, a sensor configured for determining a value of a parameter related to the fluid, and a valve configured for selectively coupling both of the first and second fluid supply paths to the sensor and to the sample separation unit, or coupling one of the first and second fluid supply paths to the sensor.

Abstract translation: 用于分离样品的样品分离装置包括用于供应第一流体的第一流体供应路径，用于供应第二流体的第二流体供应路径，适于分离样品的样品分离单元，被配置为确定 与流体相关的参数以及被配置为选择性地将第一和第二流体供应路径耦合到传感器和样品分离单元，或者将第一和第二流体供应路径之一耦合到传感器的阀。