中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

36 records (took 0.021 seconds)

    HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES
    23.
    发明申请
    HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES 有权

    公开(公告)号：US20210155976A1

    公开(公告)日：2021-05-27

    申请号：US17126439

    申请日：2020-12-18

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Frank Bergmann ,  Dieter Heindl ,  Michael Schraeml ,  Johannes Stoeckel

    IPC: C12Q1/6816

    Abstract: The present report relates to hybridizing single-stranded (ss-) oligonucleotides which entirely consist of locked nucleic acid (LNA) monomers. The present document shows hybridization experiments with pairs of entirely complementary ss-oligonucleotides which fail to form a duplex within a given time interval. The present report provides methods to identify such incompatible oligonucleotide pairs. In another aspect, the present report provides pairs of complementary ss-oligonucleotides which are capable of rapid duplex formation. The present report also provides methods to identify and select compatible oligonucleotide pairs. In yet another aspect the present report provides use of compatible oligonucleotide pairs as binding partners in binding assays, e.g. immunoassays.

    BINDING AGENT
    24.
    发明申请
    BINDING AGENT 审中-公开

    公开(公告)号：US20200277406A1

    公开(公告)日：2020-09-03

    申请号：US16821537

    申请日：2020-03-17

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

    IPC: C07K19/00 ,  C07K16/32 ,  C07K16/18 ,  C07K16/28

    Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

    BINDING AGENT
    26.
    发明申请
    BINDING AGENT 审中-公开
    绑定代理

    公开(公告)号：US20160194410A1

    公开(公告)日：2016-07-07

    申请号：US15079897

    申请日：2016-03-24

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

    IPC: C07K19/00

    CPC classification number: C07K19/00 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/626 ,  C07K2317/92 ,  C07K2317/94

    Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

    Abstract translation: 式Aa'的结合剂：aSb：b'-B：X（n），其中A和B是一价结合剂，a：a以及b：b'是一个结合对，其中a' 并且a不干扰b与b'的结合，反之亦然，S是长度至少为1nm的间隔物：X表示共价或通过结合对结合至至少一个“ ，a，b，b'或S，（n）为整数且至少为1， - 表示共价键，连接体aSb的长度为6〜100nm。 还公开了生产这种结合剂及其某些用途的方法。

Patent Agency Ranking