公开(公告)号：US20160135740A1

公开(公告)日：2016-05-19

申请号：US15003644

申请日：2016-01-21

Applicant: MC10, Inc.

Inventor： Roozbeh Ghaffari ,  Gilman Callsen ,  William J. Arora ,  Benjamin Schlatka

IPC: A61B5/00 ,  A61M25/10 ,  A61B5/02

CPC classification number: A61B5/4836 ,  A61B1/00082 ,  A61B1/3137 ,  A61B5/01 ,  A61B5/015 ,  A61B5/02007 ,  A61B5/02014 ,  A61B5/0536 ,  A61B5/6853 ,  A61B5/7271 ,  A61F2/958 ,  A61M25/10 ,  A61M2025/1086

Abstract: A system, device and method are presented for utilizing stretchable active integrated circuits with inflatable bodies. The invention allows for such operative features to come into direct contact with body structures, such as the inner wall of a lumen. Such direct contact increases accuracy of measurement and delivery of therapy.

Abstract translation: 提出了一种利用具有可充气体的可拉伸有源集成电路的系统，装置和方法。 本发明允许这样的操作特征与身体结构（例如内腔的内壁）直接接触。 这种直接接触增加了治疗的测量和传递的准确性。

公开(公告)号：US20160045162A1

公开(公告)日：2016-02-18

申请号：US14924400

申请日：2015-10-27

Applicant: MC10, Inc.

Inventor： Bassel De Graff ,  Roozbeh Ghaffari ,  William J. Arora

IPC: A61B5/00

CPC classification number: H01L27/14692 ,  A61B1/05 ,  A61B5/0024 ,  A61B5/01 ,  A61B5/03 ,  A61B5/04087 ,  A61B5/053 ,  A61B5/6821 ,  A61B5/6833 ,  A61B5/6847 ,  A61B5/6869 ,  A61B8/12 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00339 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/0212 ,  A61B2562/164 ,  A61B2562/166 ,  A61N7/022 ,  H01L27/14618 ,  H01L27/14632 ,  H01L27/14645 ,  H01L27/14687 ,  H01L2924/0002 ,  H01L2924/1433 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/19043 ,  H01L2924/30105 ,  H01L2924/00

Abstract: System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a the brain, or the surface of the heart. Such direct, conformal contact increases accuracy of measurement and delivery of therapy. Further, the invention enables the incorporation of both sensing and therapeutic devices on the same substrate allowing for faster treatment of diseased tissue and fewer devices to perform the same procedure.

Abstract translation: 提出了集成可伸缩或灵活电路的系统，设备和方法，包括用于增强感测，诊断和治疗能力的有源器件阵列。 本发明使得与感兴趣的组织（例如内腔的内壁，大脑或心脏的表面）保形感测接触。 这种直接的共形接触增加了治疗的测量和传递的准确性。 此外，本发明使得能够将感测和治疗装置两者并入同一基底上，允许更快地治疗患病组织和更少的装置来执行相同的程序。

公开(公告)号：US20150342036A1

公开(公告)日：2015-11-26

申请号：US14819040

申请日：2015-08-05

Applicant: MC10, Inc.

Inventor： Brian David Elolampi ,  Roozbeh Ghaffari ,  Bassel de Graff ,  William J. Aurora ,  Xiaolong Hu

IPC: H05K1/02 ,  H05K1/03 ,  H05K1/11 ,  H05K3/46 ,  H05K3/06

CPC classification number: H05K1/0278 ,  H01L21/6835 ,  H01L23/13 ,  H01L23/4985 ,  H01L23/5389 ,  H01L25/0655 ,  H01L25/072 ,  H01L25/50 ,  H01L2221/68318 ,  H01L2221/6835 ,  H01L2221/68368 ,  H01L2221/68381 ,  H01L2224/24137 ,  H01L2224/73267 ,  H01L2224/92244 ,  H01L2924/1461 ,  H05K1/0326 ,  H05K1/0346 ,  H05K1/115 ,  H05K3/067 ,  H05K3/4644 ,  H05K2201/0141 ,  H05K2201/0145 ,  H05K2201/0154 ,  H01L2924/00

Abstract: Flexible electronic structure and methods for fabricating flexible electronic structures are provided. An example method includes applying a first layer to a substrate, creating a plurality of vias through the first layer to the substrate, and applying a second polymer layer to the first layer such that the second polymer forms anchors contacting at least a portion of the substrate. At least one electronic device layer is disposed on a portion of the second polymer layer. At least one trench is formed through the second polymer layer to expose at least a portion of the first layer. At least a portion of the first layer is removed by exposing the structure to a selective etchant to providing a flexible electronic structure that is in contact with the substrate. The electronic structure can be released from the substrate.

Abstract translation: 提供了灵活的电子结构和制造柔性电子结构的方法。 一个示例性方法包括将第一层施加到衬底，产生通过第一层到衬底的多个通孔，以及向第一层施加第二聚合物层，使得第二聚合物形成与衬底的至少一部分接触的锚固件 。 至少一个电子器件层设置在第二聚合物层的一部分上。 通过第二聚合物层形成至少一个沟槽以暴露第一层的至少一部分。 通过将结构暴露于选择性蚀刻剂以提供与衬底接触的柔性电子结构来去除第一层的至少一部分。 电子结构可以从衬底释放。

公开(公告)号：US20150320472A1

公开(公告)日：2015-11-12

申请号：US14726136

申请日：2015-05-29

Applicant: MC10, Inc.

Inventor： Roozbeh Ghaffari ,  Robert D'Angelo ,  Dan Davis ,  Bassel De Graff ,  Kevin Dowling ,  Brian David Elolampi ,  Yung-Yu Hsu ,  Lauren Klinker ,  Stephen P. Lee ,  Cliff Liu

IPC: A61B18/02

CPC classification number: A61B5/0538 ,  A61B5/02158 ,  A61B5/026 ,  A61B5/036 ,  A61B5/0422 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/742 ,  A61B6/12 ,  A61B18/02 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/20 ,  A61B18/24 ,  A61B2017/00526 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00773 ,  A61B2018/00791 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/0212 ,  A61B2090/065 ,  A61B2562/046 ,  A61B2562/125 ,  A61B2562/222 ,  A61M25/1002 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078 ,  Y10T29/49002 ,  Y10T156/1089

Abstract: An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.

Abstract translation: 提供了用于医疗诊断和/或治疗的装置。 该装置包括形成可膨胀体的柔性基底和设置在柔性基底上的多个感测元件。 多个感测元件围绕可充气体设置，使得感测元件以放气状态设置在可充气体的最小曲率的区域。

公开(公告)号：US09123614B2

公开(公告)日：2015-09-01

申请号：US13747826

申请日：2013-01-23

Applicant: MC10, Inc.

Inventor： Bassel de Graff ,  Gilman Callsen ,  William J. Arora ,  Roozbeh Ghaffari

IPC: H01L21/00 ,  H01L27/146 ,  A61B1/04 ,  A61B5/01 ,  A61B5/145

CPC classification number: H01L27/14636 ,  A61B1/04 ,  A61B5/01 ,  A61B5/145 ,  A61B2562/02 ,  A61B2562/0204 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/0247 ,  A61B2562/046 ,  A61B2562/164 ,  H01L27/14609 ,  H01L27/14621 ,  H01L27/14683 ,  H01L27/14687 ,  H01L2224/18 ,  H01L2224/24 ,  H01L2224/24137 ,  H01L2224/82 ,  H01L2924/3512

Abstract: System, devices and methods are presented that provide an imaging array fabrication process method, comprising fabricating an array of semiconductor imaging elements, interconnecting the elements with stretchable interconnections, and transfer printing the array with a pre-strained elastomeric stamp to a secondary non-planar surface.

Abstract translation: 提供了提供成像阵列制造工艺方法的系统，装置和方法，其包括制造半导体成像元件阵列，将元件与可拉伸的互连互连，并将具有预应变弹性体印模的阵列转印到次级非平面 表面。

公开(公告)号：US09119533B2

公开(公告)日：2015-09-01

申请号：US14093329

申请日：2013-11-29

Applicant: MC10, Inc.

Inventor： Roozbeh Ghaffari

IPC: H01L21/00 ,  A61B5/00 ,  H01L27/146 ,  A61B5/01 ,  A61B5/03 ,  A61B5/053 ,  A61B18/02 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61N7/02

CPC classification number: A61B5/683 ,  A61B1/05 ,  A61B5/0024 ,  A61B5/0031 ,  A61B5/0059 ,  A61B5/01 ,  A61B5/03 ,  A61B5/04087 ,  A61B5/053 ,  A61B5/6821 ,  A61B5/6833 ,  A61B5/6847 ,  A61B5/6869 ,  A61B5/743 ,  A61B8/12 ,  A61B18/02 ,  A61B18/14 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00339 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/0212 ,  A61B2562/164 ,  A61B2562/166 ,  A61N7/022 ,  H01L27/14618 ,  H01L27/14632 ,  H01L27/14645 ,  H01L27/14687 ,  H01L27/14692 ,  H01L2924/0002 ,  H01L2924/1433 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/19043 ,  H01L2924/30105 ,  H01L2924/00

Abstract: System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a the brain, or the surface of the heart. Such direct, conformal contact increases accuracy of measurement and delivery of therapy. Further, the invention enables the incorporation of both sensing and therapeutic devices on the same substrate allowing for faster treatment of diseased tissue and fewer devices to perform the same procedure.

Abstract translation: 提出了集成可伸缩或灵活电路的系统，设备和方法，包括用于增强感测，诊断和治疗能力的有源器件阵列。 本发明使得与感兴趣的组织（例如内腔的内壁，大脑或心脏的表面）保形感测接触。 这种直接的共形接触增加了治疗的测量和传递的准确性。 此外，本发明使得能够将感测和治疗装置两者并入同一基底上，允许更快地治疗患病组织和更少的装置来执行相同的程序。

公开(公告)号：US20150069617A1

公开(公告)日：2015-03-12

申请号：US14488544

申请日：2014-09-17

Applicant: MC10, Inc.

Inventor： William J. Arora ,  Roozbeh Ghaffari

IPC: H01L23/00 ,  H01L23/528

CPC classification number: H05K1/0283 ,  A61F2/958 ,  H01L23/3121 ,  H01L23/4985 ,  H01L23/52 ,  H01L23/528 ,  H01L23/564 ,  H01L25/16 ,  H01L2924/0002 ,  H05K1/00 ,  H05K1/189 ,  H05K3/326 ,  H05K2201/09263 ,  H05K2201/10106 ,  Y10T29/4913 ,  Y10T29/49155 ,  Y10T29/49204 ,  H01L2924/00

Abstract: In embodiments, the present invention may attach at least two isolated electronic components to an elastomeric substrate, and arrange an electrical interconnection between the components in a boustrophedonic pattern interconnecting the two isolated electronic components with the electrical interconnection. The elastomeric substrate may then be stretched such that the components separate relative to one another, where the electrical interconnection maintains substantially identical electrical performance characteristics during stretching, and where the stretching may extend the separation distance between the electrical components to many times that of the un-stretched distance.

Abstract translation: 在实施例中，本发明可以将至少两个隔离的电子部件连接到弹性体基板上，并且以将两个隔离的电子部件与电互连互连的连接方式布置在组件之间的电互连。 然后弹性体基底可以被拉伸，使得部件相对于彼此分离，其中电互连在拉伸期间保持基本上相同的电性能特征，并且其中拉伸可将电气部件之间的间隔距离延伸到un 伸展距离。

公开(公告)号：US20180199884A1

公开(公告)日：2018-07-19

申请号：US15921076

申请日：2018-03-14

Applicant: MC10, Inc.

Inventor： Gilbert Lee Huppert ,  Roozbeh Ghaffari ,  Melissa Ceruolo ,  Bryan Keen ,  Milan Raj ,  Bryan McGrane

IPC: A61B5/00

CPC classification number: A61B5/6833 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/01 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/02444 ,  A61B5/0408 ,  A61B5/04085 ,  A61B5/04087 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/08 ,  A61B5/4815 ,  A61B5/4839 ,  A61B5/486 ,  A61B5/4866 ,  A61B5/4875 ,  A61B5/7271 ,  A61B2560/0214 ,  A61B2560/0475 ,  A61B2562/0219 ,  A61B2562/08 ,  A61B2562/164 ,  A61M37/00

Abstract: Systems, methods and apparatuses for monitoring cardiac activity of an individual using a conformal cardiac sensor device are presented herein. A conformal cardiac sensor device for analyzing cardiac activity includes a flexible substrate for coupling to the user, and a heart sensor component embedded on/in the substrate. The heart sensor component contacts a portion of the user's skin and measures electrical variable(s) indicative of cardiac activity. A biometric sensor component is embedded on/in the flexible substrate and measures physiological variable(s) indicative of cardiac activity of the user. A microprocessor, which is embedded on/in the flexible substrate, is communicatively coupled to the heart sensor component and biometric sensor component and operable to execute microprocessor executable instructions for controlling the measurements of electrical data and physiological data. A wireless communication component is embedded on/in the flexible substrate and is operable to transmit data indicative of the measurements obtained by the sensor components.

公开(公告)号：US20180190704A1

公开(公告)日：2018-07-05

申请号：US15620181

申请日：2017-06-12

Applicant: MC10, Inc.

Inventor： Bassel de Graff ,  Gilman Callsen ,  William J. Arora ,  Roozbeh Ghaffari

IPC: H01L27/146 ,  A61B1/04 ,  A61B5/145 ,  A61B5/01

CPC classification number: H01L27/14636 ,  A61B1/04 ,  A61B5/01 ,  A61B5/145 ,  A61B2562/02 ,  A61B2562/0204 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/0247 ,  A61B2562/046 ,  A61B2562/164 ,  H01L27/14609 ,  H01L27/14621 ,  H01L27/14683 ,  H01L27/14687 ,  H01L2224/18 ,  H01L2224/24 ,  H01L2224/24137 ,  H01L2224/82 ,  H01L2924/3512

Abstract: System, devices and methods are presented that provide an imaging array fabrication process method, comprising fabricating an array of semiconductor imaging elements, interconnecting the elements with stretchable interconnections, and transfer printing the array with a pre-strained elastomeric stamp to a secondary non-planar surface.

公开(公告)号：US09750421B2

公开(公告)日：2017-09-05

申请号：US15047333

申请日：2016-02-18

Applicant: MC10, Inc.

Inventor： Roozbeh Ghaffari ,  Stephen Lee ,  John Work ,  John A. Wright, Jr. ,  Lauren Klinker

IPC: A61B18/18 ,  A61B5/027 ,  A61N1/36 ,  A61B34/35 ,  A61B90/70 ,  A61B18/14 ,  A61N1/05 ,  A61B90/30 ,  A61B5/00 ,  A61B18/00 ,  A61B34/00 ,  A61B90/00 ,  A61N7/02 ,  A61B18/02 ,  A61B18/22

CPC classification number: A61B5/027 ,  A61B5/6851 ,  A61B18/02 ,  A61B18/1492 ,  A61B18/22 ,  A61B34/25 ,  A61B34/35 ,  A61B90/30 ,  A61B90/70 ,  A61B2018/00005 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00386 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00494 ,  A61B2018/00511 ,  A61B2018/00517 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00666 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00708 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61B2018/0212 ,  A61B2018/1861 ,  A61B2034/252 ,  A61B2034/254 ,  A61B2090/065 ,  A61N1/0514 ,  A61N1/36007 ,  A61N1/36135 ,  A61N7/02

Abstract: Devices and methods are provided for performing procedure on tissue with flow monitoring using flow sensors. The devices include an elongated member, and at least one flow sensor disposed on the elongated member. The flow sensor includes at least one temperature sensor and at least one heating element having a cavity. At least a portion of the at least one temperature sensor is housed in the cavity. A temperature measurement of the temperature sensor provides an indication of the flow rate of a fluid proximate to the flow sensor.