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    Real-time PCR monitoring apparatus and method
    21.
    发明申请
    Real-time PCR monitoring apparatus and method 有权
    实时PCR监测装置及方法

    公开(公告)号：US20050130183A1

    公开(公告)日：2005-06-16

    申请号：US10890350

    申请日：2004-07-13

    Applicant: Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    Inventor： Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    IPC: C12Q1/68 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  G01N21/03 ,  G01N21/64 ,  C12M1/34

    CPC classification number: G01N21/645 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0627 ,  B01L2300/18 ,  G01N21/0332

    Abstract: Provided are a real-time PCR monitoring apparatus and method. The real-time PCR monitoring apparatus includes a microchip-type PCR tube that has a PCR solution-containing PCR chamber, a micro-heater that applies heat to the PCR chamber of the PCR tube, a detection unit that detects a PCR product signal based on the amount of a PCR product of the PCR solution, a plurality of modules, each of which includes a cooling fan for lowering the inside air temperature and a control unit for adjusting the temperature of the PCR chamber of the PCR tube by controlling the micro-heater and the cooling fan, and receives the PCR tube, the micro-heater, and the detection unit, a base instrument that includes a power supply unit electrically connected to the modules for power supply and a data communication unit electrically connected to the modules for data communication with the control unit of each of the modules, and a display unit that displays data received from the data communication unit, wherein the control unit of each of the modules independently controls at least one of both the detection unit and the temperature of the PCR chamber of the PCR tube received in each of the modules. Therefore, co-amplification of different samples at different temperature conditions can be carried out and monitored in real time.

    Abstract translation: 提供了一种实时PCR监测装置和方法。 实时PCR监视装置包括具有含PCR溶液的PCR室的微芯片型PCR管，向PCR管的PCR室照射热的微加热器，检测基于PCR产物信号的检测单元 关于PCR溶液的PCR产物的量，多个模块，每个模块包括用于降低内部空气温度的冷却风扇和用于通过控制微管来调节PCR管的PCR室的温度的控制单元 加热器和冷却风扇，并且接收PCR管，微加热器和检测单元，基本仪器包括电连接到用于电源的模块的电源单元和与模块电连接的数据通信单元 用于与每个模块的控制单元的数据通信，以及显示单元，显示从数据通信单元接收的数据，其中每个模块的控制单元独立地控制 在每个模块中接收PCR管的PCR室的检测单元和温度中的至少一个。 因此，不同温度条件下不同样品的共扩增可以进行实时监测。

    Real-time PCR monitoring apparatus and method
    23.
    发明授权
    Real-time PCR monitoring apparatus and method 有权
    实时PCR监测装置及方法

    公开(公告)号：US07767439B2

    公开(公告)日：2010-08-03

    申请号：US10890350

    申请日：2004-07-13

    Applicant: Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    Inventor： Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    IPC: C12M1/34 ,  C12M3/00 ,  C12Q1/68 ,  G01N21/25

    CPC classification number: G01N21/645 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0627 ,  B01L2300/18 ,  G01N21/0332

    Abstract: A real time polymerase chain reaction (“PCR”) monitoring apparatus includes, a microchip-type PCR tube that has a PCR solution-containing PCR chamber, a micro-heater, a detection unit detecting a PCR product signal based on the PCR solution, a plurality of modules, each of which includes the abovementioned elements in addition to a cooling fan and a control unit controlling the micro-heater and the cooling fan to adjust the temperature of the PCR chamber, a base instrument that comprises a power supply unit connected to the modules and a data communication unit connected to the control unit of each of the modules, and a display unit displaying data from the data communication unit, wherein the control unit of each of the modules independently controls at least one of both the detection unit and the temperature of the PCR chamber of the PCR tube in each of the modules.

    Abstract translation: 实时聚合酶链式反应（“PCR”）监测装置包括：具有含PCR溶液的PCR室的微芯片型PCR管，微加热器，基于PCR溶液检测PCR产物信号的检测单元， 多个模块，每个模块除了冷却风扇之外还包括上述元件，以及控制单元，其控制微加热器和冷却风扇来调节PCR室的温度;基础仪器，包括连接的电源单元 连接到每个模块的控制单元的数据通信单元和从数据通信单元显示数据的显示单元，其中每个模块的控制单元独立地控制检测单元中的至少一个 以及每个模块中PCR管的PCR室的温度。

    Polymerase chain reaction module, and multiple polymerase chain reaction system including the module
    24.
    发明授权
    Polymerase chain reaction module, and multiple polymerase chain reaction system including the module 有权
    聚合酶链反应模块，以及多个聚合酶链反应系统，包括该模块

    公开(公告)号：US07754452B2

    公开(公告)日：2010-07-13

    申请号：US11377793

    申请日：2006-03-16

    Applicant: Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chin-sung Park ,  Yu-jin Seo

    Inventor： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chin-sung Park ,  Yu-jin Seo

    IPC: C12P19/34 ,  C12M1/36 ,  G01N15/06

    CPC classification number: B01L7/52 ,  B01L3/5027 ,  B01L9/52 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686

    Abstract: Provided are a polymerase chain reaction (PCR) module and a PCR system including the same. The PCR module includes: a detachable PCR chip including a PCR chamber unit in which a PCR solution is accommodated; a heater unit for heating the PCR solution in the PCR chip with a preset temperature; a detecting unit for detecting a PCR signal of the PCR solution; a PCR chip installation unit for mounting/detaching the PCR chip using a one-touch method, in which the heater unit is adhered to the PCR chip with a predetermined pressure when mounting the PCR chip and the heater unit is separated from the PCR chip when detaching the PCR chip; and a housing covering at least the heater unit and the detecting unit so that they are not exposed to the outside.

    Abstract translation: 提供了聚合酶链反应（PCR）模块和包括其的PCR系统。 所述PCR模块包括：可拆卸PCR芯片，其包括其中容纳PCR溶液的PCR室单元; 用于以预设温度加热PCR芯片中的PCR溶液的加热器单元; 用于检测PCR溶液的PCR信号的检测单元; 用于使用一触式方法安装/分离PCR芯片的PCR芯片安装单元，其中当将PCR芯片和加热器单元安装在PCR芯片上时，将加热器单元以预定的压力粘附到PCR芯片上，与PCR芯片分离， 分离PCR芯片; 以及至少覆盖加热器单元和检测单元的壳体，使得它们不暴露于外部。

    Method of purifying nucleic acid using silver nanoparticles
    25.
    发明申请
    Method of purifying nucleic acid using silver nanoparticles 失效
    使用银纳米粒子纯化核酸的方法

    公开(公告)号：US20060240408A1

    公开(公告)日：2006-10-26

    申请号：US11257833

    申请日：2005-10-25

    Applicant: Yoon-kyoung Cho ,  Sook-young Kim ,  Jin-tae Kim ,  Kyu-sang Lee

    Inventor： Yoon-kyoung Cho ,  Sook-young Kim ,  Jin-tae Kim ,  Kyu-sang Lee

    IPC: C12Q1/70 ,  C12Q1/68

    CPC classification number: C12N15/1006 ,  C12Q1/6806 ,  C12Q1/70 ,  Y10S977/924 ,  C12Q2563/155 ,  C12Q2523/308

    Abstract: Provided is a method of purifying a target substance using silver nanoparticles. The method includes: mixing a sample containing molecules having a thiol group with the silver nanoparticles to obtain a complex of the molecules having the thiol group with the silver nanoparticles; and isolating and removing the complex from the mixture. By using the purification method, PCR amplifiable DNAs can be rapidly purified, and thus, the method can be very efficiently applied to lab-on-chip (LOC).

    Abstract translation: 提供了使用银纳米粒子来净化目标物质的方法。 该方法包括：将含有硫醇基的分子的样品与银纳米颗粒混合，得到具有硫醇基的分子与银纳米颗粒的络合物; 并从混合物中分离并除去络合物。 通过使用纯化方法，可以快速纯化PCR扩增的DNA，因此该方法可以非常有效地应用于片上实验（LOC）。

    Optical system for analyzing multi-channel samples and multi-channel sample analyzer employing the same
    27.
    发明申请
    Optical system for analyzing multi-channel samples and multi-channel sample analyzer employing the same 有权
    用于分析多通道样品的光学系统和采用该多通道样品的多通道样品分析仪

    公开(公告)号：US20060066857A1

    公开(公告)日：2006-03-30

    申请号：US11227385

    申请日：2005-09-15

    Applicant: Gyeong-sik Ok ,  Yoon-Kyoung Cho ,  Jin-tae Kim ,  Kwang-wook Oh

    Inventor： Gyeong-sik Ok ,  Yoon-Kyoung Cho ,  Jin-tae Kim ,  Kwang-wook Oh

    IPC: G01N21/25 ,  G01J3/30

    CPC classification number: G01N21/645

    Abstract: Provided are an optical system for analyzing multi-channel samples which uses a mirror rotating at high speeds and an aspherical mirror, and a multi-channel sample analyzer employing the optical system. The optical system for analyzing multi-channel samples, includes a light source unit which emits light traveling along an optical axis; a semi-spheroid aspherical mirror disposed in rotational symmetry about the optical axis; and an inclined mirror which reflects the light exiting the light source unit to the semi-spheroid aspherical mirror, while rotating about the optical axis, wherein an opening is formed in the center of the semi-spheroid aspherical mirror such that the light exiting the light source unit enters the inclined mirror through the semi-spheroid aspherical mirror.

    Abstract translation: 提供了一种用于分析使用高速旋转的反射镜的多通道样品和非球面镜的光学系统，以及采用该光学系统的多通道样本分析仪。 用于分析多通道样品的光学系统包括发射沿着光轴行进的光的光源单元; 围绕光轴旋转对称设置的半球体非球面镜; 以及倾斜镜，其在围绕光轴旋转的同时将离开光源单元的光反射到半球形非球面镜，其中在半球镜非球面镜的中心形成开口，使得离开光的光 源单元通过半球体非球面镜进入倾斜镜。

    Optical detection apparatus for multi-channel multi-color measurement and multi-channel sample analyzer employing the same
    28.
    发明申请
    Optical detection apparatus for multi-channel multi-color measurement and multi-channel sample analyzer employing the same 有权
    用于多通道多色测量的光学检测装置和采用其的多通道样本分析仪

    公开(公告)号：US20060050277A1

    公开(公告)日：2006-03-09

    申请号：US11221055

    申请日：2005-09-07

    Applicant: Gyeong-sik Ok ,  Jin-tae Kim ,  Kwang-wook Oh ,  Sang-hyo Kim

    Inventor： Gyeong-sik Ok ,  Jin-tae Kim ,  Kwang-wook Oh ,  Sang-hyo Kim

    IPC: G01N21/64

    CPC classification number: G01N21/645 ,  G01J3/51 ,  G01N2021/6421 ,  G01N2021/6471

    Abstract: Provided are an optical detection apparatus which can measure multi-channel samples at high speed and various wavelengths using an optical detector and a multi-channel sample analyzer employing the same. The optical detection apparatus includes an optical detector; a filter wheel having at least two color filters connected to each other in the shape of a disk; a plurality of optical channels through which a plurality of beams of light enter the filter wheel; and a mirror unit including a plurality of mirrors for sequentially reflecting the plurality of beams of light transmitted through the filter wheel to the optical detector, wherein the mirror unit rotates together with the filter wheel.

    Abstract translation: 提供了一种光学检测装置，其可以使用光学检测器和使用该多通道样本的多通道样本分析仪来测量高速和各种波长的多通道样本。 光检测装置包括光检测器; 具有至少两个滤色器轮的滤光轮，所述至少两个滤色器以盘的形状彼此连接; 多个光通道，多个光束通过该光通道进入滤光轮; 以及镜单元，其包括多个反射镜，用于将透过滤光轮的多个光束顺序地反射到光学检测器，其中反射镜单元与滤光轮一起旋转。

    Method for quantifying initial concentration of nucleic acid from real-time nucleic acid amplification data
    29.
    发明申请
    Method for quantifying initial concentration of nucleic acid from real-time nucleic acid amplification data 有权

    公开(公告)号：US20060047443A1

    公开(公告)日：2006-03-02

    申请号：US11217694

    申请日：2005-09-01

    Applicant: Kak Namkoong ,  Jin-tae Kim ,  Young-sun Lee ,  Young-a Kim

    Inventor： Kak Namkoong ,  Jin-tae Kim ,  Young-sun Lee ,  Young-a Kim

    IPC: G06F19/00 ,  C12Q1/68

    CPC classification number: C12Q1/6851

    Abstract: Provided is a method for quantifying an initial concentration of a nucleic acid from a real-time nucleic acid amplification data. Nucleic acid (DNA or RNA) extracted from organism or virus is amplified using an enzyme. Then, the initial concentration of the nucleic acid is found by calculating the characteristic amplification cycle number or the characteristic amplification time at which the fluorescence intensity of the nucleic acid subtracted by the background fluorescence intensity of the nucleic acid has half of its maximum value, or the characteristic amplification cycle number or the characteristic amplification time at which the amplification efficiency has the maximum or the minimum value, or the prior-to-amplification fluorescence intensity of the nucleic acid subtracted by the background fluorescence intensity of the nucleic acid. Accordingly, the initial concentration of the nucleic acid can be calculated without differentiation or integration.

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